KEGG   ENZYME: 2.4.1.313
Entry
EC 2.4.1.313                Enzyme                                 
Name
protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase;
B3GALNT2
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-galactosamine:N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl-threonyl-[protein] 3-beta-N-acetyl-D-galactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] = UDP + 3-O-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] [RN:R10620 R12292]
Reaction(KEGG)
R10620 R12292(G);
(other) R07614(G)
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] [CPD:C20723]
Product
UDP [CPD:C00015];
3-O-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] [CPD:C20734]
Comment
The human protein is specific for UDP-N-acetyl-alpha-D-galactosamine as donor [1]. The enzyme is involved in the formation of a phosphorylated trisaccharide on a threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains.
History
EC 2.4.1.313 created 2013
Pathway
ec00515  Mannose type O-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K09654  beta-1,3-N-acetylgalactosaminyltransferase 2
Genes
HSA148789(B3GALNT2)
PTR469715(B3GALNT2)
PPS100978307(B3GALNT2)
GGO101140966(B3GALNT2)
PON100443319(B3GALNT2)
NLE100589286(B3GALNT2)
MCC711550(B3GALNT2)
MCF102146449(B3GALNT2)
CSAB103230797(B3GALNT2)
CATY105574887(B3GALNT2)
PANU101022522(B3GALNT2)
TGE112609098(B3GALNT2)
RRO104679172(B3GALNT2)
RBB108522205(B3GALNT2)
TFN117076612(B3GALNT2)
PTEH111545245(B3GALNT2)
CJC100413278(B3GALNT2)
SBQ101046032(B3GALNT2)
CSYR103254834(B3GALNT2)
MMUR105856483(B3GALNT2)
OGA100966703(B3GALNT2)
MMU97884(B3galnt2)
MCAL110307761(B3galnt2)
MPAH110333891(B3galnt2)
RNO291212(B3galnt2)
MCOC116082779(B3galnt2)
MUN110558133(B3galnt2)
CGE100768564(B3galnt2)
PLEU114685249(B3galnt2)
NGI103745134(B3galnt2)
HGL101697517(B3galnt2)
CPOC100727876(B3galnt2)
CCAN109692618(B3galnt2)
DORD105984384(B3galnt2)
DSP122113255(B3galnt2)
NCAR124961702
OCU100352278(B3GALNT2)
TUP102477401(B3GALNT2)
CFA479196(B3GALNT2)
VVP112927402(B3GALNT2)
VLG121488125(B3GALNT2)
AML100484405(B3GALNT2)
UMR103661896(B3GALNT2)
UAH113259001(B3GALNT2)
UAR123783134(B3GALNT2)
ELK111160534
LLV125084294
MPUF101690844(B3GALNT2)
ORO101372831(B3GALNT2)
EJU114210241(B3GALNT2)
ZCA113919984(B3GALNT2)
MLX118012931(B3GALNT2)
FCA101085750(B3GALNT2)
PYU121023154(B3GALNT2)
PBG122492711(B3GALNT2)
PTG102961022(B3GALNT2)
PPAD109248879(B3GALNT2)
AJU106982543(B3GALNT2)
HHV120241810(B3GALNT2)
BTA100125310(B3GALNT2)
BOM102280720(B3GALNT2)
BIU109553768(B3GALNT2)
BBUB102403318(B3GALNT2)
CHX102178329(B3GALNT2)
OAS101116957(B3GALNT2)
ODA120860495 120865421 120882502
CCAD122446618(B3GALNT2)
SSC100620910(B3GALNT2)
CFR102506122(B3GALNT2) 102522922
CBAI105075110(B3GALNT2)
CDK116147114
VPC102526503(B3GALNT2)
BACU103018636(B3GALNT2)
LVE103083400(B3GALNT2)
OOR101271023(B3GALNT2)
DLE111163939(B3GALNT2)
