KEGG   ENZYME: 2.3.1.135
Entry
EC 2.3.1.135                Enzyme                                 
Name
phosphatidylcholine---retinol O-acyltransferase;
lecithin---retinol acyltransferase;
phosphatidylcholine:retinol-(cellular-retinol-binding-protein) O-acyltransferase;
lecithin:retinol acyltransferase;
lecithin-retinol acyltransferase;
retinyl ester synthase;
LRAT;
lecithin retinol acyl transferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
phosphatidylcholine:retinol---[cellular-retinol-binding-protein] O-acyltransferase
Reaction(IUBMB)
phosphatidylcholine + retinol---[cellular-retinol-binding-protein] = 2-acylglycerophosphocholine + retinyl-ester---[cellular-retinol-binding-protein] [RN:R04514]
Reaction(KEGG)
R04514 > R08387 R08389
Substrate
phosphatidylcholine [CPD:C00157];
retinol---[cellular-retinol-binding-protein]
Product
2-acylglycerophosphocholine;
retinyl-ester---[cellular-retinol-binding-protein]
Comment
A key enzyme in retinoid metabolism, catalysing the transfer of an acyl group from the sn-1 position of phosphatidylcholine to retinol, forming retinyl esters which are then stored. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein, but has higher affinity for the bound form. Can also esterify 11-cis-retinol.
History
EC 2.3.1.135 created 1992, modified 2011
Pathway
ec00830  Retinol metabolism
ec01100  Metabolic pathways
Orthology
K00678  phosphatidylcholine-retinol O-acyltransferase
Genes
HSA9227(LRAT)
PTR471328(LRAT)
PPS100990532(LRAT)
GGO101135395(LRAT)
PON100432491(LRAT)
NLE100579669(LRAT)
MCC698871(LRAT)
MCF102123283(LRAT)
CSAB103236423(LRAT)
CATY105580675(LRAT)
PANU101020435(LRAT)
TGE112625128(LRAT)
RRO104657120(LRAT)
RBB108529031(LRAT)
TFN117086058(LRAT)
PTEH111552243(LRAT)
CJC100414604(LRAT)
SBQ101042985(LRAT)
CSYR103277419(LRAT)
MMUR105881778(LRAT)
LCAT123637689(LRAT)
OGA100966134(LRAT)
MMU79235(Lrat)
MCAL110291651(Lrat)
MPAH110319715(Lrat)
RNO64047(Lrat)
MCOC116093034(Lrat)
MUN110547199(Lrat)
CGE100769559(Lrat)
MAUA101832465(Lrat)
PLEU114682940(Lrat)
MORG121452675(Lrat)
AAMP119826390(Lrat)
NGI103751034(Lrat)
HGL101722664(Lrat)
CPOC100729755(Lrat)
CCAN109677811(Lrat)
DORD105995864(Lrat)
DSP122127237(Lrat)
NCAR124994876
OCU100354707(LRAT)
OPI101527023(LRAT)
TUP102476648(LRAT)
CFA482660(LRAT)
CLUD112654537(LRAT)
VVP112933438(LRAT)
VLG121481294(LRAT)
AML100482038(LRAT)
UMR103658037(LRAT)
UAH113255775(LRAT)
UAR123793200(LRAT)
ELK111157810
LLV125093118
MPUF101686629(LRAT)
ORO101384293(LRAT)
EJU114210180(LRAT)
ZCA113924803(LRAT)
MLX118022220(LRAT)
FCA101092432(LRAT)
PYU121028260(LRAT)
PBG122475197(LRAT)
PTG102965792(LRAT)
PPAD109262496(LRAT)
AJU106982446(LRAT)
HHV120221623(LRAT)
BTA281285(LRAT)
BOM102264381(LRAT)
BIU109571479(LRAT)
BBUB102389350(LRAT)
CHX102183532(LRAT)
OAS101104976(LRAT) 114108650
ODA120871443(LRAT)
CCAD122451286(LRAT)
SSC100513994(LRAT)
CFR102520637(LRAT)
CBAI105079734(LRAT)
CDK105089285(LRAT)
VPC102527160(LRAT)
BACU103000637(LRAT)
LVE103091446(LRAT)
OOR101278519(LRAT)
DLE111187711(LRAT)
PCAD102978609(LRAT)
PSIU116754708(LRAT)
ECB100069704(LRAT)
EPZ103553820(LRAT)
EAI106832954(LRAT)
MYB102261540(LRAT)
MYD102758952(LRAT)
MMYO118659260(LRAT)
MLF102427893(LRAT)
MNA107525620(LRAT)
PKL118711148(LRAT)
HAI109382001(LRAT)
DRO112312204(LRAT)
SHON118995378(LRAT)
AJM119065916(LRAT)
PDIC114504003(LRAT)
PHAS123813659(LRAT)
MMF118615893(LRAT)
RFQ117038411(LRAT)
PALE102888347(LRAT)
PGIG120613425(LRAT)
PVP105292190(LRAT)
RAY107507545(LRAT)
MJV108408878(LRAT)
TOD119234844(LRAT)
SARA101541430(LRAT)
