KEGG   ENZYME: 2.4.1.79
Entry
EC 2.4.1.79                 Enzyme                                 
Name
globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase;
uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase;
globoside synthetase;
UDP-N-acetylgalactosamine:globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase;
galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase;
UDP-N-acetylgalactosamine:globotriaosylceramide beta1,3-N-acetylgalactosaminyltransferase;
globoside synthase;
gUDP-N-acetyl-D-galactosamine:D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide beta-N-acetyl-D-galactosaminyltransferase;
beta3GalNAc-T1;
UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3III-beta-N-acetyl-D-galactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3III-beta-N-acetyl-D-galactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide III3-beta-N-acetyl-D-galactosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide III3-beta-N-acetyl-D-galactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R05631 R05962]
Reaction(KEGG)
R05631 R05962(G);
(other) R11321(G) R11378(G) R11379(G)
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04737]
Product
UDP [CPD:C00015];
N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Comment
Globoside is a neutral glycosphingolipid in human erythrocytes and has blood-group-P-antigen activity [4]. The enzyme requires a divalent cation for activity, with Mn2+ required for maximal activity [3]. UDP-GalNAc is the only sugar donor that is used efficiently by the enzyme: UDP-Gal and UDP-GlcNAc result in very low enzyme activity [3]. Lactosylceramide, globoside and gangliosides GM3 and GD3 are not substrates [4]. For explanation of the superscripted '3' in the systematic name, see {iupac/misc/glylp#5.3::GL-5.3.4}.
History
EC 2.4.1.79 created 1976, modified 2006
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec01100  Metabolic pathways
Orthology
K00719  galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase
Genes
HSA8706(B3GALNT1)
PTR460824(B3GALNT1)
PPS103783664(B3GALNT1)
GGO101128316(B3GALNT1)
PON100174453(B3GALNT1)
NLE100582204(B3GALNT1)
MCC703939(B3GALNT1)
MCF102122721(B3GALNT1)
MTHB126948315
CSAB103241387(B3GALNT1)
CATY105571923(B3GALNT1)
PANU101014119(B3GALNT1)
TGE112619482(B3GALNT1)
RRO104665025(B3GALNT1)
RBB108513415(B3GALNT1)
TFN117079007(B3GALNT1)
PTEH111550131(B3GALNT1)
CJC100412790(B3GALNT1)
SBQ104650882(B3GALNT1)
CSYR103270002(B3GALNT1)
MMUR105865205 105881201(B3GALNT1)
LCAT123630229(B3GALNT1)
OGA100948114(B3GALNT1)
MMU26879(B3galnt1)
MCAL110291625(B3galnt1)
MPAH110320437(B3galnt1)
RNO310508(B3galnt1)
MCOC116092991(B3galnt1)
MUN110555067(B3galnt1)
CGE100756438(B3galnt1)
MAUA101842661(B3galnt1)
PLEU114691707(B3galnt1)
MORG121452942(B3galnt1)
MFOT126504866
