KEGG   ENZYME: 2.3.1.184
Entry
EC 2.3.1.184                Enzyme                                 
Name
acyl-homoserine-lactone synthase;
acyl-homoserine lactone synthase;
acyl homoserine lactone synthase;
acyl-homoserinelactone synthase;
acylhomoserine lactone synthase;
AHL synthase;
AHS;
AHSL synthase;
AhyI;
AinS;
AinS protein;
autoinducer synthase;
autoinducer synthesis protein rhlI;
EsaI;
ExpISCC1;
ExpISCC3065;
LasI;
LasR;
LuxI;
LuxI protein;
LuxM;
N-acyl homoserine lactone synthase;
RhlI;
YspI ;
acyl-[acyl carrier protein]:S-adenosyl-L-methionine acyltranserase (lactone-forming, methylthioadenosine-releasing)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acyl-[acyl-carrier protein]:S-adenosyl-L-methionine acyltranserase (lactone-forming, methylthioadenosine-releasing)
Reaction(IUBMB)
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine = an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone [RN:R08940]
Reaction(KEGG)
R08940 > R08939
Substrate
acyl-[acyl-carrier protein] [CPD:C00173];
S-adenosyl-L-methionine [CPD:C00019]
Product
[acyl-carrier protein] [CPD:C00229];
S-methyl-5'-thioadenosine [CPD:C00170];
N-acyl-L-homoserine lactone [CPD:C18049]
Comment
Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signalling which, in turn, initiates the expression of particular virulence genes [5]. N-(3-Oxohexanoyl)-[acyl-carrier protein] and hexanoyl-[acyl-carrier protein] are the best substrates [1]. The fatty-acyl substrate is derived from fatty-acid biosynthesis through acyl-[acyl-carrier protein] rather than from fatty-acid degradation through acyl-CoA [1]. S-Adenosyl-L-methionine cannot be replaced by methionine, S-adenosylhomocysteine, homoserine or homoserine lactone [1].
History
EC 2.3.1.184 created 2007
Pathway
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K13060  acyl homoserine lactone synthase
K13061  acyl homoserine lactone synthase
K13062  acyl homoserine lactone synthase
K20248  acyl homoserine lactone synthase
K20249  acyl homoserine lactone synthase
K20250  acyl homoserine lactone synthase
K22954  acyl homoserine lactone synthase
K22955  acyl homoserine lactone synthase
K22956  acyl homoserine lactone synthase
K22957  acyl homoserine lactone synthase
K22968  acyl homoserine lactone synthase
Genes
EAUDI57_07705
ERNBFV67_10675
ECLSLI67_014625
ENXNI40_011245
LNICWR52_01005
KMIVW41_14330
CROROD_29521(croI)
CSEDJY391_03975
CAMAF384_15575
CAFAL524_07355
CFARCI104_20670
CIRC2U53_14295
CTELGBC03_09160
HDEHDEF_0873(expI)
CNTJT31_20800
CEMLH23_20280
CENLH86_18890
CLAPNCTC11466_01581(esaI)
ESCEntcl_2036
KLEAO703_12010
