KEGG   ENZYME: 2.4.1.356
Entry
EC 2.4.1.356                Enzyme                                 
Name
glucosyl-dolichyl phosphate glucuronosyltransferase;
aglG (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-glucuronate:dolichyl phosphate glucuronosyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-alpha-D-glucuronate + an archaeal dolichyl alpha-D-glucosyl phosphate = UDP + an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate [RN:R12100]
Reaction(KEGG)
R12100
Substrate
UDP-alpha-D-glucuronate [CPD:C00167];
archaeal dolichyl alpha-D-glucosyl phosphate
Product
UDP [CPD:C00015];
archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate
Comment
The enzyme, characterized from the halophilic archaeon Haloferax volcanii, participates in the protein N-glycosylation pathway. Dolichol used by archaea is different from that used by eukaryotes. It is much shorter (C55-C60) and is alpha,omega-saturated. However, in vitro the enzyme was also able to act on a substrate with an unsaturated end.
History
EC 2.4.1.356 created 2018
Orthology
K22844  glucosyl-dolichyl phosphate glucuronosyltransferase
Genes
PGHFH974_11325
CBERB5D82_09585
PEAPESP_a2846
AMCMADE_1013825
AMHI633_14630
HMIsoil367_10230
CELLCBR65_13005
MDNJT25_017430
MMAIsS8_0472
MEINmethR_P1884
TVIThivi_4052
MPURMARPU_05280
TEETel_13560
NIMW01_06470
SDRSCD_n02976
APETToN1_15770
AZOazo3260
AZIAzCIB_3669
TMZTmz1t_3250
THKCCZ27_14115 CCZ27_14120
GEMGM21_1651
GEBGM18_2476
DDEDde_2889
DASDaes_0089
PSELGM415_02340
DSXGD604_00870
DBADbac_3281
DALDalk_1973 Dalk_5204
DOVDSCO28_33390
DWDDSCW_50790
ADEAdeh_3054
ACPA2cp1_3253
SCUSCE1572_14905
RLGRleg_6733
RLBRLEG3_14775
RLNJ0663_27590
RRGJ3P73_30125
METM446_3998
MNOMnod_6856
MLGCWB41_07410
MPARF7D14_17210
LAPACP90_20640
ACRAcry_1519
AMVACMV_15640
ALIAZOLI_p60112
ATIAL072_32235
AZMDM194_27485
AOZHUE56_01020
RCERC1_2529
PPYPPE_01125
PPMPPSC2_05815(exoM)
PPOPPM_1095(exoM)
PPOLX809_05820
PPQPPSQR21_011860
PPOYRE92_06070
PMSKNP414_06723
PMQPM3016_6345
PMWB2K_32080
PTAHPL003_13880
PSABPSAB_04740
PDUPDUR_06015
PBDPBOR_05495
PGMPGRAT_05580
PODPODO_04695
PAENP40081_05780
PAEFR50345_04545
PAEQR50912_05100
PSTEPSTEL_05745
PAEAR70723_04615
PAEER70331_04620
PAEHH70357_05335
PAEJH70737_04805
PBJVN24_15590
PRIPRIO_1183
PSONJI735_14090
PPEOABE82_05920
PNPIJ22_03330
PXLBS614_10340
PDHB9T62_38130
PKBB4V02_19290
PAIHASL14_05850
PPSCEHS13_21240
PSOPKP014_08260
PTRIKDC22_04845
PTJJRJ22_04020
CLTCM240_2070
DKUDesku_2099
MSAMycsm_05794 Mycsm_06871
MPAGC0J29_13165
MCOOMCOO_21460
MVAMvan_2677
MNED174_13100
MYNMyAD_12860
MVQMYVA_2578
MCHTMCHIJ_41770
MTYMTOK_22630 MTOK_44050
MSARMSAR_28010
MANYMANY_45210
MPOFMPOR_29960
CARcauri_0410(exoM)
CMVCMUST_02370(exoM)
CTEDCTEST_02100(exoM)
CCYSSAMEA4530656_0260(exoM)
RHBNY08_2896
RFAA3L23_01108(mftF_5)
RHSA3Q41_02279(mftF_2)
RCRNCTC10994_00682
GBRGbro_3928
GORKTR9_3858
GTABCM27_20230
GOMD7316_02305(wfgD)
GODGKZ92_09835
SNZDC008_29980
SLKSLUN_02500
SGXH4W23_17630
SMOBJ7W19_17780
KITCFP65_6460
CUGC1N91_10075
CQFGBG65_13650
FRNF1C15_15175
PSNINIBR502771_05485
CCEUCBR64_03115
AUSIPK37_06835
PACDEGX94_08805
PAUSNCTC13651_02097
PPCHMPREF9154_2998
NANOG5V58_10315
TCUTcur_3588
NOABKM31_54940
NOWGBF35_41520
FRAFrancci3_1580 Francci3_3846
FRIFraEuI1c_0126 FraEuI1c_0150
