KEGG   ENZYME: 2.4.3.7
Entry
EC 2.4.3.7                  Enzyme                                 
Name
alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-alpha-sialyltransferase;
sialyltransferase;
cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase;
alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase;
SIAT7;
ST6GALNAC;
(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase;
CMP-N-acetylneuraminate:(alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3)-N-acetyl-D-galactosaminide alpha-2,6-N-acetylneuraminyl-transferase
Class
Transferases;
Glycosyltransferases;
Sialyltransferases
Sysname
CMP-N-acetylneuraminate:N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)- N-acetyl-D-galactosaminide galactosamine-6-alpha-N-acetylneuraminyltransferase
Reaction(IUBMB)
CMP-N-acetylneuraminate + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R [RN:R04635]
Reaction(KEGG)
R04635 > R05914(G) R05959(G)
Substrate
CMP-N-acetylneuraminate [CPD:C00128];
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R [CPD:C04885]
Product
CMP [CPD:C00055];
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R [CPD:C04926]
Comment
Attaches N-acetylneuraminic acid in alpha-2,6-linkage to N-acetylgalactosamine only when present in the structure of alpha-N-acetylneuraminyl-(2->3)-beta-galactosyl-(1->3)-N-acetylgalactosaminyl-R, where R may be protein or p-nitrophenol. Not identical with EC 2.4.3.3 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase.
History
EC 2.4.3.7 created 1984 as EC 2.4.99.7, modified 1986, modified 2004, transferred 2022 to EC 2.4.3.7
Pathway
ec00512  Mucin type O-glycan biosynthesis
ec00604  Glycosphingolipid biosynthesis - ganglio series
ec01100  Metabolic pathways
Orthology
K03373  N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7C)
K03374  N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7D)
Genes
HSA256435(ST6GALNAC3) 27090(ST6GALNAC4)
PTR450108(ST6GALNAC4) 450115(ST6GALNAC3)
PPS100985483(ST6GALNAC3) 100995780(ST6GALNAC4)
GGO101143514(ST6GALNAC3) 101151595(ST6GALNAC4)
PON100174350(ST6GALNAC3) 100439613(ST6GALNAC4)
NLE100598104(ST6GALNAC4) 100603395(ST6GALNAC3)
MCC705879(ST6GALNAC4) 709779(ST6GALNAC3)
MCF102122701(ST6GALNAC3) 102142909(ST6GALNAC4)
CSAB103224585(ST6GALNAC3) 103239817(ST6GALNAC4)
CATY105576245(ST6GALNAC4) 105595840(ST6GALNAC3)
PANU101003942(ST6GALNAC4) 101007845(ST6GALNAC3)
TGE112608484(ST6GALNAC4) 112627356(ST6GALNAC3)
RRO104665870(ST6GALNAC4) 104666528(ST6GALNAC3)
RBB108533045(ST6GALNAC3) 108542735(ST6GALNAC4)
TFN117072089(ST6GALNAC4) 117092117(ST6GALNAC3)
PTEH111540761(ST6GALNAC3) 111545892(ST6GALNAC4)
CJC100398966(ST6GALNAC3) 100401438(ST6GALNAC4)
SBQ101032564(ST6GALNAC3) 101037868(ST6GALNAC4)