AAMP119826479(B3galnt1)
NGI103738016(B3galnt1)
HGL101706281(B3galnt1)
CPOC100729840(B3galnt1)
CCAN109687568(B3galnt1)
DORD105985632(B3galnt1)
DSP122107279(B3galnt1)
NCAR124993439
OCU100352272(B3GALNT1)
OPI101535578(B3GALNT1)
TUP102470507(B3GALNT1)
CFA100683634(B3GALNT1)
CLUD112645890(B3GALNT1)
VVP112933319(B3GALNT1)
VLG121477463(B3GALNT1)
AML100472542(B3GALNT1)
UMR103677240(B3GALNT1)
UAH113254148(B3GALNT1)
UAR123801336(B3GALNT1)
ELK111149669
LLV125099839
MPUF101670826(B3GALNT1)
ORO101362550(B3GALNT1)
EJU114209060(B3GALNT1)
ZCA113918056(B3GALNT1)
MLX118005935(B3GALNT1)
NSU110591647(B3GALNT1)
FCA101092536(B3GALNT1)
PYU121033933(B3GALNT1)
PBG122491774(B3GALNT1)
LRUF124525900
PTG102967614(B3GALNT1)
PPAD109262073(B3GALNT1)
AJU106969458(B3GALNT1)
HHV120238283(B3GALNT1)
BTA767844(B3GALNT1)
BOM102268013(B3GALNT1)
BIU109558643(B3GALNT1)
BBUB102399951(B3GALNT1)
CHX102172392(B3GALNT1)
OAS101104544(B3GALNT1)
ODA120868988(B3GALNT1)
CCAD122444977(B3GALNT1)
SSC397634(B3GALNT1)
CFR102520987(B3GALNT1)
CBAI105066656(B3GALNT1)
CDK105085986(B3GALNT1)
VPC102528588(B3GALNT1)
BACU103007706(B3GALNT1)
LVE103081769(B3GALNT1) 103082553
OOR101281290(B3GALNT1) 101288742
DLE111174411(B3GALNT1) 111185630 111185631
PCAD102984339 102987471(B3GALNT1)
PSIU116753608(B3GALNT1)
ECB100062101(B3GALNT1)
EPZ103556050(B3GALNT1)
EAI106841036(B3GALNT1)
MYB102245995(B3GALNT1)
MYD102751273(B3GALNT1)
MMYO118676619(B3GALNT1)
MLF102437524 102439809(B3GALNT1)
MNA107539305(B3GALNT1)
PKL118722297(B3GALNT1)
HAI109373391(B3GALNT1)
DRO112307143(B3GALNT1)
SHON118987441(B3GALNT1)
AJM119046051(B3GALNT1)
PDIC114491031(B3GALNT1)
PHAS123827240(B3GALNT1)
MMF118617221(B3GALNT1) 118636326
RFQ117031627(B3GALNT1)
PALE102885235(B3GALNT1)
PGIG120598486(B3GALNT1)
PVP105305269(B3GALNT1)
RAY107513039(B3GALNT1)
MJV108396279(B3GALNT1)
TOD119257657(B3GALNT1)
SARA101549871(B3GALNT1)
LAV100672964(B3GALNT1)
TMU101351705
DNM101433163(B3GALNT1)
MDO100015392(B3GALNT1)
GAS123240276(B3GALNT1)
SHR100914641(B3GALNT1)
PCW110210070(B3GALNT1)
OAA100077633(B3GALNT1)
GGA425011(B3GALNT1)
PCOC116235495(B3GALNT1)
MGP100542332(B3GALNT1)
CJO107318361(B3GALNT1)
NMEL110397553(B3GALNT1)
APLA106019552(B3GALNT1)
ACYG106043526(B3GALNT1)
AFUL116492328(B3GALNT1)
TGU100228838(B3GALNT1)
LSR110476616(B3GALNT1)
SCAN103815586(B3GALNT1)
PMOA120504195(B3GALNT1)
OTC121336527(B3GALNT1)
PRUF121353689(B3GALNT1)
GFR102040599(B3GALNT1)
FAB101809193(B3GALNT1)
PHI102106993(B3GALNT1)
PMAJ107208685(B3GALNT1)
CCAE111933293(B3GALNT1)
CCW104688069(B3GALNT1)
CBRC103615715(B3GALNT1)
ETL114062933(B3GALNT1)
ACHL103805940(B3GALNT1)
FPG101912356(B3GALNT1)
FCH102056837(B3GALNT1)
CLV102087526(B3GALNT1)
EGZ104122266(B3GALNT1)
NNI104011569(B3GALNT1)
PLET104627882(B3GALNT1)
PCRI104028548(B3GALNT1)
TALA104363308(B3GALNT1)
PADL103925238(B3GALNT1)
AFOR103898640(B3GALNT1)
