KEGG   ENZYME: 2.2.1.10
Entry
EC 2.2.1.10                 Enzyme                                 
Name
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase;
ADH synthase;
ADHS;
MJ0400 (gene name)
Class
Transferases;
Transferring aldehyde or ketonic groups;
Transketolases and transaldolases
Sysname
L-aspartate 4-semialdehyde:1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate methylglyoxaltransferase
Reaction(IUBMB)
L-aspartate 4-semialdehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate = 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + 2,3-dioxopropyl phosphate [RN:R08568]
Reaction(KEGG)
R08568
Substrate
L-aspartate 4-semialdehyde [CPD:C00441];
1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [CPD:C16848]
Product
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate;
2,3-dioxopropyl phosphate [CPD:C16849]
Comment
The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase.
History
EC 2.2.1.10 created 2012
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K16306  fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
Genes
KPPA79E_4023
PAKHB0X70_03095
PLUICE143_03080
PTWTUM18999_11980
MANCIV454_17575
DOVDSCO28_33870(fbaA_1)
DMMdnm_078980(aroA')
DEKDSLASN_18980(aroA'_1)
MRMA7982_01287
HTQFRZ44_21680
HADHFRZ61_25400
BMETBMMGA3_07340
MLITKDJ21_015690
PTJJRJ22_24810
CSCIHDCHBGLK_02271(lsrF)
KMEH0A61_00395(griI)
MHEVMHEL_37860
NIEKV110_32290
RKOJWS14_15760 JWS14_20865
RGOKYT97_13020
GOILK459_04835
GMGNWF22_16005
SRWTUE45_01349(lsrF)
PSICJ4E96_11100
AROONQK81_43515
PSUBPelsub_P0311 Pelsub_P1007
MINFMESINF_1405
MJAMJ_0400
MFEMefer_1187
MVUMetvu_1437
MFSMFS40622_1668
MIFMetin_0016
MJHJH146_1314
MESGMLAUSG7_1335(aroA)
MESAMLASG1_0944(aroA)
MIGMetig_0643
MMPMMP0686
MMQMmarC5_0890
MMXMmarC6_0201
MMZMmarC7_1710
MMDGYY_02835
MMAKMMKA1_07380
MMAOMMOS7_07320
MMADMMJJ_02920(griI)
MAEMaeo_0316
MVNMevan_1506
MVOMvol_0365
MOKMetok_1495
METFCFE53_05110
MTHMTH_579
MMGMTBMA_c09600(fbaB)
MWOMWSIV6_0939(aroA')
MTEEMTTB_10050
METCMTCT_0503
METEtca_00548(griI)
METZMETMT2_0849
METKFVF72_08665
MTHMFZP57_04495
METJFZP68_04960
MSTMsp_0091
METBAW729_06715
MRUmru_0997
MSIMsm_0056
MEBAbm4_0656
MMILsm9_1016
MEYETL18_05340
MOLYLM1_0540
MAROMarbSA_04640
METVK4897_00700
MELMetbo_1361
MEWMSWAN_0907
METHMBMB1_1070
MFCBRM9_1272
MFIDSM1535_1956
MCUBMCBB_0939(aroA')
MSUBBK009_02850
METNBK008_10575
METTCIT01_09455
METOCIT02_02135
MEMEHYG87_09830
MFVMfer_0600
MKAMK1409(fbaB)
