KEGG   ENZYME: 2.1.1.377
Entry
EC 2.1.1.377                Enzyme                                 

Name
[methyl-Co(III) glycine betaine-specific corrinoid protein]---coenzyme M methyltransferase;
mtaA (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
methylated glycine betaine-specific corrinoid protein:CoM methyltransferase
Reaction(IUBMB)
a [methyl-Co(III) glycine betaine-specific corrinoid protein] + CoM = methyl-CoM + a [Co(I) glycine betaine-specific corrinoid protein] [RN:R10000]
Reaction(KEGG)
R10000
Substrate
[methyl-Co(III) glycine betaine-specific corrinoid protein];
CoM [CPD:C03576]
Product
methyl-CoM [CPD:C03920];
[Co(I) glycine betaine-specific corrinoid protein]
Comment
The enzyme, which is involved in methanogenesis from glycine betaine, catalyses the transfer of a methyl group bound to the cobalt cofactor of glycine betaine-specific corrinoid protein to coenzyme M, forming the substrate for EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase, which catalyses the final step in methanogenesis. The enzyme from the methanogenic archaeon Methanolobus vulcani B1d can also catalyse the activity of EC 2.1.1.246, [methyl-Co(III) methanol-specific corrinoid protein]---coenzyme M methyltransferase.
History
EC 2.1.1.377 created 2021
Orthology
K14080  [methyl-Co(III) methanol/glycine betaine-specific corrinoid protein]:coenzyme M methyltransferase
Genes
DEO: CAY53_02410
DTI: Desti_0877 Desti_2036 Desti_3217 Desti_5361
DKU: Desku_0050 Desku_0055 Desku_0060
TJR: TherJR_0470 TherJR_0979 TherJR_0982
FWA: DCMF_12445 DCMF_12460
VGU: HYG85_23900
ACAE: HYG86_16410
AMEI: LV469_06415
SRI: SELR_27690(mtbA)
TAER: GT409_09440
MST: Msp_0112(mtaA2) Msp_0182(mtaA4) Msp_0761(mtaA1) Msp_0774(mtaA3)
MSI: Msm_0518
MCUB: MCBB_1152(mtaA)
MAC: MA_0779(cmtM) MA_1615(cmtM) MA_2163(cmtM) MA_3613(cmtM) MA_4379(mtaA) MA_4559(cmtM)
MMA: MM_0176(mtaA) MM_0505 MM_1070(mtaA) MM_1932(mtbA)
MBU: Mbur_0452(mtaA) Mbur_0808 Mbur_1005(mtaA)
MEAR: Mpt1_c01960(mtAA1)
 » show all
Reference
1  [PMID:31787957]
  Authors
Creighbaum AJ, Ticak T, Shinde S, Wang X, Ferguson DJ Jr.
  Title
Examination of the Glycine Betaine-Dependent Methylotrophic Methanogenesis Pathway: Insights Into Anaerobic Quaternary Amine Methylotrophy.
  Journal
Front Microbiol 10:2572 (2019)
DOI:10.3389/fmicb.2019.02572
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.377
IUBMB Enzyme Nomenclature: 2.1.1.377
ExPASy - ENZYME nomenclature database: 2.1.1.377
BRENDA, the Enzyme Database: 2.1.1.377

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