KEGG   ENZYME: 2.4.1.212
Entry
EC 2.4.1.212                Enzyme                                 
Name
hyaluronan synthase;
spHAS;
seHAS;
Alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
Alternating UDP-N-acetyl-alpha-D-glucosamine:beta-D-glucuronosyl-(1->3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase (configuration-inverting)
Reaction(IUBMB)
(1) UDP-N-acetyl-alpha-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] = UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] [RN:R05327 R06068];
(2) UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan] = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]
Reaction(KEGG)
R05327 R06068(G)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan];
UDP-alpha-D-glucuronate [CPD:C00167];
N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]
Product
UDP [CPD:C00015];
N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan];
beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]
Comment
The enzyme from Streptococcus Group A and Group C requires Mg2+. The enzyme adds GlcNAc to nascent hyaluronan when the non-reducing end is GlcA, but it adds GlcA when the non-reducing end is GlcNAc [3]. The enzyme is highly specific for UDP-GlcNAc and UDP-GlcA; no copolymerization is observed if either is replaced by UDP-Glc, UDP-Gal, UDP-GalNAc or UDP-GalA. Similar enzymes have been found in a variety of organisms.
History
EC 2.4.1.212 created 2001, modified 2007
Orthology
K00752  hyaluronan synthase
Genes
HSA3036(HAS1) 3037(HAS2) 3038(HAS3)
PTR454195(HAS3) 468978(HAS1) 472850(HAS2)
PPS100974629(HAS1) 100978574(HAS3) 100988254(HAS2) 103785234
GGO101133545(HAS1) 101146377(HAS3) 109025003(HAS2)
PON100443159(HAS2) 100460901(HAS1) 100462167(HAS3)
NLE100598098(HAS3) 100598248(HAS1) 100603930(HAS2)
MCC703353(HAS2) 704121(HAS3) 719773(HAS1)
MCF102114972(HAS3) 102131327(HAS2) 102135282(HAS1)
CSAB103233221(HAS3) 103235145(HAS1) 103237364(HAS2)
CATY105581444(HAS3) 105584563(HAS2) 105595379(HAS1)
PANU100126662(HAS1) 100126755(HAS3) 116276403
TGE112613014(HAS1) 112613753(HAS3) 112630289(HAS2)
RRO104655585(HAS3) 104672702(HAS1) 104676637(HAS2)
RBB108514512(HAS3) 108516805(HAS2) 108523658(HAS1)
TFN117079231(HAS2) 117087961(HAS3) 117091691(HAS1)
PTEH111520171(HAS1) 111541397(HAS3) 111549871(HAS2)
CJC100398661(HAS2) 100400259(HAS3)
SBQ101041294(HAS3) 101046826(HAS1) 101048448(HAS2)
CSYR103258935(HAS2) 103272548(HAS3) 103274697(HAS1)
MMUR105858958(HAS3) 105859519(HAS2) 105882864(HAS1)
OGA100947884(HAS3) 100956461(HAS1) 100965137(HAS2)
MMU15116(Has1) 15117(Has2) 15118(Has3)
MCAL110284113(Has1) 110300324(Has3) 110310674(Has2)
MPAH110334723(Has2) 110337662(Has3) 110338278(Has1)
RNO25694(Has2) 266805(Has3) 282821(Has1)
MCOC116070107(Has3) 116079069(Has1) 116082212(Has2)