AFUAF_0108
AFGAFULGI_00001050
APOArcpr_0817
AVEArcve_1168
ASTAsulf_00941
FPLFerp_0600
GACGACE_1261
GAHGAH_01502
MBAMbar_A0753 Mbar_A0920
MBYMSBRM_0075 MSBRM_0291
MBWMSBRW_0078 MSBRW_0247
MBARMSBR2_2087 MSBR2_2305
MBAKMSBR3_2087 MSBR3_2364
MACMA_0439 MA_4591(deoC)
MMAMM_1271 MM_1627
MMAZMmTuc01_1317 MmTuc01_1701
MMJMSMAS_0045 MSMAS_3044
MMACMSMAC_0045 MSMAC_1391
MVCMSVAZ_0309 MSVAZ_3439
MEKMSKOL_0292 MSKOL_3399
MLSMSLAZ_0044 MSLAZ_0176
METMMSMTP_0060 MSMTP_2943
MEFMSWH1_0053 MSWH1_0299
MEQMSWHS_0056 MSWHS_0301
MSJMSSAC_0062 MSSAC_0390
MSZMSSIH_0055 MSSIH_0359
MSWMSSIT_0055 MSSIT_0365
MTHRMSTHT_1780 MSTHT_2145
MTHEMSTHC_1138 MSTHC_1506
MHORMSHOH_0050 MSHOH_3760
MFZAOB57_005170 AOB57_008125
MBUMbur_0917 Mbur_2001
MMETMCMEM_0229 MCMEM_1419
MELOJ7W08_05825 J7W08_11215
MMHMmah_0241 Mmah_0691
MHAZBHR79_02305 BHR79_10150
MEVMetev_1692 Metev_1714
MZHMzhil_0254 Mzhil_0268
MPYMpsy_1418 Mpsy_1446
MZIHWN40_01580 HWN40_01705
MHZMetho_0254 Metho_0268
MTPMthe_0532 Mthe_0617
MCJMCON_1478 MCON_3321
MHIMhar_1906 Mhar_2111
MHUMhun_1035 Mhun_1036
MRTJKHC33_11765 KHC33_11770
MLAMlab_0600 Mlab_1654
MEMMemar_1302 Memar_1303
MBGBN140_2035(fbaA1) BN140_2036(fbaA3)
MEMAMMAB1_2640 MMAB1_2641
MCHKMchiMG62_14880 MchiMG62_14890
MSUMOH143_00745 OH143_00750
MPIMpet_2705 Mpet_2706
MENDL6E24_08060 L6E24_08065
MBNMboo_1557 Mboo_1558
MFOMetfor_1589 Metfor_1590
MPLMpal_2610 Mpal_2611
MPDMCP_1367 MCP_1669
MEZMtc_1383(aroF) Mtc_1667
RCIRRC153(aroF)
HALVNG_0309C
HSLOE_1472F(fba2)
HDLHALDL1_05725
HHBHhub_1454
HAGSJT689_02635
HABOJRZ79_01140
HNOLT974_02305
HLULT972_11245
HANRLJ422_01350
HJEHacjB3_14310
HALHHTSR_1439(fba2)
HHSRHSR6_1511(fba2)
HSUHLASF_0623(fba1)
HSFHLASA_0619(fba1)
SALRFQU85_02205
HALREFA46_006155
HAADMW046_10360
HALXM0R89_11070
HAXZM0R88_11525
SALIL593_00075
SAIMK0C01_01385
HARAAArcS_2621
HMArrnAC1881(deoC2)
HHIHAH_2396(fbaB2)
HHNHISP_12200
HABSG26_04510
HTABVU17_11665
HALJG9465_07475
HSINKDQ40_01440
NPHNP_3160A(fba2)
NMONmlp_1197(fba2)
NHOHWV23_11585
NSALHWV07_13660
HUTHuta_1178
HTIHTIA_1098
HALAHrd1104_09430
HMUHmuk_3036
HALZE5139_02445
HALLLC1Hm_2379
HAZPGBQ70_02445
HALIBV210_04645
HSNDV733_05035
HDSHSR122_0656
HRRHZS55_09305
HPELHZS54_13385
HLTI7X12_04925
HARCHARCEL1_00665
HDOMUK72_03645
SSAIN0B31_02060
HWAHQ_1156A(fba2)
HWCHqrw_1193(fba2)
HVOHVO_0790(fba2)
HMEHFX_0749(fbaB)
HGIABY42_03765
HALEG3A49_03975
HLSKU306_08485
HBOHbor_24270
HAQDU484_08625
HAJDU500_08665
HAERDU502_05965