CSYR103249658(ST6GALNAC4) 103255472(ST6GALNAC3)
MMUR105875232(ST6GALNAC4) 105884196(ST6GALNAC3)
OGA100956132(ST6GALNAC4) 100959396(ST6GALNAC3)
MMU20447(St6galnac3) 20448(St6galnac4)
MCAL110288812(St6galnac4) 110290963(St6galnac3)
MPAH110318527(St6galnac4) 110320284(St6galnac3)
RNO29758(St6galnac3) 407764(St6galnac4)
MCOC116090006(St6galnac4) 116093960(St6galnac3)
MUN110562585(St6galnac4) 110563850
CGE100759065(St6galnac4) 100762285(St6galnac3)
PLEU114699850(St6galnac3) 114703806(St6galnac4)
NGI103727384(St6galnac4) 103746466(St6galnac3)
HGL101708035(St6galnac3) 101717187(St6galnac4)
CPOC100714995(St6galnac3) 100725743(St6galnac4)
CCAN109674707(St6galnac3) 109686789(St6galnac4)
DORD105989432(St6galnac4) 106000598(St6galnac3)
DSP122108893(St6galnac4) 122112725(St6galnac3)
NCAR124964447 124970744
OCU100345091(ST6GALNAC3) 100356933(ST6GALNAC4)
OPI101517138(ST6GALNAC3) 101530057(ST6GALNAC4)
TUP102476286(ST6GALNAC3) 102487439(ST6GALNAC4)
CFA490205(ST6GALNAC3) 609133(ST6GALNAC4)
VVP112924453(ST6GALNAC3) 112927918(ST6GALNAC4)
VLG121473947(ST6GALNAC4) 121486464(ST6GALNAC3)
AML100480565(ST6GALNAC4) 100481578(ST6GALNAC3)
UMR103662994(ST6GALNAC3) 103670294(ST6GALNAC4)
UAH113254511(ST6GALNAC3) 113266445(ST6GALNAC4)
UAR123775728(ST6GALNAC4) 123795299(ST6GALNAC3)
ELK111143388 111146222
LLV125083783 125097593
MPUF101672038(ST6GALNAC4) 101685214(ST6GALNAC3)
ORO101368864(ST6GALNAC4) 101382354(ST6GALNAC3)
EJU114208382(ST6GALNAC3) 114212880(ST6GALNAC4)
ZCA113910417(ST6GALNAC3) 113935149(ST6GALNAC4)
MLX118017643(ST6GALNAC4) 118018948(ST6GALNAC3)
FCA101091035(ST6GALNAC3) 101094459(ST6GALNAC4)
PYU121027334(ST6GALNAC3) 121035034(ST6GALNAC4)
PBG122474802(ST6GALNAC4) 122480656(ST6GALNAC3)
PTG102966320(ST6GALNAC4) 107178974(ST6GALNAC3)
PPAD109250108(ST6GALNAC4) 109266652(ST6GALNAC3)
AJU106966292(ST6GALNAC4) 113599298(ST6GALNAC3)
HHV120226552(ST6GALNAC3) 120230099(ST6GALNAC4)
BTA404124(ST6GALNAC4) 782689(ST6GALNAC3)
BOM102266270(ST6GALNAC3) 102287870(ST6GALNAC4)
BIU109556154(ST6GALNAC3)
BBUB102396911(ST6GALNAC4) 102415799(ST6GALNAC3)
CHX102170329(ST6GALNAC4) 102190655(ST6GALNAC3)
OAS101121471(ST6GALNAC3) 101123019(ST6GALNAC4)
ODA120852027(ST6GALNAC4) 120856978(ST6GALNAC3) 120861085
CCAD122436804(ST6GALNAC3) 122442199(ST6GALNAC4)
SSC100512173(ST6GALNAC3) 396676(ST6GALNAC4)
CFR102505545(ST6GALNAC3) 116663270(ST6GALNAC4)
CBAI105075522(ST6GALNAC3)
CDK105096656(ST6GALNAC3) 116152744(ST6GALNAC4)
VPC102533833(ST6GALNAC3) 116280369(ST6GALNAC4)
BACU103005340(ST6GALNAC4) 103020698(ST6GALNAC3)
LVE103085714(ST6GALNAC3) 103086160(ST6GALNAC4)
OOR101278803(ST6GALNAC4) 101285214(ST6GALNAC3)
DLE111177188(ST6GALNAC4) 111178407(ST6GALNAC3)
PCAD102980952(ST6GALNAC3) 102990591(ST6GALNAC4) 102993381
PSIU116740707(ST6GALNAC3) 116755365(ST6GALNAC4)
