KEGG   ENZYME: 2.4.1.87
Entry
EC 2.4.1.87                 Enzyme                                 

Name
N-acetyllactosaminide 3-alpha-galactosyltransferase;
alpha-galactosyltransferase;
UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase;
UDP-Gal:N-acetyllactosaminide alpha(1,3)-galactosyltransferase;
UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase;
UDP-Gal:Galbeta1->4GlcNAc-R alpha1->3-galactosyltransferase;
UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase;
UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-glycopeptide alpha-1,3-D-galactosyltransferase;
glucosaminylglycopeptide alpha-1,3-galactosyltransferase;
uridine diphosphogalactose-acetyllactosamine alpha1->3-galactosyltransferase;
uridine diphosphogalactose-acetyllactosamine galactosyltransferase;
uridine diphosphogalactose-galactosylacetylglucosaminylgalactosylglucosylceramide galactosyltransferase;
beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase;
UDP-galactose:N-acetyllactosaminide 3-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-galactose:beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R = UDP + alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R (where R can be OH, an oligosaccharide or a glycoconjugate) [RN:R02791]
Reaction(KEGG)
R02791 > R04531 R05978(G) R06145(G) R06169(G);
(other) R11320(G)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R
Product
UDP [CPD:C00015];
alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R [CPD:C04855]
Comment
Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on asialo-alpha1-acid glycoprotein and N-acetyllactosamine (beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine), but not on 2'-fucosylated-N-acetyllactosamine. The non-reducing terminal N-acetyllactosamine residues of glycoproteins can also act as acceptor. Now includes EC 2.4.1.124 and EC 2.4.1.151.
History
EC 2.4.1.87 created 1976, modified 1989, modified 2002 (EC 2.4.1.124 created 1984, incorporated 2002, EC 2.4.1.151 created 1984, incorporated 2002)
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec01100  Metabolic pathways
Orthology
K00743  N-acetyllactosaminide 3-alpha-galactosyltransferase
K20736  alpha-1,3-galactosyltransferase 2
Genes
HSA: 127550(A3GALT2)
PTR: 104007284(A3GALT2)
PPS: 100975171(A3GALT2)
GGO: 101137879(A3GALT2)
PON: 100431438(A3GALT2)
NLE: 100586880(A3GALT2)
MCC: 711045(A3GALT2)
MCF: 102136396(A3GALT2)
CSAB: 103225947(A3GALT2)
CATY: 105594799(A3GALT2)
PANU: 101020613(A3GALT2)
RRO: 104655865 104677306(A3GALT2)
RBB: 108537074 108537279(A3GALT2)
TFN: 117092920(A3GALT2) 117098733
PTEH: 111550328 111555868(A3GALT2)
CJC: 100390928(GGTA1P) 100414894(A3GALT2)
SBQ: 101033629(A3GALT2) 101038827
MMUR: 105871787(A3GALT2) 105875133
MMU: 14594(Ggta1) 215493(A3galt2)
MCAL: 110289655 110292229(A3galt2)
MPAH: 110318488 110323213(A3galt2)
RNO: 171553(A3galt2) 246766(Ggta1)
MCOC: 116090066 116096681(A3galt2)
MUN: 110548184(A3galt2) 110558641
CGE: 100754535(Ggta1) 100774283(A3galt2)
PLEU: 114682033(A3galt2) 114704707(Ggta1)
NGI: 103730905(A3galt2) 103734487
HGL: 101699219(A3galt2) 101705531
CCAN: 109686855(A3galt2) 109692479
OCU: 100339429(A3GALT2) 100348435
TUP: 102483559(A3GALT2) 102502371
CFA: 487298(A3GALT2) 491357(GGTA1)
VVP: 112927838 112931709(A3GALT2)
VLG: 121473075(GGTA1) 121498202(A3GALT2)
AML: 100479995(A3GALT2) 100482234
