KEGG   ENZYME: 2.1.1.376
Entry
EC 2.1.1.376                Enzyme                                 

Name
glycine betaine---corrinoid protein Co-methyltransferase;
mtgB (gene name);
glycine betaine methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
glycine betaine:[Co(I) glycine betaine-specific corrinoid protein] Co-methyltransferase
Reaction(IUBMB)
glycine betaine + a [Co(I) glycine betaine-specific corrinoid protein] = N,N-dimethylglycine + a [methyl-Co(III) glycine betaine-specific corrinoid protein] [RN:R12787]
Reaction(KEGG)
R12787
Substrate
glycine betaine [CPD:C00719];
[Co(I) glycine betaine-specific corrinoid protein]
Product
N,N-dimethylglycine [CPD:C01026];
[methyl-Co(III) glycine betaine-specific corrinoid protein]
Comment
The enzyme, which catalyses the transfer of a methyl group from glycine betaine to a glycine betaine-specific corrinoid protein (MtgC), is involved in methanogenesis from glycine betaine in some methanogenic archaea, and in glycine betaine degradation in some bacteria. Unlike similar enzymes involved in methanogenesis from methylated C1 compounds, this enzyme does not contain the unusual amino acid L-pyrrolysine.
History
EC 2.1.1.376 created 2021
Pathway
ec00260  Glycine, serine and threonine metabolism
ec01100  Metabolic pathways
Orthology
K25220  glycine betaine---corrinoid protein Co-methyltransferase
Genes
CACE: CACET_c34470(mttB)
GFE: Gferi_19940
DSY: DSY3156
DHD: Dhaf_4326
DDH: Desde_3695
TJR: TherJR_2945
DOR: Desor_0412
DMI: Desmer_0448
FWA: DCMF_23125 DCMF_26765
AWO: Awo_c07540(mttB10)
STED: SPTER_06970(mtgB_3)
 » show all
Reference
1  [PMID:25313086]
  Authors
Ticak T, Kountz DJ, Girosky KE, Krzycki JA, Ferguson DJ Jr.
  Title
A nonpyrrolysine member of the widely distributed trimethylamine methyltransferase family is a glycine betaine methyltransferase.
  Journal
Proc Natl Acad Sci U S A 111:E4668-76 (2014)
DOI:10.1073/pnas.1409642111
  Sequence
[dsy:DSY3156]
Reference
2  [PMID:31787957]
  Authors
Creighbaum AJ, Ticak T, Shinde S, Wang X, Ferguson DJ Jr.
  Title
Examination of the Glycine Betaine-Dependent Methylotrophic Methanogenesis Pathway: Insights Into Anaerobic Quaternary Amine Methylotrophy.
  Journal
Front Microbiol 10:2572 (2019)
DOI:10.3389/fmicb.2019.02572
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.376
IUBMB Enzyme Nomenclature: 2.1.1.376
ExPASy - ENZYME nomenclature database: 2.1.1.376
BRENDA, the Enzyme Database: 2.1.1.376

DBGET integrated database retrieval system