KEGG   ENZYME: 2.4.1.312
Entry
EC 2.4.1.312                Enzyme                                 
Name
protein O-mannose beta-1,4-N-acetylglucosaminyltransferase;
GTDC2 (gene name);
POMGNT2
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-glucosamine:alpha-D-mannosyl-threonyl-[protein] 4-beta-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] = UDP + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] [RN:R10596]
Reaction(KEGG)
R10596;
(other) R11407(G)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
3-O-(alpha-D-mannosyl)-L-threonyl-[protein] [CPD:C20722]
Product
UDP [CPD:C00015];
3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] [CPD:C20723]
Comment
The human protein is involved in the formation of a phosphorylated trisaccharide on a threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains.
History
EC 2.4.1.312 created 2013
Pathway
ec00515  Mannose type O-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K18207  protein O-mannose beta-1,4-N-acetylglucosaminyltransferase
Genes
HSA84892(POMGNT2)
PTR503649(POMGNT2)
PPS100968652(POMGNT2)
GGO101154402(POMGNT2)
PON100457180(POMGNT2)
NLE100592031(POMGNT2)
MCC717032(POMGNT2)
MCF102135133(POMGNT2)
CSAB103227475(POMGNT2)
CATY105573836(POMGNT2)
PANU101000326(POMGNT2)
TGE112619700(POMGNT2)
RRO104670961(POMGNT2)
RBB108532329(POMGNT2)
TFN117083971(POMGNT2)
PTEH111555566(POMGNT2)
CJC100387902(POMGNT2)
SBQ101039365(POMGNT2)
CSYR103273128(POMGNT2)
MMUR105874875(POMGNT2)
OGA100944535(POMGNT2)
MMU215494(Pomgnt2)
MCAL110301603(Pomgnt2)
MPAH110327674(Pomgnt2)
RNO316091(Pomgnt2)
MCOC116072476(Pomgnt2)
MUN110554668(Pomgnt2)
CGE100770708(Pomgnt2)
PLEU114707640(Pomgnt2)
NGI103747148(Pomgnt2)
HGL101711700(Pomgnt2)
CPOC100735127(Pomgnt2)
CCAN109695103(Pomgnt2)
DORD105996217(Pomgnt2)
DSP122100709(Pomgnt2)
NCAR124969452
OCU100341347(POMGNT2)
OPI101531325(POMGNT2)
TUP102470610(POMGNT2)
CFA485621(POMGNT2)
VVP112921520(POMGNT2)
VLG121478945(POMGNT2)
AML100483210(POMGNT2)
UMR103682052(POMGNT2)
UAH113253834(POMGNT2)
UAR123778639(POMGNT2)
ELK111159113
LLV125105552
MPUF101680874(POMGNT2)
ORO101374856(POMGNT2)
EJU114212296(POMGNT2)
ZCA113917189(POMGNT2)
MLX118002582(POMGNT2)
FCA101093958(POMGNT2)
PYU121033536(POMGNT2)
PBG122492091(POMGNT2)
PTG102955067(POMGNT2)
PPAD109251344(POMGNT2)
AJU106966685(POMGNT2)
HHV120243610(POMGNT2)
BTA497030(POMGNT2)
BOM102278967(POMGNT2)
BIU109576335(POMGNT2)
CHX102180708(POMGNT2)
OAS101120611(POMGNT2)
ODA120867724(POMGNT2)
CCAD122424540(POMGNT2)
SSC100524525(POMGNT2)
CFR102524427(POMGNT2)
CBAI105061783(POMGNT2)
CDK105084600(POMGNT2)
VPC102528411(POMGNT2)
BACU103020196
OOR101273887(POMGNT2)