MUN110546016(Has3) 110561355(Has2) 110563830(Has1)
CGE100751055(Has2) 100757895(Has3) 113833756
PLEU114683418(Has3) 114685184(Has1) 114694830(Has2)
NGI103734806(Has3) 103738152(Has2) 103750321(Has1)
HGL101707808(Has1) 101717946(Has3) 101724130(Has2)
CPOC100712902(Has1) 100725931(Has3) 100731804(Has2)
CCAN109677774(Has2) 109680355(Has1) 109693770(Has3)
DORD105983138(Has3) 105994185(Has1) 105997712(Has2)
DSP122102423(Has2) 122125555(Has1) 122126113(Has3)
OCU100008626(HAS2) 100009454(HAS3) 103345464(HAS1)
OPI101517221(HAS2) 101519467(HAS1) 101529773(HAS3)
TUP102483298(HAS1) 102489956(HAS3) 102491778(HAS2)
CFA482032(HAS2) 489739(HAS3) 611700(HAS1)
VVP112915955(HAS2) 112929462(HAS3) 112931490(HAS1)
VLG121484826(HAS1) 121498488(HAS2) 121499346(HAS3)
AML100471054(HAS2) 100479870(HAS1)
UMR103657359(HAS1) 103661603(HAS2) 103673621(HAS3)
UAH113247342(HAS1) 113252417(HAS3) 113252765(HAS2)
UAR123778043(HAS1) 123797742(HAS2) 123803482(HAS3)
ELK111146646 111152757 111160773
LLV125088882 125090026 125099009
MPUF101673035(HAS2) 101676618(HAS1) 101683617(HAS3)
ORO101365887(HAS2) 101373682(HAS3) 101385758(HAS1)
EJU114199520(HAS1) 114202177(HAS3) 114211198(HAS2)
ZCA113916189(HAS2) 113935815(HAS1) 113935982(HAS3)
MLX117998278(HAS1) 118015168(HAS2) 118023629(HAS3)
FCA101093224(HAS1) 101096124(HAS3) 101099432(HAS2)
PYU121009709(HAS3) 121018937(HAS1) 121042919(HAS2)
PBG122494388(HAS3) 122494775(HAS1) 122495764(HAS2)
PTG102950235(HAS2) 102953815(HAS3)
PPAD109252859(HAS1) 109270710(HAS3) 109273210(HAS2)
AJU106972080(HAS3) 106972980(HAS1) 106978179(HAS2)
HHV120222377(HAS1) 120224050(HAS3) 120228659(HAS2)
BTA281220(HAS2) 282820(HAS1) 286824(HAS3) 515601
BOM102278313(HAS2) 102278597 102283309(HAS3) 102284172 102284450(HAS1)
BIU109568300 109568691 109572178(HAS1) 109572268(HAS3)
BBUB102398314(HAS3) 102403835 102406104(HAS2) 102407583(HAS1) 112577619
CHX102170334(HAS2) 102170800 102170999(HAS3) 102180619(HAS1)
OAS101102585(HAS1) 101110341(HAS2) 101110602 101120264(HAS3)
ODA120858882 120871971(HAS1) 120872718(HAS3) 120878949(HAS2) 120878950
CCAD122420617(HAS1) 122421706(HAS3) 122423949 122451195 122451205(HAS2)
SSC100191062(HAS1) 100737755 397120(SHAS2) 408053(HAS3)
CFR102509171(HAS1) 102517693(HAS3) 102518631
CBAI105074866(HAS3) 105082905(HAS2)
CDK105088406(HAS3) 105098322(HAS2) 105106080(HAS1)
VPC102540001(HAS1) 102540878(HAS3) 102544075
BACU103000737(HAS3) 103019394(HAS1)
LVE103072634(HAS3) 103077212(HAS1) 103090515(HAS2)
OOR101274251(HAS1) 101281710 101288736(HAS3)
DLE111164375(HAS2) 111176792 111179591(HAS3) 111181081(HAS1)
PCAD102987421(HAS1) 102989832(HAS3) 102990709(HAS2)
PSIU116742407(HAS2) 116743453(HAS3) 116743778(HAS1)
ECB100009708(HAS2) 100066947(HAS3) 111775259(HAS1)
