KEGG   ENZYME: 2.4.1.22
Entry
EC 2.4.1.22                 Enzyme                                 
Name
lactose synthase;
UDP-galactose---glucose galactosyltransferase;
N-acetyllactosamine synthase;
uridine diphosphogalactose-glucose galactosyltransferase;
lactose synthetase;
UDP-galactose:D-glucose 4-beta-D-galactotransferase;
UDP-galactose:D-glucose 4-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-galactose:D-glucose 4-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + D-glucose = UDP + lactose [RN:R00503 R06067]
Reaction(KEGG)
R00503 R06067(G)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
D-glucose [CPD:C00031]
Product
UDP [CPD:C00015];
lactose [CPD:C00243]
Comment
The enzyme is a complex of two proteins, A and B. In the absence of the B protein (alpha-lactalbumin), the enzyme catalyses the transfer of galactose from UDP-alpha-D-galactose to N-acetylglucosamine (EC 2.4.1.90 N-acetyllactosamine synthase).
History
EC 2.4.1.22 created 1965
Pathway
ec00052  Galactose metabolism
ec01100  Metabolic pathways
Orthology
K00704  alpha-lactalbumin
K07966  beta-1,4-galactosyltransferase 1
K07967  beta-1,4-galactosyltransferase 2
Genes
HSA2683(B4GALT1) 3906(LALBA) 8704(B4GALT2)
PTR100613700(B4GALT1) 456522(B4GALT2) 743291(LALBA)
PPS100974756(B4GALT1) 100980267(B4GALT2) 100989301(LALBA)
GGO101133326(B4GALT2) 101138539(LALBA) 101138982(B4GALT1)
PON100437438(LALBA) 100437696(B4GALT2) 100438031(B4GALT1)
NLE100583850(LALBA) 100597531(B4GALT1) 100598306(B4GALT2)
MCC703541(B4GALT1) 704038(B4GALT2) 707442(LALBA)
MCF102131044(B4GALT1) 102146034(LALBA)
CSAB103219294(B4GALT1) 103224947(B4GALT2) 103238238(LALBA)
CATY105580409(LALBA) 105590081(B4GALT1) 105594621(B4GALT2)
PANU101007707(LALBA) 101011230(B4GALT2) 101022281(B4GALT1)
TGE112607911(B4GALT1) 112612391(B4GALT2) 112635358(LALBA)
RRO104654856(LALBA) 104669045(B4GALT2) 104674271(B4GALT1)
RBB108518246(B4GALT1) 108535685(B4GALT2) 108543906(LALBA)
TFN117069449(B4GALT1) 117091075(LALBA) 117092715(B4GALT2)
PTEH111529202(B4GALT1) 111541722(LALBA) 111548740(B4GALT2)
CJC100385157(B4GALT1) 100407698(LALBA) 100896540(B4GALT2)
SBQ101038954(LALBA) 101039415(B4GALT2) 101054125(B4GALT1)
CSYR103260760(B4GALT2) 103273467(LALBA) 103277047(B4GALT1)
MMUR105871521(LALBA) 105874372(B4GALT1) 105877433(B4GALT2)
OGA100940411(LALBA) 100945323(B4GALT2) 100962109(B4GALT1)
MMU14595(B4galt1) 16770(Lalba) 53418(B4galt2)
MCAL110292610(B4galt2) 110292819(B4galt1) 110311075(Lalba)
MPAH110322866(B4galt2) 110335295(Lalba) 110338771(B4galt1)
RNO24390(B4galt1) 24528(Lalba) 313536(B4galt2)
MCOC116080939(Lalba) 116095826(B4galt1) 116096507(B4galt2)
MUN110552917(B4galt2) 110561670(B4galt1) 110562075 110562077
CGE100689430(B4galt1) 100689434(B4galt2) 100758724(Lalba)
PLEU114703257(B4galt1) 114708525(Lalba) 114709360(B4galt2)
