KEGG   ENZYME: 2.4.1.115
Entry
EC 2.4.1.115                Enzyme                                 
Name
anthocyanidin 3-O-glucosyltransferase;
uridine diphosphoglucose-anthocyanidin 3-O-glucosyltransferase;
UDP-glucose:anthocyanidin/flavonol 3-O-glucosyltransferase;
UDP-glucose:cyanidin-3-O-glucosyltransferase;
UDP-glucose:anthocyanidin 3-O-D-glucosyltransferase;
3-GT
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-D-glucose:anthocyanidin 3-O-beta-D-glucosyltransferase
Reaction(IUBMB)
UDP-D-glucose + an anthocyanidin = UDP + an anthocyanidin-3-O-beta-D-glucoside [RN:R03797]
Reaction(KEGG)
Substrate
UDP-D-glucose [CPD:C00029];
anthocyanidin [CPD:C02003]
Product
UDP [CPD:C00015];
anthocyanidin-3-O-beta-D-glucoside
Comment
The anthocyanidin compounds cyanidin, delphinidin, peonidin and to a lesser extent pelargonidin can act as substrates. The enzyme does not catalyse glucosylation of the 5-position of cyanidin and does not act on flavanols such as quercetin and kaempferol (cf. EC 2.4.1.91 flavonol 3-O-glucosyltransferase). In conjunction with EC 1.14.20.4, anthocyanidin oxygenase, it is involved in the conversion of leucoanthocyanidin into anthocyanidin 3-glucoside. It may act on the pseudobase precursor of the anthocyanidin rather than on the anthocyanidin itself [3].
History
EC 2.4.1.115 created 1984 (EC 2.4.1.233 created 2004, incorporated 2005), modified 2005
Pathway
ec00942  Anthocyanin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K12930  anthocyanidin 3-O-glucosyltransferase
Genes
CIT102609299
CICCICLE_v10019770mg
PVY116144649
MINC123220308
TCC18599492 18599494
GRA105787922
GHI107924731 107950567
GAB108466937
DZI111296738
EGR104450361 104450379
GMX100795736
GSJ114417828
PVUPHAVU_002G214300g PHAVU_002G214400g PHAVU_002G214500g
VRA106766336
VAR108320291
VUN114176045 114179836
CCAJ109804763
CAM101489215(UGT78K4) 101501347(UGT78K5)
LJALj4g3v0434280.1(Lj4g3v0434280.1)
ADU107480473
AIP107631056
AHF112733385 112791318
FVE101300000
RCN112185370
PPER18785045 18791494
PMUM103323505 103333513
PAVI110749579 110752521
PDUL117617836
MDM103420802 103440008 103443954
PXB103951514 103957868
ZJU107414867
MNT21402630
RCU8283075
HBR110636383 110667678
MESC110621779
POP18104516 7497385
PEU105135163 105140379
PALZ118028146 118043647
QSU111985672 112012596 112012601 112037056 112037080 112037083
QLO115960228
TWL119983424 119995922
VVI100233099(UFGT) 100244489(VVGT6) 100247914(VvGT5) 100249544 100249635 100254753 100258170
VRI117916640 117916949 117924467 117924658 117925321 117925327 117925990 117933447
SLY101260093
SPEN107002755 107025544
SOT102577753
SSTN125865949
CANN107843659 107843660 107872096 107876989
NTA107781346(Nt3GT2) 107822886(Nt3GT1) 107823155 107824715
NSY104222537 104245263
NTO104093878 104111088
NAU109205262 109215787
INI109182028(UF3GT) 109191717
ITR116005478 116006041
SIND105155667 105162857
OEU111374585 111404029
EGT105952305
SSPL121788781 121788785 121794192 121797198
HAN110873488 110873490 110873554 110873558 110881267 110940191
LSV111884088 111894781
CCAV112507289
DCR108213096 108221067 108225279
CSIN114285774 114288492 114310104 114310133
BVG104888025
SOE110803459
CQI110692996 110692997 110693001 110693002 110713003 110725973
NNU104603221 104605389 104611375 104613452 104613453
MING122060248 122066715 122086308
TSS122645208 122645344 122645345 122645348 122646259 122646260
PSOM113272402 113272403 113272404 113279548 113279549 113282609 113299339 113358582
NCOL116249851
OSA4340373 4342400
DOSAOs06t0192100-00(Os06g0192100) Os07t0148200-01(Os07g0148200)
OBR102711363 121054737
BDI100841090
ATS109740107 109747995 109747997
TDC119299528 119303381 119304303 119316086 119328150 119335763 119361551
TAES123068626 123068756 123075718 123084311 123150203 123157851 123162466 123166533 123179872
TUA125521043 125542754 125542763
SBI8065445 8081542
ZMA100217238 732800
SITA101752764 101786047
SVS117851582 117865125
PVIR120670357 120702884 120702885 120709204
PHAI112889920
PDA103715944 103718397
EGU105039250 105039612
MUS103969068 103969873 103975050 103976895 108953348
DCT110095211
PEQ110031211
AOF109821966 109841711
 » show all
Reference
1  [PMID:751640]
  Authors
Kamsteeg J, van Brederode J, van Nigtevecht G.
  Title
Identification and properties of UDP-glucose: cyanidin-3-O-glucosyltransferase isolated from petals of the red campion (Silene dioica).
  Journal
Biochem Genet 16:1045-58 (1978)
DOI:10.1007/bf00484525
Reference
2  [PMID:9535914]
  Authors
Ford CM, Boss PK, Hoj PB
  Title
Cloning and characterization of Vitis vinifera UDP-glucose:flavonoid 3-O-glucosyltransferase, a homologue of the enzyme encoded by the maize Bronze-1 locus that may primarily serve to glucosylate anthocyanidins in vivo.
  Journal
J Biol Chem 273:9224-33 (1998)
DOI:10.1074/jbc.273.15.9224
  Sequence
[vvi:100233099]
Reference
3  [PMID:11316805]
  Authors
Nakajima  J, Tanaka Y, Yamazaki M, Saito K.
  Title
Reaction mechanism from leucoanthocyanidin to anthocyanidin 3-glucoside, a key reaction for coloring in anthocyanin biosynthesis.
  Journal
J Biol Chem 276:25797-803 (2001)
DOI:10.1074/jbc.M100744200
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.115
IUBMB Enzyme Nomenclature: 2.4.1.115
ExPASy - ENZYME nomenclature database: 2.4.1.115
BRENDA, the Enzyme Database: 2.4.1.115
CAS: 65607-32-1

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