KEGG ENZYME: 2.4.3.7

ENZYME: 2.4.3.7

Entry

EC 2.4.3.7                  Enzyme

Name

alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-alpha-sialyltransferase;
sialyltransferase;
cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase;
alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase;
SIAT7;
ST6GALNAC;
(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase;
CMP-N-acetylneuraminate:(alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3)-N-acetyl-D-galactosaminide alpha-2,6-N-acetylneuraminyl-transferase

Class

Transferases;
Glycosyltransferases;
Sialyltransferases

Sysname

CMP-N-acetylneuraminate:N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)- N-acetyl-D-galactosaminide galactosamine-6-alpha-N-acetylneuraminyltransferase

Reaction(IUBMB)

CMP-N-acetylneuraminate + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R [RN:R04635]

Reaction(KEGG)

R04635 > R05914(G) R05959(G)

Substrate

CMP-N-acetylneuraminate [CPD:C00128];
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R [CPD:C04885]

Product

CMP [CPD:C00055];
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R [CPD:C04926]

Comment

Attaches N-acetylneuraminic acid in alpha-2,6-linkage to N-acetylgalactosamine only when present in the structure of alpha-N-acetylneuraminyl-(2->3)-beta-galactosyl-(1->3)-N-acetylgalactosaminyl-R, where R may be protein or p-nitrophenol. Not identical with EC 2.4.3.3 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase.

History

EC 2.4.3.7 created 1984 as EC 2.4.99.7, modified 1986, modified 2004, transferred 2022 to EC 2.4.3.7

Pathway

ec00512

Mucin type O-glycan biosynthesis

ec00604

Glycosphingolipid biosynthesis - ganglio series

ec01100

Metabolic pathways

Orthology

K03373

N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7C)

K03374

N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7D)

Genes

HSA:	256435(ST6GALNAC3) 27090(ST6GALNAC4)

PTR:	450108(ST6GALNAC4) 450115(ST6GALNAC3)

PPS:	100985483(ST6GALNAC3) 100995780(ST6GALNAC4)

GGO:	101143514(ST6GALNAC3) 101151595(ST6GALNAC4)

PON:	100174350(ST6GALNAC3) 100439613(ST6GALNAC4)

NLE:	100598104(ST6GALNAC4) 100603395(ST6GALNAC3)

MCC:	705879(ST6GALNAC4) 709779(ST6GALNAC3)

MCF:	102122701(ST6GALNAC3) 102142909(ST6GALNAC4)

CSAB:

103224585(ST6GALNAC3) 103239817(ST6GALNAC4)

CATY:

105576245(ST6GALNAC4) 105595840(ST6GALNAC3)

PANU:

101003942(ST6GALNAC4) 101007845(ST6GALNAC3)

TGE:	112608484(ST6GALNAC4) 112627356(ST6GALNAC3)

RRO:	104665870(ST6GALNAC4) 104666528(ST6GALNAC3)

RBB:	108533045(ST6GALNAC3) 108542735(ST6GALNAC4)

TFN:	117072089(ST6GALNAC4) 117092117(ST6GALNAC3)

PTEH:

111540761(ST6GALNAC3) 111545892(ST6GALNAC4)

CJC:	100398966(ST6GALNAC3) 100401438(ST6GALNAC4)

SBQ:	101032564(ST6GALNAC3) 101037868(ST6GALNAC4)

CSYR:

103249658(ST6GALNAC4) 103255472(ST6GALNAC3)

MMUR:

105875232(ST6GALNAC4) 105884196(ST6GALNAC3)

OGA:	100956132(ST6GALNAC4) 100959396(ST6GALNAC3)

MMU:	20447(St6galnac3) 20448(St6galnac4)

MCAL:

110288812(St6galnac4) 110290963(St6galnac3)

MPAH:

110318527(St6galnac4) 110320284(St6galnac3)

RNO:	29758(St6galnac3) 407764(St6galnac4)

MCOC:

116090006(St6galnac4) 116093960(St6galnac3)

MUN:	110562585(St6galnac4) 110563850

CGE:	100759065(St6galnac4) 100762285(St6galnac3)

PLEU:

114699850(St6galnac3) 114703806(St6galnac4)

NGI:	103727384(St6galnac4) 103746466(St6galnac3)

HGL:	101708035(St6galnac3) 101717187(St6galnac4)

CPOC:

100714995(St6galnac3) 100725743(St6galnac4)

CCAN:

