KEGG   ENZYME: 2.4.1.122
Entry
EC 2.4.1.122                Enzyme                                 

Name
N-acetylgalactosaminide beta-1,3-galactosyltransferase;
glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase;
uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase;
UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase;
UDP-Gal:alpha-D-GalNAc-1,3-alpha-D-GalNAc-diphosphoundecaprenol beta-1,3-galactosyltransferase;
wbnJ (gene name);
wbiP (gene name);
C1GALT1 (gene name);
UDP-alpha-D-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-galactose:N-acetyl-alpha-D-galactosaminyl-R beta-1,3-galactosyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R [RN:R05908]
Reaction(KEGG)
R05908(G);
(other) R10436
Substrate
UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-alpha-D-galactosaminyl-R [CPD:C04387]
Product
UDP [CPD:C00015];
beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R [CPD:C04750]
Comment
The eukaryotic enzyme can act on non-reducing O-serine-linked N-acetylgalactosamine residues in mucin glycoproteins, forming the T-antigen. The bacterial enzyme, found in some pathogenic strains, is involved in biosynthesis of the O-antigen repeating unit.
History
EC 2.4.1.122 created 1984 (EC 2.4.1.307 created 2013, incorporated 2016), modified 2016
Pathway
ec00512  Mucin type O-glycan biosynthesis
ec00514  Other types of O-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K00731  glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase
K21366  O86/O127-antigen biosynthesis beta-1,3-galactosyltransferase
Genes
HSA: 56913(C1GALT1)
PTR: 472288(C1GALT1)
PPS: 100977740(C1GALT1)
GGO: 101145951(C1GALT1)
PON: 100452461(C1GALT1)
NLE: 100583301(C1GALT1)
MCC: 696870(C1GALT1)
MCF: 102137839(C1GALT1)
CSAB: 103226504(C1GALT1)
CATY: 105592213(C1GALT1)
PANU: 101021710(C1GALT1)
RRO: 104668754(C1GALT1)
RBB: 108543414(C1GALT1)
TFN: 117073715(C1GALT1)
PTEH: 111551061(C1GALT1)
CJC: 100406487(C1GALT1)
SBQ: 101029936(C1GALT1)
MMUR: 105867281(C1GALT1)
MMU: 94192(C1galt1)
MCAL: 110296408(C1galt1)
MPAH: 110316313(C1galt1)
RNO: 65044(C1galt1)
MCOC: 116098564(C1galt1)
MUN: 110554784(C1galt1)
CGE: 100761169(C1galt1)
PLEU: 114693464(C1galt1) 119087491
NGI: 103751705(C1galt1)
HGL: 101704643(C1galt1)
CPOC: 100714236(C1galt1)
CCAN: 109703122(C1galt1)
OCU: 100359047(C1GALT1)
OPI: 101517554(C1GALT1)
TUP: 102479007(C1GALT1)
CFA: 482314(C1GALT1)
VVP: 112923919(C1GALT1)
VLG: 121474443(C1GALT1)
AML: 100483848(C1GALT1)
UMR: 103658758(C1GALT1)
UAH: 113260469(C1GALT1)
ORO: 101378420(C1GALT1)
ELK: 111147376
MPUF: 101679626(C1GALT1)
EJU: 114222371(C1GALT1)
MLX: 118020797(C1GALT1)
FCA: 101096459(C1GALT1)
PYU: 121028699(C1GALT1)
PBG: 122487914(C1GALT1)
PTG: 102965358(C1GALT1)
PPAD: 109263732(C1GALT1)
AJU: 106970015(C1GALT1)
HHV: 120234409(C1GALT1)
BTA: 539417(C1GALT1)
BOM: 102287025(C1GALT1)
BIU: 109558238(C1GALT1)
BBUB: 102406993(C1GALT1)
CHX: 102169248(C1GALT1)
OAS: 101120567(C1GALT1)
ODA: 120877984(C1GALT1)
CCAD: 122438126(C1GALT1)
SSC: 100525767(C1GALT1)
CFR: 102514986(C1GALT1)
CBAI: 105082622(C1GALT1)
CDK: 105088713(C1GALT1)
BACU: 103001219(C1GALT1)
LVE: 103071088(C1GALT1)
OOR: 101282789(C1GALT1)
DLE: 111181388(C1GALT1)
PCAD: 102983236(C1GALT1)
PSIU: 116759501(C1GALT1)
ECB: 100063865(C1GALT1)
EPZ: 103540682(C1GALT1)
EAI: 106839569(C1GALT1)
MYB: 102244854(C1GALT1) 102250159
MYD: 102754234(C1GALT1)
MMYO: 118666189(C1GALT1)
MLF: 102421329(C1GALT1)
