KEGG   ENZYME: 2.4.3.1
Entry
EC 2.4.3.1                  Enzyme                                 
Name
beta-galactoside alpha-(2,6)-sialyltransferase;
ST6Gal-I;
CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase;
lactosylceramide alpha-2,6-N-sialyltransferase;
CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine alpha-(2->6)-N-acetylneuraminyltransferase;
beta-galactoside alpha-2,6-sialyltransferase
Class
Transferases;
Glycosyltransferases;
Sialyltransferases
Sysname
CMP-N-acetyl-beta-neuraminate:beta-D-galactoside alpha-(2->6)-N-acetylneuraminyltransferase (configuration-inverting)
Reaction(IUBMB)
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
Reaction(KEGG)
(other) R03489 R04532 R05580 R05905(G) R05906(G) R05990(G) R06121(G) R06188(G) R09298(G)
Substrate
CMP-N-acetyl-beta-neuraminate [CPD:C00128];
beta-D-galactosyl-R [CPD:C02900]
Product
CMP [CPD:C00055];
N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
Comment
The enzyme acts on the terminal non-reducing beta-D-galactosyl residue of the oligosaccharide moiety of glycoproteins and glycolipids.
History
EC 2.4.3.1 created 1972 as EC 2.4.99.1, modified 1976, modified 1986, modified 2017 (EC 2.4.99.11 created 1992, incorporated 2016), modified 2017, transferred 2021 to EC 2.4.3.1
Pathway
ec00510  N-Glycan biosynthesis
ec00514  Other types of O-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K00778  beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1)
K00779  beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 2)
K12248  beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 0160)
Genes
HSA6480(ST6GAL1) 84620(ST6GAL2)
PTR450198(ST6GAL2) 460922(ST6GAL1)
PPS100969795(ST6GAL1) 100981465(ST6GAL2)
GGO101129847(ST6GAL2) 101142727(ST6GAL1)
PON100174088(ST6GAL1) 100456090(ST6GAL2)
NLE100580010(ST6GAL2) 100599869(ST6GAL1)
MCC708113(ST6GAL1) 713552(ST6GAL2)
MCF102121444(ST6GAL1) 102142751(ST6GAL2)
CSAB103241198(ST6GAL2) 103241877(ST6GAL1)
CATY105575215(ST6GAL1) 105583608(ST6GAL2)
PANU101015073(ST6GAL1) 101020393(ST6GAL2)
TGE112604770(ST6GAL2) 112618316(ST6GAL1)
RRO104660586(ST6GAL2) 104682948(ST6GAL1)
RBB108512469(ST6GAL2) 108530462(ST6GAL1)
TFN117062254(ST6GAL2) 117084352(ST6GAL1)
PTEH111542246(ST6GAL2) 111544264(ST6GAL1)
CJC100408699(ST6GAL1) 100411939(ST6GAL2)
SBQ101032294(ST6GAL1) 101047107(ST6GAL2)
CSYR103258705(ST6GAL1) 103258958(ST6GAL2)
MMUR105856143(ST6GAL2) 105885054(ST6GAL1)
OGA100940735(ST6GAL2) 100958396(ST6GAL1)
MMU20440(St6gal1) 240119(St6gal2)
MCAL110284258(St6gal2) 110311654(St6gal1)
MPAH110329758(St6gal1) 110335627(St6gal2)
RNO25197(St6gal1) 301155(St6gal2)
MCOC116074404(St6gal2) 116086257(St6gal1)
MUN110548122(St6gal1) 110560861(St6gal2)
CGE100689389(St6gal1) 100763756(St6gal2)
PLEU114690834(St6gal2) 114697104(St6gal1)
NGI103726632(St6gal2) 103750114(St6gal1)
HGL101718025(St6gal1) 101722644(St6gal2)
