KEGG ENZYME: 2.3.1.243

ENZYME: 2.3.1.243

Entry

EC 2.3.1.243                Enzyme

Name

acyl-Kdo2-lipid IVA acyltransferase;
lpxM (gene name);
MsbB acyltransferase;
myristoyl-[acyl-carrier protein]:alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA O-myristoyltransferase;
tetradecanoyl-[acyl-carrier protein]:dodecanoyl-Kdo2-lipid IVA O-tetradecanoyltransferase;
lauroyl-Kdo2-lipid IVA myristoyltransferase

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

fatty acyl-[acyl-carrier protein]:alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-[lipid IVA] O-acyltransferase

Reaction(IUBMB)

a fatty acyl-[acyl-carrier protein] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-[lipid IVA] = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)2-[lipid IVA] + an [acyl-carrier protein]

Reaction(KEGG)

(other) R05075 R12197

Substrate

fatty acyl-[acyl-carrier protein];
alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-[lipid IVA]

Product

alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)2-[lipid IVA];
[acyl-carrier protein] [CPD:C00229]

Comment

The enzyme is involved in the biosynthesis of the phosphorylated outer membrane glycolipid lipid A. It transfers an acyl group to the 3-O position of the 3R-hydroxyacyl already attached at the 2-O position of the non-reducing glucosamine molecule. The enzyme from the bacterium Escherichia coli is specific for myristoyl (C14) acyl groups, giving the enzyme its previous accepted name. However, enzymes from different species accept highly variable substrates.

History

EC 2.3.1.243 created 2014, modified 2021

Pathway

ec00540

Lipopolysaccharide biosynthesis

ec01100

Metabolic pathways

Orthology

K02560

lauroyl-Kdo2-lipid IVA myristoyltransferase

Genes

ECO:	b1855(lpxM)

ECJ:	JW1844(lpxM)

ECD:	ECDH10B_1996(lpxM)

EBW:	BWG_1669(lpxM)

ECOK:

ECMDS42_1532(lpxM)

ECE:	Z2907(msbB) Z_L7029

ECS:	ECs_2565(lpxM) pO157p82

ECF:	ECH74115_2591(msbB) ECH74115_B0114(msbB)

ETW:	ECSP_2429(lpxM) ECSP_6105

ELX:	CDCO157_2400 CDCO157_A0085(msbB)

EOI:	ECO111_2377(lpxM) ECO111_p3-82

EOJ:	ECO26_2707(lpxM) ECO26_p1-86

EOH:	ECO103_2045(lpxM) ECO103_p23

ECOO:

ECRM13514_2363(msbB) ECRM13514_5711

ECOH:

ECRM13516_2267(msbB) ECRM13516_5476

ESL:	O3K_10655 O3K_22085

ESO:	O3O_03295 O3O_14970

ESM:	O3M_10630 O3M_21985

ECK:	EC55989_2034(lpxM) EC55989_4949(msbB)

ECG:	E2348C_1980(lpxM)

EOK:	G2583_2307(lpxM)

ELR:	ECO55CA74_11105

ELH:

ETEC_1888

ECW:	EcE24377A_2085(msbB1) EcE24377A_4852(msbB2)

EUN:	UMNK88_2327(msbB) UMNK88_5218(msbB)

ECP:

ECP_1799

ENA:	ECNA114_1903(msbB)

ECOS:

EC958_2076(msbB)

ECV:	APECO1_905(msbB)

ECOA:

APECO78_13090

ECX:	EcHS_A1948(msbB)

ECM:	EcSMS35_1331(msbB)

ECY:

ECSE_2031

ECR:	ECIAI1_1942(lpxM)

ECQ:	ECED1_2060(lpxM) ECED1_5141(msbB)

EUM:	ECUMN_2153(lpxM)

ECT:	ECIAI39_1194(lpxM) ECIAI39_4758(msbB)

EOC:	CE10_2141(lpxM) CE10_5033(msbB)

EBR:	ECB_01826(msbB)

EBL:	ECD_01826(lpxM)

EBE:	B21_01814(lpxM)

EBD:

ECBD_1783

ECI:	UTI89_C2059(msbB)

EIH:	ECOK1_1974(msbB)

ECZ:	ECS88_1912(lpxM)

ECC:	c2269(msbB)

ELO:	EC042_2022(msbB) EC042_4769(msbB2)

ELN:	NRG857_09300

ESE:

ECSF_1713

ECL:	EcolC_1777

EKO:	EKO11_1914

EKF:	KO11_13425(lpxM)

EAB:	ECABU_c21170(msbB)

