KEGG   ENZYME: 2.4.1.142
Entry
EC 2.4.1.142                Enzyme                                 
Name
chitobiosyldiphosphodolichol beta-mannosyltransferase;
guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase;
GDP-mannose-dolichol diphosphochitobiose mannosyltransferase;
GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-alpha-D-mannose:N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol 4-beta-D-mannosyltransferase (configuration-inverting)
Reaction(IUBMB)
GDP-alpha-D-mannose + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol = GDP + beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol [RN:R04502 R05972]
Reaction(KEGG)
R04502 R05972(G)
Substrate
GDP-alpha-D-mannose [CPD:C00096];
N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
Product
GDP [CPD:C00035];
beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
History
EC 2.4.1.142 created 1984, modified 2001
Pathway
ec00510  N-Glycan biosynthesis
ec00513  Various types of N-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K03842  beta-1,4-mannosyltransferase
Genes
HSA56052(ALG1)
PTR453895(ALG1)
PPS100982195(ALG1)
GGO101140257(ALG1) 115934039(ALG1L)
PON100173370(ALG1) 100431263
NLE100602863(ALG1)
MCC710713(ALG1)
MCF101865928(ALG1)
MTHB126944655
CSAB103227830(ALG1)
CATY105572133(ALG1)
PANU101017965(ALG1)
TGE112613706(ALG1)
RRO104654665(ALG1)
RBB108538315(ALG1)
TFN117097686(ALG1)
PTEH111551656(ALG1)
CJC100400085(ALG1)
SBQ101032945(ALG1)
CSYR103255713(ALG1)
MMUR105859711(ALG1)
LCAT123632353(ALG1)
OGA100962479(ALG1)
MMU208211(Alg1)
MCAL110311450(Alg1)
MPAH110329829(Alg1)
RNO360475(Alg1)
MCOC116084554(Alg1)
MUN110548788(Alg1)
CGE100773731(Alg1)
MAUA101844853(Alg1)
PLEU114682437(Alg1)
MORG121463801(Alg1)
MFOT126496787
AAMP119812766(Alg1)
NGI103744783(Alg1)
HGL101706108(Alg1)
CPOC100723491(Alg1)
CCAN109698326(Alg1)
DORD105982207(Alg1)
DSP122123868(Alg1)
NCAR124970139
OCU100353396(ALG1)
OPI101523686(ALG1)
TUP102498955(ALG1)
CFA490017(ALG1)
CLUD112640405(ALG1)
VVP112923295(ALG1)
VLG121488237(ALG1)
AML100474990(ALG1)
UMR103668569(ALG1)
UAH113270823(ALG1)
UAR123783270(ALG1)
ELK111156001
LLV125090784
MPUF101681035(ALG1)
ORO101374118(ALG1)
EJU114219888(ALG1)
ZCA113932990(ALG1)
MLX118021806(ALG1)
NSU110587879(ALG1)
FCA101091331(ALG1)
PYU121019561(ALG1)
PBG122471700(ALG1)
LRUF124517978
PTG102966396(ALG1)
PPAD109278289(ALG1)
AJU106978824(ALG1)
HHV120236506(ALG1)
BTA507210(ALG1)
BOM102269961(ALG1)
BIU109578685(ALG1)
BBUB102393158(ALG1)
CHX102187731(ALG1)
OAS101104800(ALG1)
ODA120874726(ALG1)
CCAD122433192(ALG1)
SSC100524193(ALG1)
CFR102503439(ALG1)
CBAI105065762(ALG1)
CDK105098401(ALG1)
VPC102525185(ALG1)
