KEGG   ENZYME: 2.4.1.308
Entry
EC 2.4.1.308                Enzyme                                 

Name
GDP-Fuc:beta-D-Gal-1,3-alpha-D-GalNAc-1,3-alpha-GalNAc-diphosphoundecaprenol alpha-1,2-fucosyltransferase;
WbnK
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-beta-L-fucose:beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol alpha-1,2-fucosyltransferase
Reaction(IUBMB)
GDP-beta-L-fucose + beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol = GDP + alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol [RN:R10439]
Reaction(KEGG)
R10439
Substrate
GDP-beta-L-fucose [CPD:C00325];
beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol [CPD:C20622]
Product
GDP [CPD:C00035];
alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol [CPD:C20625]
Comment
The enzyme is involved in the biosynthesis of the O-polysaccharide repeating unit of the bacterium Escherichia coli serotype O86.
History
EC 2.4.1.308 created 2013
Orthology
K21367  O86/O127-antigen biosynthesis alpha-1,2-fucosyltransferase
Genes
ECG: E2348C_2171(wbiQ)
SEEC: CFSAN002050_17370
Reference
1  [PMID:15713070]
  Authors
Yi W, Shao J, Zhu L, Li M, Singh M, Lu Y, Lin S, Li H, Ryu K, Shen J, Guo H, Yao Q, Bush CA, Wang PG
  Title
Escherichia coli O86 O-antigen biosynthetic gene cluster and stepwise enzymatic synthesis of human blood group B antigen tetrasaccharide.
  Journal
J Am Chem Soc 127:2040-1 (2005)
DOI:10.1021/ja045021y
  Sequence
Reference
2  [PMID:20418877]
  Authors
Woodward R, Yi W, Li L, Zhao G, Eguchi H, Sridhar PR, Guo H, Song JK, Motari E, Cai L, Kelleher P, Liu X, Han W, Zhang W, Ding Y, Li M, Wang PG
  Title
In vitro bacterial polysaccharide biosynthesis: defining the functions of Wzy and Wzz.
  Journal
Nat Chem Biol 6:418-23 (2010)
DOI:10.1038/nchembio.351
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.308
IUBMB Enzyme Nomenclature: 2.4.1.308
ExPASy - ENZYME nomenclature database: 2.4.1.308
BRENDA, the Enzyme Database: 2.4.1.308

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