KEGG   ENZYME: 2.4.1.228
Entry
EC 2.4.1.228                Enzyme                                 

Name
lactosylceramide 4-alpha-galactosyltransferase;
Galbeta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase;
globotriaosylceramide/CD77 synthase;
histo-blood group Pk UDP-galactose;
UDP-galactose:lactosylceramide 4II-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-(1->4)-D-glucosyl(1<->1)ceramide 4II-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide 4II-alpha-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-galactose:beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide 4II-alpha-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R03486 R05960]
Reaction(KEGG)
R03486 R05960(G);
(other) R11375(G) R11376(G) R11377(G)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C01290]
Product
UDP [CPD:C00015];
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04737]
Comment
For explanation of superscript II in systematic name, see {iupac/2carb/37#372::2-carb.37}.
History
EC 2.4.1.228 created 2002
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec01100  Metabolic pathways
Orthology
K01988  lactosylceramide 4-alpha-galactosyltransferase
Genes
HSA: 53947(A4GALT)
PTR: 470230(A4GALT)
PPS: 100981788(A4GALT)
GGO: 101148084(A4GALT)
PON: 100172807(A4GALT)
NLE: 100582945(A4GALT)
MCC: 710998(A4GALT)
MCF: 102134894(A4GALT)
CSAB: 103223426(A4GALT)
CATY: 105598322(A4GALT)
PANU: 101018834(A4GALT)
RRO: 104668998(A4GALT)
RBB: 108514019(A4GALT)
TFN: 117096373(A4GALT)
PTEH: 111548923(A4GALT)
CJC: 100399091 100399258(A4GALT)
SBQ: 101049376(A4GALT)
MMUR: 105858530(A4GALT)
MMU: 239559(A4galt)
MCAL: 110310458(A4galt)
MPAH: 110335243(A4galt)
RNO: 63888(A4galt)
MCOC: 116076817(A4galt)
MUN: 110552095(A4galt)
CGE: 100770462(A4galt)
PLEU: 114686395(A4galt) 114702818
NGI: 103743444(A4galt)
HGL: 101717743(A4galt)
CCAN: 109693113(A4galt)
OCU: 100347783(A4GALT)
OPI: 101533509(A4GALT)
TUP: 102482240(A4GALT)
CFA: 481222(A4GALT)
VVP: 112934050(A4GALT)
VLG: 121491575(A4GALT)
AML: 100473471(A4GALT)
UMR: 103674056(A4GALT)
UAH: 113241688(A4GALT)
ORO: 101378243(A4GALT)
ELK: 111157575
MPUF: 101692689(A4GALT)
EJU: 114218319(A4GALT)
MLX: 117998600(A4GALT)
FCA: 101085732(A4GALT)
PYU: 121040228(A4GALT)
PBG: 122472858(A4GALT)
PTG: 102966914(A4GALT)
PPAD: 109265669(A4GALT)
AJU: 106967275(A4GALT)
HHV: 120235109(A4GALT)
BTA: 618369(A4GALT)
BOM: 102281081(A4GALT)
BIU: 109559887(A4GALT)
BBUB: 102404141(A4GALT)
CHX: 102190112(A4GALT)
OAS: 101106675(A4GALT)
ODA: 120857564(A4GALT)
CCAD: 122423689(A4GALT)
SSC: 100524987(A4GALT)
CFR: 102519432(A4GALT)
CBAI: 105073047(A4GALT)
CDK: 105091872(A4GALT)
BACU: 103010830(A4GALT) 103013262
LVE: 103069366(A4GALT)
OOR: 101275372(A4GALT)
DLE: 111186415(A4GALT)
PCAD: 102992800(A4GALT)
ECB: 102150730(A4GALT)
EPZ: 103560176(A4GALT)
EAI: 106845936(A4GALT)
MYB: 102242406(A4GALT)
MYD: 102751675(A4GALT)
MMYO: 118651428(A4GALT)
MNA: 107535002(A4GALT)
PKL: 118712046(A4GALT)
HAI: 109371482(A4GALT)
DRO: 112321863(A4GALT)
SHON: 118974919(A4GALT)
AJM: 119060201(A4GALT)
MMF: 118624674(A4GALT)
PALE: 102884849(A4GALT)
PGIG: 120602920(A4GALT)
RAY: 107505557(A4GALT)
MJV: 108384701(A4GALT)
LAV: 100654825(A4GALT)
TMU: 101343100
MDO: 100017110(A4GALT)
SHR: 100925030(A4GALT)
PCW: 110205872(A4GALT)
OAA: 100090950(A4GALT)
GGA: 418223(A4GALT)
PCOC: 116231434(A4GALT)
MGP: 100550373(A4GALT)
CJO: 107317221(A4GALT)