EPZ103548360(HAS2) 103554212(HAS1) 103566426(HAS3)
EAI106822303(HAS1) 106822467(HAS3) 106840120(HAS2)
MYB102242326(HAS3) 102249515(HAS2)
MYD102754470 102760371(HAS2) 102768432(HAS3)
MMYO118649301(HAS1) 118670794(HAS2) 118674399(HAS3)
MLF102421035(HAS2) 102431478(HAS3)
MNA107527898(HAS3) 107533172(HAS2) 107540430
PKL118710286(HAS1) 118718252(HAS2) 118720922(HAS3)
HAI109378196(HAS1) 109389272(HAS3) 109395081(HAS2)
DRO112300794(HAS3) 112310225(HAS1) 112315538(HAS2)
SHON118983809(HAS3) 118988636(HAS2) 118999831(HAS1)
AJM119038463(HAS1) 119056717 119061929(HAS3) 119064852(HAS2)
PDIC114511118(HAS1) 114514615(HAS2) 114515501(HAS3)
PHAS123806066(HAS3) 123824148(HAS1) 123833178(HAS2)
MMF118631646(HAS2) 118638201(HAS3) 118638303(HAS1)
RFQ117033610(HAS2) 117034441(HAS1) 117035161(HAS3)
PALE102879345(HAS2) 102887158(HAS3) 102894200(HAS1)
PGIG120583982(HAS1) 120593867(HAS3) 120595512(HAS2)
PVP105292531(HAS2) 105305759(HAS3) 105306587(HAS1)
RAY107500451(HAS1) 107501437(HAS2) 107520665(HAS3)
MJV108385574(HAS1) 108393449(HAS3) 108409910(HAS2)
TOD119238456(HAS2) 119248991(HAS3) 119249642 119249643
SARA101537021(HAS2) 101546762(HAS3) 101554788(HAS1)
LAV100660025(HAS3) 100661528(HAS2) 100667758(HAS1)
TMU101343848 101347098 101348918
DNM101417802(HAS3) 101439600(HAS2)
MDO100020005(HAS3) 100025815(HAS2) 100028664(HAS1)
GAS123231948(HAS2) 123234592(HAS3) 123240792(HAS1)
SHR100915210(HAS3) 100915333(HAS1) 100935104(HAS2)
PCW110193326(HAS2) 110210473(HAS3) 110219794(HAS1)
OAA100073390(HAS2) 100077175(HAS3) 100088892(HAS1)
GGA395594(HAS2) 427564(HAS3)
PCOC116227712(HAS2) 116243685(HAS3)
MGP100542703(HAS3) 100546088(HAS2)
CJO107310516(HAS2) 107319480(HAS3)
NMEL110394121(HAS2) 110404404(HAS3)
APLA101794398 101798379(HAS2)
ACYG106038507(HAS2) 106046595(HAS3)
AFUL116486138(HAS2) 116494113(HAS3)
TGU100228837(HAS2) 115496862(HAS3)
LSR110468821(HAS3) 110479295(HAS2)
SCAN103814340(HAS2) 103816907(HAS3)
PMOA120496281(HAS3) 120505214(HAS2)
OTC121334073(HAS3) 121337448(HAS2)
PRUF121355368(HAS2) 121362687(HAS3)
GFR102044642(HAS3) 102045061(HAS2)
FAB101817917(HAS2) 101822065(HAS3)
PHI102104183(HAS3) 102113165(HAS2)
PMAJ107200974(HAS2) 107209621(HAS3)
CCAE111925089(HAS2) 111934390(HAS3)
CCW104692667(HAS2) 120410617(HAS3)
ETL114057988(HAS2) 114067933(HAS3)
ZAB102070625(HAS2) 102073257(HAS3)
FPG101913427(HAS3) 101916039(HAS2)
FCH102049447(HAS3) 102052598(HAS2)
CLV102086971(HAS3) 102087835(HAS2)
EGZ104123704(HAS2) 104129686(HAS3)
NNI104017993(HAS2) 104023561(HAS3)
ACUN113477381(HAS2)
TALA104367942(HAS2) 116960474(HAS3)
PADL103916358(HAS2)
ACHC115340802(HAS2) 115346376(HAS3)
AAM106496322(HAS2)
AROW112960959(HAS2) 112975125(HAS3)
NPD112947413(HAS2) 112947508(HAS3)
DNE112989187(HAS2) 112994994(HAS3)
ASN102373237(HAS3) 102374679(HAS1) 102388766(HAS2)
