KEGG   ENZYME: 2.4.3.1
Entry
EC 2.4.3.1                  Enzyme                                 
Name
beta-galactoside alpha-(2,6)-sialyltransferase;
ST6Gal-I;
CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase;
lactosylceramide alpha-2,6-N-sialyltransferase;
CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine alpha-(2->6)-N-acetylneuraminyltransferase;
beta-galactoside alpha-2,6-sialyltransferase
Class
Transferases;
Glycosyltransferases;
Sialyltransferases
Sysname
CMP-N-acetyl-beta-neuraminate:beta-D-galactoside alpha-(2->6)-N-acetylneuraminyltransferase (configuration-inverting)
Reaction(IUBMB)
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
Reaction(KEGG)
(other) R03489 R04532 R05580 R05905(G) R05906(G) R05990(G) R06121(G) R06188(G) R09298(G)
Substrate
CMP-N-acetyl-beta-neuraminate [CPD:C00128];
beta-D-galactosyl-R [CPD:C02900]
Product
CMP [CPD:C00055];
N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
Comment
The enzyme acts on the terminal non-reducing beta-D-galactosyl residue of the oligosaccharide moiety of glycoproteins and glycolipids.
History
EC 2.4.3.1 created 1972 as EC 2.4.99.1, modified 1976, modified 1986, modified 2017 (EC 2.4.99.11 created 1992, incorporated 2016), modified 2017, transferred 2021 to EC 2.4.3.1
Pathway
ec00510  N-Glycan biosynthesis
ec00514  Other types of O-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K00778  beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1)
K00779  beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 2)
K12248  beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 0160)
Genes
HSA: 6480(ST6GAL1) 84620(ST6GAL2)
PTR: 450198(ST6GAL2) 460922(ST6GAL1)
PPS: 100969795(ST6GAL1) 100981465(ST6GAL2)
GGO: 101129847(ST6GAL2) 101142727(ST6GAL1)
PON: 100174088(ST6GAL1) 100456090(ST6GAL2)
NLE: 100580010(ST6GAL2) 100599869(ST6GAL1)
MCC: 708113(ST6GAL1) 713552(ST6GAL2)
MCF: 102121444(ST6GAL1) 102142751(ST6GAL2)
CSAB: 103241198(ST6GAL2) 103241877(ST6GAL1)
CATY: 105575215(ST6GAL1) 105583608(ST6GAL2)
PANU: 101015073(ST6GAL1) 101020393(ST6GAL2)
TGE: 112604770(ST6GAL2) 112618316(ST6GAL1)
RRO: 104660586(ST6GAL2) 104682948(ST6GAL1)
RBB: 108512469(ST6GAL2) 108530462(ST6GAL1)
TFN: 117062254(ST6GAL2) 117084352(ST6GAL1)
PTEH: 111542246(ST6GAL2) 111544264(ST6GAL1)
CJC: 100408699(ST6GAL1) 100411939(ST6GAL2)
SBQ: 101032294(ST6GAL1) 101047107(ST6GAL2)
CSYR: 103258705(ST6GAL1) 103258958(ST6GAL2)
MMUR: 105856143(ST6GAL2) 105885054(ST6GAL1)
OGA: 100940735(ST6GAL2) 100958396(ST6GAL1)
MMU: 20440(St6gal1) 240119(St6gal2)
