KEGG   ENZYME: 2.4.1.357
Entry
EC 2.4.1.357                Enzyme                                 

Name
phlorizin synthase;
MdPGT1: P2'GT
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-glucose:phloretin 2'-O-D-glucosyltransferase
Reaction(IUBMB)
UDP-alpha-D-glucose + phloretin = UDP + phlorizin [RN:R12088]
Reaction(KEGG)
R12088
Substrate
UDP-alpha-D-glucose [CPD:C00029];
phloretin [CPD:C00774]
Product
UDP [CPD:C00015];
phlorizin [CPD:C01604]
Comment
Isolated from Malus X domestica (apple). Phlorizin inhibits sodium-linked glucose transporters. It gives the characteristic flavour of apples and cider.
History
EC 2.4.1.357 created 2018
Pathway
ec00941  Flavonoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K22845  phlorizin synthase
Genes
CIT: 102628772
CIC: CICLE_v10025535mg
TCC: 18593023 18593025 18593028
GRA: 105761417 105768674 105768679
GHI: 107930943 107955595 107955596 107955597
GAB: 108466846 108470618
DZI: 111315054
EGR: 104449844 104449845
GMX: 100787088(IF7GT6)
GSJ: 114417443
VRA: 106759717
APRC: 113874864
CAM: 101490930(UGT88F9) 101511986
LJA: Lj0g3v0272789.1(Lj0g3v0272789.1) Lj0g3v0272789.2(Lj0g3v0272789.2)
ADU: 107491529
AIP: 107645049
AHF: 112803117
LANG: 109346029
FVE: 101298317
ZJU: 107415790
RCU: 8283251
MESC: 110605933
POP: 18107945
PEU: 105108601
PALZ: 118051946
JRE: 108982034
 » show all
Reference
1  [PMID:18573104]
  Authors
Jugde H, Nguy D, Moller I, Cooney JM, Atkinson RG
  Title
Isolation and characterization of a novel glycosyltransferase that converts phloretin to phlorizin, a potent antioxidant in apple.
  Journal
FEBS J 275:3804-14 (2008)
DOI:10.1111/j.1742-4658.2008.06526.x
  Sequence
[mdm:103402192]
Reference
2  [PMID:27316677]
  Authors
Yahyaa M, Davidovich-Rikanati R, Eyal Y, Sheachter A, Marzouk S, Lewinsohn E, Ibdah M
  Title
Identification and characterization of UDP-glucose:Phloretin 4'-O-glycosyltransferase from Malus x domestica Borkh.
  Journal
Phytochemistry 130:47-55 (2016)
DOI:10.1016/j.phytochem.2016.06.004
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.357
IUBMB Enzyme Nomenclature: 2.4.1.357
ExPASy - ENZYME nomenclature database: 2.4.1.357
BRENDA, the Enzyme Database: 2.4.1.357

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