SYMK6K13_21040
PSTSE05_37800
YPEYPO0984(yspI) YPO2456(ypeI)
YPKy1733(ypeI) y3374(ytbI)
YPHYPC_0811(yspI) YPC_1671(ypeI)
YPAYPA_0280 YPA_1954
YPNYPN_2052 YPN_3182
YPMYP_2275(ypeI) YP_3455(yspI)
YPPYPDSF_0534 YPDSF_1871
YPGYpAngola_A0183(ytbI) YpAngola_A1716(ypsI)
YPZYPZ3_0754(ytbI) YPZ3_2106
YPTA1122_00060 A1122_13865
YPDYPD4_0709(ytbI) YPD4_2147
YPXYPD8_0709(ytbI) YPD8_2240
YPWCH59_4288(esaI) CH59_878(esaI)
YPJCH55_152(esaI) CH55_3555(esaI)
YPVBZ15_1072(esaI) BZ15_2588(esaI)
YPLCH46_2652(esaI) CH46_4160(esaI)
YPSYPTB2499(ypsI) YPTB3258(yspI)
YPOBZ17_3351(esaI) BZ17_4138(esaI)
YPIYpsIP31758_0719(ytbI) YpsIP31758_1546(ypsI)
YPYYPK_0792 YPK_1656
YPBYPTS_2592 YPTS_3394
YPQDJ40_3178(esaI) DJ40_4043(esaI)
YPUBZ21_1795(esaI) BZ21_2539(esaI)
YPRBZ20_2855(esaI) BZ20_3710(esaI)
YPCBZ23_2080(esaI) BZ23_2820(esaI)
YPFBZ19_1861(esaI) BZ19_2665(esaI)
YENYE1600(yenI)
YEPYE105_C2520
YEYY11_04891
YELLC20_03387 LC20_06247 LC20_06258
YEWCH47_1045(esaI)
YETCH48_48(esaI)
YEFFORC2_1632
YEEYE5303_14421(yenI)
YSIBF17_03180
YALAT01_918(esaI)
YINCH53_2504(esaI) CH53_45(esaI)
YROCH64_970(esaI)
YRUBD65_91(esaI)
YRBUGYR_00450
YAKACZ76_16870
YMADA391_13715 DA391_13770
YHID5F51_06330
YCAF0T03_08845
YMOHRD69_02710 HRD69_17490
SMARSM39_4838
SPESpro_0067
SRLSOD_c00740(esaI)
SRYM621_00125 M621_00360
SPLYQ5A_002380(esaI)
SERSSERRSCBI_00315
SFWWN53_11230
SFGAV650_06450
SERASer39006_020365
SERQCWC46_20370
SQUE4343_15935
SFJSAMEA4384070_0033(esaI_1) SAMEA4384070_0529(esaI_2)
SOFNCTC11214_01456(lasI) NCTC11214_01474(esaI)
SURIJ0X03_23660
SENPKHA73_22915
SFOZ042_04915 Z042_25655
RAQRahaq2_2658
ROXBV494_22275
RVCJ9880_21770
GQUAWC35_07385 AWC35_11230
FSMCCS41_14095
EAMEGXP68_13300
RBADH2866_07680
ECAECA0105(expI)
PATREV46_00540
PATOGZ59_01100
PCTPC1_4148
PCCPCC21_000940
PCVBCS7_00320
PWAPecwa_4429
PPARA8F97_19305
PECW5S_4607
PWSA7983_08415
PPOABJK05_17055
PBRAB5S52_21425
PPUJE2566_21030
PARII2D83_21480
PAQUDMB82_0019880
PVZOA04_01160(expI)
PPAVLOZ86_01285
DDDDda3937_03219(expI)
DZEDd1591_0101
DDCDd586_0112
DZCW909_00485
DSOA4U42_09675
CEDLH89_11670
DFNCVE23_00610
DDQDDI_4421
DAQDAQ1742_04313
DICDpoa569_003808
BRBEH207_11220
BNGEH206_08210
SGLSG0284
SODSant_3588(ypeI)
PESSOPEG_0642(ypeI)
EAMEAMY_1412(expI)
EAYEAM_1401
ETAETA_09530(expI) ETA_20810(phzI)
EPYEpC_22120(phzI)
EPREPYR_02385(expI)
EBIEbC_11190 EbC_15720(phzI)
ERJEJP617_25100(phzI)
EGEEM595_1357 EM595_p0105(esaI)
EPECI789_10715
ERWIGN242_13240
ETPLU633_05720 LU633_15180
PAMPANA_1417 PANA_1955(eanI)
PLFPANA5342_2226(eanI) PANA5342_2858(phzI)
PAJPAJ_0740 PAJ_1287(eanI)
PAQPAGR_g2152 PAGR_g2730
PVAPvag_0811(phzI) Pvag_pPag30142(pagI)