AMJ102573446(HAS2) 102576462(HAS1) 106737219(HAS3)
CPOO109310734 109321661(HAS2)
GGN109289249(HAS3) 109305166(HAS2)
PSS102445131(HAS2) 102448287 102456379(HAS3)
CMY102929705 102931765(HAS3) 102940312(HAS2) 102945687
CPIC101931459(HAS2) 101940089(HAS1) 101951574(HAS3)
TST117873783(HAS2)
CABI116819549(HAS3) 116822981(HAS2) 116838270(HAS1)
MRV120384326(HAS3) 120390381(HAS1) 120396429(HAS2)
ACS100558635(has3) 100565058(has2) 100566258(has1)
PVT110076300(HAS3) 110080529(HAS2) 110086505(HAS1)
SUND121916314(HAS1) 121927720(HAS2) 121937458(HAS3)
PBI103051686(HAS1) 103053107(HAS3) 103058218(HAS2)
PMUR107283545(HAS3) 107293265(HAS1) 107294817(HAS2)
TSR106542218(HAS3) 106555644(HAS2)
PGUT117668388(HAS2) 117671058(HAS3) 117675876(HAS1)
VKO123017460(HAS1) 123019324(HAS2) 123022158(HAS3)
PMUA114600283(HAS2) 114602088(HAS3) 114603483(HAS1)
ZVI118086337(HAS3) 118087863(HAS1) 118090434(HAS2)
GJA107106528(HAS3) 107111182(HAS2) 107124383 107124387(HAS1)
XLA108695929(has1l.L) 108705047(has1l.S) 108714068(has3.L) 108719401(has2.L) 379383(has1.S) 398074(has-rs.S) 399037(has3.S) 399146(has2.S)
XTR100145711(has2) 100145746(has1) 100487554(has3) 100491673(has1l) 116406439
NPR108784501(HAS2) 108787718(HAS3) 108801429
RTEM120916451 120917733(HAS3) 120941495(HAS2)
BBUF120980928(HAS3) 120991662(HAS1) 121002045(HAS2)
BGAR122921046(HAS3) 122929148(HAS1) 122938373(HAS2)
DRE260350(has2) 282555(has3) 403130(has1)
SRX107707223 107714739 107723422 107740342 107743236(has2)
SANH107657615 107672271 107673001 107685568 107686259 107699477
SGH107569650 107581653 107583799 107596529(has1) 107596747
CCAR109052687 109074192 109091264 109104953(has2) 109110508
CAUA113059902 113061495 113076903 113095811 113116314 113116709 113118314
IPU108263934 108265336 108265377 108273246(has2) 124626829
PHYP113526865(has1) 113534297(has3) 113542219(has2)
SMEO124383860(has2) 124384814 124396215(has3)
AMEX103032071(has2) 103045554(has3) 103047586(has1)
EEE113570601(has2) 113575671 113582290(has3)
TRU101075370 101076117(has2) 115248388(has3)
TNGGSTEN00005308G001 GSTEN00013798G001 GSTEN00035316G001
LCO104928081(has2) 104930141(has3) 104932382 109142400
NCC104949316(has3) 104952136(has2) 104954817(has1)
CGOB115009118(has3) 115021121(has1) 115021563(has2)
ELY117262040(has3) 117265438(has2) 117266247(has1)
PLEP121945787(has2) 121946093(has1) 121950644(has3)
SLUC116035365(has2) 116048649(has3) 116049312(has1)
ECRA117946632(has2) 117946905(has1) 117948624(has3)
PFLV114556556(has1) 114557860(has2) 114560638(has3)
GAT120809645 120811150(has1) 120811178(has2) 120812823
PPUG119196667(has3) 119197472(has1) 119198236(has2)
MSAM119893510(has3) 119897981(has2) 119898311(has1)
CUD121513544(has1) 121513816(has2) 121515425(has3)
MZE101465324(has1) 101466497(has2) 101487664(has3)
