KEGG   ENZYME: 2.3.1.251
Entry
EC 2.3.1.251                Enzyme                                 
Name
lipid IVA palmitoyltransferase;
PagP;
crcA (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine:lipid-IVA palmitoyltransferase
Reaction(IUBMB)
(1) 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A = 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A [RN:R11223];
(2) 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA = 2-acyl-sn-glycero-3-phosphocholine + lipid IIB [RN:R12206];
(3) 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA = 2-acyl-sn-glycero-3-phosphocholine + lipid IVB [RN:R12187]
Reaction(KEGG)
R11223 R12187 R12206;
(other) R12200 R12211
Substrate
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine [CPD:C03889];
hexa-acyl lipid A [CPD:C21193];
lipid IIA [CPD:C19884];
lipid IVA [CPD:C04919]
Product
2-acyl-sn-glycero-3-phosphocholine [CPD:C04233];
hepta-acyl lipid A [CPD:C21194];
lipid IIB [CPD:C22002];
lipid IVB [CPD:C21982]
Comment
Isolated from the bacteria Escherichia coli and Salmonella typhimurium. The enzyme prefers phosphatidylcholine with a palmitoyl group at the sn-1 position and palmitoyl or stearoyl groups at the sn-2 position. There is some activity with corresponding phosphatidylserines but only weak activity with other diacylphosphatidyl compounds. The enzyme also acts on Kdo-(2->4)-Kdo-(2->6)-lipid IVA.
History
EC 2.3.1.251 created 2015
Pathway
ec00540  Lipopolysaccharide biosynthesis
Orthology
K12973  lipid IVA palmitoyltransferase
Genes
ECOb0622(pagP)
ECJJW0617(crcA)
ECDECDH10B_0582(crcA) ECDH10B_0690(crcA)
EBWBWG_0495(pagP)
ECOKECMDS42_0483(crcA)
ECEZ0767(crcA)
ECSECs_0661(pagP)
ECFECH74115_0711(pagP)
ETWECSP_0676(crcA)
ELXCDCO157_0648(pagP)
EOIECO111_0653(crcA)
EOJECO26_0697(crcA)
EOHECO103_0630(crcA)
ECOOECRM13514_0646(pagP)
ECOHECRM13516_0591(pagP)
ESLO3K_18480(pagP)
ESOO3O_06815(pagP)
ESMO3M_18460(pagP)
ECKEC55989_0615(crcA)
ECGE2348C_0523(pagP)
EOKG2583_0786(pagP)
ELRECO55CA74_03855(pagP)
ELHETEC_0651
ECWEcE24377A_0647(pagP)
EUNUMNK88_658(crcA)
ECPECP_0653
ECOSEC958_0741(crcA)
ECVAPECO1_1430(crcA)
ECOAAPECO78_06690
ECXEcHS_A0674(pagP)
ECYECSE_0690
ECRECIAI1_0606(crcA)
ECQECED1_0619(crcA)
EUMECUMN_0715(crcA)
ECTECIAI39_0598(crcA)
EOCCE10_0621(pagP)
EBRECB_00592(crcA)
