KEGG   ENZYME: 2.3.1.43
Entry
EC 2.3.1.43                 Enzyme                                 
Name
phosphatidylcholine---sterol O-acyltransferase;
lecithin---cholesterol acyltransferase;
phospholipid---cholesterol acyltransferase;
LCAT (lecithin-cholesterol acyltransferase);
lecithin:cholesterol acyltransferase;
lysolecithin acyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
phosphatidylcholine:sterol O-acyltransferase
Reaction(IUBMB)
phosphatidylcholine + a sterol = 1-acylglycerophosphocholine + a sterol ester [RN:R02114]
Reaction(KEGG)
R02114
Substrate
phosphatidylcholine [CPD:C00157];
sterol [CPD:C00370]
Product
1-acylglycerophosphocholine [CPD:C04230];
sterol ester [CPD:C01958]
Comment
Palmitoyl, oleoyl and linoleoyl residues can be transferred; a number of sterols, including cholesterol, can act as acceptors. The bacterial enzyme also catalyses the reactions of EC 3.1.1.4 phospholipase A2 and EC 3.1.1.5 lysophospholipase.
History
EC 2.3.1.43 created 1972, modified 1976
Pathway
ec00564  Glycerophospholipid metabolism
Orthology
K00650  lecithin-cholesterol acyltransferase
Genes
HSA3931(LCAT)
PTR743056(LCAT)
PPS100976085(LCAT)
GGO109023671(LCAT)
PON103892697(LCAT)
NLE100590850(LCAT)
MCC701872(LCAT)
MCF102126888(LCAT)
MTHB126944041
CSAB103233251(LCAT)
CATY105585326(LCAT)
PANU100126664(LCAT)
TGE112614084(LCAT)
RRO104655608(LCAT)
RBB108515381(LCAT)
TFN117088469(LCAT)
PTEH111541372(LCAT)
CJC108587667(LCAT)
SBQ101036892(LCAT)
CSYR103268200(LCAT)
MMUR105858972(LCAT)
LCAT123625235(LCAT)
OGA100941922(LCAT)
MMU16816(Lcat)
MCAL110299959(Lcat)
MPAH110337669(Lcat)
RNO24530(Lcat)
MCOC116070084(Lcat)
MUN110545854(Lcat)
CGE100751451(Lcat)
MAUA101823034(Lcat)
PLEU114681054(Lcat)
MORG121447102(Lcat)
MFOT126502623
AAMP119801794(Lcat)
NGI103738876(Lcat)
HGL101700977(Lcat)
CPOC100727686(Lcat)
CCAN109691255(Lcat)
DORD105983105(Lcat)
DSP122126154(Lcat)
NCAR124967377
OCU100008978(LCAT)
OPI101526884(LCAT)
TUP102475836(LCAT)
CFA479680(LCAT)
CLUD112646516(LCAT)
VVP112929443(LCAT)
VLG121499329(LCAT)
AML100469078(LCAT)
UMR103673641(LCAT)
UAH113252389(LCAT)
UAR123803442(LCAT)
ELK111153035
LLV125088970
MPUF101671691(LCAT)
ORO101381788(LCAT)
EJU114200087(LCAT)
ZCA113936177(LCAT)
MLX118023650(LCAT)
NSU110594242(LCAT)
FCA101083225(LCAT)
PYU121045479(LCAT)
PBG122495124(LCAT)
LRUF124511416
PTG102970547(LCAT)
PPAD109270744(LCAT)
AJU106971916(LCAT)
HHV120225290(LCAT)
BTA510960(LCAT)
BOM102264672(LCAT)
BIU109572303(LCAT)
BBUB102394576(LCAT)
CHX102189984(LCAT)
OAS100302343(LCAT)
ODA120872731(LCAT)
CCAD122421343(LCAT)
SSC100303723(LCAT)
CFR102521480(LCAT)
CBAI105074847(LCAT)
CDK105088423(LCAT)
VPC102536337(LCAT)
BACU103016695(LCAT)
LVE103082679(LCAT)
OOR101284170(LCAT)
DLE111179614(LCAT)
PCAD114483914(LCAT)
PSIU116744300(LCAT)
ECB100053753(LCAT)
EPZ103549703(LCAT)
EAI106822471(LCAT)
MYB102263247(LCAT)
MYD102767701(LCAT)
MMYO118674248(LCAT)
MLF102424851(LCAT)
MNA107527882(LCAT)