CPOC100728814(St6gal2) 100730025(St6gal1)
CCAN109691378(St6gal1) 109701499(St6gal2)
DORD105999623(St6gal2) 105999709(St6gal1)
DSP122098101(St6gal1) 122121380(St6gal2)
NCAR124963670 124993421
OCU100353188(ST6GAL1) 100358153(ST6GAL2)
OPI101531549(ST6GAL1) 101536363(ST6GAL2)
TUP102499508(ST6GAL1) 102500330(ST6GAL2)
CFA478668(ST6GAL1) 481315(ST6GAL2)
VVP112915370(ST6GAL2) 112926300(ST6GAL1)
VLG121477448(ST6GAL1) 121492182(ST6GAL2)
AML100478457(ST6GAL2) 100481066(ST6GAL1)
UMR103670658(ST6GAL2) 103676045(ST6GAL1)
UAH113253796(ST6GAL1) 113267699(ST6GAL2)
UAR123775969(ST6GAL2) 123801285(ST6GAL1)
ELK111148556 111155957
LLV125101930 125109621
MPUF101672771(ST6GAL1) 101684375(ST6GAL2)
ORO101374165(ST6GAL2) 101377549(ST6GAL1)
EJU114206991(ST6GAL1) 114209673(ST6GAL2)
ZCA113916141(ST6GAL1) 113930689 113938342(ST6GAL2)
MLX117999602 118006926(ST6GAL1) 118008290(ST6GAL2)
FCA101097832(ST6GAL1) 101098620(ST6GAL2)
PYU121016472(ST6GAL2) 121034129(ST6GAL1)
PBG122491626(ST6GAL1) 122496660(ST6GAL2)
PTG102956769(ST6GAL1) 102962032(ST6GAL2)
PPAD109254527(ST6GAL2) 109275279(ST6GAL1)
AJU106968006(ST6GAL1) 106977960(ST6GAL2)
HHV120224465(ST6GAL2) 120233104(ST6GAL1)
BTA282073(ST6GAL1) 493992(ST6GAL2)
BOM102273022(ST6GAL1) 102285977(ST6GAL2)
BIU109556984(ST6GAL1) 109566122(ST6GAL2)
BBUB102400138(ST6GAL1) 102408407(ST6GAL2)
CHX100861310(ST6GAL1) 102179776(ST6GAL2)
OAS100913159(ST6GAL1) 101108300(ST6GAL2) 114113140
ODA120851443(ST6GAL2) 120872484(ST6GAL1)
CCAD122441795(ST6GAL2) 122444810(ST6GAL1)
SSC100302026(ST6GAL1) 100512775(ST6GAL2)
CFR102508797(ST6GAL2) 102512873(ST6GAL1)
CBAI105072236(ST6GAL2) 105072335(ST6GAL1)
CDK105085840(ST6GAL1) 105099139(ST6GAL2)
VPC102528330(ST6GAL1) 102531986(ST6GAL2)
BACU103009068(ST6GAL2) 103012200(ST6GAL1)
LVE103073782(ST6GAL2) 103086030(ST6GAL1)
OOR101273721(ST6GAL2) 101285111(ST6GAL1)
DLE111172829(ST6GAL1) 111187445(ST6GAL2)
PCAD102984003(ST6GAL2) 102992136(ST6GAL1)
PSIU116753628(ST6GAL1) 116764529(ST6GAL2)
ECB100059539(ST6GAL1) 100062033(ST6GAL2)
EPZ103555423(ST6GAL2) 103567256(ST6GAL1)
EAI106829390(ST6GAL2) 106832544(ST6GAL1)
MYB102241174(ST6GAL2) 102244256(ST6GAL1)
MYD102753980(ST6GAL1) 102768324(ST6GAL2)
MMYO118675025(ST6GAL2) 118675850(ST6GAL1)
MLF102428852(ST6GAL1) 102432063(ST6GAL2)
MNA107527306(ST6GAL1) 107528699(ST6GAL2)
PKL118722907(ST6GAL1) 118724274(ST6GAL2)
HAI109375943(ST6GAL2) 109396927(ST6GAL1)
DRO112297515(ST6GAL2) 112308352(ST6GAL1)
SHON118979900(ST6GAL1) 119003878(ST6GAL2)
AJM119039092(ST6GAL1) 119049381(ST6GAL2)
PDIC114490820(ST6GAL1) 114498034(ST6GAL2)
PHAS123816330(ST6GAL2) 123826798(ST6GAL1)
MMF118617058(ST6GAL1) 118626624(ST6GAL2)
RFQ117020133(ST6GAL2) 117034495(ST6GAL1)
PALE102886717(ST6GAL1) 102890603(ST6GAL2)
PGIG120584474(ST6GAL2) 120593008(ST6GAL1)
PVP105302060(ST6GAL2) 105306693(ST6GAL1)
RAY107497054(ST6GAL2) 107505891(ST6GAL1)
MJV108388564 108401260(ST6GAL1)
TOD119257382(ST6GAL1) 119259294(ST6GAL2)
