KEGG   ENZYME: 2.1.1.5
Entry
EC 2.1.1.5                  Enzyme                                 
Name
betaine---homocysteine S-methyltransferase;
betaine-homocysteine methyltransferase;
betaine-homocysteine transmethylase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
trimethylammonioacetate:L-homocysteine S-methyltransferase
Reaction(IUBMB)
betaine + L-homocysteine = dimethylglycine + L-methionine [RN:R02821]
Reaction(KEGG)
R02821
Substrate
betaine [CPD:C00719];
L-homocysteine [CPD:C00155]
Product
dimethylglycine [CPD:C01026];
L-methionine [CPD:C00073]
History
EC 2.1.1.5 created 1961
Pathway
ec00260  Glycine, serine and threonine metabolism
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K00544  betaine-homocysteine S-methyltransferase
Genes
HSA635(BHMT)
PTR461786(BHMT)
PPS100985336(BHMT)
GGO101138811(BHMT)
PON100174207(BHMT)
NLE100588814(BHMT)
MCC714363(BHMT)
MCF102117049(BHMT)
MTHB126957590
CSAB103223581(BHMT)
CATY105599167(BHMT)
PANU101022670(BHMT)
TGE112626272(BHMT)
RRO104662970(BHMT)
RBB108528900(BHMT)
TFN117065310(BHMT)
PTEH111544428(BHMT)
CJC100393375(BHMT)
SBQ101049322(BHMT)
CSYR103250081(BHMT)
MMUR105872623(BHMT)
LCAT123648430(BHMT)
OGA100945871(BHMT)
MMU12116(Bhmt)
MCAL110307549(Bhmt)
MPAH110328978(Bhmt)
RNO81508(Bhmt)
MCOC116083552(Bhmt)
MUN110539650
CGE100754488(Bhmt)
MAUA101832592(Bhmt)
PLEU114694686(Bhmt)
MORG121455833(Bhmt)
MFOT126508497
AAMP119810203(Bhmt)
NGI103750287(Bhmt)
HGL101723121(Bhmt)
CPOC100724631(Bhmt)
CCAN109675223(Bhmt)
DORD105985348(Bhmt)
DSP122117199(Bhmt)
NCAR124986895
OCU100339955(BHMT)
OPI101519034
TUP102489167(BHMT)
CFA479171(BHMT)
CLUD112653426(BHMT)
VVP112919588(BHMT)
VLG121489537(BHMT)
AML100465664(BHMT)
UMR103681460(BHMT)
UAH113255170(BHMT)
UAR123791536(BHMT)
ELK111148342
LLV125100501
MPUF101682838
ORO101373012(BHMT)
EJU114217614(BHMT)
ZCA113929554(BHMT)
MLX118017139(BHMT)
NSU110589329(BHMT)
FCA101085179(BHMT)
PYU121014017(BHMT)
PBG122490207
LRUF124504614
PTG102955687(BHMT)
PPAD109274945(BHMT)
AJU106974816(BHMT)
HHV120242011(BHMT)
BTA497025(BHMT)
BOM102286920(BHMT)
BIU109564665(BHMT)
BBUB102394345
CHX102175297
OAS101113853(BHMT)
ODA120852576(BHMT)
CCAD122443008(BHMT)
SSC397371(BHMT)
CFR102523171(BHMT)
CBAI105064349(BHMT)
CDK105084827(BHMT)
VPC102525828(BHMT)
BACU103000437(BHMT)
LVE103081575(BHMT)
OOR101282223(BHMT)
DLE111184957(BHMT)
PCAD102991634
PSIU116750387(BHMT)
ECB100073265
EPZ103548663(BHMT)
EAI106841179(BHMT)
MYB102252728(BHMT)
MYD102775016(BHMT)
MMYO118656687(BHMT)
MLF102425902(BHMT)
MNA107535044
PKL118703445(BHMT)
HAI109381916(BHMT)
DRO112307473(BHMT)
SHON118977292(BHMT)
AJM119035984(BHMT)
PDIC114510404(BHMT)
PHAS123824717(BHMT)
MMF118641671(BHMT)
RFQ117025006(BHMT)
PALE102887754(BHMT)
PGIG120612469(BHMT)
PVP105304644(BHMT)
RAY107497234(BHMT)
MJV108387740(BHMT)
TOD119260224(BHMT)
SARA101541457(BHMT)
LAV100672133(BHMT)
TMU101354749
DNM101442098
MDO100032615(BHMT)
GAS123236818
SHR100927569(BHMT)
PCW110216636
OAA100088080
GGA416371(BHMT)
PCOC116239911
MGP100541641
CJO107305933
NMEL110389382
APLA101802407
ACYG106042084
AFUL116500626
TGU100221623
LSR110470994
SCAN103819545
PMOA120502442
OTC121341255
PRUF121355361
GFR102044419(BHMT)
FAB101813460(BHMT)
PHI102112767
PMAJ107216432
CCAE111941401
CCW104695711
CBRC103622046
ETL114056915
ZAB102071668
ACHL103810908
FPG101910450(BHMT)
FCH102048321
CLV102097034
EGZ104124900
NNI104011959 104017633
PLET104615204
PCRI104037008
ACUN113489762
TALA104357116
PADL103919765
AFOR103899795
ACHC115336616
HALD104311516
CCRI104169315
CSTI104559023
EHS104509696
CMAC104481766
MUI104540707
FGA104077850
GSTE104262804
LDI104348421
MNB103767887
OHA104330961
NNT104411470
DPUB104309462