PKL118720951(LCAT)
HAI109389599(LCAT)
DRO112300810(LCAT)
SHON118983836(LCAT)
AJM119061866(LCAT)
PDIC114488112(LCAT)
PHAS123805793(LCAT)
MMF118638384(LCAT)
RFQ117034796(LCAT)
PALE102882548(LCAT)
PGIG120593891(LCAT)
PVP105305742(LCAT)
RAY107520404(LCAT)
MJV108386440(LCAT)
TOD119248970(LCAT) 119251018
SARA101550277(LCAT)
LAV100663727(LCAT)
TMU101354314
DNM101431232(LCAT)
MDO100021772(LCAT)
GAS123234631(LCAT)
SHR100916426(LCAT)
PCW110210384(LCAT)
OAA100073500(LCAT)
GGA396136(LCAT)
PCOC116243797(LCAT)
MGP100539055(LCAT)
CJO107319111(LCAT)
NMEL110404108(LCAT)
APLA101801832(LCAT)
ACYG106033314(LCAT)
AFUL116493966(LCAT)
TGU100226110(LCAT)
LSR110476261(LCAT)
SCAN103816691(LCAT)
PMOA120508134(LCAT)
OTC121333897(LCAT)
PRUF121348760(LCAT)
GFR102045237(LCAT)
FAB101808995(LCAT)
PHI102109484(LCAT)
PMAJ107209690(LCAT)
CCAE111934506(LCAT)
CCW104691778(LCAT)
CBRC103620140(LCAT)
ETL114069561(LCAT)
ZAB102070187(LCAT)
ACHL103811475(LCAT)
FPG101919855(LCAT)
FCH102054279(LCAT)
CLV102095422(LCAT)
EGZ104130251(LCAT)
NNI104017431(LCAT)
PLET104617657(LCAT)
PCRI104039132(LCAT)
PCAO104052983(LCAT)
ACUN113484238(LCAT)
TALA104366372(LCAT)
PADL103913233(LCAT)
AFOR103908397(LCAT)
ACHC115345721(LCAT)
HALD104325594(LCAT)
CCRI104159181(LCAT)
CSTI104563652(LCAT)
EHS104504370(LCAT)
CMAC104484858(LCAT)
MUI104534761(LCAT)
FGA104070446(LCAT)
GSTE104256707(LCAT)
LDI104354672(LCAT)
MNB103776393(LCAT)
OHA104328583(LCAT)
NNT104400549(LCAT)
DPUB104299849(LCAT)
ACAR104519143(LCAT)
AVIT104275786(LCAT)
CVF104294799(LCAT)
CUCA104068321(LCAT)
AAM106484516(LCAT)
AROW112975407(LCAT)
NPD112955306(LCAT)
TGT104577035(LCAT)
DNE112991037(LCAT)
SCAM104150839(LCAT)
ASN102378544(LCAT)
AMJ102562663(LCAT)
PSS102457801
CMY102935489(LCAT)
CPIC101933197(LCAT)
TST117886716(LCAT)
CABI116829610(LCAT)
MRV120384199(LCAT)
ACS100564490(lcat)
PVT110081332(LCAT)
SUND121914816(LCAT)
PBI103048717(LCAT)
PMUR107284167(LCAT)
CTIG120312628(LCAT)
TSR106551707(LCAT)
PGUT117670464(LCAT)
VKO123025363(LCAT)
PMUA114601886(LCAT)
ZVI118086877(LCAT)
GJA107108015(LCAT)
STOW125443737(LCAT)
XLA447501(lcat.L)
XTR448241(lcat)
NPR108804121(LCAT)
RTEM120917740(LCAT)
BBUF120980645(LCAT)
BGAR122920524(LCAT)
DRE793137(lcat)
SRX107707505 107714079
SANH107674949
SGH107572072(lcat)
CCAR109050579(lcat)
CAUA113043715(lcat)
PPRM120460230(lcat)
MAMB125247809(lcat)
IPU100528492(lcat)
PHYP113546498(lcat)
SMEO124385801(lcat)
TFD113635584(lcat)
AMEX103041308(lcat)
EEE113581779(lcat)
TRU101068878(lcat)
TNGGSTEN00006235G001
LCO104935935(lcat)
CGOB115010298(lcat)
ELY117261658(lcat)
EFO125887086(lcat)
PLEP121950629(lcat)
SLUC116057758(lcat)
ECRA117949378(lcat)
ESP116691154 116694194
PFLV114560231(lcat)
GAT120809156(lcat) 120812211
PPUG119195933(lcat)
MSAM119893847(lcat)
CUD121514645(lcat)
ALAT119024223(lcat)
MZE101464448(lcat)
ONL100690438(lcat)
OAU116315803(lcat)
OLA101172491(lcat)
OML112152872(lcat)
XMA102230865
XCO114133868
XHE116729819
PRET103466226(lcat)
PFOR103142508
