KEGG   ENZYME: 2.4.1.146
Entry
EC 2.4.1.146                Enzyme                                 
Name
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase;
O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II;
uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase (elongating);
elongation 3beta-GalNAc-transferase;
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to beta-D-galactose of beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->3)-[N-acetyl-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R 3-beta-N-acetyl-D-glucosaminyltransferase;
B3GNT3 (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-glucosamine:3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein] 3-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein] = UDP + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein] [RN:R04636 R05901]
Reaction(KEGG)
R04636 R05901(G)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein]
Product
UDP [CPD:C00015];
3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein]
Comment
The enzyme catalyses the addition of N-acetyl-alpha-D-glucosamine to the core 2 structure of O-glycans.
History
EC 2.4.1.146 created 1984, modified 2018
Orthology
K07970  beta-1,3-N-acetylglucosaminyltransferase 3
Genes
HSA10331(B3GNT3)
PTR455847(B3GNT3)
PPS100982986(B3GNT3)
GGO101151557(B3GNT3)
PON100433243(B3GNT3)
NLE100596245(B3GNT3)
MCC114674034(B3GNT3) 719221
MCF102134304(B3GNT3)
CSAB103234153(B3GNT3)
CATY105601677(B3GNT3)
PANU101005136(B3GNT3)
TGE112613343(B3GNT3)
RRO104660961(B3GNT3)
RBB108534279(B3GNT3)
TFN117076459(B3GNT3)
PTEH111554311(B3GNT3)
CJC100404385(B3GNT3)
SBQ101033879(B3GNT3)
MMUR105854991(B3GNT3)
OGA100961131(B3GNT3)
MMU72297(B3gnt3)
MCAL110299618(B3gnt3)
MPAH110337004(B3gnt3)
RNO290638(B3gnt3)
MCOC116071470(B3gnt3)
MUN110549208(B3gnt3)
CGE100773213(B3gnt3)
PLEU114687946(B3gnt3)
NGI103726889(B3gnt3)
HGL101713138(B3gnt3)
CPOC100713343(B3gnt3)
CCAN109698339(B3gnt3)
DSP122100853(B3gnt3)
NCAR124969063
OPI101527594(B3GNT3)
TUP102472378(B3GNT3)
CFA484831(B3GNT3)
VVP112913174(B3GNT3)
VLG121494311(B3GNT3)
AML100473756(B3GNT3)
UMR103675168(B3GNT3)
UAH113256690(B3GNT3)
UAR123780002(B3GNT3)
ELK111144118
LLV125082431
MPUF101688106(B3GNT3)
ORO101368545(B3GNT3)
EJU114226652(B3GNT3)
ZCA113917507(B3GNT3)
MLX118005244(B3GNT3)
FCA101092089(B3GNT3)
PYU121010990(B3GNT3)
PBG122487077(B3GNT3)
PTG102965987(B3GNT3)
PPAD109247961(B3GNT3)
AJU106969093(B3GNT3)
HHV120239150(B3GNT3)
BTA784997(B3GNT3)
BOM102281061(B3GNT3)
BIU109560822(B3GNT3)
BBUB102400108(B3GNT3)
CHX102171777(B3GNT3)
OAS101113066(B3GNT3)
ODA120864228(B3GNT3)
CCAD122440724(B3GNT3)
SSC100518473(B3GNT3)
CFR102512477(B3GNT3)
CBAI105082559(B3GNT3)
CDK105101856(B3GNT3)
VPC102538202(B3GNT3)
BACU103012961(B3GNT3)
LVE103080965(B3GNT3)
OOR101282171(B3GNT3)
DLE111166586(B3GNT3)
PCAD102989486(B3GNT3)
PSIU116750777(B3GNT3)
ECB100146466(B3GNT3)
EPZ103542315(B3GNT3)
EAI106830835(B3GNT3)
MYB102254606(B3GNT3)
MYD102767713(B3GNT3)
MMYO118658722(B3GNT3)
MLF102428358(B3GNT3)
MNA107535321(B3GNT3)
PKL118722609 118725871(B3GNT3)
HAI109382386(B3GNT3)
DRO112305269(B3GNT3)
SHON118975180 118975182
AJM119043950 119046818(B3GNT3) 119046819
PDIC114503731 114503735
PHAS123828315 123828458
MMF118616497(B3GNT3)
RFQ117038056(B3GNT3)
PALE102882932(B3GNT3)
PGIG120606538(B3GNT3)
PVP105296673(B3GNT3)
RAY107521817(B3GNT3)
MJV108388013(B3GNT3)
TOD119241108(B3GNT3)
SARA101553979(B3GNT3)
LAV100673587(B3GNT3)
MDO100010637(B3GNT3)
GAS123232263(B3GNT3)
SHR100920625(B3GNT3)
PCW110223495(B3GNT3)
OAA100086714(B3GNT3)
GGA112530425(B3GNT3)
PCOC116235881
MGP100549756(B3GNT3)
CJO107325454(B3GNT3)
NMEL110388735(B3GNT3)
ACYG106048207(B3GNT3)
FPG106112886(B3GNT3)
FCH102054592(B3GNT3)
CLV102095902(B3GNT3)
EGZ104124478(B3GNT3)
NNI104013696(B3GNT3)
TALA116963233 122153644
ACHC115348859(B3GNT3)
AAM106486607
AROW112965649(B3GNT3)
NPD112949098(B3GNT3)
DNE112992748(B3GNT3)
ASN102373956(B3GNT3)
AMJ106737906(B3GNT3)
CPOO109318684(B3GNT3)
GGN109302437(B3GNT3)
PSS102443521(B3GNT3)
CMY102944348(B3GNT3)