SARA101540090(ST6GAL1) 101554513(ST6GAL2)
LAV100660981(ST6GAL2) 100664378(ST6GAL1)
TMU101351955 101355743
DNM101416649(ST6GAL2) 101440843(ST6GAL1)
MDO100019249(ST6GAL2) 100617174(ST6GAL1)
GAS123242597(ST6GAL2) 123244652(ST6GAL1)
SHR100922140(ST6GAL1) 100932183(ST6GAL2)
PCW110209426(ST6GAL2) 110221205(ST6GAL1)
OAA100077134(ST6GAL2) 100093341(ST6GAL1)
GGA396169(ST6GAL1) 403122(ST6GAL2)
PCOC116230961(ST6GAL1) 116236510(ST6GAL2)
MGP100545097(ST6GAL2) 100548556 104909223(ST6GAL1)
CJO107306533(ST6GAL2) 107317947(ST6GAL1)
NMEL110397396(ST6GAL1) 110406996(ST6GAL2)
APLA101796015(ST6GAL2) 101803267(ST6GAL1)
ACYG106040277(ST6GAL1) 106041658(ST6GAL2)
AFUL116492346(ST6GAL1) 116502305(ST6GAL2)
TGU100226346(ST6GAL1) 100230425(ST6GAL2)
LSR110478726(ST6GAL2) 110484834(ST6GAL1)
SCAN103812379(ST6GAL2) 103815542(ST6GAL1)
PMOA120504713(ST6GAL2) 120511219(ST6GAL1)
OTC121342181(ST6GAL1) 121343184(ST6GAL2)
PRUF121354112(ST6GAL2) 121364093(ST6GAL1)
GFR102038321(ST6GAL2) 102042024(ST6GAL1)
FAB101810086(ST6GAL2) 101820079(ST6GAL1)
PHI102107561(ST6GAL1) 102109099(ST6GAL2)
PMAJ107208898(ST6GAL1) 107211419(ST6GAL2)
CCAE111922685(ST6GAL2) 111933760(ST6GAL1)
CCW104686087(ST6GAL2) 104693051(ST6GAL1)
ETL114057719(ST6GAL1) 114066979(ST6GAL2)
ZAB102061790(ST6GAL1) 102072477(ST6GAL2)
FPG101914140(ST6GAL2) 101924763(ST6GAL1)
FCH102056735(ST6GAL2) 102058385(ST6GAL1)
CLV102087342(ST6GAL2) 102097093(ST6GAL1)
EGZ104126364(ST6GAL2) 104135489(ST6GAL1)
NNI104019355(ST6GAL2) 104023676(ST6GAL1)
ACUN113481283(ST6GAL2) 113483390(ST6GAL1)
TALA104359297(ST6GAL2) 104362965(ST6GAL1)
PADL103912776(ST6GAL1) 103918841(ST6GAL2)
ACHC115334558(ST6GAL2) 115347041(ST6GAL1)
AAM106494052(ST6GAL2) 106496189(ST6GAL1)
AROW112972895(ST6GAL1) 112974825(ST6GAL2)
NPD112943323(ST6GAL2) 112946787(ST6GAL1)
DNE112984983(ST6GAL2) 112988867(ST6GAL1)
ASN102372316(ST6GAL2) 102373489(ST6GAL1)
AMJ102569903(ST6GAL2) 102575767(ST6GAL1)
CPOO109306264(ST6GAL2)
GGN109288223 109303134(ST6GAL2)
PSS102446128(ST6GAL1) 102453477(ST6GAL2)
CMY102941507(ST6GAL1) 102943395(ST6GAL2)
CPIC101939719 101943605(ST6GAL1) 101950728(ST6GAL2)
TST117870744(ST6GAL2) 117882544(ST6GAL1)
CABI116829117(ST6GAL2) 116835529(ST6GAL1)
MRV120371860(ST6GAL1) 120403670(ST6GAL2)
ACS100529108(st6gal2) 100529109(st6gal1)
PVT110074124(ST6GAL2) 110088940(ST6GAL1)
SUND121925605(ST6GAL2) 121926333(ST6GAL1)
PBI103050106 103061620(ST6GAL1) 103062404(ST6GAL2)
PMUR107286474 107288840(ST6GAL2)
TSR106540309(ST6GAL2) 106545885 106550706(ST6GAL1)
PGUT117666699(ST6GAL2) 117667611 117678419(ST6GAL1)
VKO123022793(ST6GAL2) 123024715(ST6GAL1)
PMUA114595050 114596422(ST6GAL2) 114597762(ST6GAL1)
ZVI118082642 118085557(ST6GAL2) 118093379(ST6GAL1)
GJA107110554(ST6GAL1) 107115211 107125130(ST6GAL2)
STOW125430673(ST6GAL2) 125437616(ST6GAL1) 125438026
XLA108708393(st6gal2.L) 108709694(st6gal2.S) 108717116(st6gal1.L) 108718183(st6gal1.S)
