KEGG   ENZYME: 2.4.1.40
Entry
EC 2.4.1.40                 Enzyme                                 
Name
glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase;
A-transferase;
histo-blood group A glycosyltransferase (Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase);
UDP-GalNAc:Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase;
alpha-3-N-acetylgalactosaminyltransferase;
blood-group substance alpha-acetyltransferase;
blood-group substance A-dependent acetylgalactosaminyltransferase;
fucosylgalactose acetylgalactosaminyltransferase;
histo-blood group A acetylgalactosaminyltransferase;
histo-blood group A transferase;
UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-D-galactose [RN:R04423]
Reaction(KEGG)
R04423;
(other) R06167(G) R06187(G) R06191(G) R06193(G) R06197(G)
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose
Product
UDP [CPD:C00015];
glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-[alpha-L-fucosyl-(1,2)]-D-galactose [CPD:C06483]
Comment
Acts on blood group substance, and can use a number of 2-fucosyl-galactosides as acceptors.
History
EC 2.4.1.40 created 1972, modified 1999
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec01100  Metabolic pathways
Orthology
K00709  histo-blood group ABO system transferase
Genes
HSA28(ABO)
PTR450164(ABO)
PPS100970130(ABO)
GGO101125978(ABO)
PON100454822(ABO)
NLE115836398(ABO)
MCC722252(ABO)
MCF102118138(ABO)
MTHB126937025
CSAB103239700(ABO)
CATY105594179(ABO)
PANU101008634(ABO)
TGE112608047(ABO)
RRO104669731(ABO)
RBB108512581 108513461(ABO)
TFN117073926(ABO) 117084469
PTEH111523986 113223108 116418560
CJC100414456(ABO)
CSYR103250932(ABO)
MMUR105876954 105880740 105880771(ABO)
LCAT123624234 123624235 123624502 123646620(ABO)
OGA100957338 100957637 105887602
MMU80908(Abo)
MCAL110289771(Abo)
MPAH110315370 110319406(Abo)
RNO100301568(Abo) 296504(Abo2) 65270(Abo3)
MCOC116091605 116091607(Abo)
CGE100754666 100757742 100758032 100772592(Abo)
MAUA101830897 106022281 110343791 121136014 121140321 121140322
PLEU114684223 114686950 114686951 114692827 114698882 114698883
MORG121449973 121462665 121462666 121462744 121462814
MFOT126486698 126486699 126496363 126509203 126509335 126509336
AAMP119818823 119819595 119819744 119821887
NGI103740691(Abo)
HGL106010599
CCAN109683353 109696117(Abo)
DORD105989363 105995629
DSP122108875 122108883 122108982 122109075 122109078
NCAR124966072 124966073
OCU100337847 100338543 100345312 100352380 103347352 108175433
OPI101526707 101528259 101528504 101528819 101533919(GBGT1)
TUP102470199 102471037
CFA100685413 111095419 119880300 491265(ABO)
CLUD112645543 112645544 112677406(ABO)
VVP112906902(ABO)
VLG121473070(ABO) 121479282 121487042
AML100466091 105235331
UMR103659300 103661988 103670246 103673989 103679813 103679933(ABO) 103681749
UAH113266557 113266558
UAR123775732 123775738 123791709 123791710 123791716 123792854
LLV125082917 125106295
MPUF101679038 101689999(ABO) 106004543
ORO101364486 101369984 101372255 101374892 101377160 101380669 101381173 101382297 105758002
EJU114204063 114204164 114211218
ZCA113908490 113912178(ABO) 113933904 113939818 118356212 118356899 118357368
MLX118007373 118007385 118008661 118011058 118013990 118015321 118015336 118017553 118018074 118026207 118026209 118026766
NSU110581635 123324868
FCA101087791
PYU121011349 121021218 121024182
PBG122474447 122474451 122474550 122475149
LRUF124511764 124522338 124522340 124522341 124522342 124522343 124522405 124522441 124522446 124525617 124525618 124525619 124525620
