KEGG   ENZYME: 2.3.1.101
Entry
EC 2.3.1.101                Enzyme                                 
Name
formylmethanofuran---tetrahydromethanopterin N-formyltransferase;
formylmethanofuran-tetrahydromethanopterin formyltransferase;
formylmethanofuran:tetrahydromethanopterin formyltransferase;
N-formylmethanofuran(CHO-MFR):tetrahydromethanopterin(H4MPT) formyltransferase;
FTR;
formylmethanofuran:5,6,7,8-tetrahydromethanopterin N5-formyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
formylmethanofuran:5,6,7,8-tetrahydromethanopterin 5-formyltransferase
Reaction(IUBMB)
formylmethanofuran + 5,6,7,8-tetrahydromethanopterin = methanofuran + 5-formyl-5,6,7,8-tetrahydromethanopterin [RN:R03390]
Reaction(KEGG)
R03390
Substrate
formylmethanofuran [CPD:C01001];
5,6,7,8-tetrahydromethanopterin [CPD:C01217]
Product
methanofuran [CPD:C00862];
5-formyl-5,6,7,8-tetrahydromethanopterin [CPD:C01274]
Comment
Methanofuran is a complex 4-substituted furfurylamine and is involved in the formation of methane from CO2 in Methanobacterium thermoautotrophicum.
History
EC 2.3.1.101 created 1989
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00672  formylmethanofuran--tetrahydromethanopterin N-formyltransferase
Genes
MCAMCA2858
METUGNH96_03555(fhcD)
MMTMetme_0668
MDNJT25_013495
MDHAYM39_03060
MKOMKLM6_0653
METLU737_20590(fhcD)
MPADKEF85_01265(fhcD)
MELLIVG45_17720(fhcD)
MAHMEALZ_1269(ffsA)
MBUREQU24_08945(fhcD)
MPSYCEK71_00135(fhcD)
MMAIsS8_3401
MMOBF6R98_03265(fhcD)
MEINmethR_P2636
MOZMoryE10_28940(ffsA)
MISZMishRS11D_09940(ffsA)
MESLKKZ03_06770(fhcD)
MEJQ7A_285(fhcD)
MECQ7C_1963
MPINLGT42_001495(fhcD)
TIGTHII_0586
BLEPAL038_10680(fhcD)
NOCNoc_0023
NHLNhal_0013
NWANwat_0021
NWRE3U44_04045(fhcD)
NTTTAO_0008
TSYTHSYN_31575
NTGNSCAC_0006(ffsA)
SEDSAAY24_01630
COXE0W60_32005(fhcD)
BUGBC1001_3973
BGFBC1003_5429
BYIBYI23_B014210
BUEBRPE67_BCDS01180(ffsA)
BUQAC233_22160
BXEBxe_B2463(fhcD)
BXBDR64_4790(fhcD)
BPHBphy_5933 Bphy_6506
BGEBC1002_3198
BPXBUPH_00557
BCAIK788_0001570 K788_0007403
PSPWBJG93_19520(fhcD)
PARABTO02_23520
PARBCJU94_31065(fhcD)
PHSC2L64_21750(fhcD) C2L64_38180(fhcD)
PTERC2L65_26245(fhcD) C2L65_34175(fhcD)
PGPCUJ91_21370(fhcD)
PCJCUJ87_23550(fhcD)
PTSCUJ90_27940(fhcD)
PGISI6I06_22595(fhcD)
PEWKZJ38_24950(fhcD)
PDIOPDMSB3_0602.1(ffsA)
BUOBRPE64_BCDS01290
VAPVapar_3065
VPDVAPA_1c31300
MPTMpe_A2625
METPC1M51_15015(fhcD)
LCHLcho_3134
RGERGE_40410(fhcD)
AONDEH84_18925(fhcD)
ATERMW290_07045(fhcD)
METRBSY238_3298(fhcD)
MFAMfla_1664
MMBMmol_0859
MEHM301_0910
MEIMsip34_1508
MEPMPQ_1571(ftr)
MBACBN1209_0741(ffsA)
MEUACJ67_06825
MPAUZMTM_11780(ffsA)
SPLBSFPGR_26040(ffsA)
AZAAZKH_p0240(fhcD)
THUAC731_004915
THKCCZ27_13180(fhcD)
DDZDSYM_25630
MCIMesci_4253
MESWA9K65_023585
MESMEJ066_29685(fhcD)
PHTBLM14_23755
RGARGR602_PC01561(ffsA)
XAUXaut_1794
SNOSnov_0757
STARG3545_09745(fhcD)