109674707(St6galnac3) 109686789(St6galnac4)

DORD:

105989432(St6galnac4) 106000598(St6galnac3)

DSP:	122108893(St6galnac4) 122112725(St6galnac3)

NCAR:

124964447 124970744

OCU:	100345091(ST6GALNAC3) 100356933(ST6GALNAC4)

OPI:	101517138(ST6GALNAC3) 101530057(ST6GALNAC4)

TUP:	102476286(ST6GALNAC3) 102487439(ST6GALNAC4)

CFA:	490205(ST6GALNAC3) 609133(ST6GALNAC4)

VVP:	112924453(ST6GALNAC3) 112927918(ST6GALNAC4)

VLG:	121473947(ST6GALNAC4) 121486464(ST6GALNAC3)

AML:	100480565(ST6GALNAC4) 100481578(ST6GALNAC3)

UMR:	103662994(ST6GALNAC3) 103670294(ST6GALNAC4)

UAH:	113254511(ST6GALNAC3) 113266445(ST6GALNAC4)

UAR:	123775728(ST6GALNAC4) 123795299(ST6GALNAC3)

ELK:	111143388 111146222

LLV:	125083783 125097593

MPUF:

101672038(ST6GALNAC4) 101685214(ST6GALNAC3)

ORO:	101368864(ST6GALNAC4) 101382354(ST6GALNAC3)

EJU:	114208382(ST6GALNAC3) 114212880(ST6GALNAC4)

ZCA:	113910417(ST6GALNAC3) 113935149(ST6GALNAC4)

MLX:	118017643(ST6GALNAC4) 118018948(ST6GALNAC3)

FCA:	101091035(ST6GALNAC3) 101094459(ST6GALNAC4)

PYU:	121027334(ST6GALNAC3) 121035034(ST6GALNAC4)

PBG:	122474802(ST6GALNAC4) 122480656(ST6GALNAC3)

PTG:	102966320(ST6GALNAC4) 107178974(ST6GALNAC3)

PPAD:

109250108(ST6GALNAC4) 109266652(ST6GALNAC3)

AJU:	106966292(ST6GALNAC4) 113599298(ST6GALNAC3)

HHV:	120226552(ST6GALNAC3) 120230099(ST6GALNAC4)

BTA:	404124(ST6GALNAC4) 782689(ST6GALNAC3)

BOM:	102266270(ST6GALNAC3) 102287870(ST6GALNAC4)

BIU:	109556154(ST6GALNAC3)

BBUB:

102396911(ST6GALNAC4) 102415799(ST6GALNAC3)

CHX:	102170329(ST6GALNAC4) 102190655(ST6GALNAC3)

OAS:	101121471(ST6GALNAC3) 101123019(ST6GALNAC4)

ODA:	120852027(ST6GALNAC4) 120856978(ST6GALNAC3) 120861085

CCAD:

122436804(ST6GALNAC3) 122442199(ST6GALNAC4)

SSC:	100512173(ST6GALNAC3) 396676(ST6GALNAC4)

CFR:	102505545(ST6GALNAC3) 116663270(ST6GALNAC4)

CBAI:

105075522(ST6GALNAC3)

CDK:	105096656(ST6GALNAC3) 116152744(ST6GALNAC4)

VPC:	102533833(ST6GALNAC3) 116280369(ST6GALNAC4)

BACU:

103005340(ST6GALNAC4) 103020698(ST6GALNAC3)

LVE:	103085714(ST6GALNAC3) 103086160(ST6GALNAC4)

OOR:	101278803(ST6GALNAC4) 101285214(ST6GALNAC3)

DLE:	111177188(ST6GALNAC4) 111178407(ST6GALNAC3)

PCAD:

102980952(ST6GALNAC3) 102990591(ST6GALNAC4) 102993381

PSIU:

116740707(ST6GALNAC3) 116755365(ST6GALNAC4)

ECB:	100066966(ST6GALNAC3) 100067121(ST6GALNAC4)

EPZ:	103544980(ST6GALNAC4) 103549422(ST6GALNAC3)

EAI:	106836550(ST6GALNAC3) 106845456(ST6GALNAC4)

MYB:	102253595(ST6GALNAC3) 102261251(ST6GALNAC4)

MYD:	102754268(ST6GALNAC4) 102760172(ST6GALNAC3)

MMYO:

118667025(ST6GALNAC4) 118676600(ST6GALNAC3)

MLF:	102416817(ST6GALNAC4) 102428142(ST6GALNAC3)