MCAL: 110284258(St6gal2) 110311654(St6gal1)
MPAH: 110329758(St6gal1) 110335627(St6gal2)
RNO: 25197(St6gal1) 301155(St6gal2)
MCOC: 116074404(St6gal2) 116086257(St6gal1)
MUN: 110548122(St6gal1) 110560861(St6gal2)
CGE: 100689389(St6gal1) 100763756(St6gal2)
PLEU: 114690834(St6gal2) 114697104(St6gal1)
NGI: 103726632(St6gal2) 103750114(St6gal1)
HGL: 101718025(St6gal1) 101722644(St6gal2)
CPOC: 100728814(St6gal2) 100730025(St6gal1)
CCAN: 109691378(St6gal1) 109701499(St6gal2)
DORD: 105999623(St6gal2) 105999709(St6gal1)
DSP: 122098101(St6gal1) 122121380(St6gal2)
NCAR: 124963670 124993421
OCU: 100353188(ST6GAL1) 100358153(ST6GAL2)
OPI: 101531549(ST6GAL1) 101536363(ST6GAL2)
TUP: 102499508(ST6GAL1) 102500330(ST6GAL2)
CFA: 478668(ST6GAL1) 481315(ST6GAL2)
VVP: 112915370(ST6GAL2) 112926300(ST6GAL1)
VLG: 121477448(ST6GAL1) 121492182(ST6GAL2)
AML: 100478457(ST6GAL2) 100481066(ST6GAL1)
UMR: 103670658(ST6GAL2) 103676045(ST6GAL1)
UAH: 113253796(ST6GAL1) 113267699(ST6GAL2)
UAR: 123775969(ST6GAL2) 123801285(ST6GAL1)
ELK: 111148556 111155957
LLV: 125101930 125109621
MPUF: 101672771(ST6GAL1) 101684375(ST6GAL2)
ORO: 101374165(ST6GAL2) 101377549(ST6GAL1)
EJU: 114206991(ST6GAL1) 114209673(ST6GAL2)
ZCA: 113916141(ST6GAL1) 113930689 113938342(ST6GAL2)
MLX: 117999602 118006926(ST6GAL1) 118008290(ST6GAL2)
FCA: 101097832(ST6GAL1) 101098620(ST6GAL2)
PYU: 121016472(ST6GAL2) 121034129(ST6GAL1)
PBG: 122491626(ST6GAL1) 122496660(ST6GAL2)
PTG: 102956769(ST6GAL1) 102962032(ST6GAL2)
PPAD: 109254527(ST6GAL2) 109275279(ST6GAL1)
AJU: 106968006(ST6GAL1) 106977960(ST6GAL2)
HHV: 120224465(ST6GAL2) 120233104(ST6GAL1)
BTA: 282073(ST6GAL1) 493992(ST6GAL2)
BOM: 102273022(ST6GAL1) 102285977(ST6GAL2)
BIU: 109556984(ST6GAL1) 109566122(ST6GAL2)
BBUB: 102400138(ST6GAL1) 102408407(ST6GAL2)
CHX: 100861310(ST6GAL1) 102179776(ST6GAL2)
OAS: 100913159(ST6GAL1) 101108300(ST6GAL2) 114113140
ODA: 120851443(ST6GAL2) 120872484(ST6GAL1)
CCAD: 122441795(ST6GAL2) 122444810(ST6GAL1)
SSC: 100302026(ST6GAL1) 100512775(ST6GAL2)
CFR: 102508797(ST6GAL2) 102512873(ST6GAL1)
CBAI: 105072236(ST6GAL2) 105072335(ST6GAL1)
CDK: 105085840(ST6GAL1) 105099139(ST6GAL2)
VPC: 102528330(ST6GAL1) 102531986(ST6GAL2)
BACU: 103009068(ST6GAL2) 103012200(ST6GAL1)
LVE: 103073782(ST6GAL2) 103086030(ST6GAL1)
OOR: 101273721(ST6GAL2) 101285111(ST6GAL1)
DLE: 111172829(ST6GAL1) 111187445(ST6GAL2)
PCAD: 102984003(ST6GAL2) 102992136(ST6GAL1)
PSIU: 116753628(ST6GAL1) 116764529(ST6GAL2)
ECB: 100059539(ST6GAL1) 100062033(ST6GAL2)
EPZ: 103555423(ST6GAL2) 103567256(ST6GAL1)
EAI: 106829390(ST6GAL2) 106832544(ST6GAL1)