BACU103007281(ALG1)
LVE103086066(ALG1)
OOR101274998(ALG1)
DLE111185277(ALG1)
PCAD102995349(ALG1)
PSIU116740326(ALG1)
ECB100147524(ALG1)
EPZ103563126(ALG1)
EAI106826034(ALG1)
MYB102247170(ALG1)
MYD102770836(ALG1)
MMYO118656164(ALG1)
MLF102436563(ALG1)
MNA107538286(ALG1)
PKL118703590(ALG1)
HAI109392138(ALG1)
DRO112298385(ALG1)
SHON118975824(ALG1)
AJM119047988(ALG1)
PDIC114502529(ALG1)
PHAS123807159(ALG1)
MMF118642668(ALG1)
RFQ117019721(ALG1)
PALE102878656(ALG1)
PGIG120620363(ALG1)
PVP105303074(ALG1)
RAY107518985(ALG1)
MJV108406665(ALG1)
TOD119241958(ALG1)
SARA101554114(ALG1)
LAV100667810(ALG1)
TMU101350793
DNM101411778(ALG1)
MDO100026716(ALG1)
GAS123232766(ALG1)
SHR100924461(ALG1)
PCW110203198(ALG1)
OAA114809056(ALG1) 114812198
GGA416393(ALG1)
PCOC116230297(ALG1)
MGP100548716
CJO107320944(ALG1)
NMEL110405759(ALG1)
APLA101797669(ALG1)
ACYG106046345(ALG1)
AFUL116495481(ALG1)
TGU100223607(ALG1)
LSR110470213(ALG1)
SCAN103817955(ALG1)
PMOA120513098(ALG1)
OTC121337187(ALG1)
PRUF121350752(ALG1)
GFR102038240(ALG1)
FAB101813767(ALG1)
PHI102110968(ALG1)
PMAJ107211330(ALG1)
CCAE111935852(ALG1)
CCW104684651(ALG1)
CBRC103620519(ALG1)
ETL114060236(ALG1)
ZAB102072026(ALG1)
ACHL103797576(ALG1)
FPG101919558(ALG1)
FCH102052995(ALG1)
CLV102084166(ALG1)
EGZ104127217(ALG1)
NNI104023535(ALG1)
PLET104614594(ALG1)
PCRI104027457
PCAO104039750
ACUN113485519(ALG1)
TALA104355769(ALG1)
PADL103917192(ALG1)
AFOR103897302(ALG1)
ACHC115335859(ALG1)
HALD104310813
CCRI104166312(ALG1)
CSTI104550033(ALG1)
EHS104509295(ALG1)
CMAC104473584(ALG1)
MUI104540451(ALG1)
FGA104069848
LDI104340654
OHA104336116(ALG1)
NNT104410732(ALG1)
DPUB104299245(ALG1)
PGUU104458627
AVIT104268026
CVF104292213(ALG1)
CUCA104068202(ALG1)
AAM106500002(ALG1)
AROW112965135(ALG1)
NPD112955678(ALG1)
TGT104570251
DNE112981065(ALG1)
SCAM104147559(ALG1)
ASN102385977(ALG1)
AMJ102560208(ALG1)
PSS102447088(ALG1)
CMY102944470(ALG1)
CPIC101939553(ALG1)
TST117883954(ALG1)
CABI116819177(ALG1)
MRV120373499(ALG1)
ACS100561527(alg1)
PVT110085605(ALG1)
SUND121914774(ALG1)
PBI103064195(ALG1)
PMUR107295340(ALG1) 107299043
CTIG120310888(ALG1)
TSR106549573(ALG1)
PGUT117667277(ALG1)
VKO123017270(ALG1)
PMUA114584218(ALG1)
ZVI118093075(ALG1)
GJA107114193(ALG1)
STOW125431794(ALG1)
XLA100037043(alg1.L)
XTR594994(alg1)
NPR108802292(ALG1)
RTEM120943610(ALG1)
BBUF121007743(ALG1)
BGAR122945852(ALG1)
DRE334161(alg1)
SRX107733873 107738611
SANH107680860 107690237
SGH107568154(alg1) 107568161 107580414
CCAR109057918 109057945(alg1)
CAUA113042932 113046998
PPRM120489543(alg1)
MAMB125275981(alg1)
IPU108256341(alg1)
PHYP113546898(alg1)
SMEO124396902(alg1)
TFD113637454(alg1)