MNA:	107535596(ST6GALNAC4) 107540092(ST6GALNAC3)

PKL:	118706661(ST6GALNAC4) 118723675(ST6GALNAC3)

HAI:	109379933(ST6GALNAC4) 109383481(ST6GALNAC3)

DRO:	112306353(ST6GALNAC4) 112309356(ST6GALNAC3)

SHON:

118980054(ST6GALNAC4)

AJM:	119040023(ST6GALNAC3) 119056496(ST6GALNAC4)

PDIC:

114497701(ST6GALNAC3) 114498801(ST6GALNAC4)

PHAS:

123816375(ST6GALNAC3) 123823346(ST6GALNAC4)

MMF:	118626740(ST6GALNAC3) 118629692(ST6GALNAC4)

RFQ:	117026467(ST6GALNAC3) 117032330(ST6GALNAC4)

PALE:

102881827(ST6GALNAC4) 102894086(ST6GALNAC3)

PGIG:

120583241(ST6GALNAC3) 120601705(ST6GALNAC4)

PVP:	105289042(ST6GALNAC3) 105294831(ST6GALNAC4)

RAY:	107503437(ST6GALNAC3) 107520248(ST6GALNAC4)

MJV:	108397264 108397977(ST6GALNAC4)

TOD:	119232115(ST6GALNAC4) 119236780(ST6GALNAC3)

SARA:

101544400(ST6GALNAC3) 101549917(ST6GALNAC4)

LAV:	100672433(ST6GALNAC3) 104845634(ST6GALNAC4)

TMU:	101349108 101358972

DNM:	101426075(ST6GALNAC3) 101428837(ST6GALNAC4)

MDO:	100010461(ST6GALNAC3) 100012077(ST6GALNAC4)

GAS:	123235247(ST6GALNAC4) 123244819(ST6GALNAC3)

SHR:	100919945(ST6GALNAC3) 100921479(ST6GALNAC4)

PCW:	110193695(ST6GALNAC4) 110195706(ST6GALNAC3)

OAA:	100078837(ST6GALNAC4) 100087849(ST6GALNAC3)

GGA:	395182(ST6GALNAC4) 404746(ST6GALNAC3)

PCOC:

116234190(ST6GALNAC4) 116236223(ST6GALNAC3)

MGP:	100540755(ST6GALNAC3) 100543224(ST6GALNAC4)

CJO:	107317527(ST6GALNAC3) 107321783(ST6GALNAC4)

NMEL:

110390579(ST6GALNAC4) 110402576(ST6GALNAC3)

APLA:

101791163(ST6GALNAC4) 101793136(ST6GALNAC3)

ACYG:

106034022(ST6GALNAC3) 106047277(ST6GALNAC4)

AFUL:

116492181(ST6GALNAC3) 116496892(ST6GALNAC4)

TGU:	100221194(ST6GALNAC3) 100232134(ST6GALNAC4)

LSR:	110469217(ST6GALNAC3) 110482257(ST6GALNAC4)

SCAN:

103814945(ST6GALNAC3) 103819159(ST6GALNAC4)

PMOA:

120503210(ST6GALNAC3) 120507386(ST6GALNAC4)

OTC:	121337065(ST6GALNAC4) 121345213(ST6GALNAC3)

PRUF:

121357598(ST6GALNAC4) 121362132(ST6GALNAC3)

GFR:	102032720(ST6GALNAC3) 102036471(ST6GALNAC4)

FAB:	101813361(ST6GALNAC3) 101817162(ST6GALNAC4)

PHI:	102101449(ST6GALNAC3) 102109129(ST6GALNAC4)

PMAJ:

107208224(ST6GALNAC3) 107211894(ST6GALNAC4)

CCAE:

111933158(ST6GALNAC3) 111936951(ST6GALNAC4)

CCW:	104688260(ST6GALNAC4) 104695278(ST6GALNAC3)

ETL:	114054554(ST6GALNAC4) 114066175(ST6GALNAC3)

ZAB:	102064533(ST6GALNAC4) 102073456(ST6GALNAC3)

FPG:	101917057(ST6GALNAC3) 101923804(ST6GALNAC4)

FCH:	102047399(ST6GALNAC3) 102056501(ST6GALNAC4)

CLV:	102084668(ST6GALNAC3) 102090323(ST6GALNAC4)

EGZ:	104122368(ST6GALNAC4) 104125535(ST6GALNAC3)

