KEGG   ENZYME: 2.1.1.369
Entry
EC 2.1.1.369                Enzyme                                 
Name
[histone H3]-lysine27 N-methyltransferase;
ATXR5 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:[histone H3]-L-lysine27 N6-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a [histone H3]-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine27
Reaction(KEGG)
(other) R03875
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine27
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6-methyl-L-lysine27
Comment
This entry describes enzymes that methylate the L-lysine-27 residue of histone H3 only once, generating a monomethylated form. This modification influences the binding of chromatin-associated proteins. The methylation of lysine-27 leads to transcriptional repression of the affected target genes. cf. EC 2.1.1.371, [histone H3]-lysine27 N-dimethyltransferase, and EC 2.1.1.356, [histone H3]-lysine27 N-trimethyltransferase.
History
EC 2.1.1.369 created 2020
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K24406  [histone H3]-lysine27 N-methyltransferase
Genes
ATHAT5G09790(ATXR5) AT5G24330(ATXR6)
ALY9309491 9310257
CRB17882998 17884103
CSAT104706745 104708138 104734978 104736453 104769169 104770824
EUSEUTSA_v10004504mg EUTSA_v10013971mg
BRP103847232 103874302
BNA106352000 106414923 106419068 106440400
BOE106305738 106319327
RSZ108815044 108852085
THJ104803335 104819316
CPAP110816170
CIT102609159 102609318
CICCICLE_v10020975mg CICLE_v10025879mg
PVY116122859 116131807
MINC123202344 123212838
TCC18605807 18611813
GRA105788091 105788702
GHI107890788 107913598 107950196 121215518
GAB108471168 108481935
DZI111290586 111293048
EGR104415871 104437619
GMX100775247 100785817 100791762
GSJ114385475 114395530 114410106
PVUPHAVU_008G015700g PHAVU_009G148600g
VRA106758877 106779733
VAR108328313 108330963
VUN114162816 114185055
CCAJ109789135 109812431
APRC113852974 113870133 113870146
MTR11425543 11425658
CAM101507618 101514911
PSAT127079465 127091922
ADU107470399 107495147
AIP107620985 107648474
AHF112715892 112755371 112755526 112784661
LANG109340713 109343411
FVE101303561 101315097
RCN112182755 112189128
PPER18787154
PMUM103333608
PAVI110749561
PDUL117618836
MDM103407840 103443933 103454199
PXB103933959 103943391
ZJU107421822
MNT21395092 21403617
CSV101205046 101221402
CMO103482982 103499650
BHJ120067963 120087712
MCHA111009360 111013416
CMAX111470402 111471537
CMOS111430195 111438342 111459438
CPEP111777127 111785341 111794611 111809026
RCU8259125 8275573
JCU105645164
HBR110648078 110650981 110668037
MESC110621573 110627877 110629362
POP18099012 7464288 7464531 7485065
PEU105124608 105125904 105131195 105139778
PALZ118032130 118033714 118040353 118057108
JRE108990487 108994017
QSU112008849 112038577
QLO115960479 115993965
TWL119986021 120004550
VVI100247284 100250306
VRI117913590 117933458
SLY101244542 101265411
SPEN107003477 107012768
SOT102584749 102592920
SSTN125844389 125859547
CANN107851724 107866114
NTA107765939 107770913 107780267 107784926 107788325
NSY104228166 104233385
NTO104093644 104102104 104109469
NAU109214519 109218226
INI109146583 109183447 109189223
ITR115999973 116014199 116019143
SIND105160321 105178107
OEU111367804 111393831 111405651
EGT105965740 105965750 105971700 105973257
SSPL121747474 121750933 121778600 121780604
HAN110903738 110935904
ECAD122596492 122605726
LSV111888890 111909687
CCAV112499883 112525579
DCR108225469
CSIN114257079 114285345
BVG104888202 104895443
SOE110783040 110791384
CQI110682019 110695182 110725520 110738847
NNU104590330 104594264
MING122062406 122074624 122093516
TSS122652115 122659036 122670125
PSOM113293160
NCOL116247550 116248542
OSA107276232 4324466
DOSAOs01t0965500-01(Os01g0965500) Os02t0122700-00(Os02g0122700)
OBR102712144 102713966
BDI100822033 100834709
ATS109752345 109778069
TDC119270652 119280280 119314458 119326748 119339257 119343748 119343749 119343871 119343872 119366085
TAES123057322 123059561 123066908 123075866 123130185 123133523 123140971
TUA125513734 125546239 125547326
SBI8055044 8077421 8082070
ZMA100857061 103626550
SITA101774352 101783142
SVS117848888 117854501
PVIR120645463 120654492 120673839 120706092 120709343
PHAI112880216 112894284 112903504
PDA103695768 103703153 103714298
EGU105038322 105052055 105054615
MUS103983235 103989048
DCT110100023 110102586 110107042
PEQ110025867
AOF109822666 109824136
ATR18447687
SMOSELMODRAFT_171548
PPP112276717
 » show all
Reference
1  [PMID:19503079]
  Authors
Jacob Y, Feng S, LeBlanc CA, Bernatavichute YV, Stroud H, Cokus S, Johnson LM, Pellegrini M, Jacobsen SE, Michaels SD
  Title
ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing.
  Journal
Nat Struct Mol Biol 16:763-8 (2009)
DOI:10.1038/nsmb.1611
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.369
IUBMB Enzyme Nomenclature: 2.1.1.369
ExPASy - ENZYME nomenclature database: 2.1.1.369
BRENDA, the Enzyme Database: 2.1.1.369

DBGET integrated database retrieval system