EDH:	EcDH1_1785

ELU:	UM146_07875

ELW:	ECW_m2030(lpxM)

ELL:	WFL_09960(lpxM)

ELC:	i14_2085(msbB)

ELD:	i02_2085(msbB)

ELP:	P12B_c1230(msbB)

ELF:	LF82_1231(lpxM)

ECOL:

LY180_09655

ECOI:

ECOPMV1_01948(msbB)

ECOJ:

P423_09845

EFE:	EFER_1217(lpxM) EFER_1914(msbB)

EAL:	EAKF1_ch4184(msbB)

EMA:	C1192_06365(msbB)

ESZ:	FEM44_24180(msbB)

ERUY:

OSH18_03970(lpxM)

STY:	STY2097(msbB)

STT:	t0988(msbB)

SEX:	STBHUCCB_10590

SENT:

TY21A_05035

STM:	STM1889(msbB)

SEO:	STM14_2297(msbB)

SEV:	STMMW_18701

SEY:	SL1344_1823(msbB)

SEM:	STMDT12_C19140(msbB)

SEJ:	STMUK_1869(msbB)

SEB:	STM474_1921(msbb)

SEF:	UMN798_1991(msbB)

SETU:

STU288_05845

SETC:

CFSAN001921_07620

SENR:

STMDT2_18171(msbB)

SEND:

DT104_19041(msbB)

SENI:

CY43_09970

SPT:	SPA0980(msbB)

SEK:

SSPA0914

SPQ:	SPAB_01277

SEI:	SPC_1825(msbB)

SEC:	SCH_1897(msbB)

SEH:	SeHA_C2103(msbB)

SHB:

SU5_02500

SENH:

CFSAN002069_22380

SEEH:

SEEH1578_18755

SEE:	SNSL254_A2048(msbB)

SENN:

SN31241_29880

SEW:	SeSA_A2043(msbB)

SEA:	SeAg_B1235(msbB)

SENS:

Q786_05755

SED:	SeD_A1359(msbB)

SEG:	SG1163(msbB)

SEL:	SPUL_1773(msbB)

SEGA:

SPUCDC_1759(msbB)

SET:	SEN1114(msbB)

SENA:

AU38_05765

SENO:

AU37_05755

SENV:

AU39_05755

SENQ:

AU40_06475

SENL:

IY59_05870

SENJ:

CFSAN001992_01985

SEEC:

CFSAN002050_15915

SEEB:

SEEB0189_010035

SEEP:

I137_08045

SENB:

BN855_19730

SENE:

IA1_09395

SENC:

SEET0819_16155

SES:	SARI_01057

SBG:	SBG_1726(msbB)

SBZ:

A464_1977

SBV:	N643_08405

SALZ:

EOS98_09660(msbB)

SFL:	CP0238(msbB2) SF1865(msbB)

SFX:	S1931(msbB)

SFV:	SFV_1857(msbB)

SFE:	SFxv_1135 SFxv_2089(lpxM) SFxv_5092(msbB2)

SFN:	SFy_1427 SFy_2673

SFS:	SFyv_1476 SFyv_2733

SFT:	NCTC1_02020(lpxM)

SSN:	SSON_1286(msbB) SSON_P182(msbB2)

SBO:	SBO_1172(msbB) SBO_P119(msbB2)

SBC:	SbBS512_A0263(msbB) SbBS512_E0951(msbB)

SDY:	SDY_1142(msbB) SDY_P110(msbB2)

SDZ:	Asd1617_01475 Asd1617_06301

SHQ:	A0259_13400

ENC:

ECL_01443

ENL:	A3UG_13915

ECLG:

EC036_26930

ECLE:

ECNIH2_13450

ECLN:

ECNIH4_09300

ECLI:

ECNIH5_12935

ECLX:

LI66_13625

ECLY:

LI62_14965

ECLZ:

LI64_13040

ECLO:

ENC_06400

EHM:	AB284_12165

EXF:	BFV63_13310

ECLA:

ECNIH3_12980

ECLC:

ECR091_12915

EAU:	DI57_05550

EKB:	BFV64_13705

ENO:	ECENHK_13650

EEC:	EcWSU1_02780(msbB1)

ELG:	BH714_09655

ECAN:

CWI88_09115(msbB)

ERN:	BFV67_13310

ECLS:

LI67_012320

ECHG:

FY206_14690(lpxM)

ESH:	C1N69_13765(msbB)

ENT:	Ent638_2424

EAS:	Entas_2562

ENR:	H650_05005

ENX:	NI40_013630

ENF:	AKI40_3572

LNI:	CWR52_21515(msbB)

EBG:	FAI37_15540(msbB)