NGI103741594(B4galt1) 103743868(B4galt2) 103750554(Lalba)
HGL101698779 101701591(Lalba) 101718811(B4galt2) 101721414(B4galt1)
CPOC100379577(Lalba) 100719604(B4galt1) 100724702(B4galt2)
CCAN109681413 109695495(B4galt2) 109703297(Lalba)
DORD105986045 105986128(B4galt2) 105987509(Lalba) 105993397(B4galt1)
DSP122106268(Lalba) 122106950(B4galt2) 122121438(B4galt1)
OCU100008717(LALBA) 100345726(B4GALT1) 100351419(B4GALT2)
OPI101522535(B4GALT1) 101526990(B4GALT2) 101530334(LALBA)
TUP102470655(B4GALT1) 102483661(LALBA) 102489782(B4GALT2)
CFA403730(LALBA) 481579(B4GALT1) 482527(B4GALT2)
VVP112914817(B4GALT2) 112921026(LALBA) 112927554(B4GALT1)
VLG121479854(LALBA) 121481279(B4GALT2) 121494980(B4GALT1)
AML100471634(B4GALT2) 100477164(B4GALT1) 100478355(LALBA)
UMR103667105(B4GALT1) 103670800(B4GALT2) 103675440(LALBA)
UAH113254774(B4GALT2) 113257366(LALBA) 113260528(B4GALT1)
UAR123781319(B4GALT1) 123793792(B4GALT2) 123794799(LALBA)
ELK111143515 111146253 111157930
LLV125083661 125098178 125107736
MPUF101678769(LALBA) 101682229(B4GALT2) 101693610(B4GALT1)
ORO101362571(B4GALT1) 101364688(B4GALT2) 101376042(LALBA)
EJU114218153(B4GALT1) 114224318(B4GALT2) 114225868(LALBA)
ZCA113922685(LALBA) 113932173(B4GALT2) 113934251(B4GALT1)
MLX118008499(LALBA) 118018025(B4GALT1) 118019513(B4GALT2)
FCA101084809(B4GALT2) 101090027(LALBA) 101100927(B4GALT1)
PYU121027002(B4GALT2) 121034567(B4GALT1) 121038651(LALBA)
PBG122472330(LALBA) 122475074(B4GALT1) 122480394(B4GALT2)
PTG102955088(B4GALT2) 102959538(B4GALT1) 102972113(LALBA)
PPAD109249040(LALBA) 109252046(B4GALT1) 109254800(B4GALT2)
AJU106969361(LALBA) 106970225(B4GALT2) 106976144(B4GALT1)
HHV120223030(LALBA) 120236082(B4GALT2) 120241747(B4GALT1)
BTA100125390(B4GALT2) 281781(B4GALT1) 281894(LALBA)
BOM102269762(B4GALT1) 102283249(B4GALT2) 102287905(LALBA)
BIU109556391(B4GALT2) 109558698(LALBA) 109563168(B4GALT1)
BBUB102389487(B4GALT1) 102408682(B4GALT2) 102410146(LALBA)
CHX100860779(LALBA) 100860927(B4GALT1) 102191101(B4GALT2)
OAS100620048(B4GALT1) 101114825(B4GALT2) 443386(LALBA)
ODA120856268(B4GALT2) 120859357 120859358 120860345 120866179
CCAD122427245(LALBA) 122431686(B4GALT1) 122437085(B4GALT2)
SSC100511655(B4GALT1) 100736821(B4GALT2) 397647(LALBA)
CFR102516080(B4GALT2) 102517623(B4GALT1) 102518569(LALBA)
CBAI105064116(B4GALT2) 105076182(LALBA) 105078745(B4GALT1)
CDK105085573(B4GALT1) 105090897(B4GALT2) 105103818(LALBA)
VPC102530069(B4GALT1) 102531520(LALBA) 102545619(B4GALT2)
BACU102999260(B4GALT1) 103001417(B4GALT2) 103011536(LALBA)
LVE103073762(LALBA) 103086401(B4GALT1) 103086978(B4GALT2)
OOR101274354(LALBA) 101285364(B4GALT1) 101285582(B4GALT2)
DLE111163203(B4GALT1) 111174066(LALBA) 111175715(B4GALT2)
PCAD102981888(B4GALT1) 102988235(LALBA) 102991108(B4GALT2)
