KEGG   ENZYME: 2.4.1.62
Entry
EC 2.4.1.62                 Enzyme                                 

Name
ganglioside galactosyltransferase;
UDP-galactose---ceramide galactosyltransferase;
uridine diphosphogalactose-ceramide galactosyltransferase;
UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase;
UDP-galactose-GM2 galactosyltransferase;
uridine diphosphogalactose-GM2 galactosyltransferase;
uridine diphosphate D-galactose:glycolipid galactosyltransferase;
UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase;
UDP-galactose-GM2 ganglioside galactosyltransferase;
GM1-synthase;
UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase;
UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-(1->4)-beta-D-glucosyl-N-acylsphingosine 3-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-galactose:N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + an N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R04631 R05941]
Reaction(KEGG)
R04631 R05941(G);
(other) R05110 R05111 R05948(G) R05953(G) R05956(G)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Product
UDP [CPD:C00015];
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Comment
The substrate is also known as gangloside GM2, the product as gangloside GM1a
History
EC 2.4.1.62 created 1972, modified 2013
Pathway
ec00604  Glycosphingolipid biosynthesis - ganglio series
ec01100  Metabolic pathways
Orthology
K00715  ganglioside galactosyltransferase
K02175  beta-1,3-galactosyltransferase / beta-1,3-N-acetylglucosaminyltransferase
Genes
HSA: 8705(B3GALT4)
PTR: 746800(B3GALT4)
PPS: 100990558(B3GALT4)
GGO: 101147230(B3GALT4)
PON: 100431810(B3GALT4)
NLE: 100581961(B3GALT4)
MCC: 718178(B3GALT4)
MCF: 101867339(B3GALT4)
CSAB: 103221668(B3GALT4)
CATY: 105593488(B3GALT4)
PANU: 101023708(B3GALT4)
RRO: 104657975(B3GALT4)
RBB: 108540279(B3GALT4)
TFN: 117087042(B3GALT4)
PTEH: 111542919(B3GALT4)
CJC: 100386867(B3GALT4)
SBQ: 101045208(B3GALT4)
MMUR: 105886003(B3GALT4)
MMU: 54218(B3galt4)
MCAL: 110284218(B3galt4)
MPAH: 110335875(B3galt4)
RNO: 171079(B3galt4)
MCOC: 116074540(B3galt4)
MUN: 110543490(B3galt4)
CGE: 100751197(B3galt4)
PLEU: 114706130(B3galt4)
NGI: 103739707(B3galt4)
HGL: 101722054(B3galt4)
CCAN: 109686699(B3galt4)
OCU: 100353929(B3GALT4)
TUP: 102493328(B3GALT4)
CFA: 481737(B3GALT4)
VVP: 112913882(B3GALT4)
VLG: 121498347(B3GALT4)
AML: 100474436(B3GALT4)
UMR: 103665497(B3GALT4)
UAH: 113243802(B3GALT4)
ORO: 101375875(B3GALT4)
ELK: 111152171
MPUF: 101682074(B3GALT4)
EJU: 114222148(B3GALT4)
MLX: 118001290(B3GALT4)
FCA: 101087480 111556175(B3GALT4)
PYU: 121029280(B3GALT4)
PTG: 102968511(B3GALT4)
PPAD: 109271436(B3GALT4)
AJU: 106976084(B3GALT4)
HHV: 120238195(B3GALT4)
BTA: 768038(B3GALT4)
BOM: 102287503(B3GALT4)
BIU: 109576550(B3GALT4)
BBUB: 102398556(B3GALT4)
CHX: 102182551(B3GALT4)
OAS: 101111585(B3GALT4)
ODA: 120869846(B3GALT4)
CCAD: 122429442(B3GALT4)
SSC: 100155431(B3GALT4)
CFR: 102504152(B3GALT4)
CBAI: 105064226(B3GALT4)
CDK: 105101388(B3GALT4)
BACU: 103004913(B3GALT4)
LVE: 103073598(B3GALT4)
OOR: 101285679(B3GALT4)
DLE: 111178678(B3GALT4)
PCAD: 102984198(B3GALT4)
ECB: 100052704(B3GALT4)
EPZ: 103567107(B3GALT4)
EAI: 106834597(B3GALT4)
MYB: 102253194(B3GALT4)
MYD: 102766372(B3GALT4)
MMYO: 118679522(B3GALT4)
MNA: 107541603(B3GALT4)
HAI: 109392428(B3GALT4)
DRO: 112302286(B3GALT4)
SHON: 118991483(B3GALT4)
AJM: 119041188(B3GALT4)
MMF: 118621058(B3GALT4)
PALE: 102882787(B3GALT4)
PGIG: 120597652(B3GALT4)
RAY: 107511980(B3GALT4)
MJV: 108396197(B3GALT4)
TOD: 119252336(B3GALT4)
LAV: 100662423(B3GALT4)
TMU: 101340682
MDO: 100618101(B3GALT4)
SHR: 100932392 105750445(B3GALT4)
PCW: 110217176(B3GALT4)
OAA: 114807618(B3GALT4)
PCOC: 116241646
PHI: 102110936
ETL: 114073638
ASN: 102386365(B3GALT4)
AMJ: 106737709(B3GALT4)
CPIC: 101953116(B3GALT4)
CABI: 116829512(B3GALT4)
PVT: 110091025(B3GALT4)
PBI: 112543393