EBLECD_00592(pagP)
EBEB21_00581(pagP)
EBDECBD_3028
ECIUTI89_C0626(crcA)
EIHECOK1_0633(pagP)
ECZECS88_0664(crcA)
ECCc0713(crcA)
ELOEC042_0658(pagP)
ELNNRG857_02830(pagP)
ESEECSF_0562
ECLEcolC_3022
EKOEKO11_3243
EKFKO11_20555(pagP)
EDHEcDH1_3003
EDJECDH1ME8569_0591(pagP)
ELUUM146_14400(pagP)
ELWECW_m0677(pagP)
ELLWFL_03365(pagP)
ELCi14_0681(pagP)
ELDi02_0681(pagP)
ELPP12B_c0606(pagP)
ELFLF82_1590(pagP)
ECOLLY180_03370(pagP)
ECOIECOPMV1_00641(pagP)
ECOJP423_03055(pagP)
EFEEFER_2481
EALEAKF1_ch0839c(pagP)
ESZFEM44_17540
STYSTY0677(pagP)
STTt2239(pagP)
SEXSTBHUCCB_23680
SENTTY21A_11355(pagP)
STMSTM0628(pagP)
SEOSTM14_0731(pagP)
SEVSTMMW_06931
SEYSL1344_0616(pagP)
SEMSTMDT12_C06900(pagP)
SEJSTMUK_0633(pagP)
SEBSTM474_0649(pagP)
SEFUMN798_0679(pagP)
SETUSTU288_11235(pagP)
SETCCFSAN001921_13895(pagP)
SENRSTMDT2_06191(pagP)
SENDDT104_06571(pagP)
SENICY43_03425(pagP)
SEENSE451236_09165(pagP)
SPTSPA2106(pagP)
SEKSSPA1958
SPQSPAB_02929
SEISPC_0643(pagP)
SEHSeHA_C0743(pagP)
SHBSU5_01318
SENHCFSAN002069_05705(pagP)
SEEHSEEH1578_12570(pagP)
SEESNSL254_A0683(pagP)
SENNSN31241_16340
SEWSeSA_A0787(pagP)
SEASeAg_B0669(pagP)
SENSQ786_03070(pagP)
SEDSeD_A0729(pagP)
SEGSG0632(pagP)
SELSPUL_2334(pagP)
SEGASPUCDC_2320(pagP)
SETSEN0597(pagP)
SENAAU38_03055(pagP)
SENOAU37_03050(pagP)
SENVAU39_03055(pagP)
SENQAU40_03360(pagP)
SENLIY59_03105(pagP)
SENJCFSAN001992_08190(pagP)
SEECCFSAN002050_09750(pagP)
SEEBSEEB0189_016145(pagP)
SEEPI137_10650(pagP)
SENBBN855_6210(pagP)
SENEIA1_03290(pagP)
SENCSEET0819_10105(pagP)
SESSARI_02305
SBGSBG_0536(pagP)
SBZA464_604
SBVN643_02665(pagP)
SALZEOS98_15980
SFLSF0658(pagP)
SFXS0681(crcA)
SFVSFV_0703(crcA)
SFESFxv_0725(pagP)
SFNSFy_0895
SFSSFyv_0933
SFTNCTC1_00707(pagP)
SSNSSON_0576(crcA)
SBOSBO_0487(crcA)
SDYSDY_0545
SHQA0259_06800(pagP)
ENCECL_03072 ECL_04468
ENLA3UG_06180(pagP) A3UG_14955
ECLGEC036_11890 EC036_38500
ECLEECNIH2_06925(pagP) ECNIH2_14910
ECLNECNIH4_16430(pagP)
ECLIECNIH5_06015(pagP) ECNIH5_13820
ECLXLI66_05890(pagP) LI66_14335
ECLYLI62_06790(pagP) LI62_15690
ECLZLI64_06360(pagP)
ECLOENC_41620
EHMAB284_11150 AB284_18975(pagP)
EXFBFV63_06020(pagP) BFV63_14080
ECLAECNIH3_06030(pagP) ECNIH3_13885
ECLCECR091_06010(pagP) ECR091_13820
EAUDI57_04820 DI57_12690(pagP)
EKBBFV64_05910(pagP)