AMEX103033036(alg1)
EEE113572876(alg1)
TRU101075446(alg1)
TNGGSTEN00015457G001 GSTEN00021284G001
LCO104923395(alg1)
NCC104948568(alg1)
ELY117268034(alg1)
EFO125879544(alg1)
PLEP121956681(alg1)
SLUC116063761(alg1)
ECRA117957632(alg1)
ESP116702967(alg1)
PFLV114570332(alg1)
GAT120827557(alg1)
PPUG119221009(alg1)
MSAM119884373 119895088(alg1)
CUD121503931(alg1)
ALAT119014720(alg1)
MZE101470141(alg1)
ONL100699734(alg1)
OAU116314268(alg1)
OLA101157620(alg1)
OML112146576(alg1)
XMA102225456(alg1)
XCO114159794(alg1)
XHE116735689(alg1)
PRET103469070(alg1)
PFOR103132206(alg1)
PLAI106940683(alg1)
PMEI106934316(alg1)
GAF122821654(alg1)
CVG107088937(alg1)
CTUL119796873(alg1)
GMU124862748 124864258
NFU107395405(alg1)
KMR108229762(alg1)
ALIM106511879 106535780(alg1)
NWH119421192(alg1)
AOCE111567271(alg1)
MCEP124997952(alg1)
CSEM103393481(alg1)
POV109634248(alg1)
SSEN122784888(alg1)
HHIP117765845(alg1)
HSP118123985(alg1)
LCF108888581
SDU111217543(alg1)
SLAL111669732(alg1)
XGL120782994(alg1)
HCQ109527774(alg1)
BPEC110154480(alg1)
MALB109962851(alg1)
BSPL114860525(alg1)
SASA106565682(alg1) 106594383
STRU115147231 115181485
OTW112240312 121839580
OMY110494400 110512418
OGO124018607 124027274
SALP112075909 112075910
SNH120042341 120042352
CCLU121551676(alg1) 121570339
ELS105030586(alg1)
SFM108941805(alg1)
PKI111849308(alg1)
AANG118216009(alg1)
LOC102698501(alg1)
PSPA121300876(alg1)
ARUT117431295(alg1)
LCM102355761(ALG1)
CMK103178836(alg1)
RTP109914501(alg1) 109935885
BFO118428827
BBEL109483457
CIN100177331
SCLV120327695
SPU115918808 587377
APLC110986124
SKO100370845
DMEDmel_CG18012(Alg1)
DER6551888
DSE6616677
DSIDsimw501_GD20206(Dsim_GD20206)
DYADyak_GE25241
DAN6501027
DSR110189921
DPO6897950
DPE6594245
DMN108154210
DWI6647805
DGR6568205
DMODmoj_GI23885
DAZ108621223
DNV108658781
DHE111601361
DVI6629657
CCAT101458669
BOD106617422
RZE108364280 108364281
MDE101889251
SCAC106081613
LCQ111684389 111687151
LSQ119606838 119610734
HIS119659899
AGAAgaP_AGAP003551
ACOZ120951414
AARA120896784
ASTE118503616
AAG5577325
AALB109427220 115257312 115261429
CQUCpipJ_CPIJ007482
CPII120427944
CNS116342341
BCOO119078029
AME551379
ACER108000117
ALAB122713629
BIM100742534
BBIF117214370
BVK117231475
BVAN117166536
BTER100651652
BPYO122572938
CCAL108629365
OBB114881807
MGEN117220867
NMEA116432624
CGIG122397180
SOC105205199
MPHA105839128
AEC105152616
ACEP105621774
PBAR105426120
VEM105566114 105570207
HST105183269
DQU106743337
CFO105249084
FEX115235904
LHU105671350
PGC109851867
OBO105279534 105279549
PCF106793480
PFUC122516482
VPS122628761
NVI100117051
CSOL105366973
TPRE106659425
MDL103569122
CGLO123268799
FAS105270827
