KEGG   ENZYME: 2.4.1.62
Entry
EC 2.4.1.62                 Enzyme                                 
Name
ganglioside galactosyltransferase;
UDP-galactose---ceramide galactosyltransferase;
uridine diphosphogalactose-ceramide galactosyltransferase;
UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase;
UDP-galactose-GM2 galactosyltransferase;
uridine diphosphogalactose-GM2 galactosyltransferase;
uridine diphosphate D-galactose:glycolipid galactosyltransferase;
UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase;
UDP-galactose-GM2 ganglioside galactosyltransferase;
GM1-synthase;
UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase;
UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-(1->4)-beta-D-glucosyl-N-acylsphingosine 3-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-galactose:N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + an N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R04631 R05941]
Reaction(KEGG)
R04631 R05941(G);
(other) R05110 R05111 R05948(G) R05953(G) R05956(G)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Product
UDP [CPD:C00015];
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Comment
The substrate is also known as gangloside GM2, the product as gangloside GM1a
History
EC 2.4.1.62 created 1972, modified 2013
Pathway
ec00604  Glycosphingolipid biosynthesis - ganglio series
ec01100  Metabolic pathways
Orthology
K00715  ganglioside galactosyltransferase
K02175  beta-1,3-galactosyltransferase / beta-1,3-N-acetylglucosaminyltransferase
Genes
HSA8705(B3GALT4)
PTR746800(B3GALT4)
PPS100990558(B3GALT4)
GGO101147230(B3GALT4)
PON100431810(B3GALT4)
NLE100581961(B3GALT4)
MCC718178(B3GALT4)
MCF101867339(B3GALT4)
MTHB126952774
CSAB103221668(B3GALT4)
CATY105593488(B3GALT4)
PANU101023708(B3GALT4)
TGE112623234(B3GALT4)
RRO104657975(B3GALT4)
RBB108540279(B3GALT4)
TFN117087042(B3GALT4)
PTEH111542919(B3GALT4)
CJC100386867(B3GALT4)
SBQ101045208(B3GALT4)
CSYR103262599(B3GALT4)
MMUR105886003(B3GALT4)
LCAT123631830(B3GALT4)
OGA100964044(B3GALT4)
MMU54218(B3galt4)
MCAL110284218(B3galt4)
MPAH110335875(B3galt4)
RNO171079(B3galt4)
MCOC116074540(B3galt4)
MUN110543490(B3galt4)
CGE100751197(B3galt4)
MAUA101834936(B3galt4)
PLEU114706130(B3galt4)
MORG121435266(B3galt4)
MFOT126499731
AAMP119823302(B3galt4)
NGI103739707(B3galt4)
HGL101722054(B3galt4)
CPOC100731582(B3galt4)
CCAN109686699(B3galt4)
DORD105999846(B3galt4)
DSP122111356(B3galt4)
NCAR124989520
OCU100353929(B3GALT4)
OPI101534884(B3GALT4)
TUP102493328(B3GALT4)
CFA481737(B3GALT4)
CLUD112641398(B3GALT4)
VVP112913882(B3GALT4)
VLG121498347(B3GALT4)
AML100474436(B3GALT4)
UMR103665497(B3GALT4)
UAH113243802(B3GALT4)
UAR123790926(B3GALT4)
ELK111152171
LLV125102664
MPUF101682074(B3GALT4)
ORO101375875(B3GALT4)
EJU114222148(B3GALT4)
ZCA113927263(B3GALT4)
MLX118001290(B3GALT4)
NSU110575576(B3GALT4)
FCA101087480 111556175(B3GALT4)
PYU121029280(B3GALT4)
PBG122489398(B3GALT4)
LRUF124528317
PTG102968511(B3GALT4)
PPAD109271436(B3GALT4)
AJU106976084(B3GALT4)
HHV120238195(B3GALT4)
BTA768038(B3GALT4)
BOM102287503(B3GALT4)
BIU109576550(B3GALT4)
BBUB102398556(B3GALT4)
CHX102182551(B3GALT4)
OAS101111585(B3GALT4)
ODA120869846(B3GALT4)
CCAD122429442(B3GALT4)
SSC100155431(B3GALT4)
CFR102504152(B3GALT4)
CBAI105064226(B3GALT4)
CDK105101388(B3GALT4)
VPC102532667(B3GALT4)
BACU103004913(B3GALT4)
LVE103073598(B3GALT4)
OOR101285679(B3GALT4)
DLE111178678(B3GALT4)
PCAD102984198(B3GALT4)
PSIU116762685(B3GALT4)
ECB100052704(B3GALT4)
EPZ103567107(B3GALT4)
EAI106834597(B3GALT4)
MYB102253194(B3GALT4)
MYD102766372(B3GALT4)
MMYO118679522(B3GALT4)
MLF102437857(B3GALT4)
MNA107541603(B3GALT4)
PKL118705663(B3GALT4)
HAI109392428(B3GALT4)