PLAI106937204
PMEI106926061(lcat)
GAF122835881(lcat)
CVG107103417(lcat)
CTUL119796761(lcat)
GMU124880823(lcat)
NFU107389202(lcat)
KMR108246908(lcat)
ALIM106520220(lcat)
NWH119416162(lcat)
AOCE111571376 111580988(lcat)
MCEP125015552(lcat)
CSEM103379476(lcat)
POV109640722(lcat)
SSEN122775468(lcat)
HHIP117763422(lcat)
HSP118109073(lcat)
LCF108902284
SDU111222526
SLAL111658753
XGL120792748(lcat)
HCQ109530510(lcat)
BPEC110169665(lcat)
MALB109962590(lcat)
BSPL114857615(lcat)
SASA106560930 106573639 106586453
STRU115151849 115160988 115196917
OTW112218440(lcat) 112239001
OMY110493939(lcat) 110520303
OGO124038056(lcat) 124044025
ONE115115763 115134388
SALP111952179 111962272 112070622
SNH120053827 120058359 120066180(lcat)
CCLU121531777(lcat) 121536317 121576734
ELS105018521(lcat) 105030834
SFM108926635(lcat)
PKI111859180(lcat)
AANG118215008(lcat)
LOC102687390 102688341
PSPA121325461(lcat)
ARUT117424391 117425440
LCM102355092(LCAT)
CMK103187891(lcat)
RTP109923672
BTAB109033542 109036505 109037623 109038896 109038931 109039462 109039469
HAZT108665134
TUT107367730 107371496
HROHELRODRAFT_188013
HRF124119025
SMMSmp_160880
EGLEGR_09212
AQU100638840 100638967 100640908 105311929
VCNVOLCADRAFT_115914
MNGMNEG_2131
CCPCHC_T00009171001
MBRMONBRDRAFT_22180 MONBRDRAFT_37422 MONBRDRAFT_9050
SREPTSG_10314
EHIEHI_136400(33.t00023)
EDIEDI_096100 EDI_137460
EIVEIN_327950
ACANACA1_052320 ACA1_219870
PFAPF3D7_0629300
PFHPFHG_00646
PREIPRSY57_0627700
PGABPGSY75_0629300
PYOPY17X_1129600
PCBPCHAS_1127600
PBEPBANKA_1128100
PVVPVVCY_1102920
PKNPKNH_1120200
PVXPVX_114565
PCYPCYB_112870
TGOTGME49_272420
PTMGSPATT00007676001 GSPATT00008044001 GSPATT00029843001 GSPATT00030228001
EHXEMIHUDRAFT_434784
GTTGUITHDRAFT_104499
NGRNAEGRDRAFT_67947 NAEGRDRAFT_67955
TVATVAG_2v0001840 TVAG_2v0075620 TVAG_2v0175570 TVAG_2v0603870 TVAG_2v0742030 TVAG_2v1037790
AVMJQX13_20765
NOWGBF35_40895
KALKALB_6769
 » show all
Reference
1
  Authors
Bartlett, K., Keat, M.J. and Mercer, E.I.
  Title
Biosynthesis of sterol esters in Phycomyces blakesleeanus.
  Journal
Phytochemistry 13:1107-1113 (1974)
Reference
2  [PMID:7061477]
  Authors
Buckley JT, Halasa LN, MacIntyre S.
  Title
Purification and partial characterization of a bacterial phospholipid: cholesterol acyltransferase.
  Journal
J Biol Chem 257:3320-5 (1982)
Reference
3  [PMID:4868699]
  Authors
Glomset JA.
  Title
The plasma lecithins:cholesterol acyltransferase reaction.
  Journal
J Lipid Res 9:155-67 (1968)
Reference
4  [PMID:4877146]
  Authors
Vahouny GV, Treadwell CR.
  Title
Enzymatic synthesis and hydrolysis of cholesterol esters.
  Journal
Methods Biochem Anal 16:219-72 (1968)
DOI:10.1002/9780470110348.ch4
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.43
IUBMB Enzyme Nomenclature: 2.3.1.43
ExPASy - ENZYME nomenclature database: 2.3.1.43
BRENDA, the Enzyme Database: 2.3.1.43
CAS: 9031-14-5

DBGET integrated database retrieval system