MYB: 102241174(ST6GAL2) 102244256(ST6GAL1)
MYD: 102753980(ST6GAL1) 102768324(ST6GAL2)
MMYO: 118675025(ST6GAL2) 118675850(ST6GAL1)
MLF: 102428852(ST6GAL1) 102432063(ST6GAL2)
MNA: 107527306(ST6GAL1) 107528699(ST6GAL2)
PKL: 118722907(ST6GAL1) 118724274(ST6GAL2)
HAI: 109375943(ST6GAL2) 109396927(ST6GAL1)
DRO: 112297515(ST6GAL2) 112308352(ST6GAL1)
SHON: 118979900(ST6GAL1) 119003878(ST6GAL2)
AJM: 119039092(ST6GAL1) 119049381(ST6GAL2)
PDIC: 114490820(ST6GAL1) 114498034(ST6GAL2)
PHAS: 123816330(ST6GAL2) 123826798(ST6GAL1)
MMF: 118617058(ST6GAL1) 118626624(ST6GAL2)
RFQ: 117020133(ST6GAL2) 117034495(ST6GAL1)
PALE: 102886717(ST6GAL1) 102890603(ST6GAL2)
PGIG: 120584474(ST6GAL2) 120593008(ST6GAL1)
PVP: 105302060(ST6GAL2) 105306693(ST6GAL1)
RAY: 107497054(ST6GAL2) 107505891(ST6GAL1)
MJV: 108388564 108401260(ST6GAL1)
TOD: 119257382(ST6GAL1) 119259294(ST6GAL2)
SARA: 101540090(ST6GAL1) 101554513(ST6GAL2)
LAV: 100660981(ST6GAL2) 100664378(ST6GAL1)
TMU: 101351955 101355743
DNM: 101416649(ST6GAL2) 101440843(ST6GAL1)
MDO: 100019249(ST6GAL2) 100617174(ST6GAL1)
GAS: 123242597(ST6GAL2) 123244652(ST6GAL1)
SHR: 100922140(ST6GAL1) 100932183(ST6GAL2)
PCW: 110209426(ST6GAL2) 110221205(ST6GAL1)
OAA: 100077134(ST6GAL2) 100093341(ST6GAL1)
GGA: 396169(ST6GAL1) 403122(ST6GAL2)
PCOC: 116230961(ST6GAL1) 116236510(ST6GAL2)
MGP: 100545097(ST6GAL2) 100548556 104909223(ST6GAL1)
CJO: 107306533(ST6GAL2) 107317947(ST6GAL1)
NMEL: 110397396(ST6GAL1) 110406996(ST6GAL2)
APLA: 101796015(ST6GAL2) 101803267(ST6GAL1)
ACYG: 106040277(ST6GAL1) 106041658(ST6GAL2)
AFUL: 116492346(ST6GAL1) 116502305(ST6GAL2)
TGU: 100226346(ST6GAL1) 100230425(ST6GAL2)
LSR: 110478726(ST6GAL2) 110484834(ST6GAL1)
SCAN: 103812379(ST6GAL2) 103815542(ST6GAL1)
PMOA: 120504713(ST6GAL2) 120511219(ST6GAL1)
OTC: 121342181(ST6GAL1) 121343184(ST6GAL2)
PRUF: 121354112(ST6GAL2) 121364093(ST6GAL1)
GFR: 102038321(ST6GAL2) 102042024(ST6GAL1)
FAB: 101810086(ST6GAL2) 101820079(ST6GAL1)
PHI: 102107561(ST6GAL1) 102109099(ST6GAL2)
PMAJ: 107208898(ST6GAL1) 107211419(ST6GAL2)
CCAE: 111922685(ST6GAL2) 111933760(ST6GAL1)
CCW: 104686087(ST6GAL2) 104693051(ST6GAL1)
ETL: 114057719(ST6GAL1) 114066979(ST6GAL2)
ZAB: 102061790(ST6GAL1) 102072477(ST6GAL2)
FPG: 101914140(ST6GAL2) 101924763(ST6GAL1)
FCH: 102056735(ST6GAL2) 102058385(ST6GAL1)
CLV: 102087342(ST6GAL2) 102097093(ST6GAL1)
EGZ: 104126364(ST6GAL2) 104135489(ST6GAL1)
NNI: 104019355(ST6GAL2) 104023676(ST6GAL1)
ACUN: 113481283(ST6GAL2) 113483390(ST6GAL1)
TALA: 104359297(ST6GAL2) 104362965(ST6GAL1)
PADL: 103912776(ST6GAL1) 103918841(ST6GAL2)