DRO112302286(B3GALT4)
SHON118991483(B3GALT4)
AJM119041188(B3GALT4)
PDIC114495132(B3GALT4)
PHAS123815910(B3GALT4)
MMF118621058(B3GALT4)
RFQ117018064(B3GALT4)
PALE102882787(B3GALT4)
PGIG120597652(B3GALT4)
PVP105300984(B3GALT4)
RAY107511980(B3GALT4)
MJV108396197(B3GALT4)
TOD119252336(B3GALT4)
SARA101557558(B3GALT4)
LAV100662423(B3GALT4)
TMU101340682
DNM101447995(B3GALT4)
MDO100618101(B3GALT4)
GAS123244584(B3GALT4)
SHR100932392 105750445(B3GALT4)
PCW110217176(B3GALT4)
OAA114807618(B3GALT4)
PCOC116241646
OTC121347883
PHI102110936
ETL114073638
ACHC115338495(B3GALT4)
AROW112963739(B3GALT4)
ASN102386365(B3GALT4)
AMJ106737709(B3GALT4)
CMY114021730(B3GALT4)
CPIC101953116(B3GALT4)
CABI116829512(B3GALT4)
MRV120394906(B3GALT4)
ACS103280835 103280836 103281647
PVT110091025(B3GALT4)
SUND121921237(B3GALT4)
PBI112543393
PMUR107299593
CTIG120318402 120318403
TSR106551469 106551472
PGUT117673480 117673484
VKO123022486(B3GALT4)
ZVI118078050 118078811
GJA107115678(B3GALT4)
STOW125424808 125424812
XLA108698545(b3galt4.L)
XTR100489366(b3galt4)
NPR108788356(B3GALT4)
RTEM120914313(B3GALT4)
BBUF121009481(B3GALT4)
BGAR122919701(B3GALT4)
DRE101883911 101886595(b3galt4)
SRX107706538
SANH107667941
SGH107549558
CCAR109078046 109078053 109078403
CAUA113107881
PPRM120481244(b3galt4)
MAMB125280481(b3galt4)
IPU108265547(b3galt4)
PHYP113533653(b3galt4)
SMEO124400434(b3galt4)
TFD113656030(b3galt4)
AMEX103044102
EEE113584319(b3galt4)
TRU101065804(b3galt4)
TNGGSTEN00033258G001
LCO104938595(b3galt4)
NCC104957801
CGOB115010910
ELY117257944(b3galt4)
EFO125891516(b3galt4)
PLEP121947253(b3galt4)
SLUC116062207(b3galt4)
ECRA117948189(b3galt4)
PFLV114559268
GAT120829380(b3galt4)
PPUG119222017(b3galt4)
MSAM119905345(b3galt4)
CUD121517185(b3galt4)
ALAT119022167(b3galt4)
MZE101480560(b3galt4)
ONL102079080
OAU116331206(b3galt4)
OLA101168709(b3galt4)
OML112159750(b3galt4)
XMA102221914
XCO114144870
XHE116728650
PRET103467526(b3galt4)
PFOR103145033
PLAI106934922
PMEI106905585
GAF122834805(b3galt4)
CVG107090384
CTUL119774046(b3galt4)
GMU124876018(b3galt4)
NFU107391227(b3galt4)
KMR108231973(b3galt4)
ALIM106522851
NWH119416772(b3galt4)
AOCE111570403(b3galt4)
MCEP125006590(b3galt4)
CSEM103385519
POV109635031(b3galt4)
SSEN122776599(b3galt4)
HHIP117764937(b3galt4)
HSP118111246(b3galt4)
LCF108898093
SDU111217361
SLAL111667144
XGL120804126(b3galt4)
HCQ109528392
BPEC110156371 110158064(b3galt4)
MALB109966040(b3galt4)
BSPL114858315(b3galt4)
SASA106571873
STRU115166337 115168435(b3galt4)
OTW112215736 112222246(b3galt4)
OMY110492437(b3galt4) 110531971
OGO124045667(b3galt4)
ONE115101626 115131850
SALP111966177 111977194
SNH120058757 120061656(b3galt4)
CCLU121537296 121545378(b3galt4)
ELS105024940(b3galt4)
SFM108940259
PKI111847794(b3galt4)
AANG118208491(b3galt4)
PSPA121304341(b3galt4)
ARUT117434196
CIN100186979 101242046
SCLV120330808 120332756 120332862 120346279
DMEDmel_CG4934(brn)
DER6550969
DSE6612539
DSIDsimw501_GD16669(Dsim_GD16669)
DYADyak_GE16330
DAN6503467
DSR110183066
DPO4815306
DPE6602768
DMN108164862
DWI6653050
DGR6566045
DMODmoj_GI16397
DAZ108618591
DNV115564488
DHE111593000
DVI6633706
CCAT101462189
BOD106617507
RZE108354177
MDE101894401 101894886
SCAC106083036
LCQ111688695
LSQ119604076
AGAAgaP_AGAP002097
ACOZ120950790
AARA120895926
ASTE118504340
AAG5576338
AALB109411046 115256312
CQUCpipJ_CPIJ018702
CPII120417065
CNS116345449
BCOO119072048 119080657
AME551589
ACER108001212
ALAB122710430
BIM100749675
BBIF117209512
BVK117234434
BVAN117158415
BTER100648600
BPYO122571423
CCAL108627205
OBB114878178
MGEN117223432
NMEA116426077
CGIG122402555
SOC105203637
MPHA105835019
AEC105143285
ACEP105623352
PBAR105432777
VEM105560864