PAGGAL522_00495 AL522_11335
PAOPat9b_1402
KLNLH22_15190
PANTPSNIH1_11580
PANPPSNIH2_01590 PSNIH2_10680
PAGCBEE12_09680 BEE12_13825
PSTWDSJ_10310 DSJ_13985
PALHB1H58_10825 B1H58_20100
PANSFCN45_07230
PEYEE896_12530
PDISD8B20_06625
PERLAC65_05825
PGZC2E15_07990 C2E15_17485
PCDC2E16_07895 C2E16_17485
MINTC7M51_00820(anoI) C7M51_02681(esaI)
MTHIC7M52_00173(esaI) C7M52_01936(anoI)
ANSArsFIN_07920(esaI_1) ArsFIN_37250(esaI_2)
AETLDL57_00620
EICNT01EI_2879
ETRETAE_2594
ETDETAF_2335(edwI)
ETEETEE_0692
ETCETAC_12470
EDWQY76_07550
EDLAAZ33_13715
EHOA9798_04340
HAVAT03_12360
HPARAL518_17100
OPODSM2777_15325
LPVHYN51_02625
PFQQQ39_10660
PRAGEKN56_09735
LRINCTC12151_01600(lasI)
XTHG4Q83_15545
SACZAOT14_07820(lasI)
LMBC9I47_0679
LYJFKV23_13885
XBAC7S18_10815
VPAVP1967
VPBVPBB_1806
VPKM636_11990
VPFM634_12050
VPHVPUCM_1253
VHAVIBHAR_02765
VCAM892_17055
VAGN646_1048
VEXVEA_003078
VDBAL552_18505
VHRAL538_03405
VOWA9237_14455
VROBSZ04_17345
VSPVS_II0261
VFUvfu_B01267
VANVAA_00956 VAA_01246
LAGN175_15970 N175_16145
VAUVANGNB10_cII0822(vanM) VANGNB10_cII0862c(vanI)
VCTJV59_29155
VTUIX91_06255
VEUIXK98_14510
VFLAL536_01165
VSCVSVS12_02830(bjaI)
VGABSQ33_14825
VSHBSZ05_20390
VQICCZ37_14510
VNLD3H41_10760
VSRVspart_01278(luxM)
VKABTD91_18330
VGIMID13_17085
VFIVF_1037(ainS) VF_A0924(luxI)
VFMVFMJ11_1119 VFMJ11_A1042
VSAVSAL_I1158(ainS) VSAL_II0957(luxI)
AWDAWOD_I_1040(ainS)
PPRPBPRB0207(AINS)
GHOAL542_16375
PAEPA1432(lasI) PA3476(rhlI)
PAEVN297_1473(lasI) N297_3599
PAEIN296_1473(lasI) N296_3599
PAUPA14_19130(rhlI) PA14_45940(lasI)
PAPPSPA7_1650(rhlL) PSPA7_3897(lasI)
PAGPLES_15361(rhlI) PLES_39821(lasI)
PAFPAM18_1489(rhlI) PAM18_3699(lasI)
PNCNCGM2_2314(lasI) NCGM2_4616(rhlI)
PAEBNCGM1900_2792(rhlI) NCGM1900_5154(lasI)
PDKPADK2_06880 PADK2_18565
PSGG655_07335 G655_18055
PRPM062_07680 M062_18540
PAEPPA1S_07935
PAERPA1R_gp1317
PAEMU769_07410 U769_18600
PAELT223_07650 T223_20340
PAESSCV20265_1566 SCV20265_3992
PAEUBN889_01520(lasI) BN889_03861(rhlL)
PAEGAI22_14715 AI22_25965
PAECM802_1470(lasI) M802_3598
PAEOM801_1472(lasI) M801_3464
PSTPSPTO_3864(psyI)
PSBPsyr_1621
PSPPSPPH_1614
PSAVPSA3335_20675
PAMGBKM19_010585
PAVLBKM03_09690
PFNHZ99_01160 HZ99_23355
PFCPflA506_2538(rhlI)
PFBVO64_0332
PCGAXG94_03615
POIBOP93_12330 BOP93_20445
PLULFOB45_16250
PBCCD58_05210 CD58_16045
PSVPVLB_02765
PCHEY04_12065 EY04_26260
PCZPCL1606_11640 PCL1606_35600
PCPJM49_05485 JM49_05810 JM49_17800
PSWLK03_00240
PSESPSCI_0294(ppuI)
PSEMTO66_12875 TO66_25920
PYMAK972_2551
PVKEPZ47_16230 EPZ47_17255
PEZHWQ56_12405
PSEPC4K39_1927 C4K39_3103
PVWHU752_023370
PTRTHU722_0016530