ACHC: 115334558(ST6GAL2) 115347041(ST6GAL1)
AAM: 106494052(ST6GAL2) 106496189(ST6GAL1)
AROW: 112972895(ST6GAL1) 112974825(ST6GAL2)
NPD: 112943323(ST6GAL2) 112946787(ST6GAL1)
DNE: 112984983(ST6GAL2) 112988867(ST6GAL1)
ASN: 102372316(ST6GAL2) 102373489(ST6GAL1)
AMJ: 102569903(ST6GAL2) 102575767(ST6GAL1)
CPOO: 109306264(ST6GAL2)
GGN: 109288223 109303134(ST6GAL2)
PSS: 102446128(ST6GAL1) 102453477(ST6GAL2)
CMY: 102941507(ST6GAL1) 102943395(ST6GAL2)
CPIC: 101939719 101943605(ST6GAL1) 101950728(ST6GAL2)
TST: 117870744(ST6GAL2) 117882544(ST6GAL1)
CABI: 116829117(ST6GAL2) 116835529(ST6GAL1)
MRV: 120371860(ST6GAL1) 120403670(ST6GAL2)
ACS: 100529108(st6gal2) 100529109(st6gal1)
PVT: 110074124(ST6GAL2) 110088940(ST6GAL1)
SUND: 121925605(ST6GAL2) 121926333(ST6GAL1)
PBI: 103050106 103061620(ST6GAL1) 103062404(ST6GAL2)
PMUR: 107286474 107288840(ST6GAL2)
TSR: 106540309(ST6GAL2) 106545885 106550706(ST6GAL1)
PGUT: 117666699(ST6GAL2) 117667611 117678419(ST6GAL1)
VKO: 123022793(ST6GAL2) 123024715(ST6GAL1)
PMUA: 114595050 114596422(ST6GAL2) 114597762(ST6GAL1)
ZVI: 118082642 118085557(ST6GAL2) 118093379(ST6GAL1)
GJA: 107110554(ST6GAL1) 107115211 107125130(ST6GAL2)
STOW: 125430673(ST6GAL2) 125437616(ST6GAL1) 125438026
XLA: 108708393(st6gal2.L) 108709694(st6gal2.S) 108717116(st6gal1.L) 108718183(st6gal1.S)
XTR: 100491268(st6gal1) 407846(st6gal2)
NPR: 108785132(ST6GAL2) 108785675(ST6GAL1)
RTEM: 120926493(ST6GAL2) 120936554
BBUF: 120995691(ST6GAL2) 120997659
BGAR: 122932146(ST6GAL2) 122934932 122935669 122935754
DRE: 403116(st6gal2a) 445376(st6gal1) 797439(st6gal2b)
SRX: 107716800 107721598 107737638 107738307 107748529 107749927
SANH: 107667425 107676409 107677626 107688722 107688830
SGH: 107551073 107557092 107559923 107579700 107590095 107596313 107602911
CCAR: 109045233 109047012 109055305 109083062
CAUA: 113038435 113050753 113053649 113064017 113096939 113108909
PPRM: 120476878 120487078(st6gal2a) 120494534(st6gal1)
MAMB: 125252389(st6gal1) 125269992(st6gal2a) 125274273(st6gal2b)
IPU: 108266814(st6gal2a) 108273345(st6gal2b) 108279262(st6gal1)
PHYP: 113525857(st6gal2) 113538434 113541806
SMEO: 124381199(st6gal2a) 124395090(st6gal2b) 124398265(st6gal1)
TFD: 113634586(st6gal2b) 113649250(st6gal1) 113654438(st6gal2a)
AMEX: 103024101(st6gal2) 103030360 103031874 103041793
EEE: 113574044 113575118 113576168(st6gal1) 113584885(st6gal2)
TRU: 445982(st6gal1) 777969(st6gal2)
TNG: GSTEN00014664G001 GSTEN00025958G001
LCO: 104921796 104932096(st6gal2) 104934011
NCC: 104957421(st6gal2)
CGOB: 115004959 115018853 115026027(st6gal2)