END:	A4308_17960

ENZ:	G0034_13575(lpxM)

ENS:	HWQ15_21825(lpxM)

ENK:	LOC22_01310(lpxM)

EHU:	D5067_0009330(lpxM)

EMOR:

L6Y89_13015(lpxM)

ENB:	ELK40_13965(msbB)

EQU:	OM418_13355(lpxM)

ESA:

ESA_01386

CSK:	ES15_1599(msbB)

CSZ:	CSSP291_06785

CSJ:	CSK29544_02695

CCON:

AFK62_11565

CDM:	AFK67_12255

CSI:	P262_02317

CMJ:	AFK66_007670

CUI:	AFK65_11955

CMW:	AFK63_06405

CTU:	CTU_25380(msbB)

KPN:	KPN_02370(msbB)

KPU:	KP1_3500(msbB)

KPM:	KPHS_33910

KPP:

A79E_1862

KPH:	KPNIH24_11630

KPZ:	KPNIH27_16365

KPV:	KPNIH29_16855

KPW:	KPNIH30_17170

KPY:	KPNIH31_16270

KPG:	KPNIH32_17065

KPC:	KPNIH10_16620

KPQ:	KPR0928_16595

KPT:	VK055_0077(msbB)

KPO:	KPN2242_14830

KPR:	KPR_3283(msbB)

KPJ:

N559_1889

KPI:	D364_12050

KPA:	KPNJ1_02050

KPS:	KPNJ2_02012

KPX:	PMK1_04732(msbB)

KPB:	FH42_07940

KPNE:

KU54_009450

KPNU:

LI86_09405

KPNK:

BN49_3476(msbB)

KVA:

Kvar_1735

KPE:	KPK_1914(msbB)

KPK:	A593_01490

KVD:	KR75_25200

KVQ:	SP68_05565

KOX:

KOX_23895

KOE:

A225_3672

KOY:	J415_13730

KOM:	HR38_22200

KMI:	VW41_13290

KOK:	KONIH1_18175

KOC:	AB185_17970

KQU:	AVR78_20975

EAE:

EAE_22825

EAR:

CCG29436

KQV:	B8P98_10470(msbB)

KLL:	BJF97_18075

KLW:	DA718_11000(msbB)

KAR:	LGL98_09045(lpxM)

KGR:	JJJ10_10895(lpxM)

KPAS:

LUW96_24510(lpxM)

KLC:	K7H21_10600(lpxM)

ROR:	RORB6_02895

RON:	TE10_18385

RPLN:

B1209_09335

RAO:	DSD31_09330(msbB)

REE:	electrica_01867(msbB)

CRO:	ROD_18961(msbB)

CKO:

CKO_01109

CFD:	CFNIH1_20435

CBRA:

A6J81_01820(msbB)

CWE:	CO701_12695(msbB)

CYO:	CD187_09915(msbB)

CPOT:

FOB25_21515(lpxM)

CFQ:	C2U38_14415(msbB)

CSED:

JY391_13205(lpxM)

CAMA:

F384_08960

CAF:	AL524_13310(msbB)

CIF:	AL515_14045(msbB)

CFAR:

CI104_15335(msbB)

CIR:	C2U53_24355(msbB)

CIE:	AN232_15330(msbB)

CPAR:

CUC49_09805(msbB)

CTEL:

GBC03_15480(lpxM)

CITZ:

E4Z61_07675(msbB)

CARS:

E1B03_15975(msbB)

CIX:	M4I31_09890(lpxM)

HDE:	HDEF_0653(lpxM)

EBT:	EBL_c23160(msbB)

CNT:	JT31_21570

CEM:	LH23_19320

CEN:	LH86_18045

CLAP:

NCTC11466_01766(msbB)

PGE:	LG71_14495

ESC:	Entcl_1935

KLE:	AO703_12500

KSA:	C813_01035

KOR:	AWR26_10345(lpxM)

KRD:	A3780_13775

KCO:	BWI95_19080

KOT:	EH164_09445(msbB)

KPSE:

IP581_13565(lpxM)

KOB:	HF650_13885(lpxM)

KOO:	O9K67_10360(lpxM)

KIE:	NCTC12125_00941(msbB)

KAS:	KATP_17640(lpxM)

KLU:	K7B04_19660(lpxM)

LAX:	APT61_08600

LEI:	C2U54_18945(msbB)

LEH:	C3F35_20810(msbB)

LEE:	DVA44_09215(msbB)

LER:	GNG29_13765(lpxM)

LEA:	GNG26_13735(lpxM)

LPNU:

KQ929_07845(lpxM)

LEY:	DVA43_03695(msbB)