PSAMHU731_009610
PQIKH389_17000
PSHHHU773_011965
PANHHU763_022785 HU763_024520
PALVKSS97_17860
PWYHU734_003555
ACBA1S_0109
ABYABAYE3761
ABCACICU_00136
ABNAB57_0151
ABBABBFA_03378(lasI)
ABXABK1_0142
ABZABZJ_00138
ABRABTJ_03695
ABDABTW07_0136
ABHM3Q_342
ABADABD1_01150
ABJBJAB07104_00145
ABABBJAB0715_00157
ABAJBJAB0868_00152
ABAZP795_16605
ABKLX00_00715
ABAUIX87_15130
ABAAIX88_02850
ABWBL01_01170
ACCBDGL_003036(solI)
ANORR32_17480
ALCOTEC02_18165
ACALBUM88_00520
ASEII8T81_18150(abaI)
ACDAOLE_18785(aqsI)
ACWA0J50_17110
SPSWSps_00211
SPSHFM037_05905
PATPatl_0361
PLZS4054249_18890
AGZM0C34_15310
SDESde_3498
MMOBF6R98_00125
HNAHneap_0965
HAKKO116_01590
HAMHALO1621
GSNYC6258_05047
ACIIC4901_07780
ATYA9R16_007185
CDIZCEDIAZO_01466(luxM)
CVICV_4091(cviI)
CHROCXB49_18340
CHRIDK842_11115
CRZD1345_21925
CHAECH06BL_04480 CH06BL_45350
JEUBJP62_08585
RSORSc3286(solI) RSp0779
RSCRCFBP_10191(solI)
RSLRPSI07_0160(solI) RPSI07_mp0704(solI)
RSNRSPO_c00170(solI)
RSMCMR15_10180(solI) CMR15_mp10744(solI)
RSEF504_3331 F504_4445(rhiL)
RSYRSUY_02100(lasI)
RPUCDC45_16810 CDC45_21505
RSGJK151_01505
CNCCNE_BB1p13480(solI)
BMABMAA1347 BMAA1577
BMVBMASAVP1_0331(bpsI)
BMLBMA10229_0609(bpsI) BMA10229_2020(bpmI)
BMNBMA10247_A0700(bpmI) BMA10247_A0960(bpsI)
BMALDM55_4175 DM55_4903
BMAEDM78_3306
BMAQDM76_3857 DM76_4875
BMAIDM57_08085 DM57_10320
BMAFDM51_3278 DM51_5000
BMAZBM44_4139 BM44_5033
BMABBM45_3261 BM45_3933
BPSBPSS0885(pmlI) BPSS1180 BPSS1570
BPMBURPS1710b_A0145(bviI) BURPS1710b_A0618(cepI) BURPS1710b_A2483(pmlI)
BPLBURPS1106A_A1221(bpsI) BURPS1106A_A1577 BURPS1106A_A2129(bpmI)
BPDBURPS668_A1293(bpsI) BURPS668_A1658 BURPS668_A2216(bpmI)
BPSEBDL_4173 BDL_4467 BDL_4919
BPSMBBQ_4578 BBQ_4988 BBQ_5252
BPSUBBN_4344 BBN_4608 BBN_5016
BPSDBBX_3632 BBX_4080 BBX_6013
BPZBP1026B_II0971(pmlI) BP1026B_II1251 BP1026B_II1673
BPQBPC006_II1237 BPC006_II1574 BPC006_II2109
BPKBBK_3553 BBK_4222 BBK_5930
BPSHDR55_3705 DR55_4147 DR55_4451
BPSABBU_4463 BBU_4881 BBU_5146
BPSOX996_3489 X996_4121 X996_4384
BUTX994_5545 X994_5975 X994_6240
BTEBTH_II0804 BTH_II1227 BTH_II1512
BTQBTQ_4090 BTQ_4512 BTQ_4799
BTJBTJ_3431 BTJ_5122 BTJ_5495
BTZBTL_3594 BTL_3957 BTL_4279
BTDBTI_4049 BTI_5704
BTVBTHA_3678 BTHA_3920 BTHA_4294
BTHEBTN_3412 BTN_3705 BTN_5576
BTHMBTRA_3584 BTRA_4163 BTRA_4404
BTHADR62_3485 DR62_3739 DR62_5758
BTHLBG87_3546 BG87_3969 BG87_4255
BOKDM82_5058 DM82_5693
BOCBG90_4939 BG90_5537
BUUWS70_21840 WS70_25095
BSAVWS86_23175 WS86_26740
BVIBcep1808_4001 Bcep1808_5262 Bcep1808_5752
BVEAK36_3637 AK36_4698 AK36_5242
BURBcep18194_B1050
BCNBcen_3641
BCHBcen2424_4726
BCMBcenmc03_4280 Bcenmc03_5574