ELY: 117249972 117251267 117270352(st6gal1)
PLEP: 121938258 121938259 121943586 121949028(st6gal2a)
SLUC: 116044405 116046205(st6gal2a) 116065100(st6gal1)
ECRA: 117953358(st6gal2a)
PFLV: 114550857 114563738(st6gal2) 114567309
GAT: 100653424(st6gal2) 100653425(st6gal1)
PPUG: 119215869(st6gal1) 119229337(st6gal2a)
MSAM: 119894937(st6gal1) 119904276 119907989
CUD: 121519008(st6gal1) 121522671(st6gal2a)
MZE: 101464130(st6gal2) 101466910
ONL: 100694560 100704184(st6gal2)
OAU: 116316053(st6gal2a) 116333190(st6gal1)
OLA: 100049380(st6gal1) 100049381(st6gal2)
OML: 112138424 112141097(st6gal1) 112154825(st6gal2a)
XMA: 102229475(st6gal2) 102231535
XCO: 114148521(st6gal2) 114152599
XHE: 116722651(st6gal2) 116727860
PRET: 103476390 103480039(st6gal2)
PFOR: 103131043 103140339(st6gal2)
PLAI: 106942835 106962186(st6gal2)
PMEI: 106906094 106920884(st6gal2)
GAF: 122840278(st6gal2a) 122845362(st6gal1)
CVG: 107090303 107096899(st6gal2)
CTUL: 119786340(st6gal2a) 119796480(st6gal1)
GMU: 124871936(st6gal2a) 124876266(st6gal1)
NFU: 107384328 107389803(st6gal2)
KMR: 108232466(st6gal2a) 108243592 108243597
ALIM: 106514661 106519824(st6gal2)
NWH: 119418902(st6gal2a) 119420388(st6gal1) 119420399
AOCE: 111563401(st6gal1) 111570337 111582969(st6gal2)
CSEM: 103391691(st6gal2)
POV: 109631344(st6gal2) 109646428
SSEN: 122762074(st6gal2a) 122779139(st6gal1)
HHIP: 117754658(st6gal2a) 117774386 117774387
LCF: 108881134 108896041 108901078(st6gal2)
SDU: 111218195(st6gal2) 111221384(st6gal1)
SLAL: 111646873 111650885 111662108(st6gal2)
XGL: 120787429 120801293 120802949(st6gal1)
HCQ: 109513608 109530661(st6gal2)
BPEC: 110165642 110173121(st6gal2)
MALB: 109965389(st6gal2) 109975054
SASA: 106574443 106575252 106581977 106586768(st6gal2) 106602846
OTW: 112217143(st6gal1) 112225352 112242254(st6gal2a) 112253842 112266493
OMY: 110490100(st6gal1) 110495849 110501323 110520551(st6gal2a) 110527464
OGO: 123994779(st6gal1) 124007870 124010940 124044204 124044292
ONE: 115106811 115117282 115125434 115129715 115133197
SALP: 111950888 111953561 111959690 111970910 111979892
SNH: 120033199 120051296 120057632(st6gal1) 120058500 120064313
ELS: 105009022 105016575(st6gal2) 105022087
SFM: 108920576 108927597 108933083(st6gal2) 108934100
PKI: 111833845(st6gal2) 111838084 111843653 111849057 111852948
AANG: 118213679(st6gal2a) 118234825(st6gal1)
LOC: 102691434(st6gal1) 102695769 102698912(st6gal2)
PSPA: 121306614 121320710 121322737 121326348 121328039
ARUT: 117404466 117405923 117407276 117416731 117422944 117968653
