KEGG   ENZYME: 2.4.1.152
Entry
EC 2.4.1.152                Enzyme                                 
Name
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase;
Lewis-negative alpha-3-fucosyltransferase;
plasma alpha-3-fucosyltransferase;
guanosine diphosphofucose-glucoside alpha1->3-fucosyltransferase;
galactoside 3-fucosyltransferase;
GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase;
GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase;
GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase;
GDP-beta-L-fucose:(1->4)-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-beta-L-fucose:beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase (configuration-inverting)
Reaction(IUBMB)
GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosaminyl-R [RN:R03519]
Reaction(KEGG)
R03519 > R05904(G) R06025(G) R06038(G) R06039(G) R06221(G) R06222(G);
(other) R06076(G) R06095(G) R06224(G) R06227(G) R06230(G)
Substrate
GDP-beta-L-fucose [CPD:C00325];
beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R [CPD:C00694]
Product
GDP [CPD:C00035];
beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosaminyl-R [CPD:C01311]
Comment
Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. This enzyme fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4, unlike EC 2.4.1.65, 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase, which fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3.
History
EC 2.4.1.152 created 1984, modified 2002, modified 2019
Pathway
ec00515  Mannose type O-glycan biosynthesis
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec01100  Metabolic pathways
Orthology
K03663  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase
K20151  alpha(1,3/1,4) fucosyltransferase
Genes
HSA10690(FUT9)
PTR449500(FUT9)
PPS100995687(FUT9)
GGO101149404(FUT9)
PON100452333(FUT9)
NLE100598858(FUT9)
MCC708361(FUT9)
MCF102130080(FUT9)
MTHB126953761
CSAB103240132(FUT9)
CATY105588961(FUT9)
PANU101018664(FUT9)
TGE112623283(FUT9)
RRO104659030(FUT9)
RBB108538590(FUT9)
TFN117097105(FUT9)
PTEH111538445(FUT9)
CJC100405706(FUT9)
SBQ101042637(FUT9)
CSYR103274710(FUT9)
MMUR105874021(FUT9)
LCAT123633085(FUT9)
OGA100956946(FUT9)
MMU14348(Fut9)
MCAL110293483(Fut9)
MPAH110338862(Fut9)
RNO84597(Fut9)
MCOC116088008(Fut9)
MUN110540879 110540880
CGE100689036(Fut9)
MAUA101829675(Fut9)
PLEU114686506(Fut9)
MORG121458268(Fut9)
MFOT126489140 126503347
AAMP119826896(Fut9)
NGI103739272(Fut9)
HGL101722848(Fut9)
CPOC100719213(Fut9)
CCAN109692033(Fut9)
DORD105985940(Fut9)
DSP122107752(Fut9)
NCAR124989006
OCU103349852(FUT9)
OPI101532027(FUT9)
TUP102469465(FUT9)
CFA449027(FUT9)
CLUD112658431(FUT9)
VVP112923162(FUT9)
VLG121473948(FUT9)
AML100482132(FUT9)
UMR103675890(FUT9)
UAH113264665(FUT9)
UAR123798494(FUT9)
ELK111158335
LLV125103178
MPUF106003397(FUT9)
ORO101373062(FUT9)
EJU114209881(FUT9)
ZCA113927423(FUT9)
MLX118001223(FUT9)
NSU110583513(FUT9)
FCA101080384(FUT9)
PYU121029798(FUT9)
PBG122489775(FUT9)
LRUF124529383