PGUU104458762
ACAR104518556
AVIT104268516
CVF104285791
AAM106490831 106499347
AROW112967357
NPD112945144
TGT104581206
DNE112987027
SCAM104152993
ASN102378363
AMJ102561209(BHMT)
CPOO109307998
GGN109297738
PSS102445649
CMY102947612
CPIC101937801
TST117878734
CABI116823758
MRV120408209
ACS100558455
PVT110073962(BHMT)
SUND121923668
PBI103049200
PMUR107287879
CTIG120312302
TSR106544491
PGUT117679272
VKO123031562
PMUA114606168
ZVI118076698(BHMT)
GJA107117367
STOW125436280
XLA495275(bhmt.L)
XTR496651(bhmt)
NPR108799975
RTEM120929341
BBUF120992415
BGAR122924738
DRE322228(bhmt)
SRX107717756 107724714(bhmt)
SANH107679462
SGH107574103
CCAR109046108
CAUA113080755 113097702
PPRM120461919(bhmt)
MAMB125252262(bhmt)
IPU108279028(bhmt)
PHYP113535813
SMEO124397867(bhmt)
TFD113646449(bhmt)
AMEX103034807
EEE113573779
TRU101061373 101062063
TNGGSTEN00030962G001
LCO104921205 104921289 104930138 104930139 104936284
NCC104943386 104943387 104948669 104948670 104966862
CGOB115013331 115013368 115013615 115016357
ELY117251874 117251875 117252237 117252925 117252926 117269200
EFO125890425 125890426 125890449 125890450 125906136
PLEP121944080 121944246 121944247 121944389
SLUC116054167 116054168 116056791 116062994(bhmt)
ECRA117945057 117945058 117945219 117959558(bhmt)
ESP116689207 116689257
PFLV114555694 114555876 114555939 114570759
GAT120830956 120830957 120831287 120832005(bhmt)
PPUG119224706 119224707 119225361 119225362 119226903
MSAM119891844 119914971(bhmt)
CUD121509995 121510073 121510074 121510092 121525687(bhmt)
ALAT119018856 119018903 119018904 119019260 119019508 119030143
MZE101464577 101482601 112435685
ONL100704302 100705166 100705436
OAU116315584 116328388 116328389
OLA101157623 101175580
OML112148056 112162826(bhmt)
XMA102218191 102225771 102226035
XCO114149906 114154707 114154708
XHE116724267 116730429 116730431
PRET103470080 103470081 103473309
PFOR103135835 103141748
PLAI106937104 106956825
PMEI106916212 106923054
GAF122819377(bhmt) 122827328 122827332
CVG107092421 107092484 107093785
CTUL119788268(bhmt) 119798561 119798562
GMU124873094(bhmt) 124877131
NFU107374849 107394162
KMR108233717 108233718 108251296(bhmt)
ALIM106513660 106532974
NWH119413898
AOCE111564721 111564722 111570352 111581621 111581625
MCEP124996948(bhmt) 125012487 125012488 125012755 125012756
CSEM103390007 103397629
POV109625962 109637078 109637079 109638087
SSEN122758689(bhmt) 122769031 122769454
HHIP117767260 117768517 117768519 117771585(bhmt)
HSP118098097 118114836 118114895 118114896
LCF108878770 108882050 108882056 108895445(bhmt)
SDU111229230 111237735 111237759 111239026
SLAL111651687 111651689 111660294 111666825
XGL120805803 120806477
HCQ109517690 109527101
BPEC110156680 110156723 110157444 110172084 110172085
MALB109953000 109956508
BSPL114862603 114867454(bhmt)
SASA100194600(bhmt) 106568115
STRU115159735 115203928
OTW112220278(bhmt) 112230819
OMY110509664 110523446(bhmt)
OGO124007416 124049093
ONE115101012 115121040
SALP111961763 111963903
SNH120021263 120025679
CCLU121541555 121582649
ELS105015174
SFM108925116 108925117(bhmt)
PKI111849814(bhmt) 111849880
AANG118213304 118213305(bhmt) 118237452
LOC102689652
PSPA121305143 121313674
ARUT117403613 117974146
LCM102351553(BHMT)
CMK103177766(bhmt)
RTP109930797(bhmt)
BFO118403599 118403625 118403740 118403835 118408941 118409375 118412861 118419165 118419166 118420119 118422786 118423158 118423159
BBEL109462372 109463244 109464847 109467561 109472834 109474178 109474209 109474210 109476287 109481064
CIN100180493 100181849 100182838 113474336
SCLV120326246 120327870 120328505 120328506 120328890