DLE111164305(POMGNT2)
PCAD102990521(POMGNT2)
PSIU116762893(POMGNT2)
ECB100067004(POMGNT2)
EPZ103566849(POMGNT2)
EAI106843158(POMGNT2)
MYB102244479(POMGNT2)
MYD102757264(POMGNT2)
MMYO118668392(POMGNT2)
MLF102438863(POMGNT2)
MNA107524271(POMGNT2)
PKL118715546(POMGNT2)
HAI109377834(POMGNT2)
DRO112309655(POMGNT2)
SHON118976187(POMGNT2)
AJM119051532(POMGNT2)
PDIC114502023(POMGNT2)
PHAS123830558(POMGNT2)
MMF118633191(POMGNT2)
RFQ117037091(POMGNT2)
PALE102883663(POMGNT2)
PGIG120582229(POMGNT2)
PVP105290309(POMGNT2)
RAY107520004(POMGNT2)
MJV108383476(POMGNT2)
TOD119258809(POMGNT2)
SARA101558353(POMGNT2)
LAV100668532(POMGNT2)
TMU101357084
DNM101445343(POMGNT2)
MDO100025375(POMGNT2)
GAS123248852(POMGNT2)
SHR100917448(POMGNT2)
PCW110213047(POMGNT2)
OAA100078600(POMGNT2)
GGA428446(POMGNT2)
PCOC116227144(POMGNT2)
MGP100549318(POMGNT2)
CJO107309310(POMGNT2)
NMEL110394329(POMGNT2)
APLA101800017(POMGNT2)
ACYG106043324(POMGNT2)
AFUL116485927(POMGNT2)
TGU100220641(POMGNT2)
LSR110468216(POMGNT2)
SCAN103812956(POMGNT2)
PMOA120503320(POMGNT2)
OTC121337677(POMGNT2)
PRUF121353128(POMGNT2)
GFR102034462(POMGNT2)
FAB101807065(POMGNT2)
PHI102114408(POMGNT2)
PMAJ107201055(POMGNT2)
CCAE111923526(POMGNT2)
CCW104689030(POMGNT2)
ETL114064424(POMGNT2)
ZAB102071811(POMGNT2)
FPG101913052(POMGNT2)
FCH102054650(POMGNT2)
CLV102097604(POMGNT2)
EGZ104127495(POMGNT2)
NNI104018482(POMGNT2)
ACUN113477085(POMGNT2)
TALA104361453(POMGNT2)
PADL103917061(POMGNT2)
ACHC115339553(POMGNT2)
AAM106491175(POMGNT2)
AROW112967156(POMGNT2)
NPD112952610(POMGNT2)
DNE112982406(POMGNT2)
ASN102376391(POMGNT2)
AMJ102567043(POMGNT2)
CPOO109311085(POMGNT2)
GGN109291724(POMGNT2)
PSS102454469(POMGNT2)
CMY102934275(POMGNT2)
CPIC101953826(POMGNT2)
TST117872430(POMGNT2)
CABI116827007(POMGNT2)
MRV120399661(POMGNT2)
ACS100557956(pomgnt2)
PVT110082156(POMGNT2)
SUND121932383(POMGNT2)
PBI103067706(POMGNT2)
PMUR107294214(POMGNT2)
TSR106545483(POMGNT2)
PGUT117656062(POMGNT2)
VKO123017684(POMGNT2)
PMUA114607367 114607441(POMGNT2)
ZVI118092344(POMGNT2) 118092360
GJA107111512(POMGNT2)
XLA444520(pomgnt2.L)
XTR496628(pomgnt2)
NPR108792069(POMGNT2)
RTEM120940297(POMGNT2)
BBUF121002118(POMGNT2)
BGAR122938750(POMGNT2)
DRE497644(pomgnt2)
SRX107732433 107751881
SANH107657577 107704096
SGH107551215 107601673
CCAR109076321
CAUA113116181
PPRM120495143(pomgnt2)
IPU108268718(pomgnt2)
PHYP113533743(pomgnt2)
SMEO124383758(pomgnt2)
TFD113644175(pomgnt2)
AMEX103031510(pomgnt2)
EEE113580583(pomgnt2)
TRU777951(pomgnt2)
TNGGSTEN00012312G001
LCO104923101(pomgnt2)
NCC104955198(pomgnt2)
ELY117264371(pomgnt2)
PLEP121946143(pomgnt2)
SLUC116066635(pomgnt2)