BCJBCAM0239a(cciI) BCAM1870(cepI)
BCENDM39_5942
BCEWDM40_4697
BCEOI35_5747(cepI)
BAMBamb_4118 Bamb_6053
BACBamMC406_4583 BamMC406_5823
BMJBMULJ_04533(bmuI)
BMUBmul_3969
BMKDM80_4757(lasI) DM80_5277
BMULNP80_4635
BCTGEM_3749
BCEDDM42_6081
BCEPAPZ15_29380
BDLAK34_3747(lasI) AK34_3771
BPYRABD05_26145
BCONNL30_02710
BUBBW23_5525
BDFWI26_22620
BLATWK25_25925
BTEIWS51_07030
BSEMWJ12_29475
BPSLWS57_04665
BMECWJ16_28080
BSTGWT74_20005 WT74_28710
BSTLBBJ41_23095
BANNJFN94_27520
BGLbglu_2g14490
BGUKS03_4490
BUGBC1001_4348
BGFBC1003_5055
BGDbgla_1p1740 bgla_2g11050
BGOBM43_89
BUKMYA_3681 MYA_4843
BULBW21_5391 BW21_6057 BW21_6274
BUQAC233_27765
BGPBGL_1c07910(bpsI) BGL_2c03980(lasI) BGL_2c09850(rhL)
BPLAbpln_1g07720 bpln_2g04430 bpln_2g10770
BUDAQ610_19425 AQ610_22930 AQ610_26240
BURKDM992_30915 DM992_35965
BXEBxe_B0608 Bxe_C0415
BXBDR64_5938(lasI) DR64_8028
BPHBphy_4437
BGEBC1002_4605
BPXBUPH_00927
BPYBphyt_0126 Bphyt_4275
BUZAYM40_23345 AYM40_24680
BFNOI25_6299(lasI)
BCAIK788_00038570
PSPWBJG93_23165
PARABTO02_23120
PARBCJU94_26410
PHSC2L64_19680
PTERC2L65_17550
PGPCUJ91_28450
PCJCUJ87_25660
PTSCUJ90_21470 CUJ90_22005
PCAFDSC91_000514
PMEGFNZ07_07520
PTROG5S35_16335 G5S35_31235
PGISI6I06_26335
PACPFAZ97_17925
PACSFAZ98_15030
PEWKZJ38_24615
PDIOPDMSB3_2770.1(lasI)
PPNODA70_23485
PPNMLV28_07225
PRBX636_03160
PSPUNA29_10350
PVEUC34_17560
POXMB84_22335
PFGAB870_04600
PNRAT302_14520
HYFDTO96_102463(anoI)
CABASBC2_27660 SBC2_36290
CARIFNU76_03440 FNU76_05245 FNU76_06155
ODIODI_R1512
RHGEXZ61_17250
AAVAave_3811
ACIOEAG14_11470
ARADKI609_09630
DELDelCs14_1734
VAPVapar_5808
VPDVAPA_2c00050(solI)
VAAAX767_02565
STHMIS481_00715
PBHAAW51_0117 AAW51_0198
KIAG8A07_12260
JAZYQ44_19400
HRBHrubri_2246(pmrI)
CFUCFU_1956(pmlI)
CARELT85_2669(solI)
CPRACPter91_2535
MASSCR152_20490
MASZC9I28_16215
MTIMDIR46_23800
MASYDPH57_05615
MALIEYF70_23230
MUMFCL38_26110
MFLAGO485_17735
MPLIE1742_03690
MANCIV454_27455
THITHI_1725(solI)
NMUNmul_A2390
NLCEBAPG3_000325
GCAGalf_1450
NIMW01_04680(lasI)
SNIVSFSGTM_11810(solI_1) SFSGTM_32150(solI_2)
FPHOSHINM1_002780(solI)
GURGura_3111
GEOGeob_2417
DESDSOUD_0200
DVEDESUT3_08260(luxI)
DMADMR_38490
DCBC3Y92_03420
DSFUWK_01065
DMMdnm_018460
NAFGQ61_01675
MLOmlr6103 mlr6385
MLNA9174_30765
MCIMesci_5572
MOPMesop_6154
MAMMesau_00935 Mesau_05623
MESWA9K65_030240
MESMEJ066_13960
MJREB229_31375
MERDEB233_29255 EB233_30020
AAKAA2016_6541
PHTBLM14_27345
ORMHTY61_12845
PMOBHG718_10825 HG718_12780
SMESMc00168(sinI)
SMKSinme_1745 Sinme_5835
SMQSinmeB_1589
SMXSM11_chr1560(sinI) SM11_pC1008(traI)
SMIBN406_01572 BN406_04334(traI) BN406_06844(traI)
SMEGC770_GR4Chr1894