PSIU116753649(B4GALT2) 116755411(B4GALT1) 116760727(LALBA)
ECB100066149(B4GALT2) 100068209(B4GALT1) 100146585(LALBA)
EPZ103548278(B4GALT2) 103555031(B4GALT1) 103563621(LALBA)
EAI106836902(LALBA) 106841463(B4GALT1) 106847911(B4GALT2)
MYB102240062(B4GALT1) 102248727(B4GALT2) 102251448(LALBA)
MYD102751484(B4GALT1) 102768578(LALBA) 102774860(B4GALT2)
MMYO118650021(LALBA) 118667396(B4GALT1) 118675840(B4GALT2)
MLF102418125(B4GALT2) 102430845(LALBA) 102435984(B4GALT1)
MNA107526700(B4GALT2) 107528145(LALBA) 107544980(B4GALT1)
PKL118716413(B4GALT1) 118722891(B4GALT2) 118730885(LALBA)
HAI109371790(B4GALT1) 109383427(B4GALT2) 109393207(LALBA)
DRO112304428(B4GALT1) 112314589(B4GALT2) 112318233(LALBA)
SHON118976418(LALBA) 118979827(B4GALT1) 119003348(B4GALT2)
AJM119041658(LALBA) 119052444(B4GALT2) 119060005(B4GALT1)
PDIC114497461(B4GALT2) 114507957(B4GALT1) 114513048(LALBA)
PHAS123813110(LALBA) 123819973(B4GALT1) 123831833(B4GALT2)
MMF118624575(LALBA) 118626982(B4GALT2) 118629472(B4GALT1)
RFQ117027748(B4GALT2) 117029449(LALBA) 117032000(B4GALT1)
PALE102878748(B4GALT1) 102884318(B4GALT2) 102892277(LALBA)
PGIG120612917(B4GALT1) 120618562(LALBA) 120619485(B4GALT2)
PVP105297100(B4GALT2) 105297512(LALBA) 105306412(B4GALT1)
RAY107499511(B4GALT2) 107502798(B4GALT1) 107514285(LALBA)
MJV108388126(LALBA) 108404111(B4GALT1) 108404461(B4GALT2)
TOD119232854(B4GALT1) 119235997(B4GALT2) 119248396(LALBA)
SARA101543700(B4GALT1) 101557595(LALBA) 101559247(B4GALT2)
LAV100657659(B4GALT2) 100659897(B4GALT1) 100677246(LALBA)
TMU101341812 101348221 101358819
DNM101415414(B4GALT1) 101435513(B4GALT2) 101441970(LALBA)
MDO100010600(B4GALT1) 100024086(LALBA) 100617718(B4GALT2)
GAS123247679(B4GALT2) 123250251(LALBA) 123250673(B4GALT1) 123253937
SHR100918732(B4GALT2) 100929465(B4GALT1) 100931076(LALBA)
PCW110194785(B4GALT1) 110200216(B4GALT2) 110201504(LALBA)
OAA100075703(B4GALT1) 100092000(B4GALT2)
GGA396121(B4GALT1) 396122(B4GALT2)
PCOC116233877(B4GALT2) 116239467(B4GALT1)
MGP100543545(B4GALT1) 100543680(B4GALT2)
CJO107306674(B4GALT1) 107317480(B4GALT2)
NMEL110389893(B4GALT1) 110402248(B4GALT2)
APLA101792817(B4GALT1)
ACYG106040136(B4GALT1) 106049039(B4GALT2)
AFUL116492193(B4GALT2) 116500363(B4GALT1)
TGU100223650(B4GALT1) 100230857(B4GALT2)
LSR110469509(B4GALT2) 110474049(B4GALT1)
SCAN103815164(B4GALT2) 103821842(B4GALT1)
PMOA120503204(B4GALT2) 120513595(B4GALT1)
OTC121332678(B4GALT1) 121345189(B4GALT2)
PRUF121361933(B4GALT2) 121363773(B4GALT1)
GFR102036032(B4GALT2) 102041517(B4GALT1)
FAB101805871(B4GALT2) 101807052(B4GALT1)
PHI102106294(B4GALT2) 102109081(B4GALT1)
PMAJ107198186(B4GALT1) 107208264(B4GALT2)
CCAE111933140(B4GALT2) 111941228(B4GALT1)
CCW104689823(B4GALT1) 104695261(B4GALT2)
ETL114057877(B4GALT1) 114061818(B4GALT2)
ZAB102061597(B4GALT2) 102064480(B4GALT1)