LAZ:	A8A57_12905

LEF:	LJPFL01_2490

LEW:	DAI21_13730(msbB)

BUF:	D8682_04790(msbB)

BAGE:

BADSM9389_17530

BFT:	MNO13_10780(lpxM)

HED:	TPER_HE00101(msbB)

GED:	FVIR_GE00162(msbB)

SYM:	K6K13_11525(lpxM)

METY:

MRY16398_35640(lpxM)

AHN:	NCTC12129_01988(msbB)

ASUB:

NLZ15_12985(lpxM)

YRE:	HEC60_07910(lpxM)

SGOE:

A8O29_009225(lpxM)

KIN:	AB182_15625

PDZ:	HHA33_18190(lpxM)

IZH:	FEM41_20330(msbB)

PSHI:

SAMEA2665130_2178(msbB)

PSGC:

G163CM_08140(lpxM)

SCOL:

KFZ77_11675(lpxM)

PVJ:	LMA04_00150(lpxM)

SUPE:

P0H77_12880(lpxM)

EBF:

D782_1783

EBC:	C2U52_26135(msbB)

EBU:	CUC76_24650(msbB)

PSTS:

E05_14680

YPE:	YPO2063(msbB)

YPK:	y2247(msbB)

YPH:	YPC_2252(lpxM)

YPA:

YPA_1446

YPN:

YPN_1540

YPM:	YP_1906(msbB)

YPP:	YPDSF_1059

YPG:	YpAngola_A2415(msbB)

YPZ:	YPZ3_1761(msbB)

YPT:	A1122_15845

YPD:	YPD4_1823(msbB)

YPX:	YPD8_1727(msbB)

YPW:	CH59_4060(msbB)

YPJ:	CH55_673(msbB)

YPV:	BZ15_1474(msbB)

YPL:	CH46_3048(msbB)

YPS:	YPTB2046(msbB)

YPO:	BZ17_419(msbB)

YPI:	YpsIP31758_2025(msbB)

YPY:

YPK_2138

YPB:

YPTS_2105

YPQ:	DJ40_262(msbB)

YPU:	BZ21_1325(msbB)

YPR:	BZ20_66(msbB)

YPC:	BZ23_1607(msbB)

YPF:	BZ19_1401(msbB)

YEN:	YE2386(msbB)

YEP:	YE105_C1903

YEY:

Y11_11761

YEL:	LC20_02453(msbB)

YEW:	CH47_1739(msbB)

YET:	CH48_3533(msbB)

YEF:	FORC2_1876

YEE:	YE5303_16671(msbB)

YSI:	BF17_19265

YAL:	AT01_581(msbB)

YFR:	AW19_1047(msbB)

YIN:	CH53_3808(msbB)

YKR:	CH54_615(msbB)

YRO:	CH64_411(msbB)

YRU:	BD65_189(msbB)

YRB:	UGYR_01025

YMA:	DA391_12185(msbB)

YHI:	D5F51_09645(msbB)

YCA:	F0T03_11740(lpxM)

YMO:	HRD69_16560(lpxM)

YAS:	N0H69_15140(lpxM)

YKI:	HRD70_16725(lpxM)

SMAR:

SM39_2245(msbB)

SMAC:

SMDB11_2040(msbB)

SMW:	SMWW4_v1c27850(lpxM)

SPE:

Spro_2771

SRR:	SerAS9_2864

SRL:	SOD_c26130(msbB)

SRY:	M621_14255

SPLY:

Q5A_014475(lpxM)

SRS:	SerAS12_2865

SRA:	SerAS13_2866

SMAF:

D781_2514

SLQ:	M495_13915

SERF:

L085_14895

SERS:

SERRSCBI_13100

SFW:	WN53_22645

SFG:	AV650_18465

SRZ:	AXX16_2612

SERA:

Ser39006_015220(msbB)

SERQ:

CWC46_15215(msbB)

SERM:

CLM71_13055(msbB)

SQU:	E4343_02215(msbB)

SFJ:	SAMEA4384070_2814(msbB)

SOF:	NCTC11214_04095(msbB)

SSUR:

ATE40_010545

SURI:

J0X03_10040(lpxM)

SRHZ:

FO014_20615(msbB)

SENP:

KHA73_13690(lpxM)

SNEM:

NLX84_14025(lpxM)

SFO:	Z042_00710

RAH:	Rahaq_1991

RACE:

JHW33_06805(lpxM)

RAQ:	Rahaq2_2136

RAA:

Q7S_10115

ROX:	BV494_04375

RVC:	J9880_19445(lpxM)