NNI:	104015564(ST6GALNAC3) 104022455(ST6GALNAC4)

ACUN:

113483151(ST6GALNAC3) 113486613(ST6GALNAC4)

TALA:

104368636(ST6GALNAC3) 116965972(ST6GALNAC4)

PADL:

103912977(ST6GALNAC4) 103925221(ST6GALNAC3)

ACHC:

115334781(ST6GALNAC4) 115348888(ST6GALNAC3)

AAM:	106495296(ST6GALNAC4) 106499457(ST6GALNAC3)

AROW:

112962996(ST6GALNAC4) 112976049(ST6GALNAC3)

NPD:	112955901(ST6GALNAC4) 112957519(ST6GALNAC3)

DNE:	112981262(ST6GALNAC3) 112991413(ST6GALNAC4)

ASN:	102383697(ST6GALNAC3) 102385694(ST6GALNAC4)

AMJ:	102575154(ST6GALNAC4) 102576099(MSH4)

CPOO:

109307370(ST6GALNAC3) 109313875(ST6GALNAC4)

GGN:	109286759(ST6GALNAC3) 109292898(ST6GALNAC4)

PSS:	102443948(ST6GALNAC4) 102457102(ST6GALNAC3)

CMY:	102932867(ST6GALNAC4) 102940238(ST6GALNAC3)

CPIC:

101940645(ST6GALNAC4) 101944048(ST6GALNAC3)

TST:	117881447(ST6GALNAC3) 117889484(ST6GALNAC4)

CABI:

116825857(ST6GALNAC3) 116835153(ST6GALNAC4)

MRV:	120371116(ST6GALNAC3) 120386924(ST6GALNAC4)

ACS:	100552238(st6galnac4) 100567272(st6galnac3)

PVT:	110078837(ST6GALNAC4) 110079526(ST6GALNAC3)

SUND:

121929779(ST6GALNAC3) 121936528(ST6GALNAC4)

PBI:	103052750(ST6GALNAC3) 103063354(ST6GALNAC4)

PMUR:

107287801(ST6GALNAC3) 107298943(ST6GALNAC4)

TSR:	106545572(ST6GALNAC3) 106551570

PGUT:

117656973(ST6GALNAC4) 117657505 117677108(ST6GALNAC3)

VKO:	123028237(ST6GALNAC4) 123028848(ST6GALNAC3)

PMUA:

114589237(ST6GALNAC4) 114598841(ST6GALNAC3)

ZVI:	118077773(ST6GALNAC4) 118088204(ST6GALNAC3)

GJA:	107105744(ST6GALNAC4) 107113018(ST6GALNAC3)

STOW:

125432945(ST6GALNAC3) 125441956(ST6GALNAC4)

XLA:	108705044 108714200(st6galnac3.L)

XTR:	100495364(st6galnac3) 779760(st6galnac4)

NPR:	108794466(ST6GALNAC4) 108799035(ST6GALNAC3)

RTEM:

120914192(ST6GALNAC4) 120946008(ST6GALNAC3)

BBUF:

120977179(ST6GALNAC4) 120979864(ST6GALNAC3)

BGAR:

122919512(ST6GALNAC4) 122944141(ST6GALNAC3)

DRE:	322609(st6galnac3) 751653(st6galnac4)

SRX:	107705960 107708685(st6galnac3) 107737196

SANH:

107661558 107675764 107681790 107703200

SGH:	107558185 107585701 107599397 107599406 107599847

CCAR:

109062816 109072017 109103371

CAUA:

113040353 113046000 113064445 113078673

PPRM:

120461442(st6galnac3) 120471265(st6galnac4)

MAMB:

125250532(st6galnac3) 125253315(st6galnac4)

IPU:	108268339(st6galnac3) 108279162(st6galnac4)

PHYP:

113535400 113540196(st6galnac3)

SMEO:

124387759(st6galnac3) 124397648(st6galnac4)

TFD:	113649124(st6galnac3) 113664034(st6galnac4)

AMEX:

103027742(st6galnac4) 103028147(st6galnac3)

EEE:	113570133(st6galnac3) 113590039

TRU:	101064537 446080(st6galnac3)

LCO:	104924497 109140213(st6galnac3) 109142950

NCC:	104946126(st6galnac4) 104965762

CGOB:

115022493(st6galnac3)

ELY:	117270042(st6galnac4) 117272007(st6galnac3)

PLEP:

121951203(st6galnac3) 121960231(st6galnac4)