DAM107040967
AGIF122853462
LHT122499555
CCIN107265628
TCA664134
DPA109546989
SOY115880589
ATD109606374
CSET123314931
AGB108912257
LDC111503191
NVL108566490
APLN108737176
PPYR116173657
OTU111419741
BMOR101745560
MSEX115447799
DPLKGM_210335
BANY112045672
NIQ126774313
PMAC106720740
PPOT106101713
PXU106121431
PRAP111003457
ZCE119840838
HAW110375585
HZE124634895
TNL113497859
SLIU111358746
OFU114363652
PXY105383608
CFEL113366122
API100166741
DNX107162181
AGS114125191
RMD113559298
BTAB109041451
DCI103508500
CLEC106663230
HHAL106686253
NLU111047467
PHUPhum_PHUM232220
FOC113208595
TPAL117653989
ZNE110837343
CSEC111862782
FCD110845894
DPXDAPPUDRAFT_304651
DMK116935751
PVM113820919
PJA122256879
PCHN125033366
HAME121878068
PCLA123757484
PTRU123506390
HAZT108679175
EAF111701598
LSM121121246
PPOI119096045
ISCIscW_ISCW018248
DSV119453289
RSAN119400192
RMP119179624
VDE111250811
VJA111266203
TUT107367870 107367873
DPTE113795843
DFR124497450
CSCU111612918
PTEP107436820
SDM118189400
CELCELE_T26A5.4(algn-1)
CBRCBG_19680
BMYBM_BM6016(Bma-algn-1)
LOALOAG_01802
NAINECAME_11542
TSPTsp_00267
HROHELRODRAFT_101462
LGILOTGIDRAFT_210506
PCAN112556926
BGT106054131
GAE121378477
HRF124142282
HRJ124280908
CRG105345972
MYI110455665
PMAX117331676
MMER123565050
OBI106882808
OSN115211047 115227148
LAK106161266 106178901
SMMSmp_005010
SHXMS3_00004096(ALG1)
OVIT265_13012
EGLEGR_04226
NVE5508433
EPA110240934
ATEN116297239
ADF107356387
AMIL114959309
PDAM113669287
SPIS111340400
DGT114537768 114537943
XEN124453255
TADTRIADDRAFT_33634
AQU100640304
ATHAT1G16570
ALY9326236
CRB17899031
CSAT104740340 104755977 104775758
EUSEUTSA_v10007520mg
BRP103842844 103872447
BNA106346759 106365597 106415989 106416106
BOE106295497 106311945
RSZ108812497 108830688 108831727
THJ104808122
CPAP110808818
CIT102618309
CICCICLE_v10001005mg
PVY116113275 116125718
MINC123229196
TCC18611902
GRA105803962
GHI107900527 107900580 121209919
GAB108454174 108473346 108473347
DZI111299750
EGR104448639
GMX100789238
GSJ114387943 114422105
PVUPHAVU_005G057900g
VRA106762646
VAR108334051
VUN114185244
CCAJ109813598
APRC113853853
MTR11416406
CAM101496914
PSAT127126831
LJALj3g3v2315540.1(Lj3g3v2315540.1)
ADU107477916
AIP107629906
AHF112737600 112789728
LANG109340589
FVE101312809
RCN112165329
PPER18778429
PMUM103325836
PAVI110772884
PDUL117626666
MDM103435652 103445749
PXB103936206 103939607 103945962
ZJU107423363
MNT21406624
CSV101218297
CMO103499272
MCHA111017980
CMAX111469703
CMOS111451822
CPEP111796158
RCU8271840
HBR110647405
MESC110624867
POP18095521
PEU105113808
PALZ118038175
JRE109018722
QSU112014619 112021241 112024707
QLO115983702
TWL119989996