FPG101916596(B4GALT2) 101918852(B4GALT1)
FCH102046112(B4GALT1) 102056545(B4GALT2)
CLV102088289(B4GALT1) 102088677(B4GALT2)
EGZ104125508(B4GALT2)
NNI104015428(B4GALT2) 104022647(B4GALT1)
ACUN113483103(B4GALT2) 113490200(B4GALT1)
TALA104358205(B4GALT2) 116963851(B4GALT1)
PADL103921076(B4GALT1)
ACHC115337075(B4GALT1) 115349431(B4GALT2)
AAM106484931(B4GALT2) 106486901(B4GALT1)
AROW112975301(B4GALT1) 112975984(B4GALT2)
NPD112942436(B4GALT2) 112948927(B4GALT1)
DNE112981279(B4GALT2) 112989803(B4GALT1)
ASN102372956(B4GALT1) 102376584(B4GALT2)
AMJ102558168(B4GALT2) 102559129(B4GALT1)
CPOO109307391(B4GALT2) 109323453(B4GALT1)
GGN109286748(B4GALT2) 109298077(B4GALT1)
PSS102459690(B4GALT1)
CMY102941864(B4GALT2) 102942662(B4GALT1)
CPIC101932379(B4GALT1) 101945883(B4GALT2)
TST117878876(B4GALT1) 117881649(B4GALT2)
CABI116816411(B4GALT2) 116829702(B4GALT1)
MRV120370392(B4GALT2) 120393939 120407933
ACS100557558(b4galt2) 100561064(b4galt1)
PVT110073738(B4GALT2) 110087350(B4GALT1)
SUND121921206(B4GALT1) 121929239(B4GALT2)
PBI103065477(B4GALT1) 103068203(B4GALT2)
PMUR107283468(B4GALT2) 107285615(B4GALT1)
TSR106546760(B4GALT2) 106557055(B4GALT1)
PGUT117661724(B4GALT1) 117664107(B4GALT2)
VKO123017487(B4GALT1) 123029475(B4GALT2)
PMUA114587454(B4GALT1) 114599120(B4GALT2)
ZVI118088949(B4GALT2) 118097645(B4GALT1)
GJA107110573(B4GALT1) 107120293(B4GALT2)
XLA100190782(b4galt2.S) 108704693(b4galt1l.S) 108706812(b4galt1.1.S) 108706813(b4galt1.2.S) 108712215(b4galt1.1.L) 108712216(b4galt1.2.L) 108712940 108712957(b4galt1l.L) 108714282(b4galt2.L)
XTR100145518(b4galt1.1) 100485024(b4galt1l) 100492356(b4galt2) 549418(b4galt1.2)
NPR108788802 108792261 108802209
RTEM120915210(B4GALT1) 120932030 120946150(B4GALT2)
BBUF120979298(B4GALT2) 120989596 120989622(B4GALT1)
BGAR122923553(B4GALT2) 122927900(B4GALT1) 122928504
DRE100148828(b4galt2) 550425(b4galt1) 768123(b4galt1l)
SRX107713046 107723150 107723151 107730805(b4galt2) 107750327 107751321 107758898
SANH107657457 107665944 107677371 107692709 107697619 107700994
SGH107557142 107557953 107562374 107565367 107587100 107599894
CCAR109046140 109046469 109047435 109090593 109108968 109113239(b4galt2)
CAUA113038257 113044328 113045530 113057637 113057644 113105615 113113860 113118763
IPU108260689 108267387(b4galt2) 108277608(b4galt1l)
PHYP113540104(b4galt1) 113540513(b4galt2)
SMEO124381523 124387942(b4galt2) 124396963(b4galt1l)
AMEX103028729 103033307(b4galt2) 103039461
EEE113583532 113583542 113584665(b4galt2) 113587936
TRU101061762 101061991 101063106 101065400 101066088 101072068(b4galt2) 101077184 115248431
TNGGSTEN00007296G001 GSTEN00010496G001 GSTEN00012074G001 GSTEN00026511G001
LCO104917723(b4galt2) 104938299(b4galt1) 109137286 109138027
NCC104951664
CGOB115022447(b4galt2) 115025593