ONL100692993(has3) 100695119(has2) 100707580
OAU116318737 116326759(has2) 116330991(has3)
OLA101165478(has3) 101171028 101174410(has2)
OML112140506(has2) 112143940(has1) 112152616(has3)
XMA102217002 102229462(has3) 102236901(has2)
XCO114139426(has1) 114143823(has2) 114152197(has3)
XHE116715137(has1) 116717926(has2) 116731148(has3)
PRET103466738(has3) 103478284(has2) 103478477(has1)
PFOR103142560(has2) 103143133 103156942(has3)
PLAI106937670 106951038(has1) 106953067(has2)
PMEI106919183(has1) 106921505(has3) 106926240(has2)
GAF122831352(has1) 122831553(has2) 122836113(has3)
CVG107086349(has2) 107093702(has3)
CTUL119773282(has3) 119783795 119783796 119786252(has2)
GMU124864450(has2) 124864594 124880027(has3)
NFU107374122 107378946(has2) 107389167(has3)
KMR108232248(has2) 108250006(has1) 108250938(has3)
ALIM106517893(has2) 106522596(has3) 106523247(has1)
NWH119409472(has1) 119410205(has2) 119415463(has3)
AOCE111572958(has2) 111577077(has1) 111585026(has3)
CSEM103379751(has3) 103388529(has1) 103388789(has2)
POV109631998(has2) 109633177 109645899 109646031
SSEN122761747 122774229(has2) 122774549(has1) 122775537(has3)
HHIP117763361(has3) 117777306(has2) 117777350(has1)
LCF108888012(has2) 108890341(has1) 108902235(has3)
SDU111227829(has2) 111229825(has3) 111234063
SLAL111647684(has3) 111658043(has2) 111664991(has1)
XGL120783775(has1) 120784807(has2) 120793407(has3)
HCQ109520699(has3) 109525696(has1) 109529616(has2)
BPEC110169489(has3) 110171491(has1) 110171748(has2)
MALB109954038 109958497(has2) 109964862(has1) 109974397(has3)
SASA106560880(has3) 106573695 106578351 106591270 106592862 106596886 106605656
OTW112218491(has3) 112222758(has1) 112225184(has2) 112227043 112252314
OMY110494478(has3) 110510523 110519986 110520721(has2) 110538188
OGO123992368 123998011 124006200 124018338 124018341 124037660(has3)
ONE115108898 115116712 115134331(has3) 115140874
SALP111952887 111953782 111958616 111962329(has3) 112072845
SNH120030790 120043474 120047793(has2) 120048559 120053438 120065789(has3)
ELS105016535(has2) 105018589(has3) 105019096(has1)
SFM108922203(has1) 108926644(has3) 108940476(has2)
PKI111844575(has2) 111845814 111851808(has3) 111855629
AANG118211456 118211463 118211468 118215397(has3) 118223745(has2)
LOC102682245(has2) 102690710(has3) 102693980
PSPA121296654 121299205(has1) 121299297 121313294 121314881 121325340
ARUT117394927 117399966 117424436 117425059 117433846 117434057 117964945 117971156
LCM102352892(HAS3) 102359069(HAS2) 102363484(HAS1)
CMK103173266 103183203(has2) 103188089(has3)
RTP109912726 109918906 109927057
BFO118410184 118426833 118427439 118427717 118428100
BBEL109463883
PANPODANSg8543
MTMMYCTH_10713
MGRMGG_15353
FOXFOXG_08805
TRETRIREDRAFT_122993
TRRM419DRAFT_142146