PTG102953801(FUT9)
PPAD109263431(FUT9)
AJU106980088(FUT9)
HHV120224966(FUT9)
BTA282853(FUT9)
BOM102265797(FUT9)
BIU109563638(FUT9)
BBUB102409102(FUT9)
CHX102190604(FUT9)
OAS106990120(FUT9)
ODA120862973(FUT9)
CCAD122422898(FUT9)
SSC102160171(FUT9)
CFR102504781(FUT9)
CBAI105063779(FUT9)
CDK105092259(FUT9)
VPC102532980(FUT9)
BACU103013395(FUT9)
LVE103076056(FUT9)
OOR101282525(FUT9)
DLE111163781(FUT9)
PCAD102993317(FUT9)
PSIU116763692(FUT9)
ECB100071396(FUT9)
EPZ103548330(FUT9)
EAI106832465(FUT9)
MYB102244048(FUT9)
MYD102761474(FUT9)
MMYO118660694(FUT9)
MLF102419938(FUT9)
MNA107542762(FUT9)
PKL118705973(FUT9)
HAI109373534(FUT9)
DRO112296963(FUT9)
SHON118982384(FUT9)
AJM119048781(FUT9)
PDIC114493774(FUT9)
PHAS123821597(FUT9)
MMF118621887(FUT9)
RFQ117020375(FUT9)
PALE102880999(FUT9)
PGIG120594861(FUT9)
PVP105292511(FUT9)
RAY107505442(FUT9)
MJV108394441(FUT9)
TOD119252707(FUT9)
SARA101547764(FUT9)
LAV100666316(FUT9)
TMU101343680
DNM101443516(FUT9)
MDO100014877 100020278(FUT9)
GAS123247816(FUT9)
SHR100925710(FUT9)
PCW110216512(FUT9)
OAA100075626(FUT9)
GGA771133(FUT9)
PCOC116240730(FUT9)
MGP100538515(FUT9)
CJO107311931(FUT9)
NMEL110396445(FUT9)
APLA101799797(FUT9)
ACYG106035417(FUT9)
AFUL116487092(FUT9)
TGU100230065(FUT9)
LSR110478545(FUT9)
SCAN103819045(FUT9)
PMOA120512026(FUT9)
OTC121340023(FUT9)
PRUF121359314(FUT9)
GFR102034715(FUT9)
FAB101814999(FUT9)
PHI102108313(FUT9)
PMAJ107202583(FUT9)
CCAE111925714(FUT9)
CCW104692122(FUT9)
CBRC103619227(FUT9)
ETL114062084(FUT9)
ZAB102068744(FUT9)
ACHL103800723(FUT9)
FPG101916872(FUT9)
FCH102057900(FUT9)
CLV102090826(FUT9)
EGZ104135407(FUT9)
NNI104021938(FUT9)
PLET104617475(FUT9)
PCRI104032905(FUT9)
ACUN113478454(FUT9)
TALA104361773(FUT9)
PADL103913625(FUT9)
AFOR103896043(FUT9)
ACHC115347875(FUT9)
HALD104324183(FUT9)
CCRI104157920(FUT9)
CSTI104555540(FUT9)
EHS104516070(FUT9)
CMAC104480372(FUT9)
MUI104545473(FUT9)
FGA104073804(FUT9)
GSTE104255833(FUT9)
LDI104354125(FUT9)
MNB103772238(FUT9)
OHA104337441(FUT9)
NNT104406599(FUT9)
DPUB104298079(FUT9)
PGUU104462717(FUT9)
ACAR104532073(FUT9)
AVIT104275377(FUT9)
CVF104289967(FUT9)
AAM106489650(FUT9)
AROW112973640(FUT9)
NPD112947151(FUT9)
TGT104570019(FUT9)
DNE112996569(FUT9)
SCAM104148899(FUT9)
ASN102381575(FUT9)
AMJ102560865(FUT9)
CPOO109311875(FUT9)
GGN109299674(FUT9)
PSS102445061(FUT9)
CMY114022634(FUT9)
CPIC101939838(FUT9)
TST117875094(FUT9)
CABI116821141(FUT9)
MRV120402246(FUT9)
ACS100565195(fut9)
PVT110074019(FUT9)
SUND121919792(FUT9)
PBI103053931
PMUR107292255(FUT9) 107297567
CTIG120307698(FUT9) 120316867
TSR106541661(FUT9) 106554991
PGUT117660780(FUT9) 117675804
VKO123033010(FUT9)
PMUA114593968
ZVI118082852(FUT9)
GJA107121221(FUT9)
STOW125431393(FUT9)
XLA100337597(fut9.S) 108716340(fut9.L)
XTR548391(fut9)
NPR108788910(FUT9)
RTEM120937125(FUT9)
BBUF120998200(FUT9)
BGAR122922859(FUT9)
DRE100093713(fut9b.5) 100124609(zgc:165582) 503885(fut9d) 792063(ft2) 796410(fut9a)
SRX107751748 107752528 107752989 107752990 107754429 107755789