HRAEI982_07830
HLMDV707_12100
HALMFCF25_10565
HLAHlac_1274
HALPDOS48_06125
HALBEKH57_03855
HEZZEO776_07625
HALQHrr1229_015385
HSSJ7656_08775
HSAIHPS36_14190
HAZZKI388_05335
SRUBC2R22_04735
HAEhalTADL_0575
HALNB4589_008625
HALGHUG10_01095
HALUHUG12_16500
HMPK6T50_14120
HREK6T36_14065
HRMK6T25_02715
HACBHbl1158_05910
HDFAArcSl_0487
HAHHalar_3168
HTUHtur_0853
HDABB347_01155
HSALJMJ58_04710
HLOJ0X27_10770
HAKZJ0X25_11090
NMGNmag_2815
HXAHalxa_4013
NATNJ7G_4134
NPENatpe_3297
NVRFEJ81_15780
NPLFGF80_14890
NAYHYG81_12485
HALYHYG82_17225
HJTDVR14_06585
NGENatgr_0761
HRUHalru_2303
NOUNatoc_0637
HLRHALLA_07800
HLCCHINAEXTREME00240
NAJB1756_17155
NAGAArcMg_1455
NANAArc1_2141
NBGDV706_03245
NASGCU68_10270
SAWLNGM29_18115
MELUMTLP_01120
MEAMMU439_07195
TARTALC_00560 TALC_00670
MAXMMALV_05100
MERMMINT_14400
MEARMpt1_c09850(aroA'1) Mpt1_c10430(aroA'2)
MEUZKRP56_03645
MARCAR505_0508
SACDHS1genome_2052
THBN186_00460
TCBTCARB_0208 TCARB_1172
THFMA03_02210 MA03_05420
THELIG193_03385
NMRNmar_0553
NIRNSED_02805
NKRNKOR_02865
NIDNPIRD3C_1721(aroA)
NINNADRNF5_1625(aroA)
NIWNisw_02100
NCLC5F47_02845
NOXC5F49_03025
NUEC5F50_04220
NIPNsoK4_05575
NCTNMSP_1118(aroA'_2)
NICDSQ20_03075
CSYCENSYa_0200
NGANgar_c16210(aroGFH)
NVNNVIE_005850(aroGFH)
NEVNTE_01960
TAANMY3_02544(griI)
NFNNFRAN_0128(aroA)
NCVNCAV_0390(aroGFH)
CSUCSUB_C0867 CSUB_C0895
NBVT478_0480
TAHSU86_003320
NIUDSQ19_02830
NDVNDEV_0554(aroA)
CCAINAS2_0559
BARBAOA66_0830(aroA')
LOKILokiarch_06380(aroA'_1) Lokiarch_41970(aroA'_2)
 » show all
Reference
1  [PMID:15182204]
  Authors
White RH
  Title
L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii.
  Journal
Biochemistry 43:7618-27 (2004)
DOI:10.1021/bi0495127
  Sequence
[mja:MJ_0400]
Reference
2  [PMID:18318840]
  Authors
Samland AK, Wang M, Sprenger GA
  Title
MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity.
  Journal
FEMS Microbiol Lett 281:36-41 (2008)
DOI:10.1111/j.1574-6968.2008.01079.x
  Sequence
[mja:MJ_0400]
Reference
3  [PMID:17713928]
  Authors
Morar M, White RH, Ealick SE.
  Title
Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids.
  Journal
Biochemistry 46:10562-71 (2007)
DOI:10.1021/bi700934v
  Sequence
[mja:MJ_0400]
Other DBs
ExplorEnz - The Enzyme Database: 2.2.1.10
IUBMB Enzyme Nomenclature: 2.2.1.10
ExPASy - ENZYME nomenclature database: 2.2.1.10
BRENDA, the Enzyme Database: 2.2.1.10

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