PCAD102976716(B3GALNT2)
PSIU116741479(B3GALNT2)
ECB100058647(B3GALNT2)
EPZ103547683(B3GALNT2)
EAI106834710(B3GALNT2)
MYB102240384(B3GALNT2)
MYD102762905(B3GALNT2)
MMYO118649761 118678743(B3GALNT2)
MLF102422746(B3GALNT2)
MNA107527201(B3GALNT2)
PKL118727687(B3GALNT2)
HAI109387715(B3GALNT2)
DRO112306100(B3GALNT2)
SHON118980670(B3GALNT2)
AJM119044225(B3GALNT2)
PDIC114512317(B3GALNT2)
PHAS123832228(B3GALNT2)
MMF118640731(B3GALNT2)
RFQ117018531(B3GALNT2)
PALE102897229(B3GALNT2)
PGIG120592623(B3GALNT2)
PVP105302726(B3GALNT2)
RAY107520055(B3GALNT2)
MJV108401878(B3GALNT2)
TOD119244585(B3GALNT2)
SARA101546071(B3GALNT2)
LAV100663890(B3GALNT2)
TMU101358044
DNM101426827(B3GALNT2)
MDO100617587(B3GALNT2)
GAS123247102(B3GALNT2)
SHR100921524(B3GALNT2)
PCW110217849(B3GALNT2)
OAA100081648(B3GALNT2)
GGA430770(B3GALNT2)
PCOC116228320(B3GALNT2)
MGP100538415(B3GALNT2)
CJO107311372(B3GALNT2)
NMEL110396188(B3GALNT2)
APLA101803248(B3GALNT2)
ACYG106048080(B3GALNT2)
AFUL116487155(B3GALNT2)
TGU100218422(B3GALNT2)
LSR110468868(B3GALNT2)
SCAN103818567(B3GALNT2)
PMOA120501152(B3GALNT2)
OTC121340901(B3GALNT2)
PRUF121363278(B3GALNT2)
GFR102040498(B3GALNT2)
FAB101813810(B3GALNT2)
PHI102113102(B3GALNT2)
PMAJ107201263(B3GALNT2)
CCAE111927067(B3GALNT2)
CCW104684442(B3GALNT2)
ETL114066550(B3GALNT2)
ZAB102071174(B3GALNT2)
FPG101914116(B3GALNT2)
FCH102053282(B3GALNT2)
CLV102094245(B3GALNT2)
EGZ104131046(B3GALNT2)
NNI104019876(B3GALNT2)
ACUN113477903(B3GALNT2)
TALA104360176(B3GALNT2)
PADL103921275(B3GALNT2)
ACHC115349793(B3GALNT2)
AAM106486759(B3GALNT2)
AROW112964560(B3GALNT2)
NPD112951944(B3GALNT2)
DNE112989001(B3GALNT2)
ASN102378749(B3GALNT2)
AMJ102570410(B3GALNT2)
CPOO109319102(B3GALNT2)
GGN109304241(B3GALNT2)
PSS102458995(B3GALNT2)
CMY102938135(B3GALNT2)
CPIC101933681(B3GALNT2)
TST117874692(B3GALNT2)
CABI116826427(B3GALNT2)
MRV120401460(B3GALNT2)
ACS100557470(b3galnt2)
PVT110075614(B3GALNT2)
SUND121926050(B3GALNT2)
PBI103057702(B3GALNT2)
PMUR107288312(B3GALNT2)
TSR106538193(B3GALNT2)
PGUT117671974(B3GALNT2)
VKO123018214(B3GALNT2)
PMUA114594411(B3GALNT2)
ZVI118081866(B3GALNT2)
GJA107117761(B3GALNT2)
XLA431874(b3galnt2.L)
XTR496641(b3galnt2)
NPR108802270(B3GALNT2)
RTEM120924684(B3GALNT2)
BBUF120991231(B3GALNT2)
BGAR122937988(B3GALNT2)
DRE553716(b3galnt2)
SRX107728324 107730378
SANH107667096 107691207(b3galnt2)
SGH107557719(b3galnt2)
CAUA113056633(b3galnt2)
PPRM120461138(b3galnt2)
IPU108263411(b3galnt2)
PHYP113541960(b3galnt2)
SMEO124376785(b3galnt2)
TFD113645019(b3galnt2)
AMEX103030528(b3galnt2)
EEE113577753(b3galnt2)
TRU101071098 105419396
TNGGSTEN00030871G001
LCO104934548(b3galnt2)
NCC104960299(b3galnt2)
CGOB115020522(b3galnt2)
ELY117247938(b3galnt2)
PLEP121954705(b3galnt2)
SLUC116051160(b3galnt2)
ECRA117960477(b3galnt2)
PFLV114572511(b3galnt2)
GAT120820346(b3galnt2)
PPUG119214534(b3galnt2)
MSAM119917470(b3galnt2)
CUD121510883(b3galnt2)