LCM: 102359235(ST6GAL2) 102360214 102360354
CMK: 103172241(st6gal2) 103174913
RTP: 109913154 109918596(st6gal1) 109934254
BFO: 118418499
BBEL: 109473601
SLIU: 111356139
LSM: 121120432 121124334 121124515 121124600 121124615 121124811 121124886 121127991 121131888
CITZ: E4Z61_12370
SGOE: A8O29_017140
HDU: HD_0053
HPAA: E5Q53_07855
PMU: PM0188
PMV: PMCN06_1112
PUL: NT08PM_1144
PMP: Pmu_11250
PMUL: DR93_1878
PDAG: 4362423_01162
SWP: swp_5060
 » show all
Reference
1  [PMID:5726897]
  Authors
Spiro MJ, Spiro RG.
  Title
Glycoprotein biosynthesis: studies on thyroglobulin. Thyroid sialyltransferase.
  Journal
J Biol Chem 243:6520-8 (1968)
Reference
2  [PMID:4313609]
  Authors
Hickman J, Ashwell G, Morell AG, van den Hamer CJ, Scheinberg IH.
  Title
Physical and chemical studies on ceruloplasmin. 8. Preparation of N-acetylneuraminic acid-1-14C-labeled ceruloplasmin.
  Journal
J Biol Chem 245:759-66 (1970)
Reference
3  [PMID:4723915]
  Authors
Bartholomew BA, Jourdian GW, Roseman S.
  Title
The sialic acids. XV. Transfer of sialic acid to glycoproteins by a sialyltransferase from colostrum.
  Journal
J Biol Chem 248:5751-62 (1973)
Reference
4  [PMID:849932]
  Authors
Paulson JC, Beranek WE, Hill RL.
  Title
Purification of a sialyltransferase from bovine colostrum by affinity chromatography on CDP-agarose.
  Journal
J Biol Chem 252:2356-62 (1977)
Reference
5  [PMID:6366476]
  Authors
Schachter H, Narasimhan S, Gleeson P, Vella G.
  Title
Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type.
  Journal
Methods Enzymol 98:98-134 (1983)
DOI:10.1016/0076-6879(83)98143-0
Reference
6  [PMID:2460092]
  Authors
Albarracin I, Lassaga FE, Caputto R.
  Title
Purification and characterization of an endogenous inhibitor of the sialyltransferase CMP-N-acetylneuraminate: lactosylceramide alpha 2,6-N-acetylneuraminyltransferase (EC 2.4.99.-).
  Journal
Biochem J 254:559-65 (1988)
DOI:10.1042/bj2540559
Other DBs
ExplorEnz - The Enzyme Database: 2.4.3.1
IUBMB Enzyme Nomenclature: 2.4.3.1
ExPASy - ENZYME nomenclature database: 2.4.3.1
BRENDA, the Enzyme Database: 2.4.3.1
CAS: 9075-81-4

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Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (21)   
   KEGG COMPOUND (8)   
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Chemical reaction (11)   
   KEGG REACTION (9)   
   KEGG RCLASS (2)   
Gene (622)   
   KEGG ORTHOLOGY (3)   
   KEGG GENES (619)   
Protein sequence (1)   
   PMD (1)   
All databases (662)   

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