SANH107670988 107670991 107680752 107682543 107682550 107683254(fut9) 107693061 107699637 107699665
SGH107549854 107552177 107552178 107552179 107552180 107553051 107553052 107560043 107564944 107583473
CCAR109061376 109064072 109069167 109069172 109069186 109071560 109097854
CAUA113052735 113052738 113052797 113052798 113059359 113060727 113071724 113078773 113101286 113106950 113106951 113106952 113119816 113120213 113120219
PPRM120479298(fut9a)
MAMB125263849 125268489(fut9a)
IPU108256900 108263097 108270007(fut9a) 108274821(si:ch1073-440p11.2)
PHYP113523898 113525256 113525258 113533973 113541870 113546219
SMEO124376144 124376256 124389712(fut9a) 124402243
TFD113651290(fut9a) 113655369 113656736 113661962
AMEX103029489 103039268 103042515(fut9) 103042542 103044280 111197691
EEE113569622 113576992 113583857 113587304 113587844 113587875 113590563(fut9) 113590641 113590697 113590698 113590700 113592116
TRU101067562 101073723 101074839 105419315 105419496 115246822 115246823 115247519 115247520 445968(fut9b) 445969(fut9c) 446062(fut9a)
TNGGSTEN00006850G001 GSTEN00006851G001 GSTEN00009901G001 GSTEN00010864G001 GSTEN00029413G001 GSTEN00031978G001 GSTEN00031979G001 GSTEN00031980G001
LCO104940156
CGOB115027783(fut9)
ELY117267621(fut9a)
EFO125901397(fut9a)
PLEP121953153(fut9a) 121958066 121961113
SLUC116057595(fut9a)
ECRA117935606(fut9a) 117938449 117956386
ESP116669661 116674819 116679803 116701912 116702039 116702040
PFLV114546824(fut9) 114567778 114567781
GAT120817152 120826554 120833105(fut9a)
PPUG119210223 119210224 119210366 119210367 119210369 119210370 119210372 119218705 119219414 119227768(fut9a)
MSAM119909917(fut9a)
CUD121524205 121526025(fut9a)
ALAT119015233 119034243(fut9a)
MZE101475990
ONL100697219 100697405 100703945 100707879 100708150 100708772 106098048 106098049 109204044 109204126
OAU116311514 116317002 116317003 116326060 116326090
OLA100302422(fut9a) 100302423(fut9b) 100302424(fut9c)
OML112142744 112142760(fut9a) 118597874
XMA102222498 102225778 102231995 111612181
XCO114134012 114134013 114134015
XHE116708987(fut9)
PRET103457330 103458746 103458791
PFOR103154983 103154988 107832863
PLAI106937698 106964672
PMEI106906607 106906618 106906628
GAF122846325(fut9a)
CVG107096914 107096915 107096916 107096920
CTUL119775109 119775123 119775134(fut9a) 119775173
GMU124855798 124855799 124855957 124856049
NFU107392154 107392156(fut9)
KMR108233304 108237367(fut9a)
ALIM106518428 106518446(fut9)
NWH119427641(fut9a)
AOCE111573291(fut9)
MCEP125023963(fut9a)
CSEM103378711(fut9) 103382673 103382674 103382681 103382682 103394628 103394629 103394630 103394631
POV109631852 109632694 109636489(fut9)
SSEN122783199(fut9a) 122786685 122786687 122786690 122786812
HHIP117755521(fut9a) 117757654 117757729
HSP118101583 118101620 118117070(fut9a)
LCF108874965(fut9a) 108876746 108876755 108889252
SDU111223224 111223389 111224570 111224641 111226005(fut9)
SLAL111651020(fut9) 111656473 111656503 111656904 111656933