XTR100491268(st6gal1) 407846(st6gal2)
NPR108785132(ST6GAL2) 108785675(ST6GAL1)
RTEM120926493(ST6GAL2) 120936554
BBUF120995691(ST6GAL2) 120997659
BGAR122932146(ST6GAL2) 122934932 122935669 122935754
DRE403116(st6gal2a) 445376(st6gal1) 797439(st6gal2b)
SRX107716800 107721598 107737638 107738307 107748529 107749927
SANH107667425 107676409 107677626 107688722 107688830
SGH107551073 107557092 107559923 107579700 107590095 107596313 107602911
CCAR109045233 109047012 109055305 109083062
CAUA113038435 113050753 113053649 113064017 113096939 113108909
PPRM120476878 120487078(st6gal2a) 120494534(st6gal1)
MAMB125252389(st6gal1) 125269992(st6gal2a) 125274273(st6gal2b)
IPU108266814(st6gal2a) 108273345(st6gal2b) 108279262(st6gal1)
PHYP113525857(st6gal2) 113538434 113541806
SMEO124381199(st6gal2a) 124395090(st6gal2b) 124398265(st6gal1)
TFD113634586(st6gal2b) 113649250(st6gal1) 113654438(st6gal2a)
AMEX103024101(st6gal2) 103030360 103031874 103041793
EEE113574044 113575118 113576168(st6gal1) 113584885(st6gal2)
TRU445982(st6gal1) 777969(st6gal2)
TNGGSTEN00014664G001 GSTEN00025958G001
LCO104921796 104932096(st6gal2) 104934011
NCC104957421(st6gal2)
CGOB115004959 115018853 115026027(st6gal2)
ELY117249972 117251267 117270352(st6gal1)
PLEP121938258 121938259 121943586 121949028(st6gal2a)
SLUC116044405 116046205(st6gal2a) 116065100(st6gal1)
ECRA117953358(st6gal2a)
PFLV114550857 114563738(st6gal2) 114567309
GAT100653424(st6gal2) 100653425(st6gal1)
PPUG119215869(st6gal1) 119229337(st6gal2a)
MSAM119894937(st6gal1) 119904276 119907989
CUD121519008(st6gal1) 121522671(st6gal2a)
MZE101464130(st6gal2) 101466910
ONL100694560 100704184(st6gal2)
OAU116316053(st6gal2a) 116333190(st6gal1)
OLA100049380(st6gal1) 100049381(st6gal2)
OML112138424 112141097(st6gal1) 112154825(st6gal2a)
XMA102229475(st6gal2) 102231535
XCO114148521(st6gal2) 114152599
XHE116722651(st6gal2) 116727860
PRET103476390 103480039(st6gal2)
PFOR103131043 103140339(st6gal2)
PLAI106942835 106962186(st6gal2)
PMEI106906094 106920884(st6gal2)
GAF122840278(st6gal2a) 122845362(st6gal1)
CVG107090303 107096899(st6gal2)
CTUL119786340(st6gal2a) 119796480(st6gal1)
GMU124871936(st6gal2a) 124876266(st6gal1)
NFU107384328 107389803(st6gal2)
KMR108232466(st6gal2a) 108243592 108243597
ALIM106514661 106519824(st6gal2)
NWH119418902(st6gal2a) 119420388(st6gal1) 119420399
AOCE111563401(st6gal1) 111570337 111582969(st6gal2)
CSEM103391691(st6gal2)
POV109631344(st6gal2) 109646428
SSEN122762074(st6gal2a) 122779139(st6gal1)
HHIP117754658(st6gal2a) 117774386 117774387
LCF108881134 108896041 108901078(st6gal2)
SDU111218195(st6gal2) 111221384(st6gal1)
SLAL111646873 111650885 111662108(st6gal2)
XGL120787429 120801293 120802949(st6gal1)
HCQ109513608 109530661(st6gal2)
BPEC110165642 110173121(st6gal2)
MALB109965389(st6gal2) 109975054
SASA106574443 106575252 106581977 106586768(st6gal2) 106602846