HST105184588
DQU106744767
CFO105250101
FEX115241693
LHU105678723
PGC109859477
OBO105278266
PCF106791384
PFUC122523580
VPS122629979
NVI100679450
CSOL105367310
TPRE106660382
MDL103572997
CGLO123269520
FAS105265973
DAM107041937
AGIF122852204
CCIN107272322
TCA661418
DPA109543621
SOY115891535
ATD109594188
CSET123317488 123317489
AGB108907869
LDC111514425
NVL108568068
APLN108733038 112904194
PPYR116168189
OTU111427886 111427954
BMOR733133(Bm_Bre5)
BMAN114244639
MSEX115451835
DPLKGM_215053
BANY112046556
PMAC106718256
PXU106116218 106119123
PRAP110996374 110997620 110998479
ZCE119832244
HAW110378227
HZE124633483
TNL113492219
SLIU111351040 111359277 111359853
OFU114356139
PXY105389814 105390413(bre-5)
API100164641
DNX107166093
AGS114124984
RMD113553214
BTAB109035846
DCI103510227
CLEC106665695
HHAL106682910
NLU111054451
PHUPhum_PHUM278100
FOC113211952
TPAL117646735
ZNE110836445
CSEC111875172
FCD110845484 110845485 110846305 110856195 110862185
DPXDAPPUDRAFT_66289
DMK116922454 123466382 123471529 123471540
PVM113814456
PJA122263616
PCHN125032776 125042967
HAME121876189
PCLA123764163 123765523
PTRU123503416 123515942
HAZT108665864
EAF111704047
PPOI119108919 119108920 119108923
ISCIscW_ISCW005339 IscW_ISCW007178 IscW_ISCW007342 IscW_ISCW010896 IscW_ISCW013734 IscW_ISCW014983 IscW_ISCW014984
DSV119432928 119448348 119455931
RSAN119378880 119404949
RMP119162043 119162045 119172723 119187537
VDE111247359 111249037 111249712 111252487
VJA111263934 111266965 111273729
TUT107369713
DPTE113797676
DFR124491063
CSCU111641196
PTEP107439835
SDM118196228
CELCELE_T12G3.8(bre-5)
CBRCBG_06216(Cbr-bre-5)
BMYBM_BM5757(Bma-bre-5)
LOALOAG_09610
NAINECAME_07961
HROHELRODRAFT_84672
PCAN112553274 112569600
BGT106051264
CRG105317293 105322782 105331369 105332568 105334278 109620855 117680769 117684511 117684906 117692837
MYI110440246 110440864 110443682 110443698 110444412 110445052 110445909 110449420 110449421 110451039 110451742 110451752 110451782 110452065 110452229 110452234 110452238 110453247 110453258 110456350 110456822 110457161 110457668 110457671 110458134 110459672 110461148 110461707 110464579
PMAX117314790 117315091 117315382 117315401 117315822 117317336 117319939 117321246 117322795 117323873 117325181 117325182 117325183 117326096 117329749 117332397 117332555 117332783 117337888 117339598 117339809 117340743 117342078 117342795
OSN115224367
LAK106180776
SMMSmp_014260 Smp_014280 Smp_151210
SHXMS3_00007254(B3GALT1_3) MS3_00007265
OVIT265_07747 T265_08677 T265_14897
EGLEGR_10081 EGR_11071
EPA110246985
ATEN116300017
HMG100202706
 » show all
Reference
1  [PMID:5842076]
  Authors
Basu S, Kaufman B, Roseman S.
  Title
Conversion of Tay-Sachs ganglioside to monosialoganglioside by brain uridine diphosphate D-galactose: glycolipid galactosyltransferase.
  Journal
J Biol Chem 240:4115-7 (1965)
Reference
2  [PMID:4987145]
  Authors
Yip GB, Dain JA.
  Title
The enzymic synthesis of ganglioside. II. UDP-galactose: N-acetylgalactosaminyl-(N-acetylneuraminyl)galactosyl-glucosyl-ceramide galactosyltransferase in rat brain.
  Journal
Biochim Biophys Acta 206:252-60 (1970)
DOI:10.1016/0005-2744(70)90108-7
Reference
3  [PMID:5484669]
  Authors
Yip MC, Dain JA.
  Title
Frog brain uridine diphosphate galactose-N-acetylgalactosaminyl-N-acetylneuraminylgalactosylglucosylceram ide galactosyltransferase.
  Journal
Biochem J 118:247-52 (1970)
DOI:10.1042/bj1180247
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.62
IUBMB Enzyme Nomenclature: 2.4.1.62
ExPASy - ENZYME nomenclature database: 2.4.1.62
BRENDA, the Enzyme Database: 2.4.1.62
CAS: 37217-28-0

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