PPAD109258275(ABO)
AJU106989205(ABO)
HHV120227623 120227624 120227830
BTA515340(ABO)
BOM102283688(ABO)
BIU109565683(ABO)
BBUB102414923(ABO)
CHX102168916(ABO)
OAS101114008(ABO)
ODA120852322(ABO)
CCAD122421289 122442346
SSC396713(ABO)
CFR102523444(ABO)
CBAI105069746
CDK105105838(ABO)
VPC102537037(ABO)
BACU102997485
DLE111171008(ABO)
PCAD102987697(ABO)
ECB100147494 102149124(ABO) 111767452
EPZ103542251 103542252 103547710 103565343(ABO)
EAI106829212 106829214 106845296 106845360 123275605
MYB102239108(ABO) 102250048
MYD102751691 102765942(ABO)
MMYO118666916(ABO)
MLF102435523 102436658 102436972
MNA107524627(ABO)
PKL118708875 118708888
DRO112320051(ABO)
SHON118982529(ABO)
AJM119037339(ABO)
PDIC114510857(ABO)
PHAS123823700(ABO)
MMF118629595(ABO) 118629684
RFQ117031856(ABO)
TOD119230358(ABO) 119231020 119250209
LAV100670655(ABO)
TMU101341957 101344015 101351903 101353602 101353733 101356026
DNM101413351 101421983
MDO100017917(ABO)
GAS123235204(ABO)
PCW110205086(ABO)
OAA100075215 100092870
TGU100223725
LSR110480583
SCAN103821701
PMOA120496584
OTC121347679
PRUF121351121 121354041
GFR102039105
FAB101817249
PHI102113787
PMAJ107215091
CCAE111940162
CCW104697784
CBRC103624609
ZAB102063040(ABO)
PCRI104028332
ACUN113484656
PADL103917374
AFOR103893960
MUI104538838(ABO)
FGA104080004
GSTE104256454
DPUB104299235
AVIT104272769
CVF104290417
AAM106488041
PSS102449345 102451371 102455524 102462837(ABO) 106732582
CPIC101943564 101944820 101945105 101953665
TST117885399
CABI116816446 116817454 116823991
MRV120386651 120386990 120386991
GJA107119149(ABO) 107125123
STOW125441582(ABO)
XLA108698211(abo.2.L) 108698863(abo.4.L) 108699511(abo.5.L) 108699512(abo.6.L) 108699928(abo.6.S) 108714350 108715628 495825(abo.3.L)
XTR100488200 100491571 100491742 100491908 100492744 100492907 100497509(abo.4) 101734865 116406760 549437(abo.3) 549858(abo.2) 550054(abo.1)
NPR108791544 108791554 108793312 108793313 108801426 108803271
RTEM120913786 120914023 120914065
BBUF120977361 120977362 120977364 120977397 120977991 121009511
BGAR122919453 122919647 122919883 122922624 122945936 122946179 122946259 122946276 122946277 122946287 122946310 122946643 122946791
SRX107747826 107747839
SANH107680349 107687664 107687695 107694233
SGH107569538 107581033 107592359
CCAR109056910
CAUA113039522 113039523 113039530 113048792
IPU108262359
PHYP113531017
EEE113569626 113583526
OMY110525108
SALP112074307
BFO118403702
GAE121392028
 » show all
Reference
1  [PMID:5661629]
  Authors
Kobata A, Grollman EF, Ginsburg V.
  Title
An enzymic basis for blood type A in humans.
  Journal
Arch Biochem Biophys 124:609-12 (1968)
DOI:10.1016/0003-9861(68)90373-1
Reference
2  [PMID:2341371]
  Authors
Takeya A, Hosomi O, Ishiura M.
  Title
Complete purification and characterization of alpha-3-N-acetylgalactosaminyltransferase encoded by the human blood group A gene.
  Journal
J Biochem (Tokyo) 107:360-8 (1990)
DOI:10.1093/oxfordjournals.jbchem.a123051
Reference
3  [PMID:6434182]
  Authors
Yates AD, Feeney J, Donald AS, Watkins WM.
  Title
Characterisation of a blood-group A-active tetrasaccharide synthesised by a blood-group B gene-specified glycosyltransferase.
  Journal
Carbohydr Res 130:251-60 (1984)
DOI:10.1016/0008-6215(84)85283-0
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.40
IUBMB Enzyme Nomenclature: 2.4.1.40
ExPASy - ENZYME nomenclature database: 2.4.1.40
BRENDA, the Enzyme Database: 2.4.1.40
CAS: 9067-69-0

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