GQU:	AWC35_00420

FSM:	CCS41_11100(msbB)

RBAD:

H2866_17715(lpxM)

RCB:	O1V66_04585(lpxM)

ECA:	ECA2482(msbB)

PATR:

EV46_11955

PATO:

GZ59_20740(msbB)

PCT:

PC1_1829

PCC:	PCC21_018360

PCV:	BCS7_09160

PWA:	Pecwa_2113

PPAR:

A8F97_08300

PEC:

W5S_2058

PWS:	A7983_17810

PPOA:

BJK05_04195

PBRA:

B5S52_12520

PPUJ:

E2566_09805(msbB)

PARI:

I2D83_10000(lpxM)

PAQU:

DMB82_0011795(lpxM)

PVZ:	OA04_24320(msbB)

PPAV:

LOZ86_09415(lpxM)

PQU:	IG609_008790(lpxM)

PPOO:

LW347_09590(lpxM)

PCAC:

OI450_10385(lpxM)

PACB:

M9782_11695(lpxM)

DDD:	Dda3937_04573(lpxM)

DZE:	Dd1591_2249

DDC:	Dd586_2192

DZC:	W909_09150

DSO:	A4U42_19050

CED:	LH89_02125

DFN:	CVE23_10645(msbB)

DDQ:

DDI_1830

DAQ:	DAQ1742_02299(lpxM)

DIC:	Dpoa569_002025(msbB)

DLC:	O1Q98_02315(lpxM)

DDA:	Dd703_2140

BGJ:	AWC36_08795

BRB:	EH207_09715(msbB)

BNG:	EH206_12545(msbB)

BIZ:	HC231_09655(lpxM)

LBQ:	CKQ53_14850(msbB)

LPOP:

I6N93_08750(lpxM)

SGL:

SG1265

SOD:	Sant_1692(lpxM)

PES:	SOPEG_2620(lpxM)

SLIG:

GTU79_16180(lpxM)

EAM:	EAMY_2057(msbB)

EAY:	EAM_1998(msbB)

ETA:	ETA_14950(msbB)

EPY:	EpC_15700(msbB)

EPR:	EPYR_01691(msbB)

EBI:	EbC_25030(msbB)

ERJ:	EJP617_31290(msbB)

EPE:	CI789_06565(msbB)

EHD:	ERCIPSTX3056_291(lpxM)

ERWI:

GN242_11415(lpxM)

ETP:	LU633_11440(lpxM)

ERP:	LJN55_13340(lpxM)

EGE:	EM595_2127(msbB)

PAM:	PANA_2195(msbB)

PLF:	PANA5342_1969(msbB)

PAJ:	PAJ_1509(msbB)

PAQ:	PAGR_g1900

PVA:	Pvag_1660(msbB)

PAGG:

AL522_15430(msbB)

PAO:	Pat9b_2304

KLN:	LH22_11205

PANT:

PSNIH1_14735

PANP:

PSNIH2_06420

HHS:	HHS_05980(msbB)

PCK:	BMSBPS_0227

PAGC:

BEE12_18360

PSTW:

DSJ_15250

PALH:

B1H58_16070

PANS:

FCN45_11010(msbB)

PEY:	EE896_08180(lpxM)

PDIS:

D8B20_09795(msbB)

PER:	LAC65_08685(lpxM)

PJI:	KTJ90_07985(lpxM)

PANO:

OJ965_10385(lpxM)

PGZ:	C2E15_12205(msbB)

PCD:	C2E16_12445(msbB)

MINT:

C7M51_01633(lpxM)

MTHI:

C7M52_01187(lpxM)

MHAN:

K6958_11980(lpxM)

TCI:	A7K98_10735

TPTY:

NCTC11468_02115(msbB)

KPIE:

N5580_07385(lpxM)

PLU:	plu2117(msbB)

PLUM:

A4R40_10615

PAY:	PAU_02464(msbB)

PTT:	VY86_20380

PAKH:

B0X70_10990

PLUI:

CE143_10905(msbB)

PMR:	PMI1154(msbB)

PMIB:

BB2000_1160(msbB)

PVL:	AOB99_07690

PVG:	CRN77_12255(msbB)

PHAU:

PH4a_16165(msbB)

PROT:

BTA34_08325

PCOL:

F1325_10010(lpxM)

PCIB:

F9282_10035(lpxM)

PPEE:

I6G31_00375(lpxM)

XBO:	XBJ1_2230(lpxM)

XBV:	XBW1_1951(msbB)

XNE:	XNC1_2167(lpxM)

XNM:	XNC2_2096(lpxM)

XDO:	XDD1_2073(msbB)