ENOECENHK_06275(pagP) ECENHK_14430(pagP)
EECEcWSU1_01206(crcA)
ELGBH714_02125(pagP)
ECANCWI88_08080 CWI88_16225(pagP)
ERNBFV67_05675(pagP)
ECLSLI67_006935(pagP)
ECHGFY206_07300 FY206_15985
ESHC1N69_06025(pagP)
ENTEnt638_1158 Ent638_2570
EASEntas_1138 Entas_3340
ENRH650_21950(pagP)
ENXNI40_005685(pagP) NI40_014375
ENFAKI40_2109(pagP)
LNICWR52_06235 CWR52_20650
EBGFAI37_00535 FAI37_14730
ENDA4308_09990(pagP)
ENZG0034_06025 G0034_15030
ENSHWQ15_14495(pagP) HWQ15_22545(pagP)
ENKLOC22_02360(pagP) LOC22_16765(pagP)
EHUD5067_0008625 D5067_0016670(pagp)
EMORL6Y89_05875(pagP) L6Y89_14020(pagP)
ENBELK40_06565 ELK40_14695
ESAESA_02705
CSKES15_2776(pagP)
CSZCSSP291_12755(pagP)
CSJCSK29544_03991
CCONAFK62_05740
CDMAFK67_05945
CSIP262_04048
CMJAFK66_013960
CUIAFK65_05725
CMWAFK63_12940
CTUCTU_12560(crcA)
KPNKPN_00655(crcA)
KPUKP1_1610(crcA)
KPMKPHS_14940
KPPA79E_3584
KPHKPNIH24_21340
KPZKPNIH27_06935
KPVKPNIH29_07630
KPWKPNIH30_07660
KPYKPNIH31_07535
KPGKPNIH32_07765
KPCKPNIH10_07450
KPQKPR0928_07360
KPTVK055_1877
KPOKPN2242_06150(pagP)
KPRKPR_3920(crcA)
KPJN559_3668
KPID364_03440(pagP)
KPAKPNJ1_03923
KPSKPNJ2_03913
KPXPMK1_02989(pagP)
KPBFH42_24320
KPNEKU54_018995
KPNULI86_18820
KPNKBN49_1714(crcA)
KVAKvar_2130 Kvar_3711
KPEKPK_3918(pagP) KPK_A0097
KVDKR75_15215 KR75_27110
KVQSP68_21830
KOXKOX_14170(pagP) KOX_24295(pagP)
KOEA225_1653 A225_3758
KOYJ415_13335(pagP) J415_23370(pagP)
KOMHR38_12910 HR38_22630
KMIVW41_05645(pagP)
KOKKONIH1_08115 KONIH1_18945
KOCAB185_02015 AB185_17310 AB185_28010
KQUAVR78_11950
EAEEAE_13800(pagP)
EARCCG31211
KQVB8P98_20405
KLLBJF97_08490 BJF97_18710
KLWDA718_10465 DA718_20155
KARLGL98_18020(pagP)
KGRJJJ10_10200(pagP) JJJ10_20060(pagP)
RORRORB6_03255(pagP) RORB6_11790(pagP)
RONTE10_09090 TE10_18860
RPLNB1209_09750 B1209_19495
RAODSD31_09705 DSD31_18325
RTGNCTC13098_02444(pagP_1) NCTC13098_05374(pagP_2)
REEelectrica_01950(pagP_1) electrica_03676(pagP_2) electrica_05241(pagP_3)
CROROD_06371(pagP)
CKOCKO_02535
CFDCFNIH1_13280(pagP)
CBRAA6J81_09955(pagp)
CWECO701_15660(pagP)
CYOCD187_17110(pagP)
CPOTFOB25_04585(pagp)
CFQC2U38_07095(pagp)
CSEDJY391_15240(pagP)
CAMAF384_02760(pagP)
CAFAL524_19530(pagp)
CIFAL515_07770(pagp)
CFARCI104_07470(pagP)
CIRC2U53_16675(pagp)
CIEAN232_23205(pagp)
CPARCUC49_02905(pagp)
CTELGBC03_22810(pagp)