SPU100891161 105438577 105447246 115918144 115918913 115928328 115929946 575553 579857 580174 582813 588895 589758 752628
APLC110974267 110984631 110984637 110984652 110984655 110984668 110984669 110984679 110986934 110987105 110988857 110990180
SKO100371248 100372758 100372908 100374951 100376137 100376292 100376443 100376597 100378429 100378580 100378727 102807376
PVM113817434 113819630
PJA122245301 122247003 122258389 122266441
PCHN125033259 125033278 125035210 125035256
HAME121878891 121878895
PCLA123771683
PTRU123504391 123504392 123504421 123512443
HAZT108678493
EAF111700817 111700974 111708867
LSM121129618
PPOI119090929 119094136 119096867
ISCIscW_ISCW001818
DSV119442634
RSAN119387357 119387358
RMP119188312
CSCU111619880
PTEP107451377
SDM118188532 118195838
LGILOTGIDRAFT_183387 LOTGIDRAFT_217867 LOTGIDRAFT_230320 LOTGIDRAFT_233748
PCAN112572659
HRF124110370 124129484 124129727 124137148 124138282 124138283 124138284 124138305 124140307 124140311 124140312 124146516 124146517 124146524
HRJ124262605 124262606 124262607 124262608 124262609 124269213 124269214 124280593 124289090 124291430 124291446
CRG105318322 105339804
MYI110455538 110456381 110456382 110456384 110456469 110458153 110464929 110464943 110467328
PMAX117326857 117326858 117326859 117327192 117327193 117327194 117327227 117328542 117330294 117331264 117331595
MMER123527072 123528071 123536698 123546866 123546873 123548659 123548660 123550078 123551339 123551340 123551349
OBI106875610 106880067
OSN115222737 115222981 115223003
LAK106156503 106166038 106166449 106167822 106171079 106171080 106171100 106178981 106179201
NVE5519847
EPA110231416 110238130 110238131 110238132 110240957 110240959 110240960 110242935 110246242
ATEN116294619 116295943 116297504 116297506 116297515 116301137
ADF107340042 107342964
AMIL114950037 114953867 114960594 114974172
PDAM113672660 113673312 113674473 113682319 113686957
SPIS111324403 111336507 111338100 111344161
DGT114518175 114533873 114540583
XEN124453110 124455543
HMG100206048
TADTRIADDRAFT_63716 TRIADDRAFT_63717
AQU100638323 100639967 100640174 100640299 105315720
ACANACA1_155280
PSKYA6B44_09920
FPHFphi_0698
FPTBZ13_1329
FPIBF30_905
FPMLA56_1471
FPXKU46_649
FPZLA55_102
FPJLA02_579
FRTF7308_0118
FRFLO80_06845
FHACDV26_01030
FRXF7310_00640
FRCKX01_643 KX01_645
FADCDH04_09075
FMIF0R74_09025 F0R74_09035
FSRKQR59_00590
SPIUSPICUR_03835
SROSBBH56_03220
CSACsal_0065
SUTRL0B52_00870
DRTDret_2255
DALKDSCA_49870
OCDFHY55_16660
THWBMG03_09465
TECAKL02_008645
PUBSAR11_1173(bhmT)
APCHIMB59_00001060 HIMB59_00005120 HIMB59_00005130
APMHIMB5_00004530
BSHILGQ02_01385
OIHOB0691
HHDHBHAL_1691
HMNHM131_17460
HLIHLI_07355
VIRX953_04635
VHLBME96_03820
VIGBKP57_05720
VILCFK37_04880
VNECFK40_05435
VPNA21D_02277
VPTKBP50_17210
LAOAOX59_16950
SJEAAV35_009460
POFGS400_01695
BBEVBBEV_2151(yitJ-1)
BSEBsel_2622
SHVAAT16_06155
PMARB0X71_09835
SPAEE2C16_15420
PSAIC3B54_11833
BRXBH708_15645
BRVCFK39_10470
BRZCFK38_00255
BSAUDWV08_16395
SERJSGUI_2075
BLYA2T55_13075
BLINBLSMQ_2928
BCAUI6G59_17580
DCOSAMEA4475696_1438(metH_1)
ERZER308_05595
KBSEPA93_23460
TTRTter_2133
FSIFlexsi_0945
 » show all
Reference
1  [PMID:14456704]
  Authors
KLEE WA, RICHARDS HH, CANTONI GL.
  Title
The synthesis of methionine by enzymic transmethylation. VII. Existence of two separate homocysteine methylpherases on mammalian liver.
  Journal
Biochim Biophys Acta 54:157-64 (1961)
DOI:10.1016/0006-3002(61)90948-9
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.5
IUBMB Enzyme Nomenclature: 2.1.1.5
ExPASy - ENZYME nomenclature database: 2.1.1.5
BRENDA, the Enzyme Database: 2.1.1.5
CAS: 9029-78-1

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