SMELSM2011_c00168(sinI)
SMERDU99_10035 DU99_23000
SMDSmed_1560 Smed_5375 Smed_6489
RHINGR_a04220(traI) NGR_c16900
SFHSFHH103_01572(sinI)
SFDUSDA257_c41150(traI)
SIXBSY16_6089
SAMESAMCFNEI73_Ch2069(traI) SAMCFNEI73_pB0529(traI)
SINOSS05631_a49690 SS05631_c18490
EADOV14_3020 OV14_c0101(traI)
EAHFA04_07990
ESJSJ05684_a41360 SJ05684_c17460
EAKEKH55_1681 EKH55_5883
EMXFKV68_10595 FKV68_22630 FKV68_24680
ATUAtu6042(traI)
ARAArad_14182(traI) Arad_8456(traIa)
ATAAWN88_00840
ATFAch5_52110(traI)
AVIAvi_1889(avsI) Avi_8335(traI) Avi_9270(traI)
AGCBSY240_350 BSY240_4768
AROB0909_23965
ALFCFBP5473_22130 CFBP5473_24970
ARUIG6M88_22620 G6M88_24085 G6M88_25510(traI)
RETRHE_CH02916(cinI) RHE_PA00179(traIa) RHE_PF00440(raiI)
RECRHECIAT_CH0003073(cinI) RHECIAT_PC0000663(raiI)
RELREMIM1_CH02968(raiI-1) REMIM1_PC00262(traI) REMIM1_PF00437(raiI-2)
REPIE4803_CH03150(raiI-1) IE4803_PB00505 IE4803_PC00490(raiI-2)
REIIE4771_CH03188(raiI-1) IE4771_PA00226(traI-1) IE4771_PB00397(traI-2) IE4771_PD00500(raiI-2)
RLERL3378(raiI) pRL70091(traIp7)
RLTRleg2_2668
RLGRleg_2929 Rleg_5481
RLBRLEG3_02880 RLEG3_25240
RLURLEG12_00075 RLEG12_10470 RLEG12_24445
RTRRTCIAT899_PA01110(traIa) RTCIAT899_PB02960(traIb)
RHLLPU83_pLPU83a0051
RGARGR602_CH03096(traI-1) RGR602_PA00197(traI-2) RGR602_PB00514(traI-3)
RHNAMJ98_CH03088(raiI-1) AMJ98_PE00518(raiI-2)
RPHAAMC79_CH03088(raiI-1) AMC79_PD00656(raiI-2)
RHXAMK02_CH03019(raiI)
RHVBA939_15190
RHKKim5_CH03137(raiI-1) Kim5_PC00448(raiI-2)
REZAMJ99_CH03087(raiI-1) AMJ99_PD00518(raiI-2)
RJGCCGE525_32000 CCGE525_36820
RHRCKA34_24970
RADCO657_13550 CO657_27805
ROYG3A56_26905
RIIFFM53_020500
RHIDFFM81_006550 FFM81_024975
RBQJ2J99_15370 J2J99_30165 J2J99_30635 J2J99_31245 J2J99_32255
RLNJ0663_02125 J0663_23995 J0663_30110
RBANJ2J98_14740 J2J98_22825 J2J98_27230
RRGJ3P73_17270 J3P73_25170 J3P73_34950
RLSHB780_00710 HB780_09065 HB780_13300
NGLRG1141_PB01730(traI)
NENNCHU2750_55770(traI) NCHU2750_59450(traI)
RFVRFYW14_04144 RFYW14_04521
SHZshn_30465 shn_33220 shn_33715 shn_34470
SZOK8M09_22825
ABAWD5400_01965
PDESFE840_014870
OPSA8A54_21015
OCRHGK82_24420
BJUBJ6T_20600
BJPRN69_10080
BBTBBta_5196 BBta_p0259(traI)
BICLMTR13_23840
BRKCWS35_28820 CWS35_32080
BGQX265_06165 X265_13355 X265_36350
BGZXH91_35555
BARHWN72_33600 WN72_44480
BELBE61_24920
BSEPHAP48_0000025 HAP48_0001175 HAP48_0008550
BQBJ4P68_0013705 J4P68_0027065 J4P68_0041080
RPCRPC_2029
RPXRpdx1_0582
NHANham_4570
OCGOCA5_pHCG301280(traI)
OCOOCA4_pHCG3B01270(traI)
TRBHB776_18155
BVVBHK69_30960
XDIEZH22_29960
STARG3545_26270
LNEFZC33_11790
APOLK9D25_21695(traI) K9D25_24595(traI)