XGL120795617(fut9a)
HCQ109517458(fut9)
BPEC110153654(fut9) 110164782 110165578
MALB109968070(fut9)
BSPL114848026(fut9a)
SASA100195769(fut9) 106561893 106564979 106571726 106571727 106576449 106576450 106596297 106596632 106601669 106606824 106607721(fut9) 106608151 106608177 106608180 106608181 106608194 106609044 106609585 106610592
STRU115162448 115162603 115164203 115171580 115174563 115174576 115201968 115202820 115204446 115208496
OTW112217886 112217898 112217900 112217903 112217904 112218062 112226226 112237397 112250498 112250512 112256439 112263440 112265903 112267801 121838771 121845275
OMY100136100(fut9) 110486734 110490571 110493783 110499900 110505253 110506253(fut9a) 110520969 110522510 110522523 110522524 110522526 110522527 110529796 110529812 110538683
OGO123991672 123991676 123995340 123995352 123995354 123995355 123995559 123995717 123995761 123995782 123995784 123995921 123995930 123998685 124015049 124016913 124035936 124045201
ONE115104355 115107338 115107343 115113439 115116763 115119926 115124479 115132924 115138268 115139182 115140449 115140450 115140508 115143587
SALP111954144 111954634 111969172 111973023 111973326 111980394 112068670 112068681 112072440 112080443 112080722
SNH120019384 120019385 120019502 120019551 120019553 120019570 120022436 120023361 120024210 120024535 120025172(fut9a) 120032330 120032346 120034273 120034279 120049410
CCLU121539685 121540918 121544444 121548569 121549224 121549347 121549351 121550909 121552496 121570375 121573051
ELS105006941(fut9) 105009923 105017585 105017586 105017587 105024824 106023859 114829408 114840820 114840824 114840825 114840826 114840827 114840828 114840829
SFM108929150 108929240 108929252 108935735
PKI111843009(fut9) 111849225
AANG118220399(fut9a) 118229305 118229916 118229917 118229919 118230399
LOC102691696 102694658(fut9) 107078908
PSPA121315239 121316605
ARUT117403347 117411608
LCM102347013(FUT9)
CMK103178281 103178282(fut9a)
RTP109935545 109935547 109935548
CIN100183411
DSV119466642
HRF124130906
TADTRIADDRAFT_62619
PTDPTET_a0498
AGZM0C34_01580
FGUSD28_06620
HMARHVMH_0588
MARDIBG28_16530
AJPAMJAP_0620
EBHBSEPE_0695
PNUPnuc_0251
BPSIIX83_03990
SLTSlit_2890
NIMW01_02790
HPYHP_0379 HP_0651
HEOC694_01925 C694_03365
HPJjhp_0596(fucT) jhp_1002(fucU)
HPAHPAG1_0636 HPAG1_1013
HPSHPSH_03605 HPSH_05520
HHPHPSH112_03760 HPSH112_05330
HHQHPSH169_03340 HPSH169_05305
HHRHPSH417_03150 HPSH417_05070
HPGHPG27_1018 HPG27_613
HPPHPP12_0664(fucT) HPP12_1042
HPBHELPY_0720(futB) HELPY_1046(futA)
HPLHPB8_427(fucT1) HPB8_854(fucT7)
HPCHPPC_03535 HPPC_05220
HCAHPPC18_03150 HPPC18_05315
HPMHPSJM_03315 HPSJM_05295
HPEHPELS_01320 HPELS_03280
HPOHMPREF4655_20949 HMPREF4655_21266
HPIhp908_0664(fucT)
HPQhp2017_0641(fucT)
HPWhp2018_0642(fucT)
HPUHPCU_03535 HPCU_05450
HEFHPF16_0660(fucT) HPF16_1018(fucT)
HPFHPF30_0312(fucT) HPF30_0677(fucT)
HEQHPF32_0329(fucT) HPF32_0668(fucT)
HEXHPF57_0674(fucT) HPF57_1038(fucT)
HPTHPSAT_03535 HPSAT_05130