MNA: 107541729(C1GALT1)
PKL: 118714261(C1GALT1)
HAI: 109394810(C1GALT1)
DRO: 112319804(C1GALT1)
SHON: 118987327(C1GALT1)
AJM: 119042884(C1GALT1)
PDIC: 114507535(C1GALT1)
MMF: 118620030(C1GALT1)
RFQ: 117012257(C1GALT1)
PALE: 102883390(C1GALT1)
PGIG: 120614990(C1GALT1)
RAY: 107504471(C1GALT1)
MJV: 108406054(C1GALT1)
TOD: 119242618(C1GALT1)
LAV: 100670784(C1GALT1)
TMU: 101357588
GAS: 123249369(C1GALT1)
SHR: 100932643(C1GALT1)
PCW: 110217609(C1GALT1)
OAA: 103169736(C1GALT1)
GGA: 420575(C1GALT1)
PCOC: 116243206(C1GALT1)
MGP: 100542429(C1GALT1)
CJO: 107309116(C1GALT1)
NMEL: 110394018(C1GALT1)
APLA: 101797632(C1GALT1)
ACYG: 106037532(C1GALT1)
TGU: 100221974(C1GALT1)
LSR: 110474721(C1GALT1)
SCAN: 103812837(C1GALT1)
PMOA: 120502061(C1GALT1)
OTC: 121334270 121338046(C1GALT1)
PRUF: 121352968(C1GALT1) 121356355
GFR: 102032158(C1GALT1)
FAB: 101810221(C1GALT1)
PHI: 102103229(C1GALT1) 102104490
PMAJ: 107199204 107200786(C1GALT1)
CCAE: 111924251(C1GALT1) 111944042
CCW: 104689153(C1GALT1)
ETL: 114073121(C1GALT1)
FPG: 101923797(C1GALT1)
FCH: 102059381(C1GALT1)
CLV: 102088254(C1GALT1)
EGZ: 104129130(C1GALT1)
ACUN: 113476756(C1GALT1)
PADL: 103922365(C1GALT1)
AAM: 106483404(C1GALT1) 106492776
AROW: 112961596 112969388(C1GALT1)
NPD: 112944755(C1GALT1) 112959427
DNE: 112982817(C1GALT1)
AMJ: 102558826(C1GALT1) 102575907
CPOO: 109309104(C1GALT1) 109324423
GGN: 109291436(C1GALT1)
PSS: 102460792(C1GALT1)
CPIC: 101931210 101942937(C1GALT1) 101945118
ACS: 100554192 100562160(c1galt1)
PVT: 110070539 110073023(C1GALT1)
SUND: 121922342 121934781(C1GALT1)
PBI: 103050549(C1GALT1) 103063573
PMUR: 107283657(C1GALT1) 107288525
TSR: 106539635 106540395(C1GALT1)
PGUT: 117655262(C1GALT1) 117666500
VKO: 123022727(C1GALT1) 123029802
PMUA: 114586421 114607087(C1GALT1)
ZVI: 118079220 118092007(C1GALT1)
XLA: 108707741 108708597 108708598 108709868(XB5871033.S) 108709869 108718847(c1galt1.L) 108719911(c1galt1.S) 444326(XB5871033.L)
DRE: 337131(c1galt1b) 555344(si:dkey-202e17.1) 557675(c1galt1a)
IPU: 108272220(c1galt1b) 108276279
PHYP: 113530505 113532793(c1galt1) 113545818
CGOB: 115008682 115010640 115015764(c1galt1)
ELY: 117257023(c1galt1b) 117257789(c1galt1a) 117263960(si:dkey-202e17.1)
PLEP: 121947115(c1galt1a) 121955764(c1galt1b) 121957882(si:dkey-202e17.1)
SLUC: 116035927(si:dkey-202e17.1) 116039016(c1galt1a) 116065426(c1galt1b)
ECRA: 117943918(c1galt1b) 117947780(c1galt1a) 117956694(si:dkey-202e17.1)
PFLV: 114554259 114559121 114567801(c1galt1)
GAT: 120826843(si:dkey-202e17.1) 120829107(c1galt1a) 120835601(c1galt1b)
PPUG: 119219412(si:dkey-202e17.1) 119223437(c1galt1a) 119229543(c1galt1b)
MSAM: 119886155(c1galt1b) 119906013(c1galt1a) 119907962(si:dkey-202e17.1)
OAU: 116315572 116325895(c1galt1a) 116336515
OML: 112136909(si:dkey-202e17.1) 112145592(c1galt1b) 112159664(c1galt1a)
PRET: 103465384 103467345 103471939(c1galt1)
GAF: 122830784(c1galt1a) 122834728(c1galt1b) 122843788(si:dkey-202e17.1)
CTUL: 119776665(c1galt1b) 119776727(si:dkey-202e17.1) 119782263
KMR: 108235736(c1galt1b) 108244574(c1galt1a)
AOCE: 111566642 111575167(c1galt1) 111587244
CSEM: 103385080 103385956 103394502(c1galt1)
SSEN: 122768836(c1galt1b) 122777116(c1galt1a) 122786564(si:dkey-202e17.1)
HHIP: 117761302(c1galt1b) 117765025(c1galt1a) 117771128(si:dkey-202e17.1)
SLAL: 111667825 111668780(c1galt1) 111668905
XGL: 120786241(si:dkey-202e17.1) 120804220(c1galt1a) 120807520(c1galt1b)