PLJVFPFJ_06525
PFYPFICI_14978
SSLSS1G_06158
BFUBCIN_05g04280
MBEMBM_00056 MBM_01384
PSCOLY89DRAFT_627847
AORAO090005000353
ANGANI_1_1476064(An07g01110)
AFVAFLA_003137
ALUCAKAW2_12026S
APUUAPUU_80940A
TMFPMAA_050710
TRGTRUGW13939_04055
PNOSNOG_10021
BSCCOCSADRAFT_45972
AALTCC77DRAFT_1075822
ZTRMYCGRDRAFT_12516
PFJMYCFIDRAFT_126498
NPAUCRNP2_6525 UCRNP2_705 UCRNP2_7343 UCRNP2_7533
PPLPOSPLDRAFT_91687
TVSTRAVEDRAFT_137322
SHSSTEHIDRAFT_105280 STEHIDRAFT_107339 STEHIDRAFT_64713
GTRGLOTRDRAFT_28815
APRSBI364_05235
RINACS15_5509
PHSC2L64_46140
HYFDTO96_102200(icaA)
DAERH9K75_17445
DMADMR_08420
DCBC3Y92_16270
DASDaes_1886
DMLDmul_09820 Dmul_39050
DATHRM2_22260(hasA) HRM2_46450(nodC)
SURSTAUR_4010
LLUAKJ09_05354
MRMA7982_03714
DAODesac_0261
DBRDeba_0216
BSEDDN745_00810
PHLKKY_942
BAHBAMEG_A0121
BAXH9401_5599
BANTA16_60215
BANRA16R_61235
BANSBAPAT_pXO10122
BANHHYU01_28605
BANVDJ46_5700
BCXBCA_A0112
BALBACI_pCIXO101130
BEOBEH_04450
LSPBsph_0547
LGYT479_18785
LFUHR49_05095
LYSLBYS11_18310
LYBC3943_21345
LPAKGDS87_19405
NMKCHR53_24290
MSEMGMB29_02700
MDGK8L98_24545
LWIUE46_10245
BBEBBR47_57500
BCHSJNE38_18280
GYMGYMC10_2037
PIHUB51_14975
PIBBBD41_04885
PVOPVOR_12680
PLWD5F53_19460
PLENEIM92_09805
PRZGZH47_13880
PLYCGXP70_02810
COHNKCTCHS21_25300
CCHLFPL14_26470
SPORSporoP33_09435
SPOPSporoP37_09810
SURESporoP32a_09745
PABSJIR001_26500(hasA)
LLDP620_14685
SPYSPy_2200(hasA)
SPZM5005_Spy1851(hasA)
SPYMM1GAS476_1901(hasA)
SPYAA20_1895(hasA)
SPMspyM18_2236(hasA)
SPGSpyM3_1851(hasA)
SPSSPs1847
SPHMGAS10270_Spy1970(hasA)
SPJMGAS2096_Spy1882(hasA)
SPKMGAS9429_Spy1862(hasA)
SPFSpyM51824(hasA)
SPAM6_Spy1869
STGMGAS15252_1740(hasA)
STXMGAS1882_1774(hasA)
SOZSpy49_1804(hasA)
STZSPYALAB49_001853
SPYHL897_09190
SPYOSTAB901_09020
STESTER_0149
STNSTND_0048
SEZSez_0199(hasA)
SEQSZO_01700
SEZOSeseC_00231(hasA)
SEQUQ426_08280
SEUSEQ_0269
SUBSUB1697(hasA)
STKSTP_1716(hasA)
SIKK710_1994
SIQDQ08_09415
SIODW64_09395
SIZSI82_09370
ESSATZ33_06070
EGVEGCR1_03140
CSQCSCA_2368
CCKCcar_02835
CBUTATN24_15250
CARGRSJ17_16560
CDRKB9W14_07835
CALEFDN13_13810
CPYCphy_2212
ACELacsn021_20710
ROCHF520_04155
CADCuri_c20950
SEDZJYG23_05575
SSGSelsp_0180
SRISELR_02040
PUFUFO1_1769
PFTJBW_01491
STEDSPTER_10250
AINAcin_0825
ERDG7062_10410
MSAMycsm_04036
MSMMSMEG_0476
MSGMSMEI_0464
MSBLJ00_02360
MSNLI99_02360
MSHLI98_02360
MCBMycch_4139
CCYSSAMEA4530656_0482(pgaC_1)
SCBSCAB_60711
SDVBN159_3692
SCWTU94_00560
SXISXIM_46150
STSIA4E84_30860
SCADDN051_10820
SLSSLINC_6403
SSIAA7J05_01625
SHAWCEB94_31445
SFYGFH48_19800
SCOECP976_33215
STUIGCM10017668_36950(hasA)
KSKKSE_12220
LSEF1C12_14955
CPHYB5808_16860
HUMDVJ78_04020
LVIG7068_06750 G7068_11625
CFLCfla_3194
CELZE5225_01385
CEJGC089_01400
DEMLGT36_003425
ACTWF7P10_28055
FREFranean1_7281