CITZE4Z61_10460(pagp)
CARSE1B03_08280(pagp)
EBTEBL_c27410(crcA)
CNTJT31_06595(pagP)
CEMLH23_11330(pagP)
CENLH86_10760(pagP)
CLAPNCTC11466_03319(pagP)
PGELG71_21810(pagP)
ESCEntcl_3173
KLEAO703_06405
KSAC813_08515(pagP)
KORAWR26_17950(pagP)
KRDA3780_06305(pagP)
KCOBWI95_12025(pagP)
KOTEH164_16065
KPSEIP581_06345(pagP)
KOBHF650_06960(pagP)
KIENCTC12125_00667(pagP)
KASKATP_32490(pagP_1) KATP_47230(pagP_2)
KLUK7B04_12045(pagP)
LAXAPT61_16475(pagP)
LEIC2U54_10985(pagP)
LEHC3F35_05485(pagP)
LEEDVA44_17595
LERGNG29_06195(pagP)
LEAGNG26_05885(pagP)
LPNUKQ929_14995(pagP)
LAZA8A57_05595 A8A57_06120(pagP)
LEFLJPFL01_1208 LJPFL01_2681
LEWDAI21_13025 DAI21_20670(pagp)
BUFD8682_09300
BAGEBADSM9389_29800
BFTMNO13_18020(pagP)
SYMK6K13_04660(pagP)
METYMRY16398_36900(pagP)
AHNNCTC12129_03574(pagP)
ASUBNLZ15_06805(pagP)
YREHEC60_00370(pagP)
SGOEA8O29_016415(pagP)
PDZHHA33_18690(pagP)
IZHFEM41_13060
PSGCG163CM_22170(pagP)
SCOLKFZ77_05335(pagP)
EBFD782_3218
EBCC2U52_26850
EBUCUC76_08115
PSTSE05_07370
YPEYPO1744
YPKy2563(crcA)
YPHYPC_2537
YPAYPA_1118
YPNYPN_2378
YPMYP_1485(crcA)
YPPYPDSF_1378
YPGYpAngola_A1664(pagP)
YPZYPZ3_1969
YPTA1122_17145(pagP)
YPDYPD4_1547
YPXYPD8_2007(crcA)
YPWCH59_3421
YPJCH55_933
YPVBZ15_1803
YPLCH46_3377
YPSYPTB1622
YPOBZ17_880
YPIYpsIP31758_2380(pagP)
YPYYPK_2476
YPBYPTS_1744
YPQDJ40_601
YPUBZ21_972
YPRBZ20_353
YPCBZ23_1250
YPFBZ19_1049
YENYE1762
YEPYE105_C2405
YEYY11_06171
YELLC20_03171
YEWCH47_1162
YETCH48_4060
YEFFORC2_1755
YEEYE5303_15641
YSIBF17_17405
YALAT01_819
YFRAW19_1512
YINCH53_4365
YKRCH54_151
YROCH64_859
YRUBD65_583
YRBUGYR_03135
YAKACZ76_00330
YMADA391_10005
YHID5F51_06880
YCAF0T03_09460
YMOHRD69_14315(pagP)
YASN0H69_12265(pagP)
SMARSM39_0311
SMACSMDB11_0251
SMWSMWW4_v1c09490(pagP)
SPESpro_0993
SRRSerAS9_0918
SRLSOD_c08470(pagP)
SRYM621_04655
SPLYQ5A_004510(pagP)
SRSSerAS12_0918
SRASerAS13_0918
SMAFD781_0938
SLQM495_04210
SERFL085_23805(pagP)
SERSSERRSCBI_04390(pagP)
SFWWN53_13910 WN53_24440
SFGAV650_09460 AV650_20065
SRZAXX16_4161
SERMCLM71_04580
SQUE4343_11495
SFJSAMEA4384070_1031(pagP)
SOFNCTC11214_00489(pagP)
SSURATE40_001460
SURIJ0X03_19175(pagP)
SRHZFO014_05200
SENPKHA73_04440(pagP)
SFOZ042_18505
RAHRahaq_3420
RACEJHW33_11315(pagP) JHW33_11320(pagP)
RAQRahaq2_3499
RAAQ7S_17220(pagP)
ROXBV494_12160