ACHC115347025(B3GALNT1)
HALD104314644(B3GALNT1)
CCRI104160078(B3GALNT1)
CSTI104560631(B3GALNT1)
CMAC104475757(B3GALNT1)
MUI104539654(B3GALNT1)
FGA104080350(B3GALNT1)
GSTE104253870(B3GALNT1)
LDI104353329(B3GALNT1)
MNB103779678(B3GALNT1)
OHA104334441(B3GALNT1)
NNT104403793(B3GALNT1)
DPUB104301660(B3GALNT1)
PGUU104463437(B3GALNT1)
ACAR104523712(B3GALNT1)
AVIT104270872(B3GALNT1)
CVF104285904(B3GALNT1)
AAM106495105(B3GALNT1)
AROW112961979(B3GALNT1)
NPD112952483(B3GALNT1)
TGT104565268(B3GALNT1)
DNE112986451(B3GALNT1)
SCAM104140021(B3GALNT1)
ASN102381398(B3GALNT1)
AMJ102574149(B3GALNT1)
CPOO109310352(B3GALNT1)
GGN109287747(B3GALNT1)
PSS102454980(B3GALNT1)
CMY102942089(B3GALNT1)
CPIC101934527(B3GALNT1)
TST117882635(B3GALNT1)
CABI116823590(B3GALNT1)
MRV120372022(B3GALNT1)
ACS100564179(b3galnt1)
PVT110078057(B3GALNT1)
SUND121927083(B3GALNT1)
VKO123025660(B3GALNT1)
PMUA114597936(B3GALNT1)
ZVI118093800(B3GALNT1)
GJA107107027(B3GALNT1)
STOW125437503(B3GALNT1)
LOC102690089(b3galnt1)
PSPA121322566 121323543 121326691
ARUT117416799 117423202
LCM102358886 102363803
SPU115927124 765098
SKO102800712 102807352
HRF124150667
HRJ124259260 124269462 124290859
CRG105335519 105335520
MYI110441288 110452220 110453853 110460297 110463413
PMAX117335478 117337035
LAK112042554
 » show all
Reference
1  [PMID:4632917]
  Authors
Chien JL, Williams T, Basu S.
  Title
Biosynthesis of a globoside-type glycosphingolipid by a  -N-acetylgalactosaminyltransferase from embryonic chicken brain.
  Journal
J Biol Chem 248:1778-85 (1973)
Reference
2  [PMID:4433547]
  Authors
Ishibashi T, Kijimoto S, Makita A.
  Title
Biosynthesis of globoside and Forssman hapten from trihexosylceramide and properties of beta-N-acetyl-galactosaminyltransferase of guinea pig kidney.
  Journal
Biochim Biophys Acta 337:92-106 (1974)
DOI:10.1016/0005-2760(74)90043-5
Reference
3  [PMID:6425294]
  Authors
Taniguchi N, Makita A.
  Title
Purification and characterization of UDP-N-acetylgalactosamine: globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase, a synthase of human blood group P antigen, from canine spleen.
  Journal
J Biol Chem 259:5637-42 (1984)
Reference
4  [PMID:10993897]
  Authors
Okajima T, Nakamura Y, Uchikawa M, Haslam DB, Numata SI, Furukawa K, Urano T, Furukawa K
  Title
Expression cloning of human globoside synthase cDNAs. Identification of beta 3Gal-T3 as UDP-N-acetylgalactosamine:globotriaosylceramide beta 1,3-N-acetylgalactosaminyltransferase.
  Journal
J Biol Chem 275:40498-503 (2000)
DOI:10.1074/jbc.M006902200
  Sequence
[hsa:8706]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.79
IUBMB Enzyme Nomenclature: 2.4.1.79
ExPASy - ENZYME nomenclature database: 2.4.1.79
BRENDA, the Enzyme Database: 2.4.1.79
CAS: 62213-46-1

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