ACTAC1701_25400
AOSAXE84_06230
ANEAN27039_1339
AHWNCTC11636_00398(pgaC)
ASLANCTC11923_02063(pgaC) NCTC11923_02064
AVCNCTC10951_02593(pgaC)
CWOCwoe_1375
SHTKO02_15915
SPHNBV902_01765
SPDRG6053_00720
STHANCTC11429_01469(pgaC_3)
SMUII6J00_17675
SSIYJVX97_02610
MDAIPZ59_13080
GFOGFO_0015(hasA)
GRLLPB144_05310
FPSZAMR72_00595
FJOFjoh_4840
FJGBB050_02730(pgaC_3)
FFAFFWV33_12445
FKIFK004_12570
FALBHYN59_01825
FCRHYN56_23755
FAKFUA48_09480
FFLHYN86_19880
FENJ0383_17030
CATCA2559_10838
MARMYQ22_09155
MARTBTR34_09245
MARBCJ263_07270
MAREEJ994_12355
CAOCelal_4149
CLYCelly_0658
CLHIX49_03045
CBALM667_17100
CBATM666_17120
KDIKrodi_0331
DOKMED134_02590
DDOI597_2649(pgaC)
DODDCS32_10465
LANLacal_0533
LVNBWR22_13300
SPONHME9304_01695
AEVEI546_04195
PTQP700755_000315
MYRMYRA21_2331
MPWMPR_1080
MODAS202_11375
MYZBK054_10980
MOAI6I89_09475
SALTAO058_00495
SMISLDL76_16685
SEONBWZ22_11870
OLLCW732_06060
OAQDZC78_12615
TAJC1A40_11265
AQBD1818_01215
AQAD1815_06260
AQDD1816_23695
PSYNE9099_04125
AFLAFHG64_02960
ANPFK178_02700
GAAHX109_04425
CAGGHYG79_07290
MARXINR76_12040
ASAGFGM00_16125
FLGLV716_06695
BIAGMA17_10070
FBAFIC_01710
EAOBD94_2931
EMNM876_11925
EENBBD30_11850
ELBVO54_03644(pgaC)
EMGBBD33_08290
EGOBBD34_04060
EGMAYC65_02420
CCASEIB73_03420
THPBG95_00535
THERY592_00540
NAYHYG81_15510
NKRNKOR_02285
NGANgar_c30470
NVNNVIE_010470 NVIE_023880 NVIE_023920
NEVNTE_00306 NTE_02402 NTE_03155 NTE_03158
TAANMY3_02483(pgaC_2)
NFNNFRAN_0027(pgaC)
 » show all
Reference
1  [PMID:8366070]
  Authors
DeAngelis PL, Papaconstantinou J, Weigel PH
  Title
Molecular cloning, identification, and sequence of the hyaluronan synthase gene from group A Streptococcus pyogenes.
  Journal
J Biol Chem 268:19181-4 (1993)
  Sequence
Reference
2  [PMID:10988250]
  Authors
Jing W, DeAngelis PL.
  Title
Dissection of the two transferase activities of the Pasteurella multocida hyaluronan synthase: two active sites exist in one polypeptide.
  Journal
Glycobiology 10:883-9 (2000)
DOI:10.1093/glycob/10.9.883
  Sequence
[pmp:Pmu_08530]
Reference
3  [PMID:10473619]
  Authors
DeAngelis PL.
  Title
Molecular directionality of polysaccharide polymerization by the Pasteurella multocida hyaluronan synthase.
  Journal
J Biol Chem 274:26557-62 (1999)
DOI:10.1074/jbc.274.37.26557
Reference
4  [PMID:15248781]
  Authors
Tlapak-Simmons VL, Baron CA, Weigel PH.
  Title
Characterization of the purified hyaluronan synthase from Streptococcus equisimilis.
  Journal
Biochemistry 43:9234-42 (2004)
DOI:10.1021/bi049468v
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.212
IUBMB Enzyme Nomenclature: 2.4.1.212
ExPASy - ENZYME nomenclature database: 2.4.1.212
BRENDA, the Enzyme Database: 2.4.1.212
CAS: 39346-43-5

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