ECB100066966(ST6GALNAC3) 100067121(ST6GALNAC4)
EPZ103544980(ST6GALNAC4) 103549422(ST6GALNAC3)
EAI106836550(ST6GALNAC3) 106845456(ST6GALNAC4)
MYB102253595(ST6GALNAC3) 102261251(ST6GALNAC4)
MYD102754268(ST6GALNAC4) 102760172(ST6GALNAC3)
MMYO118667025(ST6GALNAC4) 118676600(ST6GALNAC3)
MLF102416817(ST6GALNAC4) 102428142(ST6GALNAC3)
MNA107535596(ST6GALNAC4) 107540092(ST6GALNAC3)
PKL118706661(ST6GALNAC4) 118723675(ST6GALNAC3)
HAI109379933(ST6GALNAC4) 109383481(ST6GALNAC3)
DRO112306353(ST6GALNAC4) 112309356(ST6GALNAC3)
SHON118980054(ST6GALNAC4)
AJM119040023(ST6GALNAC3) 119056496(ST6GALNAC4)
PDIC114497701(ST6GALNAC3) 114498801(ST6GALNAC4)
PHAS123816375(ST6GALNAC3) 123823346(ST6GALNAC4)
MMF118626740(ST6GALNAC3) 118629692(ST6GALNAC4)
RFQ117026467(ST6GALNAC3) 117032330(ST6GALNAC4)
PALE102881827(ST6GALNAC4) 102894086(ST6GALNAC3)
PGIG120583241(ST6GALNAC3) 120601705(ST6GALNAC4)
PVP105289042(ST6GALNAC3) 105294831(ST6GALNAC4)
RAY107503437(ST6GALNAC3) 107520248(ST6GALNAC4)
MJV108397264 108397977(ST6GALNAC4)
TOD119232115(ST6GALNAC4) 119236780(ST6GALNAC3)
SARA101544400(ST6GALNAC3) 101549917(ST6GALNAC4)
LAV100672433(ST6GALNAC3) 104845634(ST6GALNAC4)
TMU101349108 101358972
DNM101426075(ST6GALNAC3) 101428837(ST6GALNAC4)
MDO100010461(ST6GALNAC3) 100012077(ST6GALNAC4)
GAS123235247(ST6GALNAC4) 123244819(ST6GALNAC3)
SHR100919945(ST6GALNAC3) 100921479(ST6GALNAC4)
PCW110193695(ST6GALNAC4) 110195706(ST6GALNAC3)
OAA100078837(ST6GALNAC4) 100087849(ST6GALNAC3)
GGA395182(ST6GALNAC4) 404746(ST6GALNAC3)
PCOC116234190(ST6GALNAC4) 116236223(ST6GALNAC3)
MGP100540755(ST6GALNAC3) 100543224(ST6GALNAC4)
CJO107317527(ST6GALNAC3) 107321783(ST6GALNAC4)
NMEL110390579(ST6GALNAC4) 110402576(ST6GALNAC3)
APLA101791163(ST6GALNAC4) 101793136(ST6GALNAC3)
ACYG106034022(ST6GALNAC3) 106047277(ST6GALNAC4)
AFUL116492181(ST6GALNAC3) 116496892(ST6GALNAC4)
TGU100221194(ST6GALNAC3) 100232134(ST6GALNAC4)
LSR110469217(ST6GALNAC3) 110482257(ST6GALNAC4)
SCAN103814945(ST6GALNAC3) 103819159(ST6GALNAC4)
PMOA120503210(ST6GALNAC3) 120507386(ST6GALNAC4)
OTC121337065(ST6GALNAC4) 121345213(ST6GALNAC3)
PRUF121357598(ST6GALNAC4) 121362132(ST6GALNAC3)
GFR102032720(ST6GALNAC3) 102036471(ST6GALNAC4)
FAB101813361(ST6GALNAC3) 101817162(ST6GALNAC4)
PHI102101449(ST6GALNAC3) 102109129(ST6GALNAC4)
PMAJ107208224(ST6GALNAC3) 107211894(ST6GALNAC4)
CCAE111933158(ST6GALNAC3) 111936951(ST6GALNAC4)
CCW104688260(ST6GALNAC4) 104695278(ST6GALNAC3)
ETL114054554(ST6GALNAC4) 114066175(ST6GALNAC3)
ZAB102064533(ST6GALNAC4) 102073456(ST6GALNAC3)
FPG101917057(ST6GALNAC3) 101923804(ST6GALNAC4)
FCH102047399(ST6GALNAC3) 102056501(ST6GALNAC4)
CLV102084668(ST6GALNAC3) 102090323(ST6GALNAC4)
EGZ104122368(ST6GALNAC4) 104125535(ST6GALNAC3)
NNI104015564(ST6GALNAC3) 104022455(ST6GALNAC4)