XPO:	XPG1_1803(msbB)

XHO:	A9255_04455

XBU:	HGO23_10665(lpxM)

PSI:

S70_20290

PSX:	DR96_2957(msbB)

PSTA:

BGK56_02280

PRG:	RB151_020960(msbB)

PALA:

CO695_15180(msbB)

PHEI:

NCTC12003_02171(msbB)

PRQ:	CYG50_06365(lpxM)

PRJ:	NCTC6933_01805(msbB)

PVC:	G3341_11035(lpxM)

PMAG:

JI723_10930(lpxM)

MMK:

MU9_2024

ANS:	ArsFIN_18390(lpxM)

AED:	E3U36_09670(msbB)

AET:	LDL57_08255(lpxM)

AAPC:

QG404_08755(lpxM)

MWI:	MNY66_07730(lpxM)

EIC:	NT01EI_1604

ETR:	ETAE_1445(msbB)

ETD:

ETAF_1340

ETE:	ETEE_3443(msbB)

ETC:	ETAC_06790

EDW:	QY76_12695

EDL:	AAZ33_07515(lpxM)

EHO:	A9798_09775

HAV:	AT03_09805

HPAR:

AL518_15965(msbB)

OPO:	DSM2777_09850

LPV:	HYN51_02130(msbB)

PFQ:	QQ39_09975

PRAG:

EKN56_08875(msbB)

LRI:	NCTC12151_01984(msbB)

HIN:

HI_0199

HIT:	NTHI0296(msbB)

HIP:	CGSHiEE_02255

HIQ:	CGSHiGG_03610

HIF:	HIBPF_20300(msbB)

HIL:	HICON_12760(msbB)

HIU:

HIB_02510

HIE:	R2846_0439(msbB)

HIZ:	R2866_0389(msbB)

HIK:	HifGL_000883(msbB)

HIA:

H733_0084

HIH:	NF38_04430

HIW:	NTHI477_01231(msbB)

HIC:	NTHIC486_00832(msbB)

HIX:	NTHI723_01505(msbB)

HPR:	PARA_19060

HDU:	HD_0404(lpxM)

HAY:	C3V42_01590(msbB)

HPIT:

NCTC13334_01240(msbB)

HHZ:	NCTC10839_01759(msbB)

HAEG:

NCTC8502_01040(msbB)

HPAA:

E5Q53_02200(msbB)

HSEM:

L3077_08355(lpxM)

HAP:	HAPS_1668(lpxM)

HPAZ:

K756_11275

HPAS:

JL26_09805

HPAK:

JT17_06555

GLE:	CJD39_01055(msbB)

HSO:	HS_1202(msbB)

HSM:

HSM_0361

PMU:	PM0362(msbB)

PMV:	PMCN06_0381(msbB)

PUL:	NT08PM_0954

PMP:	Pmu_04260(msbB)

PMUL:

DR93_1136(msbB)

PDAG:

4362423_00497(msbB)

PSKY:

A6B44_07675

PATL:

KGI96_08525(lpxM)

PCAI:

K7G93_000407(lpxM)

MSU:	MS0869(htrB)

BSUN:

A4G13_02130

MHT:	D648_6610(msbB)

MHQ:	D650_21000(msbB)

MHAT:

B824_7110(msbB)

MHX:	MHH_c12630(msbB)

MHAE:

F382_11430

MHAM:

J450_10095

MHAO:

J451_11535

MHAL:

N220_03545

MHAQ:

WC39_10325

MHAY:

VK67_10325

MVR:	X781_18010

MVI:

X808_5310

MVG:

X874_5440

MVE:	X875_15420

MANN:

GM695_10395(lpxM)

MGRA:

A4G16_00990

MBOS:

ICJ55_05080(lpxM)

MPEG:

HV560_10060(lpxM)

APL:	APL_0172(msbB)

APJ:	APJL_0173(lpxM)

APA:	APP7_0174(msbB)

ASU:

Asuc_0969

ASI:	ASU2_06230

ASS:	ASU1_06295

AEU:	ACEE_06425

APOR:

DDU33_10575(msbB)

AIO:	EXH44_08855(msbB)

ADP:	NCTC12871_00096(msbB)

ALIG:

NCTC10568_00198(lpxM)

AART:

NYR89_00700(lpxM)

AAP:	NT05HA_0370

AAZ:	ADJ80_06430

AAT:

D11S_1610

AAO:	ANH9381_1981

AAN:

D7S_00155

AAH:	CF65_02504

AACN:

AANUM_1836

AACT:

ACT75_00590

ASEG:

NCTC10977_01147(msbB)

AGJ:	J5A60_03335(lpxM)