LAV100667142(LRAT)
TMU101341410
DNM101439300(LRAT)
MDO100017333(LRAT)
GAS123251508(LRAT)
SHR100931949(LRAT)
PCW110213622(LRAT)
OAA100080154(LRAT)
GGA422403(LRAT)
PCOC116243136(LRAT)
MGP104910504(LRAT)
CJO107313043(LRAT)
NMEL110398861(LRAT)
APLA101795343(LRAT)
AFUL116489174(LRAT)
TGU100224470(LRAT)
LSR110470513(LRAT)
SCAN103825960(LRAT)
PMOA120498061(LRAT)
OTC121331385(LRAT)
PRUF121360299(LRAT)
FAB101813271(LRAT)
PHI102105659(LRAT)
PMAJ107202673(LRAT)
CCW120409867(LRAT)
CBRC103617430(LRAT)
ETL114066333(LRAT)
ZAB102061781(LRAT)
FPG106112170(LRAT)
FCH102048889(LRAT)
CLV102087929(LRAT)
NNI104021236(LRAT)
TALA116965187(LRAT)
ACHC115343577(LRAT)
AAM106492096(LRAT)
NPD112949245(LRAT)
ASN102378402(LRAT)
AMJ102557704(LRAT)
CPOO109309692(LRAT)
GGN109300838(LRAT)
PSS102463592(LRAT)
CMY102938217(LRAT)
CPIC101949409(LRAT)
TST117877603(LRAT)
CABI116824081(LRAT)
MRV120406935(LRAT)
ACS100552136(lrat)
PVT110072772(LRAT)
SUND121931889(LRAT)
PBI103061458(LRAT)
PMUR107287990(LRAT)
TSR106550018(LRAT)
PGUT117674727(LRAT)
VKO123023801(LRAT)
PMUA114604741(LRAT) 114604742
ZVI118083689(LRAT)
GJA107109450(LRAT)
STOW125440301(LRAT)
XLA108699284 108706650 443823(lrat.L)
XTR394746(lrat)
NPR108788202 108788203(LRAT)
RTEM120920155 120920168
BBUF120990059 120990060
BGAR122941866 122942060
DRE553239(lrata) 553501(lratb) 556575(lratb.2) 566123(si:dkey-30k22.5)
SRX107714135 107714151 107714634 107757590 107758847 107758870
SANH107665938 107665945 107692632 107692634 107695853 107695864 107700276
SGH107564312 107564324 107572196 107572197 107590728 107590773 107598257(lrat)
CCAR109053612 109085059 109107035 109107036
CAUA113044499 113044500 113044789 113100968 113107983 113109892
PPRM120462844 120462893(lratb.2) 120487494(si:dkey-30k22.5) 120494742(lrata)
MAMB125271444(si:dkey-30k22.5) 125272421(lrata) 125272763 125272764(lratb.2)
IPU108258976(lratb.2) 108258977 108261015(lrata)
PHYP113524574 113524578
SMEO124378050 124378533(lratb.2) 124381673(lrata)
TFD113634831(lrata) 113652968 113652969(lratb.2)
AMEX103023349 103023667 103037297(lrat)
EEE113574913 113583875
TRU101076520 101076751(lrat)
TNGGSTEN00000329G001 GSTEN00000330G001 GSTEN00013684G001 GSTEN00013685G001
LCO104917826 104917836(lrat) 109137012
NCC104949063 104966386(lrat)
CGOB115012347(lrat) 115012675
ELY117245752 117255851(si:dkey-30k22.5) 117255891(lrata) 117272810
EFO125883429 125884286 125886067(lrata) 125886068(si:dkey-30k22.5)
PLEP121941462(si:dkey-30k22.5) 121942700(lrata) 121962221(lratb.1) 121962534(lratb.2) 121963621
SLUC116051743 116052082 116052147
ECRA117941032 117954676
PFLV114545934 114546175 114557758 114562873
GAT120821314 120825187(lrata)
PPUG119218293(lrata) 119223041
MSAM119884110 119884111 119898789(lrata) 119898790(si:dkey-30k22.5) 119911806
CUD121504089 121504935(lratb.2) 121509047(lrata) 121509055(si:dkey-30k22.5)
ALAT119022749(lrata) 119023300 119026604 119027440(lratb.2)
MZE101468959 101469269 101485910 101486513
ONL100695577 100704704 100712580 109194412
OAU116312398(si:dkey-30k22.5) 116312412(lrata) 116326521(lratb.2) 116326574
OLA101158747 101162811 101172026 105356312
OML112137530(lrata) 112137644(si:dkey-30k22.5) 112156356 112156374(lratb.2)
XMA102217705 102223500 102225752
XCO114144069 114156863 114158010
XHE116719317 116732228 116733392
PRET103461909(lrat) 103480983 103480984
PFOR103149051 103149052 103156491
PLAI106949946 106949947 106953329(lrat)
PMEI106904117(lrat) 106910222 106910223
GAF122821042 122821063(lratb.2) 122830425
CVG107082284 107082299 107094918
