KEGG   ENZYME: 2.4.1.317
Entry
EC 2.4.1.317                Enzyme                                 

Name
O-mycaminosyltylonolide 6-deoxyallosyltransferase;
tylN (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
dTDP-6-deoxy-alpha-D-allose:5-O-beta-D-mycaminosyltylonolide 23-O-6-deoxy-alpha-D-allosyltransferase
Reaction(IUBMB)
5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose = dTDP + demethyllactenocin [RN:R06451]
Reaction(KEGG)
R06451
Substrate
5-O-beta-D-mycaminosyltylonolide [CPD:C12002];
dTDP-6-deoxy-alpha-D-allose [CPD:C11912]
Product
dTDP [CPD:C00363];
demethyllactenocin [CPD:C12003]
Comment
The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria.
History
EC 2.4.1.317 created 2014
Pathway
ec00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K15993  O-mycaminosyltylonolide 6-deoxyallosyltransferase
Reference
1  [PMID:9651492]
  Authors
Wilson VT, Cundliffe E
  Title
Characterization and targeted disruption of a glycosyltransferase gene in the tylosin producer, Streptomyces fradiae.
  Journal
Gene 214:95-100 (1998)
DOI:10.1016/S0378-1119(98)00210-8
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.317
IUBMB Enzyme Nomenclature: 2.4.1.317
ExPASy - ENZYME nomenclature database: 2.4.1.317
BRENDA, the Enzyme Database: 2.4.1.317

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