PMUR: 107299593
GJA: 107115678(B3GALT4)
XLA: 108698545(b3galt4.L)
XTR: 100489366(b3galt4)
NPR: 108788356(B3GALT4)
DRE: 101883911 101886595(b3galt4)
SRX: 107706538
SANH: 107667941
SGH: 107549558
CAUA: 113107881
IPU: 108265547(b3galt4)
PHYP: 113533653(b3galt4)
AMEX: 103044102
EEE: 113584319(b3galt4)
TRU: 101065804(b3galt4)
LCO: 104938595(b3galt4)
NCC: 104957801
CGOB: 115010910
ELY: 117257944(b3galt4)
PLEP: 121947253(b3galt4)
SLUC: 116062207(b3galt4)
ECRA: 117948189(b3galt4)
PFLV: 114559268
GAT: 120829380(b3galt4)
MSAM: 119905345(b3galt4)
CUD: 121517185(b3galt4)
MZE: 101480560(b3galt4)
ONL: 102079080
OAU: 116331206(b3galt4)
OLA: 101168709(b3galt4)
OML: 112159750(b3galt4)
XMA: 102221914
XCO: 114144870
XHE: 116728650
PRET: 103467526(b3galt4)
CVG: 107090384
CTUL: 119774046(b3galt4)
NFU: 107391227(b3galt4)
KMR: 108231973(b3galt4)
ALIM: 106522851
AOCE: 111570403(b3galt4)
CSEM: 103385519
POV: 109635031(b3galt4)
LCF: 108898093
SDU: 111217361
SLAL: 111667144
XGL: 120804126(b3galt4)
HCQ: 109528392
BPEC: 110156371 110158064(b3galt4)
MALB: 109966040(b3galt4)
SASA: 106571873
OMY: 110492437(b3galt4) 110531971
SNH: 120058757 120061656(b3galt4)
ELS: 105024940(b3galt4)
SFM: 108940259
PKI: 111847794(b3galt4)
AANG: 118208491(b3galt4)
PSPA: 121304341(b3galt4)
ARUT: 117434196
DME: Dmel_CG4934(brn)
DER: 6550969
DSE: 6612539
DSI: Dsimw501_GD16669(Dsim_GD16669)
DAN: 6503467
DSR: 110183066
DPE: 6602768
DMN: 108164862
DWI: 6653050
DGR: 6566045
DAZ: 108618591
DNV: 115564488
DHE: 111593000
DVI: 6633706
CCAT: 101462189
LCQ: 111688695
ACOZ: 120950790
AARA: 120895926
AAG: 5576338
CPII: 120417065
AME: 551589
ACER: 108001212
BIM: 100749675
BBIF: 117209512
BTER: 100648600
CCAL: 108627205
OBB: 114878178
MGEN: 117223432
NMEA: 116426077
CGIG: 122402555
SOC: 105203637
MPHA: 105835019
AEC: 105143285
ACEP: 105623352
PBAR: 105432777
VEM: 105560864
HST: 105184588
DQU: 106744767
CFO: 105250101
FEX: 115241693
LHU: 105678723
PGC: 109859477
OBO: 105278266
PCF: 106791384
NVI: 100679450
CSOL: 105367310
MDL: 103572997
CCIN: 107272322
TCA: 661418
DPA: 109543621
ATD: 109594188
AGB: 108907869
LDC: 111514425
NVL: 108568068
PPYR: 116168189
BMOR: 733133(Bm_Bre5)
BMAN: 114244639
MSEX: 115451835
BANY: 112046556
PMAC: 106718256
PRAP: 110997620
ZCE: 119832244
HAW: 110378227
TNL: 113492219
PXY: 105389814 105390413(bre-5)
API: 100164641
DNX: 107166093
AGS: 114124984
RMD: 113553214
BTAB: 109035846
DCI: 103510227
CLEC: 106665695
HHAL: 106682910
NLU: 111054451
ZNE: 110836445
CSEC: 111875172
PVM: 113814456
HAME: 121876189
EAF: 111704047
TUT: 107369713
DPTE: 113797676
CSCU: 111641196
PTEP: 107439835
SDM: 118196228
CEL: CELE_T12G3.8(bre-5)
CBR: CBG06216(Cbr-bre-5)
BMY: BM_BM5757(Bma-bre-5)
BGT: 106051264
LAK: 106180776
EPA: 110246985
ATEN: 116300017
HMG: 100202706
 » show all
Reference
1  [PMID:5842076]
  Authors
Basu S, Kaufman B, Roseman S.
  Title
Conversion of Tay-Sachs ganglioside to monosialoganglioside by brain uridine diphosphate D-galactose: glycolipid galactosyltransferase.
  Journal
J Biol Chem 240:4115-7 (1965)
Reference
2  [PMID:4987145]
  Authors
Yip GB, Dain JA.
  Title
The enzymic synthesis of ganglioside. II. UDP-galactose: N-acetylgalactosaminyl-(N-acetylneuraminyl)galactosyl-glucosyl-ceramide galactosyltransferase in rat brain.
  Journal
Biochim Biophys Acta 206:252-60 (1970)
DOI:10.1016/0005-2744(70)90108-7
Reference
3  [PMID:5484669]
  Authors
Yip MC, Dain JA.
  Title
Frog brain uridine diphosphate galactose-N-acetylgalactosaminyl-N-acetylneuraminylgalactosylglucosylceram ide galactosyltransferase.
  Journal
Biochem J 118:247-52 (1970)
DOI:10.1042/bj1180247
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.62
IUBMB Enzyme Nomenclature: 2.4.1.62
ExPASy - ENZYME nomenclature database: 2.4.1.62
BRENDA, the Enzyme Database: 2.4.1.62
CAS: 37217-28-0

DBGET integrated database retrieval system