KEGG   ENZYME: 2.4.1.357
Entry
EC 2.4.1.357                Enzyme                                 
Name
phlorizin synthase;
MdPGT1: P2'GT
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-glucose:phloretin 2'-O-D-glucosyltransferase
Reaction(IUBMB)
UDP-alpha-D-glucose + phloretin = UDP + phlorizin [RN:R12088]
Reaction(KEGG)
R12088
Substrate
UDP-alpha-D-glucose [CPD:C00029];
phloretin [CPD:C00774]
Product
UDP [CPD:C00015];
phlorizin [CPD:C01604]
Comment
Isolated from Malus X domestica (apple). Phlorizin inhibits sodium-linked glucose transporters. It gives the characteristic flavour of apples and cider.
History
EC 2.4.1.357 created 2018
Pathway
ec00941  Flavonoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K22845  phlorizin synthase
Genes
CIT102628772
CICCICLE_v10025535mg
TCC18593023 18593025 18593028
GRA105761417 105768674 105768679
GHI107930943 107955595 107955596 107955597
GAB108466846 108470618
DZI111315054
EGR104449844 104449845
GMX100787088(IF7GT6)
GSJ114417443
PVUPHAVU_005G005500g PHAVU_005G005600g
VRA106759717
VAR108332538 108333069
VUN114186917 114186935 114186948
CCAJ109805617 109805618 109806020
APRC113874864
MTR25488512 25488513
CAM101490930(UGT88F9) 101511986
LJALj0g3v0272789.1(Lj0g3v0272789.1) Lj0g3v0272789.2(Lj0g3v0272789.2)
ADU107491529
AIP107645049
AHF112803117
LANG109346029
FVE101298317
RCN112177051 112180056 112202849 112202850
PPER18775123 18789262 18789439 18789761 18792481
PMUM103319270 103319271 103319329 103329047
PAVI110755978 110759101 110767050 110767051 110767054 110767066 110772231
PDUL117615538 117620112 117629570
MDM103402192 103409768 103420359 103425310
PXB103952554 103967781 103967800 103967813
ZJU107415790
MNT21391667 21391669
RCU8283251
JCU105636738 105636739 105643989
HBR110642627 110669034
MESC110605933
POP18107945
PEU105108601
PALZ118051946
JRE108982034
QSU111988070 112001084 112001087 112038347
QLO115975110 115977881
VVI100243118 100247599 100247819 100249347 100249918 100254461 100259577 100264736 100264754 100265364 100265418 100853698 100853970 100854044 100854078 100854186 104882785
VRI117905356 117905933 117906001 117906024 117906141 117906173 117907780
CSIN114284897 114323023
NNU104588566 104589090 104590055 104590056 104590057 104608194
MING122068851 122070114 122076358 122078877 122083533 122086353
TSS122641361 122641362 122641372 122643931 122643932 122663262 122663434
 » show all
Reference
1  [PMID:18573104]
  Authors
Jugde H, Nguy D, Moller I, Cooney JM, Atkinson RG
  Title
Isolation and characterization of a novel glycosyltransferase that converts phloretin to phlorizin, a potent antioxidant in apple.
  Journal
FEBS J 275:3804-14 (2008)
DOI:10.1111/j.1742-4658.2008.06526.x
  Sequence
[mdm:103402192]
Reference
2  [PMID:27316677]
  Authors
Yahyaa M, Davidovich-Rikanati R, Eyal Y, Sheachter A, Marzouk S, Lewinsohn E, Ibdah M
  Title
Identification and characterization of UDP-glucose:Phloretin 4'-O-glycosyltransferase from Malus x domestica Borkh.
  Journal
Phytochemistry 130:47-55 (2016)
DOI:10.1016/j.phytochem.2016.06.004
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.357
IUBMB Enzyme Nomenclature: 2.4.1.357
ExPASy - ENZYME nomenclature database: 2.4.1.357
BRENDA, the Enzyme Database: 2.4.1.357

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