KEGG   ENZYME: 2.4.2.44
Entry
EC 2.4.2.44                 Enzyme                                 
Name
S-methyl-5'-thioinosine phosphorylase;
MTIP;
MTI phosphorylase;
methylthioinosine phosphorylase
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
Sysname
S-methyl-5'-thioinosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase
Reaction(IUBMB)
S-methyl-5'-thioinosine + phosphate = hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate [RN:R09668]
Reaction(KEGG)
R09668
Substrate
S-methyl-5'-thioinosine [CPD:C19787];
phosphate [CPD:C00009]
Product
hypoxanthine [CPD:C00262];
S-methyl-5-thio-alpha-D-ribose 1-phosphate [CPD:C04188]
Comment
No activity with S-methyl-5'-thioadenosine. The catabolism of of 5'-methylthioadenosine in Pseudomonas aeruginosa involves deamination to S-methyl-5'-thioinosine (EC 3.5.4.31, S-methyl-5'-thioadenosine deaminase) and phosphorolysis to hypoxanthine [1].
History
EC 2.4.2.44 created 2011
Pathway
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K19696  5'-methylthioinosine phosphorylase
Genes
XFAXF_2353
XFTPD_1381(deoD)
XFMXfasm12_1523
XFNXfasM23_1466
XFFXFLM_01035
XFLP303_06620
XFSD934_11000
XFHXFHB_03330
XTWAB672_04720
XCCXCC1285(deoD)
XCBXC_2956
XCAxcc-b100_3018
XCPXCR_1540
XCVXCV1388(deoD)
XAXXACM_1319(deoD)
XACXAC1336(deoD)
XCIXCAW_03012(deoD)
XCTJ151_01480
XCJJ158_01476
XCUJ159_01476
XCNJ169_01476
XCWJ162_01476
XCRJ163_01476
XCMJ164_01476
XCFJ172_01471
XFUXFF4834R_chr31650(deoD)
XAOXAC29_06735
XOMXOO1764(XOO1764)
XOOXOO1869(deoD)
XOPPXO_01730
XOYAZ54_15170
XORXOC_3170
XOZBE73_06940
XALXALC_2532
XSASB85_06500
XTNFD63_05890
XFRBER92_07025
XVEBJD12_20060
XPEBJD13_09925
XHRXJ27_08380
XGABI317_07830
XPHXppCFBP6546_04755(XppCFBP6546P_04755)
XVAC7V42_07230
XANAC801_06820
XARXB05_01640
XHYFZ025_16390
XCZEBN15_05590
XTHG4Q83_00635
XEUXSP_001367
XHDLMG31886_29900
XPRMUG10_03070
SMLSmlt3536
SMTSmal_2966
BUJBurJV3_2996
SMZSMD_3117(mtaP)
SACZAOT14_13000(mtaP)
STEKAXG53_11505
SRHBAY15_2727
SLMBIZ42_04430
STENCCR98_15430
STEMCLM74_15740
STESMG068_15315
SINCDAIF1_30880
SPAQSTNY_R31390
PSUPsesu_1333
PSUWWQ53_00595
PSDDSC_11520
PMEXH4W19_01970
PJPLAG73_09995
PDDMNQ95_15405
LABLA76x_3472
LAQGLA29479_4716
LCPLC55x_3420
LGULG3211_1764
LEZGLE_1720(mtnP)
LEMLEN_3247(mtaP)
LMBC9I47_1296
LYTDWG18_08360
LUEDCD74_03010