LNEFZC33_09305(fhcD)
ANCGBB76_00785(fhcD)
APRAG3A50_16530(fhcD)
APOLK9D25_20155(fhcD)
MEAMex_1p1756(fhcD)
MDIMETDI2508(fhcD)
MEXMext_1825
MCHMchl_2160
MPOMpop_1776
MZAB2G69_16785
MRDMrad2831_0524
METM446_5774
MNOMnod_5998
MORMOC_0679(fhcD)
METAY590_08740
MAQUMaq22A_c16440(fhcD)
MPHYMCBMB27_00101
MEEDA075_05675(fhcD)
METDC0214_10495(fhcD)
METXA3862_28330
METSDK389_20625(fhcD)
METIDK427_18415(fhcD)
MMESMMSR116_16660(fhcD)
MTEADK419_10765(fhcD)
MINDmvi_45840(ffsA)
MOGMMB17_20055(fhcD)
MSLMsil_2402
MTUNMTUNDRAET4_2739(ffsA)
MLGCWB41_06010(fhcD)
HDNHden_1609
HDTHYPDE_29918
HMCHYPMC_1887(ffsA)
HNIW911_13340
FILBN1229_v1_0555(fhcD)
FIYBN1229_v1_0557(fhcD)
MCGGL4_1794
METGHT051_10145(fhcD)
MSCBN69_0584
MBRYB1812_16145
MROSEHO51_08980(fhcD)
MHEYH2LOC_018910(fhcD)
MPARF7D14_18745(fhcD)
MTWCQW49_03835(fhcD)
CMETK6K41_25510(fhcD)
PLEOOHA_1_00509(fhcD)
HDIHDIA_2304(fhcD)
AALAIGS74_05810(fhcD)
AALMLUX29_06565(fhcD)
AUBLXB15_01015(fhcD)
GBEGbCGDNIH1_0780
GBHGbCGDNIH2_0780
GBCGbCGDNIH3_0780
GBSGbCGDNIH4_0780
ALIAZOLI_p10692(ffsA1) AZOLI_p10895(ffsA2)
ABSAZOBR_p270089(ffsA)
ABQABAZ39_25435
ABFAMK58_22365
ATIAL072_27050
AZTTSH58p_01170(fhcD)
AZMDM194_17105(fhcD)
AOZHUE56_08950(fhcD)
FWADCMF_03905 DCMF_14865
HASHalsa_0945
RBARB9835(ffsA)
PSLPsta_0715
PIRVN12_16340(fhcD_1) VN12_25910(fhcD_2)
RULUC8_09150(fhcD_1) UC8_33780(fhcD_2)
RMLFF011L_22160(fhcD_1) FF011L_54310(fhcD_2)
MFFMFFC18_20420(fhcD)
ROLCA51_12000(fhcD_1) CA51_13910(fhcD_2)
AHELQ31a_04500(fhcD_1) Q31a_36640(fhcD_2)
LCREPla8534_21150(fhcD)
AAGGETAA8_53250(fhcD)
BVOPan97_37010(fhcD)
RLCK227x_47420(fhcD_1) K227x_49350(fhcD_2)
LPAVPLANPX_0512
AMUCPan181_03870(fhcD)
PNDPla175_42740(fhcD)
AMOBHG15A2_01040(fhcD)
PLMPlim_0767
PEHSpb1_16490(fhcD)
PBSPlabr_2746
PLSVT03_25050(fhcD_1) VT03_26560(fhcD_2)
PLHVT85_05450(fhcD)
FMRFuma_04732(fhcD)
GMRGmarT_39510(fhcD)
GIMF1728_26355(fhcD)
GPNPan110_38360(fhcD)
MRIMal4_35610(fhcD_1) Mal4_53660(fhcD_2)
SDYNMal52_51090(fhcD)
PLONPla110_03360(fhcD_1) Pla110_31860(fhcD_2)
GESVT84_05645(fhcD_1) VT84_15260(fhcD_2)
GOGC1280_03970(fhcD) C1280_18540(fhcD)
GMSSOIL9_37840 SOIL9_85360
TIMGMBLW1_15700 GMBLW1_28450
LRSPX52LOC_00703 PX52LOC_07047(fhcD)
FTJFTUN_4729 FTUN_5703
ULIETAA1_01420(fhcD_1) ETAA1_48410(fhcD_2)
TSPHKIH39_17475(fhcD)
IPAIsop_0523
SACISinac_1239
PBORBSF38_00166(fhcD)
AGVOJF2_59260(fhcD)
AMOAnamo_1138
MOXDAMO_0459(fhcD)
MJAMJ_0318
MFEMefer_1275
MVUMetvu_0497
MFSMFS40622_1090
MIFMetin_0870
MJHJH146_0889
MESGMLAUSG7_1535(ftr)
MESAMLASG1_1139(ftr)
MIGMetig_0697
MMPMMP1609(ftr)
MMQMmarC5_1799
MMXMmarC6_1060
MMZMmarC7_0857
MMDGYY_08900
MMAKMMKA1_18400(ftr)
MMAOMMOS7_17220(ftr)
MMADMMJJ_12270(fhcD)
MAEMaeo_0224
MVNMevan_0919
MVOMvol_1497
MOKMetok_0159
METFCFE53_06700(fhcD)
MTHMTH_1259 MTH_403
MMGMTBMA_c08020(ehaS) MTBMA_c16460(ftr)
MWOMWSIV6_0792(ehaS) MWSIV6_1651(ftr)
MTEEMTTB_01700 MTTB_07390