UMR: 103670365
UAH: 113266361 113268332(A3GALT2)
MPUF: 101671456(A3GALT2) 101677189 101677943
MLX: 118017738(GGTA1) 118019722(A3GALT2)
FCA: 101084042(A3GALT2) 493877(GGTA1)
PTG: 102965067 107180570(A3GALT2)
AJU: 106973174(A3GALT2) 106986621
HHV: 120232112(A3GALT2) 120233405 120233419(GGTA1)
BTA: 281780(GGTA1) 617693(A3GALT2)
BOM: 102276118(A3GALT2) 102282898
BIU: 109566417 109575981(A3GALT2)
BBUB: 102398588 102402563(A3GALT2)
CHX: 102168270 108637492(A3GALT2)
OAS: 101103704(A3GALT2) 443282(GGTA2P)
ODA: 120851938(GGTA1) 120854762(A3GALT2)
SSC: 100739829(A3GALT2) 396733(GGTA1P)
CFR: 102516495(A3GALT2) 102516521
CBAI: 105065260
CDK: 105104406 116156821(A3GALT2)
BACU: 103006673
LVE: 103079826(A3GALT2) 103089836
OOR: 101277096(GLT6D1) 101279702(A3GALT2)
DLE: 111175451(A3GALT2) 111177259(GLT6D1)
PCAD: 102975905(GLT6D1) 102996822(A3GALT2)
ECB: 100067589 106782783(A3GALT2)
EPZ: 103555510 103557792(A3GALT2)
EAI: 106824198 106829012(A3GALT2)
MYB: 102261921
MYD: 102751930 102753567(A3GALT2)
MMYO: 118667122(GGTA1) 118675052(A3GALT2)
MNA: 107537664 107542062(A3GALT2)
DRO: 112299104(A3GALT2) 112306460
SHON: 118995989(GGTA1) 118997700(A3GALT2)
AJM: 119046898(GGTA1) 119052438(A3GALT2)
MMF: 118627073(A3GALT2) 118630216(GGTA1)
PALE: 102885392(A3GALT2) 102892029
PGIG: 120582036(A3GALT2) 120605761(GGTA1)
RAY: 107513619(A3GALT2) 107516315
MJV: 108401813(A3GALT2) 108405129(GLT6D1)
TOD: 119232266(GGTA1) 119236484(A3GALT2)
LAV: 100655343 100671107(A3GALT2)
OAA: 100089476
PSS: 102447976(A3GALT2)
CMY: 102941601(A3GALT2)
ACS: 103281997
PVT: 110078804
PBI: 103058654
PMUR: 107295054
TSR: 106542602
PGUT: 117676609
PMUA: 114589231(GLT6D1)
ZVI: 118083828(GLT6D1)
GJA: 107118477
NPR: 108793736
TRU: 101078261(a3galt2)
LCO: 104919360
NCC: 104957307(a3galt2)
CGOB: 115004723 115007798(a3galt2)
MZE: 101476245(a3galt2)
XMA: 102225862(a3galt2)
XCO: 114135833(a3galt2) 114142426
PRET: 103462901 103464476(a3galt2)
CVG: 107087544
AOCE: 111574913 111588016(a3galt2)
POV: 109638603
SDU: 111224019
SLAL: 111658256
BPEC: 110168737
MALB: 109958978
ELS: 105017413
SFM: 108918234(a3galt2) 108924914
LOC: 102684573(a3galt2)
LCM: 102357128
CMK: 103181344(a3galt2)
RTP: 109918400 109924380(a3galt2)
 » show all
Reference
1  [PMID:4632915]
  Authors
Basu M, Basu S.
  Title
Enzymatic synthesis of a blood group B-related pentaglycosylceramide by an alpha-galactosyltransferase from rabbit bone marrow.
  Journal
J Biol Chem 248:1700-6 (1973)
Reference
2  [PMID:3932335]
  Authors
Blanken WM, Van den Eijnden DH.
  Title
Biosynthesis of terminal Gal alpha 1----3Gal beta 1----4GlcNAc-R oligosaccharide sequences on glycoconjugates. Purification and acceptor specificity of a UDP-Gal:N-acetyllactosaminide alpha 1----3-galactosyltransferase from calf thymus.
  Journal
J Biol Chem 260:12927-34 (1985)
Reference
3  [PMID:6787040]
  Authors
Blake DA, Goldstein IJ.
  Title
An alpha-D-galactosyltransferase activity in Ehrlich ascites tumor cells. Biosynthesis and characterization of a trisaccharide (alpha-D-galactose-(1 goes to 3)-N-acetyllactosamine).
  Journal
J Biol Chem 256:5387-93 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.87
IUBMB Enzyme Nomenclature: 2.4.1.87
ExPASy - ENZYME nomenclature database: 2.4.1.87
BRENDA, the Enzyme Database: 2.4.1.87
CAS: 128449-51-4

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