MZE101477300(b3galnt2)
ONL100693767(b3galnt2)
OAU116318511(b3galnt2)
OLA101169879(b3galnt2)
OML112162201(b3galnt2)
XMA102234069(b3galnt2)
XCO114138582(b3galnt2)
XHE116713769(b3galnt2)
PRET103477261(b3galnt2)
PFOR103137691(b3galnt2)
PLAI106949762(b3galnt2)
PMEI106930335(b3galnt2)
GAF122842964(b3galnt2)
CVG107087799(b3galnt2)
CTUL119782941(b3galnt2)
GMU124859564(b3galnt2)
NFU107375431(b3galnt2)
KMR108240630(b3galnt2)
ALIM106515875(b3galnt2)
NWH119424188(b3galnt2)
AOCE111573739(b3galnt2)
CSEM103387616(b3galnt2)
POV109642026(b3galnt2)
SSEN122782189(b3galnt2)
HHIP117775784(b3galnt2)
LCF108885798(b3galnt2)
SDU111220668(b3galnt2)
SLAL111659007(b3galnt2)
XGL120796886(b3galnt2)
HCQ109516187(b3galnt2)
BPEC110157249(b3galnt2)
MALB109962360(b3galnt2)
SASA106578767(b3galnt2)
OTW112237453(b3galnt2)
OMY110491207(b3galnt2)
OGO124048033(b3galnt2)
SALP112071951(b3galnt2)
SNH120046044(b3galnt2)
ELS105006091(b3galnt2)
SFM108926991 108933762(b3galnt2)
PKI111835667 111856374(b3galnt2)
AANG118218459(b3galnt2)
LOC102691105(b3galnt2)
PSPA121316077 121317203
ARUT117402669 117410811(b3galnt2)
LCM102359133(B3GALNT2)
CMK103178875(b3galnt2)
BFO118425673
BBEL109472289
CIN100184607
SCLV120326995
SPU100893207
APLC110978840
SKO100372327
BTAB109031387
CLEC106672465
HHAL106689487
NLU111058580
PHUPhum_PHUM612020
FOC113208270
ZNE110828299
CSEC111869785
PVM113806206
PJA122265206
PCHN125025680
HAME121872679
PCLA123759295
PTRU123504780
DSV119449330
RSAN119382341
RMP119178637
VDE111244927
VJA111268042
TUT107363544
DPTE113790809
CSCU111636005
PTEP107441986
SDM118192090
HROHELRODRAFT_154688
PCAN112570564
BGT106068129
GAE121371645
CRG105332774
MYI110454356
PMAX117324411
MMER123546429
OBI106876718
NVE5507055
EPA110233214
ATEN116303868
ADF107345723
AMIL114965109
PDAM113667536
SPIS111330956
DGT114516906
XEN124437811 124441626 124441633 124443248 124445906 124456397 124456398 124459024 124459042
HMG100200949
TADTRIADDRAFT_52586
SREPTSG_06143
 » show all
Reference
1  [PMID:14724282]
  Authors
Hiruma T, Togayachi A, Okamura K, Sato T, Kikuchi N, Kwon YD, Nakamura A, Fujimura K, Gotoh M, Tachibana K, Ishizuka Y, Noce T, Nakanishi H, Narimatsu H
  Title
A novel human beta1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAcbeta1-3GlcNAc.
  Journal
J Biol Chem 279:14087-95 (2004)
DOI:10.1074/jbc.M310614200
  Sequence
[hsa:148789]
Reference
2  [PMID:23929950]
  Authors
Yoshida-Moriguchi T, Willer T, Anderson ME, Venzke D, Whyte T, Muntoni F, Lee H, Nelson SF, Yu L, Campbell KP
  Title
SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.
  Journal
Science 341:896-9 (2013)
DOI:10.1126/science.1239951
  Sequence
[hsa:148789]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.313
IUBMB Enzyme Nomenclature: 2.4.1.313
ExPASy - ENZYME nomenclature database: 2.4.1.313
BRENDA, the Enzyme Database: 2.4.1.313

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