LYJFKV23_10675
LSOLGOY17_12480
LSXH8B22_01730
LAREHIV01_002115
LHXLYSHEL_02090
LCASLYSCAS_02090
LCICINQ41_09595
LAVIINQ42_09040
LLZLYB30171_01001
LUMCNR27_10760
LUSE5843_10275
LUGFPZ22_11600
THESFHQ07_02995
THEHG7079_09620
TCNH9L16_10840
TBVH9L17_14925
XBCELE36_09425
FAUFraau_1690
RHDR2APBS1_2224
RGLCS053_10465
RTHLRK53_11920
DJICH75_10725
DJAHY57_14340
DTXATSB10_08500
DYEEO087_14650
DCSISN74_07480
DTLH8F01_21475
DTADYST_00856
DKOI596_506
LRZBJI69_16210
LPYFIV34_08540
LANHKR767_19780
XBAC7S18_15955
RBDALSL_1163
PAEPA3004
PAEVN297_3110(mtnP)
PAEIN296_3110(mtnP)
PAUPA14_25210
PAPPSPA7_2155(mtnP)
PAGPLES_20581
PAFPAM18_1956
PNCNCGM2_4119
PAEBNCGM1900_3301
PDKPADK2_09325
PSGG655_09765
PRPM062_16070
PAEPPA1S_10370
PAERPA1R_gp0837
PAEMU769_09910
PAELT223_10385
PAESSCV20265_2044
PAEUBN889_03356
PAEGAI22_23500
PAECM802_3107(mtnP)
PAEOM801_2975(mtnP)
PMYPmen_1591
PREPCA10_21210
PPSEBN5_1390(mtaP)
PFUWKF707C_34410
PALCA0T30_14460
PCQPcP3B5_19240
PMUIG4G71_20240
PORAPT59_16560
PSTPSPTO_3506
PSBPsyr_3280
PSYRN018_16460
PSPPSPPH_3200(mtaP)
PSAVPSA3335_12835
PAMGBKM19_019205
PCIPCH70_31780
PAVLBKM03_11705
PVDCFBP1590__3384
PCABJGS08_10500
PCOFPOR16_14955
PTREI9H09_10310
PSYIMME58_16815
PASTN015_10660
PFOPfl01_3869
PMANOU5_5481
PCGAXG94_24755
PMEDE3Z27_09345
PLULFOB45_18475
PBCCD58_09740
PPUUPputUW4_03513(mtnP)
PDRH681_16205
PKCPKB_3776
PCHEY04_09400
PCPJM49_20450
PLQAA042_02940
PKRAYO71_21210
PPSLBJP27_08245
PSETTHL1_2136
PSILPMA3_08645
PKEDLD99_19325
PALLUYA_08265
PUMHGP31_09445
POJPtoMrB4_17380
PGGFX982_04572
PPSHG5J76_09770
PGYAWU82_11970
PLALFXN65_09865
PSEJHNQ25_16480
PVKEPZ47_09530
PKHJLK41_08210
PTYJWV26_18615
PMAOPMYSY11_2789
PATAJWU58_09465
PZEHU754_020590
PMOEHV782_019785
PCAMHNE05_05585
PTZHU718_020770
PHVHU739_000270
PNNKEM63_09070
PAZEKSS91_09230
PALVKSS97_10085
PPHABVH74_12950
PTWTUM18999_18130
PIEHU724_019465
PGFJ0G10_20805
PCAVD3880_14190
PHFNLY38_17190
PPHNHU825_13025
PIZLAB08_R16940
PSIINF676_18425
PSAPST_1738
PSZPSTAB_1632
PSRPSTAA_1752
PSCA458_12095
PSHPsest_2642
PSTUUIB01_13365
PSTTCH92_13710
PSEDDM292_10955
PCHLLLJ08_12665
PBMCL52_11975
PKGLW136_09905
SDEGGOM96_18250
AVNAvin_14550
AVLAvCA_14550
AVDAvCA6_14550
ACXAchr_28290
PBBAKN87_00985
HPEGEAO82_14125
HAESLO767_05270
MAQMaqu_1935
MHCMARHY1370
MADHP15_2259
MBSMRBBS_1057(mtnP)