HPZHPKB_0693 HPKB_1004
HPVHPV225_0659
HPXHMPREF0462_0710 HMPREF0462_1089
HENHPSNT_03355
HPHHPLT_03250 HPLT_05320
HEGHPGAM_03360 HPGAM_05520
HPNHPIN_03385
HEPHPPN120_03460 HPPN120_05205
HEUHPPN135_03215 HPPN135_05490
HESHPSA_03080 HPSA_05205
HCNHPB14_03415 HPB14_05015
HPDKHP_0670(fucTa) KHP_0977(fucTb)
HEYMWE_0857 MWE_1252
HERC695_01925 C695_03370
HEIC730_01925 C730_03370
HPYAHPAKL117_03085 HPAKL117_05025
HPYKHPAKL86_04810 HPAKL86_05545
HPYOHPOK113_0665 HPOK113_1036
HPYLHPOK310_0645 HPOK310_0973
HPYBHPOKI102_03755 HPOKI102_05640
HPYCHPOKI112_03785 HPOKI112_05675
HPYDHPOKI128_05060
HPYEHPOKI154_03330 HPOKI154_05345
HPYFHPOKI422_03760 HPOKI422_05665
HPYGHPOKI673_03310 HPOKI673_05330
HPYHHPOKI828_03320 HPOKI828_05335
HPYJHPOKI898_03755 HPOKI898_05650
HPYRK747_05675 K747_07345
HPYIK750_05570
HPYUK751_02280 K751_04125
HPYMK749_00370 K749_01980
HEMK748_00470 K748_06920
HEBU063_0955 U063_1387
HEZU064_0959 U064_1392
HHEHH_1776
HACHac_1063(fuc)
HFEHFELIS_11760
HBIHBZC1_11830
HCEHCW_04425
HCMHCD_06740
HSHNHP194022_13850
SUASaut_1498
SULRB649_10005
ADEAdeh_3056
ACPA2cp1_3255
RBERBE_0503
RBOA1I_02895
MLGCWB41_07360
AZLAZL_007090
ALIAZOLI_0610
ABSAZOBR_p1120031
ABQABAZ39_20530
ABFAMK58_20385
ATIAL072_00805
AHUA6A40_02580
AZTTSH58p_24720
AZMDM194_02250
AOZHUE56_20210
MAGXXM1_1803
MAGNWV31_16795
BDQCIK05_07105
BHUbhn_I0452
PFACPFJ30894_01738
PMCP9515_13921
SNGSNE_A13120
CAACaka_2548
AMUAmuc_0760
AGLPYTT_1437
LPAVPLANPX_5568
PLMPlim_1042
BHYBHWA1_00146
BHDBHYOB78_02265
BHPBHAMNSH16_01940
BFSBF9343_3370
BNOK8P02_19270
PPNPalpr_1132 Palpr_1136
COPRCop2CBH44_18030
LACSH4075_02030
FLPLK994_12525
PHEPhep_0149
PCMAY601_4410
PEJFYC62_14360
PROEH9L23_20465
MUCMuYL_4908
MMABHQ865_11965
ALMAO498_13665
HQIH9L05_02385
FFAFFWV33_07715
FCRHYN56_01635
FNKE1750_13960
CAPFFOC45_00305
ZPRZPR_1106
KDIKrodi_2047
AFLAFHG64_04105
MRUmru_1527
MELMetbo_0771
 » show all
Reference
1  [PMID:7295318]
  Authors
Johnson PH, Yates AD, Watkins WM.
  Title
Human salivary fucosyltransferases : evidence for two distinct alpha-3-L-fucosyltransferase activities one or which is associated with the Lewis blood group Le gene.
  Journal
Biochem Biophys Res Commun 100:1611-8 (1981)
DOI:10.1016/0006-291X(81)90703-8
Reference
2  [PMID:6366476]
  Authors
Schachter H, Narasimhan S, Gleeson P, Vella G.
  Title
Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type.
  Journal
Methods Enzymol 98:98-134 (1983)
DOI:10.1016/0076-6879(83)98143-0
Reference
3  [PMID:12676935]
  Authors
Ma B, Wang G, Palcic MM, Hazes B, Taylor DE
  Title
C-terminal amino acids of Helicobacter pylori alpha1,3/4 fucosyltransferases determine type I and type II transfer.
  Journal
J Biol Chem 278:21893-900 (2003)
DOI:10.1074/jbc.M301704200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.152
IUBMB Enzyme Nomenclature: 2.4.1.152
ExPASy - ENZYME nomenclature database: 2.4.1.152
BRENDA, the Enzyme Database: 2.4.1.152
CAS: 39279-34-0

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