GAN:	UMN179_02010

BTO:

WQG_6660

BTRE:

F542_15400

BTRH:

F543_17070

BTRA:

F544_6990

APAG:

EIA51_07300(msbB)

AVT:	NCTC3438_01132(msbB)

RHEY:

FEE42_12580(msbB)

RHAE:

IHV77_03650(lpxM)

OOI:	A6A10_02415

FCL:	A4G17_00300

BHUD:

A6A11_07445

MSEP:

CEP49_01120(msbB)

PAET:

NCTC13378_00464(msbB)

VCH:

VC_0212

VCF:	IR04_05990

VCS:

MS6_0079

VCE:	Vch1786_I2494

VCQ:	EN18_17960

VCJ:	VCD_001404

VCI:

O3Y_00970

VCO:	VC0395_A2591(msbB)

VCR:	VC395_0244(msbB)

VCL:	VCLMA_A0183

VCX:	VAA049_3489(msbB)

VCZ:	VAB027_3638(msbB)

VVU:	VV1_0797(msbB)

VVY:

VV0326

VVM:	VVMO6_02793

VVL:	VV93_v1c03120

VPA:

VP0213

VPB:

VPBB_0221

VPK:	M636_20700

VPF:	M634_03060

VPH:	VPUCM_0210

VHA:	VIBHAR_00681

VCA:	M892_09445

VAG:

N646_2398

VEX:	VEA_001793

VDB:	AL552_09405(msbB)

VHR:	AL538_10635(msbB)

VNA:	PN96_12360

VOW:	A9237_07210

VSP:	VS_0199(WaaN)

VEJ:	VEJY3_00950

VFU:	vfu_A00135

VNI:	VIBNI_A2544

VAN:

VAA_02451

LAG:	N175_01950

VAU:	VANGNB10_cI2552(msbB)

VCY:	IX92_15425

VCT:	JV59_38685

VTU:	IX91_00535

VEU:	IXK98_09225(lpxM)

VSI:	MTO69_00505(lpxM)

VFL:	AL536_19660(msbB)

VMI:	AL543_10160(msbB)

VBR:	A6E01_00935

VSC:	VSVS12_00354(lpxM)

VGA:	BSQ33_09650

VSH:	BSZ05_07440

VQI:	CCZ37_12635(msbB)

VTA:	A1253(msbB)

VNL:	D3H41_01075(msbB)

VCC:	FAZ90_14215(msbB)

VAS:	GT360_13640(lpxM)

VAQ:	FIV01_00700(msbB)

VSR:	Vspart_00138(msbB)

VKA:	BTD91_05505(lpxM)

VZI:	G5S32_14015(lpxM)

VNV:	IF132_14070(lpxM)

VGI:	MID13_00965(lpxM)

VSL:	LTQ54_07805(lpxM)

VPL:	SA104470976_02532(msbB)

VJP:	NP165_12435(lpxM)

VPG:	LZI70_06025(lpxM)

VTI:	CEQ48_18060(msbB)

VCRA:

IS519_09500(lpxM)

VLE:	ISX51_00620(lpxM)

VFI:	VF_1799(msbB)

VFM:	VFMJ11_1931(msbB)

VSA:	VSAL_I2175

AWD:	AWOD_I_1920

PPR:	PBPRA0219(ECS2565)

PGB:	H744_2c0486

PDS:	CAY62_13400

PGH:	FH974_00820(lpxM)

GHO:	AL542_08650(msbB)

PMAI:

CF386_12305

SALY:

E8E00_12685

SKS:	FCN78_00975(msbB)

SCOT:

HBA18_00850

SPRO:

N7E60_00965

SON:	SO_2088(lpxM)

SDN:

Sden_1605

SFR:

Sfri_1711

SAZ:

Sama_1950

SBL:

Sbal_1876

SBM:	Shew185_1903

SBN:	Sbal195_1910

SBP:	Sbal223_2416

SBT:	Sbal678_1949

SBS:	Sbal117_1994

SBB:	Sbal175_2478

SLO:

Shew_2213

SPC:	Sputcn32_1831

SHP:	Sput200_2161

SSE:

Ssed_2595

SPL:

Spea_2467

SHE:	Shewmr4_1811

SHM:	Shewmr7_2166

SHN:	Shewana3_1866

SHW:	Sputw3181_2178

SHL:

Shal_1815

SWD:

Swoo_2069

SWP:

swp_3012

SVO:

SVI_2513

SHF:	CEQ32_05740(msbB)

SJA:	SJ2017_1761

SPSW:

Sps_01329

SBJ:	CF168_11400(msbB)