OTW112217143(st6gal1) 112225352 112242254(st6gal2a) 112253842 112266493
OMY110490100(st6gal1) 110495849 110501323 110520551(st6gal2a) 110527464
OGO123994779(st6gal1) 124007870 124010940 124044204 124044292
ONE115106811 115117282 115125434 115129715 115133197
SALP111950888 111953561 111959690 111970910 111979892
SNH120033199 120051296 120057632(st6gal1) 120058500 120064313
ELS105009022 105016575(st6gal2) 105022087
SFM108920576 108927597 108933083(st6gal2) 108934100
PKI111833845(st6gal2) 111838084 111843653 111849057 111852948
AANG118213679(st6gal2a) 118234825(st6gal1)
LOC102691434(st6gal1) 102695769 102698912(st6gal2)
PSPA121306614 121320710 121322737 121326348 121328039
ARUT117404466 117405923 117407276 117416731 117422944 117968653
LCM102359235(ST6GAL2) 102360214 102360354
CMK103172241(st6gal2) 103174913
RTP109913154 109918596(st6gal1) 109934254
BFO118418499
BBEL109473601
SLIU111356139
LSM121120432 121124334 121124515 121124600 121124615 121124811 121124886 121127991 121131888
CITZE4Z61_12370
SGOEA8O29_017140
HDUHD_0053
HPAAE5Q53_07855
PMUPM0188
PMVPMCN06_1112
PULNT08PM_1144
PMPPmu_11250
PMULDR93_1878
PDAG4362423_01162
SWPswp_5060
 » show all
Reference
1  [PMID:5726897]
  Authors
Spiro MJ, Spiro RG.
  Title
Glycoprotein biosynthesis: studies on thyroglobulin. Thyroid sialyltransferase.
  Journal
J Biol Chem 243:6520-8 (1968)
Reference
2  [PMID:4313609]
  Authors
Hickman J, Ashwell G, Morell AG, van den Hamer CJ, Scheinberg IH.
  Title
Physical and chemical studies on ceruloplasmin. 8. Preparation of N-acetylneuraminic acid-1-14C-labeled ceruloplasmin.
  Journal
J Biol Chem 245:759-66 (1970)
Reference
3  [PMID:4723915]
  Authors
Bartholomew BA, Jourdian GW, Roseman S.
  Title
The sialic acids. XV. Transfer of sialic acid to glycoproteins by a sialyltransferase from colostrum.
  Journal
J Biol Chem 248:5751-62 (1973)
Reference
4  [PMID:849932]
  Authors
Paulson JC, Beranek WE, Hill RL.
  Title
Purification of a sialyltransferase from bovine colostrum by affinity chromatography on CDP-agarose.
  Journal
J Biol Chem 252:2356-62 (1977)
Reference
5  [PMID:6366476]
  Authors
Schachter H, Narasimhan S, Gleeson P, Vella G.
  Title
Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type.
  Journal
Methods Enzymol 98:98-134 (1983)
DOI:10.1016/0076-6879(83)98143-0
Reference
6  [PMID:2460092]
  Authors
Albarracin I, Lassaga FE, Caputto R.
  Title
Purification and characterization of an endogenous inhibitor of the sialyltransferase CMP-N-acetylneuraminate: lactosylceramide alpha 2,6-N-acetylneuraminyltransferase (EC 2.4.99.-).
  Journal
Biochem J 254:559-65 (1988)
DOI:10.1042/bj2540559
Other DBs
ExplorEnz - The Enzyme Database: 2.4.3.1
IUBMB Enzyme Nomenclature: 2.4.3.1
ExPASy - ENZYME nomenclature database: 2.4.3.1
BRENDA, the Enzyme Database: 2.4.3.1
CAS: 9075-81-4

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