FALFRAAL6119
FSYFsymDg_0812 FsymDg_0823
MMARMODMU_0426 MODMU_1369
PSEQAD006_05850
PECQAD017_13670
PHHAFB00_11445
PAUTPdca_67620
ACTNL083_4864
AFSAFR_25005
VERHUT12_11950
ATLAthai_48990
AMYADJ76_00970
SOOFBF35_08225
EUZDVS28_a0104
HHGXM38_025220
PSEUPse7367_1203
CYCPCC7424_4247
CYNCyan7425_1956
TERTery_4122
MPROBJP34_10360
GLJGKIL_2393
CALOCal7507_5897
NCNBZZ01_23925
PLPPle7327_2126
DETDET0203
DEBDehaBAV1_0150
DEVDhcVS_191
DMDdcmb_206
DMYX793_00940
DUCUCH007_02330
DPDDeipe_2799
TRATrad_1473
PBORBSF38_01361
AGVOJF2_64400(kfoC)
DYSG7050_06300
AFDAlfi_2222
AOKA3BBH6_04990
ACOUA5CBH24_06830
CPICpin_4699
CHIHGWR21_01350
PGINFRZ67_01070
FLSGLV81_05530
PROEH9L23_02700
SBXCA265_01775
SLISlin_4093
RHOZGXP67_24590
MTTFtrac_3795
NSDBST91_07980
NJANSJP_0243
MMAKMMKA1_03830
ASTAsulf_01103
PYNPNA2_1059
THEGQS_06820
THMCL1_0993
TTDA3L14_01120
TICFH039_01050
TCQTIRI35C_0013
MTHRMSTHT_0726 MSTHT_1194
MTHEMSTHC_2110 MSTHC_2543
MFZAOB57_010390
HALVNG_1067G(exoM)
HSLOE_2547R(aglG)
HAGSJT689_05630
HABOJRZ79_04095
HANRLJ422_04375
HALHHTSR_0846
HHSRHSR6_0873
HSUHLASF_1521
HSFHLASA_1508
HALREFA46_009400
HARAAArcS_2654
HAADMW046_02030
HMArrnAC0430(exoM)
HHIHAH_1203(exoM)
HHNHISP_06155
HABSG26_13805
HTABVU17_05850
HALJG9465_10530
HSINKDQ40_07480
NPHNP_1916A(aglG)
NMONmlp_3535(aglG)
NHOHWV23_14205
NSALHWV07_17710
HUTHuta_0540
HTIHTIA_2653
HALAHrd1104_03855
HMUHmuk_2753
HALZE5139_01060
HALLLC1Hm_2097(aglG)
HAZPGBQ70_01060
HALIBV210_00415
HSNDV733_14245
HRRHZS55_17105
HPELHZS54_20450
HLTI7X12_18560
HDOMUK72_10565
HWAHQ_2692A(aglG)
HWCHqrw_3044(aglG)
HVOHVO_1529(aglG)
HALEG3A49_10765
HBOHbor_36110
HAQDU484_15380
HAJDU500_15400
HAERDU502_13480
HRAEI982_17695
HLMDV707_04345
HLAHlac_1063
HALPDOS48_05355
HALBEKH57_05755
HEZZEO776_06740
HALQHrr1229_001120
HSSJ7656_09890
HSAIHPS36_00280
HAZZKI388_04270
SRUBC2R22_09330
HAEhalTADL_1026 halTADL_2410
HALNB4589_014270
HALGHUG10_00435
HALUHUG12_17325
HDFAArcSl_2615
HAHHalar_1600
HTUHtur_2956
HDABB347_08855
HJTDVR14_14330
HLOJ0X27_11640
HAKZJ0X25_01410
NMGNmag_0926
HXAHalxa_2341 Halxa_2355
NATNJ7G_1723
NPENatpe_1006
NVRFEJ81_05200
NPLFGF80_05655
NAYHYG81_05445
NGENatgr_2244
HRUHalru_0990 Halru_1002
NOUNatoc_2650 Natoc_3556
SAIMK0C01_09225
HLRHALLA_07250
HLCCHINAEXTREME09045
NAJB1756_14510
NAGAArcMg_2848
NANAArc1_0854
NBGDV706_10775
NASGCU68_01305
MERMMINT_15130
 » show all
Reference
1  [PMID:18631242]
  Authors
Yurist-Doutsch S, Abu-Qarn M, Battaglia F, Morris HR, Hitchen PG, Dell A, Eichler J
  Title
AglF, aglG and aglI, novel members of a gene island involved in the N-glycosylation of the Haloferax volcanii S-layer glycoprotein.
  Journal
Mol Microbiol 69:1234-45 (2008)
DOI:10.1111/j.1365-2958.2008.06352.x
  Sequence
[hvo:HVO_1529]
Reference
2  [PMID:28809486]
  Authors
Elharar Y, Podilapu AR, Guan Z, Kulkarni SS, Eichler J
  Title
Assembling Glycan-Charged Dolichol Phosphates: Chemoenzymatic Synthesis of a Haloferax volcanii N-Glycosylation Pathway Intermediate.
  Journal
Bioconjug Chem 28:2461-2470 (2017)
DOI:10.1021/acs.bioconjchem.7b00436
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.356
IUBMB Enzyme Nomenclature: 2.4.1.356
ExPASy - ENZYME nomenclature database: 2.4.1.356
BRENDA, the Enzyme Database: 2.4.1.356

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