MEAMex_p10049(tslI)
MNOMnod_0941
MINDmvi_61410
CDQBOQ54_03250 BOQ54_04505
HDTHYPDE_27393 HYPDE_40418
RVARvan_2683
METGHT051_00880
MROSEHO51_00120
CMETK6K41_23200
BRND1F64_17050
RBMTEF_15775
PPHRAPZ00_10305
LAGGB0E33_18855
ACUTMRB58_08460
AEXAstex_2428
SILSPO0372
RUAD1823_12070
RUTFIU92_01425(lasI1)
JANJann_0620
RDERD1_1639(tral)
RLIRLO149_c030680 RLO149_c036210 RLO149_c036590
RPONG3256_15250
DSHDshi_0312(luxI) Dshi_2851 Dshi_4152
KVLKVU_2075
KVUEIO_2568
PGAPGA1_c03890(raiI)
PGLPGA2_c03440(raiI)
PGDGal_02723 Gal_03113
PHPPhaeoP97_02967(raiI)
PPICPhaeoP14_00306(raiI)
PHQD1820_01690 D1820_05530 D1820_14805
OATOAN307_c41320
OCTFTO60_01855 FTO60_13685
LMDMETH_03425
LEJETW24_04260 ETW24_10670 ETW24_22620
LAQUR2C4_13525
REDroselon_01587
CIDP73_3850
CMARIMCC12053_3004
CEHCEW89_10015
MALGMALG_02721
TPROGa0080559_TMP1103
PABYGa0080574_TMP3173
SULZC1J03_18080
SULIC1J05_18005
SULDB5M07_05745
SPOTG6548_15620
SPSESULPSESMR1_00412(lasI)
TOMBWR18_01140
RIDRIdsm_00061(lasI_1) RIdsm_00113(lasI_2)
ROMEI983_02570 EI983_03040
ROHFIU89_18765(lasI)
AHTANTHELSMS3_02147(bjaI)
SAGUCDO87_04285
THAACFI11_20720
OCDFHY55_02580 FHY55_05970 FHY55_12695
MARUFIU81_04200(bjaI)
ROTFIV09_01495(lasI) FIV09_13055(bjaI)
MALUKU6B_41630(cerI)
TGLHFZ77_08315
HATRC74_04125 RC74_09435
PALXGQA70_04855
RCPRCAP_rcc00329
RHPLPB142_13725
PAMIJCM7686_3181
PARSDRW48_06500
PARREOJ32_05620 EOJ32_16465 EOJ32_17410 EOJ32_18715
PPANESD82_17935
PLIAE4191_12965 E4191_21075
RSUNHU_00742
RHMB5V46_04560
RHCRGUI_0606
DAAAKL17_0454
DONBSK21_00900
TECAKL02_002795
SALOEF888_18435
SEDIEBB79_02345 EBB79_14915
HMLHmaOT1_10645
BOOE2K80_17845
LITFPZ52_01410
PPRUFDP22_03545
PAEDG5B38_08450
PAMOBAR1_00400
POZI0K15_03190
PPAFI8N54_16805
PGVSL003B_0643 SL003B_0702 SL003B_p0045
RBZB9057_00680
THASC6Y53_10550 C6Y53_19680
CMAGCBW24_13505
FAQG5B39_05205
NREBES08_30415
SECHB18_00435 B18_18930
GDIGDI2836
ASZASN_861(raiI)
APERA0U91_00230 A0U91_10770
ATOCIW82_07775
AOTAcetOri_orf01265 AcetOri_orf04004
AZLAZL_a05890
SKTIGS68_20745 IGS68_34240
RRURru_A3396
RRFF11_17405
RPMRSPPHO_02249
MGYMGMSRv2__0751
MGRYMSR1_16140(lasI)
DEXHWD60_04150
AFRAFE_1999
AFELferr_1666
AFJAFERRID_29920
PBUTDTO10_21605
PPRTET464_09550
NWLNWFMUON74_51530
ROPROP_pROB01-03570
BRTJ4N02_15865
MICHFJK98_31890
ADAA5CPEGH6_01570
FAEFAES_2036
NMVNITMOv2_0516
NIONITINOP_1358
NJANSJP_1610(aubI)
NKFNkreftii_003518
 » show all
Reference
1  [PMID:8790360]
  Authors
Schaefer AL, Val DL, Hanzelka BL, Cronan JE Jr, Greenberg EP
  Title
Generation of cell-to-cell signals in quorum sensing: acyl homoserine lactone synthase activity of a purified Vibrio fischeri LuxI protein.
