KEGG   ENZYME: 2.3.1.211
Entry
EC 2.3.1.211                Enzyme                                 
Name
bisdemethoxycurcumin synthase;
CUS;
curcuminoid synthase (ambiguous)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
4-coumaroyl-CoA:malonyl-CoA 4-coumaryltransferase (bisdemethoxycurcumin-forming)
Reaction(IUBMB)
2 4-coumaroyl-CoA + malonyl-CoA + H2O = 3 CoA + bisdemethoxycurcumin + 2 CO2 [RN:R10233]
Reaction(KEGG)
R10233
Substrate
4-coumaroyl-CoA [CPD:C00223];
malonyl-CoA [CPD:C00083];
H2O [CPD:C00001]
Product
CoA [CPD:C00010];
bisdemethoxycurcumin [CPD:C17743];
CO2 [CPD:C00011]
Comment
A polyketide synthase characterized from the plant Oryza sativa (rice) that catalyses the formation of the C6-C7-C6 diarylheptanoid scaffold of bisdemethoxycurcumin. Unlike the process in the plant Curcuma longa (turmeric), where the conversion is carried out via a diketide intermediate by two different enzymes (EC 2.3.1.218, phenylpropanoylacetyl-CoA synthase and EC 2.3.1.217, curcumin synthase), the diketide intermediate formed by this enzyme remains within the enzyme's cavity and is not released to the environment.
History
EC 2.3.1.211 created 2013
Pathway
ec00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K17212  bisdemethoxycurcumin synthase
Genes
AJM119054186
OSA107276120 107276706 107276873 107278066 4338103 4342896 4343313 4343430 4343431 4343432 4348146 4348180 4350633 4350634 4350635
DOSAOs05t0212600-00(Os05g0212600) Os05t0212900-00(Os05g0212900) Os05t0213100-00(Os05g0213100) Os07t0271500-01(Os07g0271500) Os07t0501100-01(Os07g0501100) Os07t0525500-00(Os07g0525500) Os07t0525900-00(Os07g0525900) Os07t0526400-01(Os07g0526400) Os10t0158400-00(Os10g0158400) Os10t0162856-00(Os10g0162856) Os10t0167900-00(Os10g0167900) Os10t0168300-00(Os10g0168300) Os10t0168500-00(Os10g0168500) Os10t0177300-00(Os10g0177300) Os11t0529500-00(Os11g0529500) Os11t0529800-00(Os11g0529800)
OBR102700556 102703597 102703882 102704434 102706796 102707711 102715335 102717542 102717654 102717817 102721773
BDI100829126 100834852 100835138 100840879 100840881 100842932
ATS109734579 109739828 109739833 109747018 109755590 109759063 109765137 109765413 109768737 109770988 109770996 109771086 109772782 109782591
TDC119289266 119289823 119289825 119289826 119293030 119293199 119295516 119297968 119297970 119297971 119298470 119301023 119301039 119306583 119310160 119314905 119319037 119319257 119322210 119325182 119325577 119325838 119334584 119335697 119343513 119344226 119344637 119345768 119347449 119348997 119349006 119353258 119358583 119358621 119358657 119359730 119360255 119360418 119366792 119366798 119366799 119366801 119367015
TAES123039832 123039933 123039936 123039940 123039941 123039943 123039945 123040289 123048185 123048188 123048189 123048226 123048375 123055486 123061245 123061498 123071282 123075735 123080099 123082453 123083302 123083314 123083315 123083316 123083320 123086130 123086143 123088021 123088283 123090365 123094229 123099363 123100622 123107793 123108430 123115201 123116940 123120911 123128323 123129943 123130662 123131625 123133160 123135413 123138170 123140724 123142988 123145428 123154401 123162881 123164097 123165621 123166936 123170070 123174079 123175145 123184202 123184256 123184258
TUA125505947 125505948 125506418 125513206 125514546 125524928 125534681 125534739 125534741 125534743 125535104 125540632 125540646 125540662 125553407
SBI8056971 8056973 8056974 8057988 8062654 8062655 8064807 8064810 8064811 8068873 8068891 8074891 8077473 8080715 8080716 8084297
ZMA100272924 103626945 103650032 103650033 103650038 103654408 103654409 109940988 118476652
SITA101754841 101755242 101758341 101759154 101759479 101759670 101759838 101760477 101764244 101776434 101777243 101777759
SVS117833629 117833679 117833800 117834705 117837149 117843158 117844783 117845618 117845854 117845895 117866513 117866594 117866815
PVIR120644542 120646300 120646301 120656230 120658676 120658938 120658940 120658942 120659286 120660974 120660982 120660990 120660997 120661012 120661029 120661045 120662830 120664885 120664897 120664907 120684423 120684465 120685007 120685923 120686400 120686430 120686727 120695494 120695495 120696168 120696169 120696170 120696171 120696172
PHAI112877195 112879578 112881218 112882055 112882770 112882870 112903005 112903025 112903116 112903125 112903169
 » show all
Reference
1  [PMID:21041675]
  Authors
Morita H, Wanibuchi K, Nii H, Kato R, Sugio S, Abe I
  Title
Structural basis for the one-pot formation of the diarylheptanoid scaffold by curcuminoid synthase from Oryza sativa.
  Journal
Proc Natl Acad Sci U S A 107:19778-83 (2010)
DOI:10.1073/pnas.1011499107
  Sequence
[osa:4342896]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.211
IUBMB Enzyme Nomenclature: 2.3.1.211
ExPASy - ENZYME nomenclature database: 2.3.1.211
BRENDA, the Enzyme Database: 2.3.1.211

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