VVI100247296
VRI117907493
SLY101244134
SPEN107031903
SOT102587872
SSTN125865267
CANN107844012
NTA107777499 107778138
NSY104226827
NTO104098177
NAU109233058
INI109155997
ITR115997451
SIND105155191 105165506
OEU111387922 111402403
EGT105957105
SSPL121775584 121776108
HAN110889756
ECAD122591229
LSV111914429
CCAV112507769
DCR108215574
CSIN114282856 114317551
BVG104902686
SOE110785228
CQI110691945 110701994
NNU104608625
MING122077078
TSS122655984
PSOM113283512 113346270 113356223
NCOL116263269
OSA4331831 4341323
DOSAOs03t0180700-01(Os03g0180700)
OBR102709541
BDI100828564
ATS109736324 109753462
TDC119284537 119291652 119302681
TAES123084710 123093393 123098666 123104615 123122393
TUA125510179
SBI8082012
ZMA100282626 109942894
SITA101780939
SVS117840629
PVIR120647110 120689864
PHAI112874446
PDA103711321 120106571
EGU105060664
MUS103995356
DCT110104743
PEQ110022877
AOF109820107
ATR18446975
SMOSELMODRAFT_82712
PPP112275208
CRECHLRE_12g516550v5
VCNVOLCADRAFT_57730
MNGMNEG_3336
CSLCOCSUDRAFT_13297
CVRCHLNCDRAFT_142075
APROF751_2569
OLUOSTLU_18368
OTAOT_ostta16g02020
BPGBathy16g01550
MISMICPUN_68238
MPPMICPUCDRAFT_2692
CMECYME_CMR050C
GSLGasu_12290
SCEYBR110W(ALG1)
SEUBDI49_1141
SPAOSPAR_B02110
AGOAGOS_ADL338C
ERCEcym_3466
KLAKLLA0_B09405g
KMXKLMA_80292(ALG1)
LTHKLTH0F10604g
VPOKpol_1065p18
ZROZYRO0C16368g
CGRCAGL0K12342g
NCSNCAS_0I01090(NCAS0I01090)
NDINDAI_0A07910(NDAI0A07910)
TPFTPHA_0A03560(TPHA0A03560)
TBLTBLA_0H01550(TBLA0H01550)
TDLTDEL_0C05030(TDEL0C05030)
TGBHG536_0B02170
KAFKAFR_0D02690(KAFR0D02690)
KNGKNAG_0B01470(KNAG0B01470)
ZMKHG535_0A02230
PPAPAS_chr2-1_0759
DHADEHA2D10516g
PICPICST_39314(ALG1)
PGUPGUG_04668
SPAASPAPADRAFT_58808
LELLELG_04510
CALCAALFM_C406000WA(ALG1)
CTPCTRG_03901
COTCORT_0B01640
CDUCD36_45550
CTENCANTEDRAFT_101732
YLIYALI0E34133g
CLUCLUG_01323
CLUSA9F13_06g01287
CAURCJI97_002931
SLBAWJ20_4743(ALG1)
PKZC5L36_0A08390
BNNFOA43_003844
BBRXBRETT_000555
OPAHPODL_04499
SLUDSCDLUD_000575
NCRNCU07261
NTENEUTE1DRAFT121451(NEUTE1DRAFT_121451)
SMPSMAC_00796
PANPODANS72p130
MTMMYCTH_2298352
CTHRCTHT_0035300
MGRMGG_10494
PPEIPpBr36_00107
TMNUCRPA7_3377
SSCKSPSK_09170
FGRFGSG_09631
FPUFPSE_05911
FVRFVEG_04190
FOXFOXG_06338
NHENECHADRAFT_91181
TRETRIREDRAFT_103850
TRRM419DRAFT_5621
MAWMAC_06369
MAJMAA_05105
CMTCCM_04210
PLJVFPFJ_00832
VALVDBG_00999
VDAVDAG_00610
CFJCFIO01_03667
CLUPCLUP02_17726
CHIGCH63R_13965
SAPOSAPIO_CDS8446
ELAUCREL1_1987
PFYPFICI_04935
SSLSS1G_02996
BFUBCIN_06g07440(Bcalg1)
MBEMBM_01584
PSCOLY89DRAFT_697098
GLZGLAREA_12739
ANIAN5346.2
AFMAFUA_6G14180
ACTACLA_087290
NFINFIA_060060
AORAO090103000403
ANGANI_1_124054(An06g01100)
AFVAFLA_013129
