Entry
Name
tRNA-guanosine34 queuine transglycosylase;
QTRT1 (gene name);
QTRT2 (gene name);
TGT (ambiguous);
guanine insertion enzyme (ambiguous);
tRNA transglycosylase (ambiguous);
Q-insertase (ambiguous);
queuine34 transfer ribonucleate ribosyltransferase;
transfer ribonucleate glycosyltransferase (ambiguous);
tRNA guanine34 transglycosidase (ambiguous);
queuine tRNA-ribosyltransferase;
[tRNA]-guanine34:queuine tRNA-D-ribosyltransferase;
transfer ribonucleic acid guanine34 transglycosylase (ambiguous)
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
tRNA-guanosine34:queuine tRNA-D-ribosyltransferase
Reaction(IUBMB)
guanine34 in tRNA + queuine = queuine34 in tRNA + guanine [RN:
R03789 ]
Reaction(KEGG)
Substrate
guanine34 in tRNA;
queuine [CPD:
C01449 ]
Product
queuine34 in tRNA;
guanine [CPD:
C00242 ]
Comment
Certain prokaryotic and eukaryotic tRNAs contain the modified base queuine at position 34. In eukaryotes and a small number of prokaryotes queuine is salvaged and incorporated into tRNA directly via a base-exchange reaction, replacing guanine. cf. EC
2.4.2.29 , tRNA-guanosine34 preQ1 transglycosylase.
History
EC 2.4.2.64 created 2020 (EC 2.4.2.29 created 1984, modified 2007, modified 2012, part transferred 2020 to EC 2.4.2.64)
Orthology
K00777 queuine tRNA-ribosyltransferase catalytic subunit
Genes
SHR : 100917837(QTRT1) 116422291
ACHC : 115338391 115348220
SANH : 107661875 107670462
CCAR : 109052182 109052203
MASI : 127450646 127451639
ARUT : 117409793 117965604
LPIC : 129277936 129277937
DSI : Dsimw501_GD23082(Dsim_GD23082)
AALB : 109411099 115267336
CFEL : 113376544 113376708
SGRE : 126272962 126315410
PPOI : 119103769 119106840
CBR : CBG_06200(Cbr-tgt-1)
BMY : BM_BM7559(Bma-tgt-1)
LJA : Lj1g3v1515820.1(Lj1g3v1515820.1) Lj1g3v4103630.1(Lj1g3v4103630.1) Lj1g3v4103630.2(Lj1g3v4103630.2)
AHF : 112711296 112755781 112770842
SSPL : 121784035 121787951
PSOM : 113330574 113332046 113357897
DOSA : Os09t0469900-01(Os09g0469900)
TDC : 119287197 119301900 119310307
TAES : 123104043 123112271 123121793
PVIR : 120660706 120695694
SMO : SELMODRAFT_110632 SELMODRAFT_430565
NTE : NEUTE1DRAFT121512(NEUTE1DRAFT_121512)
ANG : ANI_1_1052124(An14g00580)
ABP : AGABI1DRAFT37677(AGABI1DRAFT_37677)
ABV : AGABI2DRAFT69071(AGABI2DRAFT_69071)
SCM : SCHCO_02634555(SCHCODRAFT_02634555)
EHI : EHI_035660(17.t00053)
PTM : GSPATT00020710001 GSPATT00021975001
SMIN : v1.2.005466.t1(symbB.v1.2.005466.t1)
TCR : 507023.200 511751.30
TVA : TVAG_2v0054450 TVAG_2v0240130 TVAG_2v0536770
» show all
Taxonomy
Reference
Authors
Howes NK, Farkas WR.
Title
Studies with a homogeneous enzyme from rabbit erythrocytes catalyzing the insertion of guanine into tRNA.
Journal
J Biol Chem 253:9082-7 (1978)
Reference
Authors
Shindo-Okada N, Okada N, Ohgi T, Goto T, Nishimura S
Title
Transfer ribonucleic acid guanine transglycosylase isolated from rat liver.
Journal
Reference
Authors
Boland C, Hayes P, Santa-Maria I, Nishimura S, Kelly VP
Title
Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase.
Journal
Sequence
Reference
Authors
Yuan Y, Zallot R, Grove TL, Payan DJ, Martin-Verstraete I, Sepic S, Balamkundu S, Neelakandan R, Gadi VK, Liu CF, Swairjo MA, Dedon PC, Almo SC, Gerlt JA, de Crecy-Lagard V.
Title
Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.64
ExPASy - ENZYME nomenclature database: 2.4.2.64