MSRAU15_10190
MSXAU14_14935
MPQABA45_05460
MARIACP86_01455
MLQASQ50_19135
MSQBKP64_03130
MARAD0851_04540
MARJMARI_15850
HMIsoil367_06315
ALKMNKI27_11710
CEGD0C16_05985
SDESde_1793
SAGAM5M_01190
MARQMARGE09_P3657
SPOIIMCC21906_02058
SNANI6N98_10025
STAWNCG89_01810
ZALAZF00_07850
OSGBST96_16555
HJABST95_11395
HALCEY643_11000
MCAMCA1986
METUGNH96_07215
MMTMetme_2293
MDNJT25_019590
MDHAYM39_11905
MKOMKLM6_2455
METLU737_09915
MPADKEF85_11115
MELLIVG45_02795
MAHMEALZ_3520(mtnP)
MBUREQU24_18730
MPSYCEK71_10260(mtnP)
MMAIsS8_5293
MMOBF6R98_13905
MEINmethR_P3532
MOZMoryE10_18430
MISZMishRS11D_30560
MESLKKZ03_18950
MEJQ7A_1240
MECQ7C_636
MPINLGT42_012255
CYQQ91_0834
CZACYCME_1746
CYYCPC19_08455(mtnP)
TIGTHII_0201
BLEPAL038_16670
THISHZT40_09555
TUNJ9260_09655
TLOJ9253_03375
TSBHMY34_17420
TANIJ8380_11685
TWNL2Y54_17850
NOCNoc_0457
NHLNhal_2866
NWANwat_2653
NWRE3U44_11495
ALVAlvin_0498
ATEPAtep_12550
TVIThivi_3164
TMBThimo_1899
MPURMARPU_07970
TEETel_08760
NTTTAO_0458
TSYTHSYN_09380
TTPE6P07_04355
THIPN838_04135
CJAPGWK36_10905
THIMKFB96_05535
TBOGLT988_00875
AEHMlg_1329
HHAHhal_1259
HHKHH1059_12640
HHCM911_09740
EBSECTOBSL9_2897
TGRTgr7_1751
TKMTK90_1246
TNITVNIR_1603(mtnP_[H])
TTITHITH_08640
TVRTVD_06670
SSALSPISAL_04185
SPIZGJ672_04545
APRSBI364_08555
NAXHC341_09350
HNAHneap_1396
HAZA9404_03950
WMAWM2015_1355
WEZIC757_09365
WOCBA177_07835
GAIIMCC3135_23780
GHLGM160_08885
TTCFOKN1_2126
THICTspCOW1_05220
HCHHCH_02681(mtaP)
HAHEENC22_18205
HAFC8233_06810
CMAIBFX80_12880
CAMHLCW13_04390
KUYFY550_07220
PAURFGL86_12630
ABOABO_1021(deoD)
ADIB5T_01828(deoD)
APACS7S_10135
ALNAS19_10860
AXEP40_08710
KAKKalk_02995(mtnP)
TOLTOL_2082
TORR615_07240
TWANHUF19_10520
OAIOLEAN_C17000(mtaP)
BSANCHH28_16990
BMARHF888_07080
VCWGJQ55_08310
BACZKFF03_11450
GSNYC6258_03262
RFOREIFOR_01731
OMEOLMES_2972
SOKD0B54_06660
SINIGT972_06360
FCEJN531_015850
GBIPG2T_04065
SLIMSCL_1235
SVASVA_2035
ACIIC4901_11940
ATYA9R16_004860
SALNSALB1_2782
TBNTBH_C1140
SEDSAAY24_03900
PSPIPS2015_1876
REVHUE57_12490
EPSL0Y14_07940
ENMEBS_1162(mtaP)
NELNELON_07680
NWESAMEA3174300_0313
NSIA6J88_08290
NMJNM96_02970
NEIBG910_00080
NEKCGZ77_09250
NFVFAH67_03980
NSFFAH66_04005
NZLD0T92_04780
NAQD0T90_00720
NBLGJV52_00300
NZOSAMEA4504057_0296
NCINCTC10296_01113
NANINCTC12227_00412
NBCH3L91_06195
NWDH3L96_00890