CTUL119797130 119797138 119797181(si:dkey-30k22.5)
GMU124867780 124880260 124881075
NFU107396750 107396751
KMR108228851(lrata) 108248302 108248305(lratb.2) 108249452(si:dkey-30k22.5)
ALIM106519616(lrat) 106529231 106529233
NWH119417279 119419524 119422878(lrata)
AOCE111575111 111575125 111582913 111582918
MCEP125000078(lrata) 125000083(si:dkey-30k22.5) 125009964(lratb.2) 125010096
CSEM103383311 103389580(lrat)
POV109634737 109634762 109641900 109641901
SSEN122766322 122771684(si:dkey-30k22.5) 122771685(lrata)
HHIP117751915 117760283(lrata) 117762673(si:dkey-30k22.5)
HSP118102938 118115361(lrata) 118115874(si:dkey-30k22.5)
LCF108874763 108874769 108886657 108901657
SDU111216694 111216699 111237528 111237529
SLAL111649474 111649477 111663255 111663312(lrat)
XGL120797300 120797305(lratb.2) 120800556(si:dkey-30k22.5) 120800617(lrata)
HCQ109506952 109511520 109511521
BPEC110157705 110159451 110166097 110166259(lrat)
MALB109968215 109972941
BSPL114843882 114850357 114850374 114860244(lrata) 114862030(si:dkey-30k22.5) 121202087
SASA100195897(lrat) 106578168 106578182(LRAT) 106602563 106609867
OTW112237687 112241754(lratb.1) 112262267 112262268 121847620
OMY110497453 110497454 110500951 110532986 110534421 118965977
OGO124002061 124002231 124008728 124008746 124013001 124028892
ONE115126778 115127009 115137336 115146554 115146555
SALP111958377 111958474 111971325 111971625
SNH120030189 120030694(lratb.1) 120034718 120035021 120049187 120051975 120052209
CCLU121558040 121558042 121558804 121558808 121572686
ELS105022864 105022865(lrat) 105030634 105030635
SFM108924362 108924447 108930780
PKI111833401 111837433 111837434
AANG118226830(lrata) 118228340(si:dkey-30k22.5) 118231467 118232461(lratb.2)
LOC102689719 102698541
PSPA121295181 121300150
ARUT117409620 117420592 117420657
LCM102361576(LRAT)
CMK103189387
RTP109935078(lrat)
BFO118431595
FCD110849237
PCAN112574694 112576349
BGT106052893 106077869
CRG105325359 105325365 109619122 117681093 117692902
MMER123524717 123562300
ATEN116308361 116308362
 » show all
Reference
1  [PMID:3410848]
  Authors
MacDonald PN, Ong DE.
  Title
Evidence for a lecithin-retinol acyltransferase activity in the rat small intestine.
  Journal
J Biol Chem 263:12478-82 (1988)
  Sequence
[rno:64047]
Reference
2  [PMID:2722792]
  Authors
Saari JC, Bredberg DL.
  Title
Lecithin:retinol acyltransferase in retinal pigment epithelial microsomes.
  Journal
J Biol Chem 264:8636-40 (1989)
  Sequence
[bta:281285]
Reference
3  [PMID:8489497]
  Authors
Saari JC, Bredberg DL, Farrell DF
  Title
Retinol esterification in bovine retinal pigment epithelium: reversibility of lecithin:retinol acyltransferase.
  Journal
Biochem J 291 ( Pt 3):697-700 (1993)
DOI:10.1042/bj2910697
Reference
4  [PMID:9767084]
  Authors
Mata NL, Tsin AT
  Title
Distribution of 11-cis LRAT, 11-cis RD and 11-cis REH in bovine retinal pigment epithelium membranes.
  Journal
Biochim Biophys Acta 1394:16-22 (1998)
DOI:10.1016/S0005-2760(98)00078-2
Reference
5  [PMID:9920938]
  Authors
Ruiz A, Winston A, Lim YH, Gilbert BA, Rando RR, Bok D
  Title
Molecular and biochemical characterization of lecithin retinol acyltransferase.
  Journal
J Biol Chem 274:3834-41 (1999)
DOI:10.1074/jbc.274.6.3834
  Sequence
[hsa:9227] [bta:281285]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.135
IUBMB Enzyme Nomenclature: 2.3.1.135
ExPASy - ENZYME nomenclature database: 2.3.1.135
BRENDA, the Enzyme Database: 2.3.1.135
CAS: 117444-03-8

DBGET integrated database retrieval system