ELY117250533 117250550 117250570 117256405(b4galt1l) 117264448 117264493 117264494 117265022 117265080 117272280(b4galt2)
PLEP121948152(b4galt1l) 121951595(b4galt2) 121960985 121960986
SLUC116046231(b4galt2) 116051105 116060258(b4galt1l)
ECRA117938145 117941477 117954208(b4galt2)
PFLV114549363 114562966(b4galt1) 114565336(b4galt2)
GAT120811611 120816058(b4galt2) 120817303(b4galt1l)
PPUG119199018 119199020 119209336(b4galt2) 119211455(b4galt1l)
MSAM119884175 119901943(b4galt2) 119908413
CUD121516558(b4galt1l) 121519912(b4galt2) 121527509 121527692 121527693
MZE101464552 101472320(b4galt1) 101486761 112429855 112432595
ONL100691259 100692426 100692970 100711524(b4galt2)
OAU116315312(b4galt2) 116328309 116332053(b4galt1l) 116332060
OLA100301598(b4galt2) 101171148(b4galt1)
OML112147730(b4galt2) 112153596(b4galt1l)
XMA102216445(b4galt1) 102219706 102223611 102224977 102231933(b4galt2) 102235410 106700428 111606172 111606205 111606296
XCO114136451 114136452 114136454 114136457 114136458 114137012 114139607(b4galt1) 114146508(b4galt2)
XHE116712151 116712154 116712173 116712176 116712231 116712342 116714600(b4galt1) 116721474(b4galt2)
PRET103456521 103457015 103457016 103457033 103457329 103471786(b4galt1) 103479896
PFOR103130223 103131055 103131056 103135266 103135710(b4galt2) 103155973(b4galt1)
PLAI106940656 106940657 106944964 106958577(b4galt1)
PMEI106903670 106910870 106910871 106914697 106922898(b4galt1) 106933219
GAF122824275 122824447 122836758(b4galt1l) 122841067(b4galt2)
CVG107081704(b4galt2) 107082712(b4galt1) 107085956 107094320 107097868
CTUL119776087 119781275 119784548(b4galt1l) 119784620 119787615 119787995
GMU124857899 124857910 124858162 124858164 124858166 124858167 124858187 124860126(b4galt1l) 124861147 124869258(b4galt2)
NFU107373064 107381099(b4galt1) 107382441 107382995 107383812(b4galt2) 107395677 107396800
KMR108241697(b4galt2) 108243995 108248973(b4galt1l) 108249546 108250944
ALIM106517566 106531648 106532850(b4galt2) 106533299(b4galt1)
NWH119408817(b4galt1l) 119415178(b4galt2) 119426702
AOCE111565921 111569747 111569748 111579296(b4galt2) 111585098 111585099 111586043(b4galt1)
CSEM103376904 103390794(b4galt1) 103396367(b4galt2)
POV109629466 109647156(b4galt2)
SSEN122759998(b4galt2) 122774288 122778195(b4galt1l)
HHIP117753741 117769188 117778416(b4galt2)
LCF108879172 108883305(b4galt2) 108885296(b4galt1) 108900792
SDU111230961(b4galt2) 111233512(b4galt1) 111237265
SLAL111656997(b4galt2) 111662869 111665610(b4galt1)
XGL120785455(b4galt1l) 120790010 120799105(b4galt2)
HCQ109508336 109524074(b4galt2)
BPEC110161009 110164179(b4galt2) 110168019(b4galt1)
MALB109955445(b4galt2) 109963721
SASA106569086 106597479 106599387 106602598 106602599 106604638 106611645
OTW112220987 112226941(b4galt2) 112231601 112231848 112245005 112256274 112260467