RVCJ9880_02835(pagP) J9880_21480(pagP)
GQUAWC35_06700
FSMCCS41_07420
EAMEGXP68_04225
RBADH2866_12310(pagP)
ECAECA0175(pagP)
PATREV46_00910
PATOGZ59_01860(pagP)
PCTPC1_4079
PCCPCC21_001640
PCVBCS7_00690
PWAPecwa_4360
PPARA8F97_19645
PECW5S_4511
PWSA7983_08760
PPOABJK05_17390
PBRAB5S52_21040
PPUJE2566_20625
PARII2D83_21130(pagP)
PAQUDMB82_0019500(pagP)
PVZOA04_01930(pagP)
PPAVLOZ86_01715(pagP)
PQUIG609_019285(pagP)
PPOOLW347_20720(pagP)
DDDDda3937_02050(crcA)
DZEDd1591_3937
DDCDd586_0173
DZCW909_00845
DSOA4U42_09990
CEDLH89_11360
DFNCVE23_00920
DDQDDI_4497
DDADd703_0182
BGJAWC36_19695
BRBEH207_15290
BNGEH206_01000
BIZHC231_00985(pagP)
LBQCKQ53_05945
SGLSG1577
SODSant_1379(pagP)
EAMEAMY_1108(crcA)
EAYEAM_1115(pagP)
ETAETA_23630(pagP)
EPYEpC_24980(pagP)
EPREPYR_02703(crcA)
EBIEbC_12320(pagP) EbC_27780
ERJEJP617_22300(pagP)
EPECI789_12685
ERWIGN242_14975(pagP)
ETPLU633_08620(pagP)
ERPLJN55_06050(pagP)
PAMPANA_1113(crcA)
PLFPANA5342_3176(crcA)
PAJPAJ_0434(crcA)
PAQPAGR_g3045
PVAPvag_pPag30356(crcA1) Pvag_pPag30521(crcA3)
PAGGAL522_01030 AL522_01755
PAOPat9b_1049 Pat9b_5533
KLNLH22_16980
PANTPSNIH1_10015
PAGCBEE12_20640 BEE12_21460
PSTWDSJ_07960
PANSFCN45_05490 FCN45_20705
PEYEE896_21150(pagP)
PDISD8B20_05000
PERLAC65_04280(pagP)
TCIA7K98_05905
TPTYNCTC11468_01149(pagP)
PLUplu2784
PLUMA4R40_13880
PAYPAU_01754(crcA)
PTTVY86_17375
PAKHB0X70_14195
PLUICE143_14190
PMRPMI1595(pagP)
PVLAOB99_09930
PVGCRN77_11050
PHAUPH4a_17625
PROTBTA34_09545
PCOLF1325_11180
PCIBF9282_11500
PPEEI6G31_16880(pagP)
XHOA9255_02805
PSIS70_01305(pagP)
PSTABGK56_04240
PRGRB151_024850(pagP)
PALACO695_13300
PHEINCTC12003_01779(pagP)
PRQCYG50_03815
PRJNCTC6933_02143(pagP)
PVCG3341_09245
PMAGJI723_09105(pagP)
MMKMU9_2523
ANSArsFIN_24350(pagP)
AETLDL57_06590(pagP)
MWIMNY66_09030(pagP)
EICNT01EI_2996
ETRETAE_2687(crcA)
ETDETAF_2422(pagP)
ETEETEE_0789(pagP)
ETCETAC_12895(pagP)
EDWQY76_07075
EDLAAZ33_14190(pagP)
EHOA9798_03850
HAVAT03_11985
HPARAL518_14125
OPODSM2777_15715
LPVHYN51_14690
PFQQQ39_12925
PRAGEKN56_16845
LRINCTC12151_01055(pagP)
LPNlpg0025
LPHLPV_0029(rcp)
LPOLPO_0026(rcp)
LPULPE509_03219
LPMLP6_0026(pagP)
LPFlpl0026(rcp)
LPPlpp0025(rcp)
LPCLPC_0026
LPAlpa_00034
LPElp12_0025
LLOLLO_0052
LFALFA_0031
LHALHA_0032
LOKLoa_02891(pagP)
LCDclem_14745(pagP)