ACUN113483151(ST6GALNAC3) 113486613(ST6GALNAC4)
TALA104368636(ST6GALNAC3) 116965972(ST6GALNAC4)
PADL103912977(ST6GALNAC4) 103925221(ST6GALNAC3)
ACHC115334781(ST6GALNAC4) 115348888(ST6GALNAC3)
AAM106495296(ST6GALNAC4) 106499457(ST6GALNAC3)
AROW112962996(ST6GALNAC4) 112976049(ST6GALNAC3)
NPD112955901(ST6GALNAC4) 112957519(ST6GALNAC3)
DNE112981262(ST6GALNAC3) 112991413(ST6GALNAC4)
ASN102383697(ST6GALNAC3) 102385694(ST6GALNAC4)
AMJ102575154(ST6GALNAC4) 102576099(MSH4)
CPOO109307370(ST6GALNAC3) 109313875(ST6GALNAC4)
GGN109286759(ST6GALNAC3) 109292898(ST6GALNAC4)
PSS102443948(ST6GALNAC4) 102457102(ST6GALNAC3)
CMY102932867(ST6GALNAC4) 102940238(ST6GALNAC3)
CPIC101940645(ST6GALNAC4) 101944048(ST6GALNAC3)
TST117881447(ST6GALNAC3) 117889484(ST6GALNAC4)
CABI116825857(ST6GALNAC3) 116835153(ST6GALNAC4)
MRV120371116(ST6GALNAC3) 120386924(ST6GALNAC4)
ACS100552238(st6galnac4) 100567272(st6galnac3)
PVT110078837(ST6GALNAC4) 110079526(ST6GALNAC3)
SUND121929779(ST6GALNAC3) 121936528(ST6GALNAC4)
PBI103052750(ST6GALNAC3) 103063354(ST6GALNAC4)
PMUR107287801(ST6GALNAC3) 107298943(ST6GALNAC4)
TSR106545572(ST6GALNAC3) 106551570
PGUT117656973(ST6GALNAC4) 117657505 117677108(ST6GALNAC3)
VKO123028237(ST6GALNAC4) 123028848(ST6GALNAC3)
PMUA114589237(ST6GALNAC4) 114598841(ST6GALNAC3)
ZVI118077773(ST6GALNAC4) 118088204(ST6GALNAC3)
GJA107105744(ST6GALNAC4) 107113018(ST6GALNAC3)
STOW125432945(ST6GALNAC3) 125441956(ST6GALNAC4)
XLA108705044 108714200(st6galnac3.L)
XTR100495364(st6galnac3) 779760(st6galnac4)
NPR108794466(ST6GALNAC4) 108799035(ST6GALNAC3)
RTEM120914192(ST6GALNAC4) 120946008(ST6GALNAC3)
BBUF120977179(ST6GALNAC4) 120979864(ST6GALNAC3)
BGAR122919512(ST6GALNAC4) 122944141(ST6GALNAC3)
DRE322609(st6galnac3) 751653(st6galnac4)
SRX107705960 107708685(st6galnac3) 107737196
SANH107661558 107675764 107681790 107703200
SGH107558185 107585701 107599397 107599406 107599847
CCAR109062816 109072017 109103371
CAUA113040353 113046000 113064445 113078673
PPRM120461442(st6galnac3) 120471265(st6galnac4)
MAMB125250532(st6galnac3) 125253315(st6galnac4)
IPU108268339(st6galnac3) 108279162(st6galnac4)
PHYP113535400 113540196(st6galnac3)
SMEO124387759(st6galnac3) 124397648(st6galnac4)
TFD113649124(st6galnac3) 113664034(st6galnac4)
AMEX103027742(st6galnac4) 103028147(st6galnac3)
EEE113570133(st6galnac3) 113590039
TRU101064537 446080(st6galnac3)
LCO104924497 109140213(st6galnac3) 109142950
NCC104946126(st6galnac4) 104965762
CGOB115022493(st6galnac3)
ELY117270042(st6galnac4) 117272007(st6galnac3)
PLEP121951203(st6galnac3) 121960231(st6galnac4)
SLUC116046170(st6galnac3) 116062920(st6galnac4)
ECRA117953946(st6galnac3) 117959873(st6galnac4)
PFLV114565919(st6galnac3) 114570630
GAT120816641(st6galnac3) 120831557(st6galnac4)