OMY110488860 110497417 110505061 110508729 110530319 110533181 110534462
OGO124009391 124010901 124012113 124012114 124019097 124041857(b4galt2)
ONE115103087 115114420 115116662 115116883 115129493 115130741 115137371 115137545
SALP111956847 111965773 111967527 111971603 111971604 111979246 112068292
SNH120020114 120034976 120048073 120052222 120052908 120055875 120062281
ELS105007535(b4galt1) 105008881 105009278 105021088 105022694(b4galt2) 105022911 105022912 106024204
SFM108925913 108925916 108927818 108935233(b4galt2) 108938816
PKI111846077(b4galt2) 111848718(b4galt1)
AANG118227568 118229995(b4galt2) 118231327(b4galt1l)
LOC102691443 102695017(b4galt2) 107077118(b4galt1)
PSPA121294868 121323269 121326361 121330481(b4galt2)
ARUT117409235(b4galt1l) 117410521(b4galt2) 117417473 117420622
LCM102350195(B4GALT2) 102357329
CMK103177647(b4galt1l) 103181973 103182791(b4galt2)
RTP109917086 109923637
BBEL109465953
CIN100175041 100176804 100178997 100182676 100184328 100185960 445802(b4galt)
SCLV120329201 120329647 120330046 120330214 120330942 120330957 120331029 120331072 120331073 120332406 120332407 120332559 120333694 120340941 120341047 120341050 120342054 120342359 120342426 120343041 120343171 120343172 120343369
NVL108562525 108564564
API100302475(NV135)
DNX107166054
AGS114128088
RMD113554920
NLU111053488
PVM113821378
PJA122242953 122252242 122259436 122263470
PTRU123502121 123520613
HAZT108682369
EAF111706000 111706179
RSAN119391351
VDE111243827
VJA111265628
DPTE113790588 113798918
DFR124497241
LGILOTGIDRAFT_113306
BGT106050436 106050804 106051360 106055260 106055622 106055624 106055625 106055626 106056375 106056376 106068703 106074439
HRF124140904 124140990
HRJ124256641 124269486
CRG105325103 105325111 105333755 105341851
MYI110446269
PMAX117324455 117344964 117345202
MMER123523476 123530326 123551421 123553112
LAK106153491 106159675 106164999 106177178
OVIT265_05578 T265_09073
XEN124455180
 » show all
Reference
1  [PMID:5440844]
  Authors
Fitzgerald DK, Brodbeck U, Kiyosawa I, Mawal R, Colvin B, Ebner KE.
  Title
Alpha-lactalbumin and the lactose synthetase reaction.
  Journal
J Biol Chem 245:2103-8 (1970)
Reference
2  [PMID:812340]
  Authors
Hill RL, Brew K.
  Title
Lactose synthetase.
  Journal
Adv Enzymol Relat Areas Mol Biol 43:411-90 (1975)
DOI:10.1002/9780470122884.ch5
Reference
3  [PMID:14005251]
  Authors
WATKINS WM, HASSID WZ.
  Title
The synthesis of lactose by particulate enzyme preparations from guinea pig and bovine mammary glands.
  Journal
J Biol Chem 237:1432-40 (1962)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.22
IUBMB Enzyme Nomenclature: 2.4.1.22
ExPASy - ENZYME nomenclature database: 2.4.1.22
BRENDA, the Enzyme Database: 2.4.1.22
CAS: 9030-11-9

DBGET integrated database retrieval system