ALUCAKAW2_51942A(ALG1)
ACHEACHE_10050A(ALG1)
APUUAPUU_10155A(ALG1)
PCSPc22g00440
PDPPDIP_46460
TMFPMAA_016060
TRGTRUGW13939_11699
CIMCIMG_02876
CPWCPC735_035820
UREUREG_02969
PBLPAAG_03450
PBNPADG_06380
ABEARB_01551
TVETRV_02548
AJEHCAG_08624
BGHBDBG_05786
PNOSNOG_09656
PTEPTT_11774
BZECOCCADRAFT_3086
BSCCOCSADRAFT_118454
BORCOCMIDRAFT_88685
AALTCC77DRAFT_1021974
ZTRMYCGRDRAFT_72947(Mg84326)
PFJMYCFIDRAFT_28456
FFUCLAFUR5_08849
BCOMBAUCODRAFT_34604
NPAUCRNP2_7078
TMLGSTUM_00011329001
SPOSPAC23C4.14(alg1)
CNECNA06670
CNBCNBA6490
CNGCNAG_00689
CGICGB_A7480W
TMSTREMEDRAFT_45381
TASAA1Q1_07303
TVSTRAVEDRAFT_160169
DSQDICSQDRAFT_66828
PCOPHACADRAFT_246222
SHSSTEHIDRAFT_47713
HIRHETIRDRAFT_31631
PSQPUNSTDRAFT_78889
ADLAURDEDRAFT_77986
FMEFOMMEDRAFT_107171
GTRGLOTRDRAFT_69536
LBCLACBIDRAFT_300879(ALG1)
CCICC1G_03729
ABPAGABI1DRAFT51041(AGABI1DRAFT_51041)
ABVAGABI2DRAFT197784(AGABI2DRAFT_197784)
PCUBJR316_0000774
MRRMoror_339
MOREE1B28_009832
SCMSCHCO_048280(SCHCODRAFT_048280)
CPUTCONPUDRAFT_94665
SLASERLADRAFT_478855
WSEWALSEDRAFT_61318
WICJ056_000994
UMAUMAG_04649
PFPPFL1_04546
MGLMGL_3730
MRTMRET_1696
MSYMMSY001_0066(ALG1)
PGRPGTG_10245
MLRMELLADRAFT_25337
MBRMONBRDRAFT_29828
SREPTSG_12858
DDIDDB_G0286011(alg1)
DPPDICPUDRAFT_52859
DFADFA_00740(alg1)
EHIEHI_028950(192.t00014)
EDIEDI_136480
EIVEIN_484820
ACANACA1_270180
BEQBEWA_012290
CPVcgd7_1810
CHOChro.70211
TGOTGME49_230590
TETTTHERM_00954200
PTMGSPATT00028628001
SMINv1.2.027383.t1(symbB.v1.2.027383.t1)
PTIPHATRDRAFT_14002
FCYFRACYDRAFT_273942
TPSTHAPSDRAFT_14643
AAFAURANDRAFT_23258
PIFPITG_11648
PSOJPHYSODRAFT_554865
SPARSPRG_12416
GTTGUITHDRAFT_166291
TBRTb10.389.0250
TBGTbgDal_X15970
TCR504215.20
LMALMJF_18_0900
LIFLINJ_18_0900
LDOLDBPK_180900
LMILMXM_18_0900
LBZLBRM_18_0960
LPANLPMP_180900
NGRNAEGRDRAFT_1813
TVATVAG_2v0168360 TVAG_2v0528650
 » show all
Reference
1  [PMID:6215245]
  Authors
Sharma CB, Lehle L, Tanner W.
  Title
Solubilization and characterization of the initial enzymes of the dolichol pathway from yeast.
  Journal
Eur J Biochem 126:319-25 (1982)
DOI:10.1111/j.1432-1033.1982.tb06781.x
Reference
2  [PMID:10704531]
  Authors
Takahashi T, Honda R, Nishikawa Y
  Title
Cloning of the human cDNA which can complement the defect of the yeast mannosyltransferase I-deficient mutant alg 1.
  Journal
Glycobiology 10:321-7 (2000)
DOI:10.1093/glycob/10.3.321
  Sequence
[hsa:56052]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.142
IUBMB Enzyme Nomenclature: 2.4.1.142
ExPASy - ENZYME nomenclature database: 2.4.1.142
BRENDA, the Enzyme Database: 2.4.1.142
CAS: 83380-85-2

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