NMEL: 110396623(A4GALT)
APLA: 101791613(A4GALT)
ACYG: 106038268(A4GALT)
LSR: 110475200(A4GALT)
OTC: 121332070(A4GALT)
PRUF: 121352094(A4GALT)
GFR: 102036341 102038089(A4GALT)
PHI: 102110169(A4GALT) 106628858
ETL: 114068557(A4GALT)
FPG: 101921227(A4GALT) 101921402
PADL: 103924312(A4GALT) 103924314
AROW: 112967088
NPD: 112960148(A4GALT)
DNE: 112991535(A4GALT)
ASN: 102382036(A4GALT)
AMJ: 102568489(A4GALT)
CPOO: 109316363(A4GALT)
GGN: 109297044(A4GALT)
PSS: 102459009(A4GALT)
CMY: 102947245(A4GALT)
CPIC: 101950887(A4GALT)
TST: 117883679(A4GALT)
CABI: 116822229(A4GALT)
ACS: 100558212(a4galt)
PVT: 110087161(A4GALT)
PMUA: 114596898(A4GALT)
ZVI: 118096287(A4GALT)
GJA: 107120303(A4GALT)
XLA: 108710180(a4galt.L)
XTR: 100495236(a4galt)
NPR: 108804610(A4GALT)
RTP: 109916623(a4galt)
DME: Dmel_CG17223(alpha4GT1) Dmel_CG5878(alpha4GT2)
DSI: Dsimw501_GD11999(Dsim_GD11999) Dsimw501_GD21237(Dsim_GD21237)
DSR: 110183976
DWI: 6642353
CCAT: 101455647
BOD: 106622044
MDE: 101898147
SCAC: 106082269
LCQ: 111687695
BIM: 100740409
BBIF: 117204463
BVK: 117233190
BVAN: 117153713
BTER: 100650768
OBB: 114871060
MGEN: 117222510
NMEA: 116425188
CGIG: 122395080
SOC: 105196183
MPHA: 105835340
AEC: 105145775
HST: 105190591
DQU: 106752134
LHU: 105678152
PGC: 109860132
PCF: 106792676
PFUC: 122518159
NVI: 100115564
CSOL: 105359116
FAS: 105265524
CCIN: 107268984
TCA: 658448
AGB: 108914028
LDC: 111506093
NVL: 108558122
APLN: 108735466
BMOR: 101745697
MSEX: 115448675
PRAP: 111002820
DNX: 107166115
AGS: 114120620
RMD: 113556895
DCI: 103505501
NLU: 111043264
FOC: 113213782
PTEP: 107445145
SDM: 118194672
DGT: 114528755
LJA: Lj1g3v2311890.1(Lj1g3v2311890.1) Lj1g3v2311900.1(Lj1g3v2311900.1) Lj6g3v2044530.1(Lj6g3v2044530.1)
LANG: 109329644
OSA: 4336475
DOSA: Os04t0529700-01(Os04g0529700)
OBR: 102717891
BDI: 100831105
ATS: 109732097
SBI: 8082872
ZMA: 100283564
SITA: 101786409
PVIR: 120642424
PHAI: 112899501
MUS: 103968640
DCT: 110109954
AOF: 109820034
SMO: SELMODRAFT_419460(GT32A2)
 » show all
Reference
1  [PMID:3099784]
  Authors
Bailly P, Piller F, Cartron JP, Leroy Y, Fournet B.
  Title
Identification of UDP-galactose: lactose (lactosylceramide) alpha-4 and beta-3 galactosyltransferases in human kidney.
  Journal
Biochem Biophys Res Commun 141:84-91 (1986)
DOI:10.1016/S0006-291X(86)80338-2
Reference
2  [PMID:10747952]
  Authors
Steffensen R, Carlier K, Wiels J, Levery SB, Stroud M, Cedergren B, Nilsson Sojka B, Bennett EP, Jersild C, Clausen H.
  Title
Cloning and expression of the histo-blood group Pk UDP-galactose: Ga1beta-4G1cbeta1-cer alpha1, 4-galactosyltransferase. Molecular genetic basis of the p phenotype.
  Journal
J Biol Chem 275:16723-9 (2000)
DOI:10.1074/jbc.M000728200
  Sequence
[hsa:53947]
Reference
3  [PMID:10748143]
  Authors
Kojima Y, Fukumoto S, Furukawa K, Okajima T, Wiels J, Yokoyama K, Suzuki Y, Urano T, Ohta M, Furukawa K.
  Title
Molecular cloning of globotriaosylceramide/CD77 synthase, aglycosyltransferase that initiates the synthesis of globo seriesglycosphingolipids.
  Journal
J Biol Chem 275:15152-6 (2000)
DOI:10.1074/jbc.M909620199
  Sequence
[hsa:53947]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.228
IUBMB Enzyme Nomenclature: 2.4.1.228
ExPASy - ENZYME nomenclature database: 2.4.1.228
BRENDA, the Enzyme Database: 2.4.1.228
CAS: 52725-57-2

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