NMUSH7A79_0378
NSCJ7445_04680
NPFLPB400_06970
NDNH3L92_02145
NWXCGZ65_07010
NDULVJ88_12405
NMBMON40_08165
AFFH3L97_00600
MCERMON37_06015
CVCBKX93_10220
CHROCXB49_01890
CHRIDK842_04515
CHRBDK843_09980
CRZD1345_18330
CHRMFYK34_14145
CHAECH06BL_37260
LHKLHK_02867
PSENH8B_0479
JEUBJP62_01800
AQLBXU06_09960
AMAHDLM_4551
AQSDKK66_04790
BTDBTI_4930
BOKDM82_6373
BOCBG90_4301
BSAVWS86_29505
BHGI6G56_28390
BULBW21_4458
BUDAQ610_30830
PLGNCTC10937_01954
HYFDTO96_102316
LMIRNCTC12852_01651
LIMNHKT17_07870
CARIFNU76_22430
PIGEGT29_14900
PACRFXN63_10720
SUTTSUTMEG_07820
SUTKFG381_04140
SWSI6J16_06925
BBAGE1O_08810
BBAYA4V04_05915
NITNAL212_2410
NIINit79A3_2232
NCOAAW31_14690
NURATY38_00485
NSTNstercoris_02139
NLCEBAPG3_005380
NIZNNRS527_00656
SHDSUTH_01614
METRBSY238_185(mtnP)
DOEDENOEST_1015
TBDTbd_0778
MFAMfla_1467
MMBMmol_1175
MEHM301_1387
MEIMsip34_1418
MEPMPQ_1492
MBACBN1209_0791
MBATBN1208_0756
MEUACJ67_06075
SLTSlit_1295
GCAGalf_1202
FAMOYT1_ch1111
NIMW01_05950
NARCNTG6680_1591
FKUFGKAn22_09960
SEMEMIZ01_1682
SDRSCD_n01661
SPLBSFPGR_08740
SNIVSFSGTM_07160
SLACSKTS_24600
URUDSM104443_01020
UPLDSM104440_00932
DSUDsui_2698
ARESIWH25_13095
RBUPG1C_09555
OTROTERR_16780(mtap)
NIVJY500_11445
ABREpbN1_38810
APETToN1_09540
ATWC0099_07920
RBHB4966_07510
DEYHYN24_08635
AZOazo1998
AOAdqs_2153
AZAAZKH_2797(mtap)
AZIAzCIB_2753
ACOMCEW83_04805
AZDCDA09_14880
AZRCJ010_12990(mtnP)
TMZTmz1t_2182
THUAC731_005125
TCLTchl_2776
THKCCZ27_08505
TAKTharo_2070
AZQG3580_10500
ZPAC3497_06780
FPHOSHINM1_011360
APPCAP2UW1_3627
DDZDSYM_14440
BEBAEM42_12455
BEBABWI17_22135
SECHB18_27995
AFRAFE_0365(mtaP)
AFELferr_0535
ACUAtc_2490
ACZAcaty_c2333
AFIAcife_2672
AFJAFERRID_10420
AFPK1Y48_08450
HTLHPTL_1072
PLANA1s21148_02325
NPYNPRO_01690
SBUSpiBuddy_1733
SGPSpiGrapes_3280
 » show all
Reference
1  [PMID:21197954]
  Authors
Guan R, Ho MC, Almo SC, Schramm VL
  Title
Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and annotation of a novel enzyme in quorum sensing.
  Journal
Biochemistry 50:1247-54 (2011)
DOI:10.1021/bi101642d
  Sequence
[pae:PA3004]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.44
IUBMB Enzyme Nomenclature: 2.4.2.44
ExPASy - ENZYME nomenclature database: 2.4.2.44
BRENDA, the Enzyme Database: 2.4.2.44

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