  Journal
Proc Natl Acad Sci U S A 93:9505-9 (1996)
DOI:10.1073/pnas.93.18.9505
Reference
2  [PMID:11717525]
  Authors
Watson WT, Murphy FV 4th, Gould TA, Jambeck P, Val DL, Cronan JE Jr, Beck von Bodman S, Churchill ME.
  Title
Crystallization and rhenium MAD phasing of the acyl-homoserinelactone synthase EsaI.
  Journal
Acta Crystallogr D Biol Crystallogr 57:1945-9 (2001)
DOI:10.1107/S0907444901014512
Reference
3  [PMID:12736370]
  Authors
Chakrabarti S, Sowdhamini R.
  Title
Functional sites and evolutionary connections of acylhomoserine lactone synthases.
  Journal
Protein Eng 16:271-8 (2003)
DOI:10.1093/proeng/gzg031
Reference
4  [PMID:10482519]
  Authors
Hanzelka BL, Parsek MR, Val DL, Dunlap PV, Cronan JE Jr, Greenberg EP
  Title
Acylhomoserine lactone synthase activity of the Vibrio fischeri AinS protein.
  Journal
J Bacteriol 181:5766-70 (1999)
DOI:10.1128/JB.181.18.5766-5770.1999
Reference
5  [PMID:10200267]
  Authors
Parsek MR, Val DL, Hanzelka BL, Cronan JE Jr, Greenberg EP.
  Title
Acyl homoserine-lactone quorum-sensing signal generation.
  Journal
Proc Natl Acad Sci U S A 96:4360-5 (1999)
DOI:10.1073/pnas.96.8.4360
  Sequence
[pae:PA3476]
Reference
6  [PMID:15466564]
  Authors
Ulrich RL.
  Title
Quorum quenching: enzymatic disruption of N-acylhomoserine lactone-mediated bacterial communication in Burkholderia thailandensis.
  Journal
Appl Environ Microbiol 70:6173-80 (2004)
DOI:10.1128/AEM.70.10.6173-6180.2004
Reference
7  [PMID:15306017]
  Authors
Gould TA, Schweizer HP, Churchill ME
  Title
Structure of the Pseudomonas aeruginosa acyl-homoserinelactone synthase LasI.
  Journal
Mol Microbiol 53:1135-46 (2004)
DOI:10.1111/j.1365-2958.2004.04211.x
Reference
8  [PMID:15723540]
  Authors
Raychaudhuri A, Jerga A, Tipton PA
  Title
Chemical mechanism and substrate specificity of RhlI, an acylhomoserine lactone synthase from Pseudomonas aeruginosa.
  Journal
Biochemistry 44:2974-81 (2005)
DOI:10.1021/bi048005m
Reference
9  [PMID:16385066]
  Authors
Gould TA, Herman J, Krank J, Murphy RC, Churchill ME.
  Title
Specificity of acyl-homoserine lactone synthases examined by mass spectrometry.
  Journal
J Bacteriol 188:773-83 (2006)
DOI:10.1128/JB.188.2.773-783.2006
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.184
IUBMB Enzyme Nomenclature: 2.3.1.184
ExPASy - ENZYME nomenclature database: 2.3.1.184
BRENDA, the Enzyme Database: 2.3.1.184
CAS: 176023-66-8

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