BPEC: 110161213(c1galt1) 110164964 110168386
SFM: 108918317 108935659(c1galt1)
AANG: 118207879(c1galt1a) 118210935(c1galt1b) 118216359 118221645
LOC: 102690951(c1galt1) 102699134
ARUT: 117401069 117433417 117435759(si:dkey-202e17.1) 117962369
CMK: 103173764(c1galt1b) 103183841 103185987(si:dkey-202e17.1)
RTP: 109910639(c1galt1) 109927325
CIN: 100182788
DME: Dmel_CG2975(CG2975) Dmel_CG2983(CG2983) Dmel_CG3119(CG3119) Dmel_CG34056(CG34056) Dmel_CG34057(CG34057) Dmel_CG34451(CG34451) Dmel_CG34452(CG34452) Dmel_CG7440(tgy) Dmel_CG8708(CG8708) Dmel_CG9520(C1GalTA)
DSI: Dsimw501_GD10181(Dsim_GD10181) Dsimw501_GD12540(Dsim_GD12540) Dsimw501_GD12541(Dsim_GD12541) Dsimw501_GD13582(Dsim_GD13582) Dsimw501_GD22375(Dsim_GD22375) Dsimw501_GD22798(Dsim_GD22798) Dsimw501_GD23186(Dsim_GD23186) Dsimw501_GD23187(Dsim_GD23187) Dsimw501_GD24465(Dsim_GD24465) Dsimw501_GD27301(Dsim_GD27301)
PGC: 109856374
NVI: 100120600
BMOR: 101746328
BANY: 112045043
PMAC: 106709178
PPOT: 106107663
PXU: 106127176
PRAP: 110993263
ZCE: 119830789
HAW: 110374915
TNL: 113498994
API: 100168660
DNX: 107167669
AGS: 114122443
RMD: 113549883
BTAB: 109042199
ZNE: 110837984
CEL: CELE_C38H2.2(C38H2.2)
CBR: CBG_18398
BMY: BM_BM2667(Bm2667)
TSP: Tsp_00464
ATEN: 116305555
ADF: 107348169
AMIL: 114954137
PDAM: 113668011
SPIS: 111340814
DGT: 114516537
SMIN: v1.2.011019.t1(symbB.v1.2.011019.t1)
NGD: NGA_0449900(C1GALT1)
ECG: E2348C_2172(wbiP)
 » show all
Reference
1  [PMID:6789880]
  Authors
Hesford FJ, Berger EG, Van den Eijnden DH.
  Title
Identification of the product formed by human erythrocyte galactosyltransferase.
  Journal
Biochim Biophys Acta 659:302-11 (1981)
DOI:10.1016/0005-2744(81)90056-5
Reference
2  [PMID:6801057]
  Authors
Mendicino J, Sivakami S, Davila M, Chandrasekaran EV.
  Title
Purification and properties of UDP-gal:N-acetylgalactosaminide mucin: beta 1,3-galactosyltransferase from swine trachea mucosa.
  Journal
J Biol Chem 257:3987-94 (1982)
Reference
3  [PMID:6366476]
  Authors
Schachter H, Narasimhan S, Gleeson P, Vella G.
  Title
Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type.
  Journal
Methods Enzymol 98:98-134 (1983)
DOI:10.1016/0076-6879(83)98143-0
Reference
4  [PMID:11677243]
  Authors
Ju T, Brewer K, D'Souza A, Cummings RD, Canfield WM
  Title
Cloning and expression of human core 1 beta1,3-galactosyltransferase.
  Journal
J Biol Chem 277:178-86 (2002)
DOI:10.1074/jbc.M109060200
  Sequence
[hsa:56913] [mmu:94192] [rno:65044] [cel:CELE_C38H2.2] [dme:Dmel_CG9520 Dmel_CG8708]
Reference
5  [PMID:18179256]
  Authors
Yi W, Perali RS, Eguchi H, Motari E, Woodward R, Wang PG
  Title
Characterization of a bacterial beta-1,3-galactosyltransferase with application in the synthesis of tumor-associated T-antigen mimics.
  Journal
Biochemistry 47:1241-8 (2008)
DOI:10.1021/bi7020712
Reference
6  [PMID:20418877]
  Authors
Woodward R, Yi W, Li L, Zhao G, Eguchi H, Sridhar PR, Guo H, Song JK, Motari E, Cai L, Kelleher P, Liu X, Han W, Zhang W, Ding Y, Li M, Wang PG
  Title
In vitro bacterial polysaccharide biosynthesis: defining the functions of Wzy and Wzz.
  Journal
Nat Chem Biol 6:418-23 (2010)
DOI:10.1038/nchembio.351
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.122
IUBMB Enzyme Nomenclature: 2.4.1.122
ExPASy - ENZYME nomenclature database: 2.4.1.122
BRENDA, the Enzyme Database: 2.4.1.122
CAS: 97089-61-7

DBGET integrated database retrieval system