ECRA117946590(pomgnt2)
PFLV114557049(pomgnt2)
GAT120810019(pomgnt2)
PPUG119197677(pomgnt2)
MSAM119898116(pomgnt2)
CUD121513885(pomgnt2)
MZE101467114(pomgnt2)
ONL100709211(pomgnt2)
OAU116312151(pomgnt2)
OLA101172435(pomgnt2)
OML112152176(pomgnt2)
XMA102225885(pomgnt2)
XCO114144724(pomgnt2)
XHE116717158(pomgnt2)
PRET103465884(pomgnt2)
PFOR103136957(pomgnt2)
PLAI106953448(pomgnt2)
PMEI106917527(pomgnt2)
GAF122831788(pomgnt2)
CVG107080768(pomgnt2)
CTUL119776915(pomgnt2)
GMU124866022(pomgnt2)
NFU107396256(pomgnt2)
KMR108229753(pomgnt2)
ALIM106519275(pomgnt2)
NWH119410273(pomgnt2)
AOCE111573758(pomgnt2)
CSEM103388754(pomgnt2)
POV109631931(pomgnt2)
SSEN122767628 122775255(pomgnt2)
HHIP117776224(pomgnt2)
LCF108876318(pomgnt2)
SDU111225902(pomgnt2)
SLAL111652527(pomgnt2)
XGL120784519(pomgnt2)
HCQ109531057(pomgnt2)
BPEC110171853(pomgnt2)
MALB109966635(pomgnt2)
SASA106579937(Glyt) 106605419
OTW112222815 112228390
OMY110485998 110512912
OGO123996546 124006437
ONE115102845 115140959
SALP111958562 111964975
SNH120031705 120047660
ELS105025919(pomgnt2)
SFM108940488(pomgnt2)
PKI111840939(pomgnt2)
AANG118215506(pomgnt2)
LOC102697824(pomgnt2)
PSPA121313360 121314802
ARUT117394291 117399418
LCM102346285(POMGNT2)
CMK103187059(pomgnt2)
RTP109919835(pomgnt2)
BFO118417908
BBEL109473802
SPU586701
APLC110974705
SKO100373117
BTAB109033581
CLEC106672864
HHAL106682054
NLU111043642
PHUPhum_PHUM177410
FOC113204747
CSEC111873617
PVM113816943
PJA122257631
PCHN125041915
HAME121856513
PCLA123773489
PTRU123506638
ISCIscW_ISCW017298
DSV119460388
RSAN119379128
RMP119175912
VDE111245537
VJA111265382
TUT107360858
DPTE113793569
DFR124491749
CSCU111642238
PTEP107443180
SDM118188052
HROHELRODRAFT_105809
LGILOTGIDRAFT_194055
PCAN112576492
BGT106069623
GAE121388654
HRF124112843
HRJ124266354
CRG105322469
MYI110449930
PMAX117338398
MMER123549317
OBI106882276
OSN115211636
LAK106153956
NVE5518534
EPA110232451
ATEN116304718
ADF107355681
AMIL114957735
PDAM113665965
SPIS111337713
DGT114516421
XEN124436356
HMG100205038
TADTRIADDRAFT_12816
MBRMONBRDRAFT_31627
SREPTSG_12894
 » show all
Reference
1  [PMID:23929950]
  Authors
Yoshida-Moriguchi T, Willer T, Anderson ME, Venzke D, Whyte T, Muntoni F, Lee H, Nelson SF, Yu L, Campbell KP
  Title
SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.
  Journal
Science 341:896-9 (2013)
DOI:10.1126/science.1239951
  Sequence
[hsa:84892]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.312
IUBMB Enzyme Nomenclature: 2.4.1.312
ExPASy - ENZYME nomenclature database: 2.4.1.312
BRENDA, the Enzyme Database: 2.4.1.312

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