SLUC:

116046170(st6galnac3) 116062920(st6galnac4)

ECRA:

117953946(st6galnac3) 117959873(st6galnac4)

PFLV:

114565919(st6galnac3) 114570630

GAT:	120816641(st6galnac3) 120831557(st6galnac4)

PPUG:

119209319(st6galnac3) 119226347(st6galnac4)

MSAM:

119901800(st6galnac3) 119914226(st6galnac4)

CUD:	121520398(st6galnac3) 121525037(st6galnac4)

MZE:	101465741 101474314(st6galnac3)

ONL:	100701389 100708358(st6galnac3)

OAU:	116313434(st6galnac3) 116331888(st6galnac4)

OLA:	100049534(st6galnac3) 101164661(st6galnac4)

OML:	112152397(st6galnac3) 112163504(st6galnac4)

XMA:	102226898 102236276(st6galnac3)

XCO:	114145824(st6galnac3) 114149160

XHE:	116722236(st6galnac3) 116724412

PRET:

103473419(st6galnac4) 103479928(st6galnac3)

PFOR:

103148582(st6galnac3) 103151471 103151474

PLAI:

106953151(st6galnac3) 106964897(st6galnac4)

PMEI:

106913132 106922380(st6galnac3)

GAF:	122840894(st6galnac3) 122846780(st6galnac4)

CVG:	107089777(st6galnac4) 107094225(st6galnac3) 107104669

CTUL:

119787899(st6galnac3) 119799012(st6galnac4)

GMU:	124869812(st6galnac3) 124872269(st6galnac4)

NFU:	107374797(st6galnac4) 107383508(st6galnac3)

KMR:	108230860(st6galnac4) 108232955(st6galnac3)

ALIM:

106516293 106520778(st6galnac3)

NWH:	119414772(st6galnac3) 119424510(st6galnac4)

AOCE:

111564085 111586859

CSEM:

103390091(st6galnac4) 103396703(st6galnac3)

POV:	109625944 109637616(st6galnac3) 109642757

SSEN:

122758722(st6galnac4) 122772328(st6galnac3)

HHIP:

117771556(st6galnac4) 117778820(st6galnac3)

LCF:	108874088 108884275(st6galnac3) 108891392

SDU:	111231135(st6galnac3) 111237383

SLAL:

111668031 111668378

XGL:	120799100(st6galnac3) 120805975(st6galnac4)

HCQ:	109516873(st6galnac3) 109517192

BPEC:

110155713(st6galnac3) 110157454

MALB:

109955309(st6galnac3) 109972319

SASA:

100196729(st6galnac4) 106569362 106591001

OTW:	112220107(st6galnac4) 112237760(st6galnac3)

OMY:	110516817(st6galnac3) 110523308(st6galnac4)

OGO:	124009255(st6galnac3) 124047947(st6galnac4)

ONE:

115119707

SALP:

111961873

SNH:	120025749(st6galnac4)

ELS:	105009744(st6galnac3) 105015283

SFM:	108923702(st6galnac3) 108935911(st6galnac4)

PKI:	111841806 111846074(st6galnac3)

AANG:

118212821(st6galnac4) 118230247(st6galnac3)

LOC:	102696800(st6galnac4) 102697043(st6galnac3)

PSPA:

121309740(st6galnac4) 121326373 121330564

ARUT:

117400557 117416846 117421946 117964676

LCM:	102356696(ST6GALNAC3) 102363654(ST6GALNAC4)

CMK:	103174732(st6galnac3)

RTP:

109923725

» show all

Reference

1 [PMID:6190802]

Authors

Bergh ML, Hooghwinkel GJ, van den Eijnden DH.

Title

Biosynthesis of the O-glycosidically linked oligosaccharide chains of fetuin. Indications for an alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase with a narrow acceptor specificity in fetal calf liver.

Journal

J Biol Chem 258:7430-6 (1983)

Other DBs

ExplorEnz - The Enzyme Database:

2.4.3.7

IUBMB Enzyme Nomenclature:

2.4.3.7

ExPASy - ENZYME nomenclature database:

2.4.3.7

BRENDA, the Enzyme Database:

2.4.3.7

CAS:	129924-24-9

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Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (10)   
   KEGG COMPOUND (4)   
   KEGG GLYCAN (6)   
Chemical reaction (5)   
   KEGG REACTION (3)   
   KEGG RCLASS (2)   
Gene (510)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (508)   
All databases (531)   

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