CPIC101936651(B3GNT3)
TST117869061(B3GNT3)
CABI116833222(B3GNT3)
MRV120391923(B3GNT3)
PVT110072506(B3GNT3)
SUND121936496(B3GNT3)
PBI103061136(B3GNT3)
PMUR107285005 107285006 107296837(B3GNT3) 114922368
TSR106556824
PGUT117670585(B3GNT3)
VKO123018694(B3GNT3)
PMUA114588656(B3GNT3)
ZVI118087801(B3GNT3)
GJA107120629(B3GNT3)
XLA108703715(b3gnt3.2.S) 108711807 734264(b3gnt3.2.L)
XTR100145701(b3gnt3.2) 100380117(b3gnt3.1) 100494334 101733889 116409851
NPR108790801 108793753 108803023
RTEM120909662 120909687 120914440 120933672 120933692
BBUF120989390(B3GNT3) 121009144
BGAR122919843 122920562(B3GNT3)
DRE100002020(b3gnt3.2) 561172(b3gnt3.4)
SRX107755313
SANH107665060 107700302(b3gnt3)
SGH107599054
CCAR109083431 109099585
CAUA113049247 113077616 113099571
PPRM120474104(b3gnt3.4) 120474110
IPU108265513 108265849 108266016 108266017
PHYP113525137(b3gnt3)
SMEO124399388 124400092 124400431
TFD113634256 113634260 113642616 113642617 113642618 113642619 113642620 125146324
AMEX103026573(b3gnt3)
EEE113587291 113587962
TRU101072648(b3gnt3)
TNGGSTEN00019098G001 GSTEN00019099G001 GSTEN00019100G001
LCO104935378 109139021(b3gnt3) 109139346 109139347
NCC104958016
CGOB115007161(b3gnt3)
ELY117253529 117263620 117264498
PLEP121941118 121952728
SLUC116055449
ECRA117950580
PFLV114561872(b3gnt3)
GAT120824339
PPUG119217180
MSAM119900537 119900538 119900539 119917039
CUD121512695 121519212 121519214 121519215
MZE101474209 105940915
ONL100700249 100710618 102077342(b3gnt3)
OAU116328445 116328458 116331915 116333906
OLA101163432 101173163 101173646 101175309
OML112138882 112139123 112142676 112142717 112150918 112150945
XMA102222047 102226121 102235218(b3gnt3) 111606492
XCO114137712 114137713 114150430 114151525 114152730
XHE116713044 116713045 116725213 116725996 116727933
PRET103463427 103463431 103475708 103476783
PFOR103129919 103129923 103133540 103133955
PLAI106937802 106937900 106947686 106955559
PMEI106906127 106914022 106914028 106914127
GAF122838849 122838850 122842547 122845157
CVG107095630 107103340(b3gnt3) 107103343 107103671 107104833
CTUL119773651 119786226 119786238 119787603 119787742 119790866
GMU124858982 124873366 124874498 124876850
NFU107376009 107386572 107392806
KMR108234252 108234256 108243045 108247418 119616708
ALIM106519220 106519221 106533410
NWH119407675 119407676 119420122 119430271
AOCE111576549(b3gnt3)
CSEM103395334 103395738 103395759 103399385
POV109636623(b3gnt3)
SSEN122780488 122781014 122781015
HHIP117760258 117760259 117760260 117760575 117760577
LCF108881191 108893170
SDU111218271(b3gnt3) 111235274
SLAL111669970(b3gnt3) 111670022
XGL120790634 120791330 120802899
HCQ109519123(b3gnt3)
BPEC110160181
MALB109958356
SASA106573871(b3gnt3) 106578060 106613654
OTW112250760(b3gnt3.4) 112252159
OMY110496754 110524171
OGO123996683 123998437 124007935
ONE115109173
SALP111953012(b3gnt3)
SNH120053736 120054432
ELS105007499 105011432(b3gnt3) 105031420
SFM108930515(b3gnt3)
PKI111860178(b3gnt3)
AANG118221742 118226430
LOC102687306(b3gnt3)
PSPA121301356 121301670
ARUT117401222 117966163 117966195 117966263 117966282 117966310 117968039 117972057
LCM102345207(B3GNT3)
CMK103181970
RTP109918138
MSEX115456046
PPOT106102791
 » show all
Reference
1  [PMID:6226356]
  Authors
Brockhausen I, Rachaman ES, Matta KL, Schachter H.
  Title
The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis.
  Journal
Carbohydr Res 120:3-16 (1983)
DOI:10.1016/0008-6215(83)88002-1
Reference
2  [PMID:11042166]
  Authors
Shiraishi N, Natsume A, Togayachi A, Endo T, Akashima T, Yamada Y, Imai N, Nakagawa S, Koizumi S, Sekine S, Narimatsu H, Sasaki K
  Title
Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family.
  Journal
J Biol Chem 276:3498-507 (2001)
DOI:10.1074/jbc.M004800200
  Sequence
[hsa:10331]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.146
IUBMB Enzyme Nomenclature: 2.4.1.146
ExPASy - ENZYME nomenclature database: 2.4.1.146
BRENDA, the Enzyme Database: 2.4.1.146
CAS: 87927-99-9

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