METCMTCT_0346 MTCT_1150
METEtca_00370(fhcD_1) tca_01215(fhcD_2)
METZMETMT2_0534 METMT2_1264
METKFVF72_00375 FVF72_05280(fhcD)
MTHMFZP57_03785 FZP57_08075(fhcD)
METJFZP68_02705(fhcD) FZP68_08825
MSTMsp_0070(ftr2) Msp_1502(ftr1)
METBAW729_06880 AW729_07855
MRUmru_1393(ftr1) mru_2022(ftr2)
MSIMsm_0308 Msm_1092
MEBAbm4_0936(ftr1) Abm4_1598(ftr2)
MMILsm9_0727(ftr1) sm9_2108(ftr2)
MEYETL18_03515 TL18_09675
MOLYLM1_0892 YLM1_1463
MAROMarbSA_03240 MarbSA_10120
METVK4897_02055 K4897_06005(fhcD)
MELMetbo_0252 Metbo_1272
MEWMSWAN_0958 MSWAN_2195
METHMBMB1_1128(ehaS) MBMB1_1832(ftr)
MFCBRM9_1337(ftr) BRM9_2162(ftr2)
MFIDSM1535_1101(ftr) DSM1535_2022(ehaS)
MCUBMCBB_1014(ehaS) MCBB_2124(ftr)
MSUBBK009_02535 BK009_08310
METNBK008_03985 BK008_10190
METTCIT01_00445 CIT01_04260(fhcD)
METOCIT02_02460 CIT02_08420(fhcD)
MEMEHYG87_01525 HYG87_05445(fhcD)
MFVMfer_0535 Mfer_1096
MKAMK0116(ftr_1) MK0816(ftr_2)
AFUAF_2073 AF_2207
AFGAFULGI_00023420 AFULGI_00024790
APOArcpr_0160
AVEArcve_0336 Arcve_1202
ASTAsulf_00215 Asulf_00752
FPLFerp_0657 Ferp_1323
GACGACE_0426 GACE_2049
GAHGAH_00633 GAH_01298
MBAMbar_A0980
MBYMSBRM_3513
MBWMSBRW_3742
MBARMSBR2_3465
MBAKMSBR3_3472
MACMA_0010(ftr)
MMAMM_1321
MMAZMmTuc01_1368
MMJMSMAS_3341
MMACMSMAC_3365
MVCMSVAZ_3505
MEKMSKOL_3473
MLSMSLAZ_3094
METMMSMTP_3245
MEFMSWH1_3192
MEQMSWHS_3401
MSJMSSAC_4333
MSZMSSIH_3834
MSWMSSIT_3904
MTHRMSTHT_1825
MTHEMSTHC_1461
MHORMSHOH_4088
MFZAOB57_008395(fhcD)
MBUMbur_1728(ftr)
MMETMCMEM_2199
MELOJ7W08_10015(fhcD)
MMHMmah_2027
MHAZBHR79_03500
MEVMetev_1828
MZHMzhil_2022
MPYMpsy_1734
MZIHWN40_01035(fhcD)
MHZMetho_2457
MTPMthe_1643
MCJMCON_1472(fhcD)
MHIMhar_2214
MHUMhun_1808
MRTJKHC33_05365(fhcD)
MLAMlab_0215
MEMMemar_0628
MBGBN140_1723(ftr)
MEMAMMAB1_2217(ftr)
MCHKMchiMG62_07570
MPIMpet_1069 Mpet_2482
MBNMboo_0593 Mboo_0993
MFOMetfor_1973 Metfor_2598
MPLMpal_2244
MPDMCP_1033(ftr)
MEZMtc_1916(ftr)
RCILRC202(ftr)
MELUMTLP_04500(fhcD) MTLP_05130
MEAMMU439_06340
BARCAOA65_1220(ftr_1) AOA65_2064(ftr_2)
BARBAOA66_0598(ftr)
LOKILokiarch_11730(ftr_1) Lokiarch_20800(ftr_2)
PSYTDSAG12_02401(ftr)
 » show all
Reference
1  [PMID:3097011]
  Authors
Donnelly MI, Wolfe RS.
  Title
The role of formylmethanofuran: tetrahydromethanopterin formyltransferase in methanogenesis from carbon dioxide.
  Journal
J Biol Chem 261:16653-9 (1986)
Reference
2
  Authors
Leigh, J.A., Rinehart, K.L. and Wolfe, R.S.
  Title
Structure of methanofuran, the carbon-dioxide reduction factor of Methanobacterium thermoautotrophicum.
  Journal
J Am Chem Soc 106:3636-3640 (1984)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.101
IUBMB Enzyme Nomenclature: 2.3.1.101
ExPASy - ENZYME nomenclature database: 2.3.1.101
UM-BBD (Biocatalysis/Biodegradation Database): 2.3.1.101
BRENDA, the Enzyme Database: 2.3.1.101
CAS: 105669-83-8

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