LSHCAB17_04570
LLG44548918_02710(pagP)
LIBE4T55_06725(pagP)
LGTE4T54_05800
LJRNCTC11533_02884(pagP)
LCJNCTC11976_00705(pagP)
LWASAMEA4504053_0027(pagP)
LSSNCTC12082_02050(pagP)
LADLNCTC12735_00196(pagP)
LANTTUM19329_03200(pagP)
LLYJ2N86_00120(pagP)
TMCLMI_0024
FPPFPB0191_00507
PTESJQU52_01475(pagP)
CRZD1345_21345
CHAECH06BL_44260(pagP)
LHKLHK_03209
PSENH8B_3870
AMAHDLM_1012
AQSDKK66_00335
DTKK4H28_12675(pagP)
VOGLCH97_11760(pagP)
PACSFAZ98_04025
PPKU875_16900
PPNODA70_08970
PPNMLV28_21840
PRBX636_17520
PPULRO07_16230
PSPUNA29_20930
PAPISG18_00070
POXMB84_11820
PFGAB870_18175
PNRAT302_26565
PANDDRB87_06750
PFIBPI93_020360(pagP)
PCOMNTU39_08495(pagP)
BPEBP3006
BPCBPTD_2973(pagP)
BPERBN118_3128
BPETB1917_0828(pagP)
BPEUQ425_23490(pagP)
BPARBN117_0949
BPABPP3735
BBHBN112_4234
BBRBB4181
BBMBN115_3863
BBXBBS798_3959(pagP)
BAVBAV2864(pagP)
BHOD560_0675
BHMD558_0661
BHZACR54_03924(pagP)
BTRMSAMEA390648700533(pagP)
BBROBAU06_20305
BPDZBBN53_03425
BOHAKI39_19550
AXYAXYL_00807(pagP)
AXONH44784_013231
AXNAX27061_0835
AXXERS451415_00823(pagP)
ADTAPT56_04430
AISBUW96_21555
ASWCVS48_02380
ACHRC2U31_08860
ACHBDVB37_03485
ADYHLG70_01020 HLG70_17830(pagP)
ACHOH4P35_03580(pagP)
ODIODI_R2313
BOZDBV39_12835
SWSI6J16_09430
MFAMfla_0865 Mfla_1009
MMBMmol_1609
MEHM301_0969
AIQAzoinq_10175(pagP)
RBUPG1C_02075
OTROTERR_05700(pagP)
NIVJY500_17465
FPHOSHINM1_015250(pagP)
APPCAP2UW1_2728
BPRCD521_2046(pagP)
 » show all
Reference
1  [PMID:11013210]
  Authors
Bishop RE, Gibbons HS, Guina T, Trent MS, Miller SI, Raetz CR
  Title
Transfer of palmitate from phospholipids to lipid A in outer membranes of gram-negative bacteria.
  Journal
EMBO J 19:5071-80 (2000)
DOI:10.1093/emboj/19.19.5071
  Sequence
[eco:b0622]
Reference
2  [PMID:20826347]
  Authors
Cuesta-Seijo JA, Neale C, Khan MA, Moktar J, Tran CD, Bishop RE, Pomes R, Prive GG
  Title
PagP crystallized from SDS/cosolvent reveals the route for phospholipid access to the hydrocarbon ruler.
  Journal
Structure 18:1210-9 (2010)
DOI:10.1016/j.str.2010.06.014
  Sequence
[eco:b0622]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.251
IUBMB Enzyme Nomenclature: 2.3.1.251
ExPASy - ENZYME nomenclature database: 2.3.1.251
BRENDA, the Enzyme Database: 2.3.1.251

DBGET integrated database retrieval system