PPUG119209319(st6galnac3) 119226347(st6galnac4)
MSAM119901800(st6galnac3) 119914226(st6galnac4)
CUD121520398(st6galnac3) 121525037(st6galnac4)
MZE101465741 101474314(st6galnac3)
ONL100701389 100708358(st6galnac3)
OAU116313434(st6galnac3) 116331888(st6galnac4)
OLA100049534(st6galnac3) 101164661(st6galnac4)
OML112152397(st6galnac3) 112163504(st6galnac4)
XMA102226898 102236276(st6galnac3)
XCO114145824(st6galnac3) 114149160
XHE116722236(st6galnac3) 116724412
PRET103473419(st6galnac4) 103479928(st6galnac3)
PFOR103148582(st6galnac3) 103151471 103151474
PLAI106953151(st6galnac3) 106964897(st6galnac4)
PMEI106913132 106922380(st6galnac3)
GAF122840894(st6galnac3) 122846780(st6galnac4)
CVG107089777(st6galnac4) 107094225(st6galnac3) 107104669
CTUL119787899(st6galnac3) 119799012(st6galnac4)
GMU124869812(st6galnac3) 124872269(st6galnac4)
NFU107374797(st6galnac4) 107383508(st6galnac3)
KMR108230860(st6galnac4) 108232955(st6galnac3)
ALIM106516293 106520778(st6galnac3)
NWH119414772(st6galnac3) 119424510(st6galnac4)
AOCE111564085 111586859
CSEM103390091(st6galnac4) 103396703(st6galnac3)
POV109625944 109637616(st6galnac3) 109642757
SSEN122758722(st6galnac4) 122772328(st6galnac3)
HHIP117771556(st6galnac4) 117778820(st6galnac3)
LCF108874088 108884275(st6galnac3) 108891392
SDU111231135(st6galnac3) 111237383
SLAL111668031 111668378
XGL120799100(st6galnac3) 120805975(st6galnac4)
HCQ109516873(st6galnac3) 109517192
BPEC110155713(st6galnac3) 110157454
MALB109955309(st6galnac3) 109972319
SASA100196729(st6galnac4) 106569362 106591001
OTW112220107(st6galnac4) 112237760(st6galnac3)
OMY110516817(st6galnac3) 110523308(st6galnac4)
OGO124009255(st6galnac3) 124047947(st6galnac4)
ONE115119707
SALP111961873
SNH120025749(st6galnac4)
ELS105009744(st6galnac3) 105015283
SFM108923702(st6galnac3) 108935911(st6galnac4)
PKI111841806 111846074(st6galnac3)
AANG118212821(st6galnac4) 118230247(st6galnac3)
LOC102696800(st6galnac4) 102697043(st6galnac3)
PSPA121309740(st6galnac4) 121326373 121330564
ARUT117400557 117416846 117421946 117964676
LCM102356696(ST6GALNAC3) 102363654(ST6GALNAC4)
CMK103174732(st6galnac3)
RTP109923725
 » show all
Reference
1  [PMID:6190802]
  Authors
Bergh ML, Hooghwinkel GJ, van den Eijnden DH.
  Title
Biosynthesis of the O-glycosidically linked oligosaccharide chains of fetuin. Indications for an alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase with a narrow acceptor specificity in fetal calf liver.
  Journal
J Biol Chem 258:7430-6 (1983)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.3.7
IUBMB Enzyme Nomenclature: 2.4.3.7
ExPASy - ENZYME nomenclature database: 2.4.3.7
BRENDA, the Enzyme Database: 2.4.3.7
CAS: 129924-24-9

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