SMAV:

CFF01_08160(msbB)

SHEW:

CKQ84_18125(msbB)

SALG:

BS332_17095

SLJ:	EGC82_13195(msbB)

SMAI:

EXU30_18815(msbB)

SPOL:

FH971_08435(msbB)

SBK:	SHEWBE_2445(lpxM)

SKH:	STH12_01639(msbB)

SAES:

HBH39_07545(lpxM)

SLIT:

JQC75_09975(lpxM)

SCAA:

TUM17387_21860(lpxM)

SPSH:

FM037_16260(msbB)

SEUR:

FM038_010285(lpxM)

SCYP:

JYB88_07820(lpxM)

SSEM:

JYB85_08000(lpxM)

SGLA:

FJ709_10965(msbB)

SINV:

K8B83_14525(lpxM)

SXM:	MKD32_09105(lpxM)

SVM:	KDH10_001243(lpxM)

SHEJ:

MZ182_09250(lpxM)

SSEH:

N7V09_14055(lpxM)

SCHK:

GII14_10730(lpxM)

AGZ:	M0C34_11670(lpxM)

AGQ:	LQZ07_11530(lpxM)

PIN:

Ping_1974

PSY:	PCNPT3_05975

FBL:	Fbal_2157 Fbal_2158

MVS:

MVIS_2077

MYA:	MORIYA_0634

MMAA:

FR932_07395(lpxM)

MOQ:	HWV03_12045(lpxM)

TLO:	J9253_00985

TSB:	HMY34_05400

TANI:

J8380_06275

MMW:	Mmwyl1_0060

MPC:	Mar181_0047

MPRI:

MP3633_0064

MARD:

IBG28_00300(lpxM)

MFOI:

JSY38_09560(lpxM)

MPRF:

J8N69_08255(lpxM)

MRHI:

KDW99_00275(lpxM)

AHA:	AHA_2101(msbB) AHA_2102

AHY:	AHML_12495 AHML_12500

AHD:	AI20_07535 AI20_07540

AHR:	V428_12895 V428_12900

AHP:	V429_12915 V429_12920

AHJ:	V469_10145 V469_10150

AHH:	RY45_12315 RY45_12320

AHI:	VU14_09910 VU14_09915

AAJ:	BOQ57_12125 BOQ57_12130

ASA:	ASA_2195(msbB2) ASA_2196(msbB1)

AEO:	O23A_p1260 O23A_p1262

AVR:	B565_1725 B565_1726

AVO:	AMS64_08525 AMS64_08530

AMED:

B224_2092 B224_2094

ASR:	WL1483_1174

ADH:	CK627_14285(msbB) CK627_14290

ACAV:

VI35_10170 VI35_10175

AEM:	CK911_05480(msbB) CK911_05485

AEA:	C2U39_10080 C2U39_10085

ARV:	C7N77_14920 C7N77_14925(msbB)

AES:	C2U30_03590 C2U30_03595

AEL:	NCTC12917_01970(msbB1) NCTC12917_01971(msbB2)

ASIM:

FE240_04615(msbB) FE240_07685

AALL:

I6G90_06635 I6G90_06640(lpxM)

AJD:	I6H43_01010 I6H43_01015(lpxM)

ARIV:

KYK33_10990 KYK33_10995

ASAA:

KXJ75_11255 KXJ75_11260

AEJ:	E5E97_17135 E5E97_17140(msbB)

ABES:

IU367_11755 IU367_11760(lpxM)

TAU:

Tola_2206

OCE:

GU3_09565

OCM:	CBP12_02965

OPF:	CBP31_00535

ZDF:	AN401_08620

ORB:	IPMB12_04995(lpxM)

ATY:	A9R16_000665

SADE:

GFK82_00252(lpxM)

» show all

Reference

1 [PMID:9099672]

Authors

Clementz T, Zhou Z, Raetz CR

Title

Function of the Escherichia coli msbB gene, a multicopy suppressor of htrB knockouts, in the acylation of lipid A. Acylation by MsbB follows laurate incorporation by HtrB.

Journal

J Biol Chem 272:10353-60 (1997)
DOI:10.1074/jbc.272.16.10353

Sequence

[eco:b1855]

Reference

2 [PMID:27681620]

Authors

Dovala D, Rath CM, Hu Q, Sawyer WS, Shia S, Elling RA, Knapp MS, Metzger LE 4th.

Title

Structure-guided enzymology of the lipid A acyltransferase LpxM reveals a dual activity mechanism.

Journal

Proc Natl Acad Sci U S A 113:E6064-E6071 (2016)
DOI:10.1073/pnas.1610746113