KEGG   ENZYME: 2.4.3.9
Entry
EC 2.4.3.9                  Enzyme                                 
Name
lactosylceramide alpha-2,3-sialyltransferase;
cytidine monophosphoacetylneuraminate-lactosylceramide alpha2,3- sialyltransferase;
CMP-acetylneuraminate-lactosylceramide-sialyltransferase;
CMP-acetylneuraminic acid:lactosylceramide sialyltransferase;
CMP-sialic acid:lactosylceramide-sialyltransferase;
cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase;
ganglioside GM3 synthetase;
GM3 synthase;
GM3 synthetase;
SAT 1;
CMP-N-acetylneuraminate:lactosylceramide alpha-2,3-N-acetylneuraminyltransferase;
CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-beta-D-glucosyl(1<->1)ceramide alpha-(2->3)-N-acetylneuraminyltransferase
Class
Transferases;
Glycosyltransferases;
Sialyltransferases
Sysname
CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide alpha-(2->3)-N-acetylneuraminyltransferase
Reaction(IUBMB)
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R03488 R05937]
Reaction(KEGG)
R03488 R05937(G);
(other) R04630 R04647 R06003(G) R06007(G)
Substrate
CMP-N-acetylneuraminate [CPD:C00128];
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C01290]
Product
CMP [CPD:C00055];
alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Comment
Lactose cannot act as acceptor.
History
EC 2.4.3.9 created 1984 as EC 2.4.99.9, modified 1986, transferred 2022 to EC 2.4.3.9
Pathway
ec00604  Glycosphingolipid biosynthesis - ganglio series
ec01100  Metabolic pathways
Orthology
K03370  lactosylceramide alpha-2,3-sialyltransferase (sialyltransferase 9)
Genes
HSA8869(ST3GAL5)
PTR459371(ST3GAL5)
PPS100974771(ST3GAL5)
GGO101127197(ST3GAL5)
PON100458488(ST3GAL5)
NLE100581835(ST3GAL5)
MCC696842(ST3GAL5)
MCF102139258(ST3GAL5)
CSAB103219931(ST3GAL5)
CATY105587659(ST3GAL5)
PANU101025433(ST3GAL5)
TGE112604851(ST3GAL5)
RRO104677060(ST3GAL5)
RBB108518136(ST3GAL5)
TFN117062146(ST3GAL5)
PTEH111551103(ST3GAL5)
CJC100399856(ST3GAL5)
SBQ101033571(ST3GAL5)
CSYR103266514(ST3GAL5)
MMUR105876608(ST3GAL5)
OGA100951715(ST3GAL5)
MMU20454(St3gal5)
MCAL110293442 110296137(St3gal5)
MPAH110316218(St3gal5)
RNO83505(St3gal5)
MCOC116099070(St3gal5)
MUN110558892(St3gal5)
CGE100754838(St3gal5)
PLEU114685874(St3gal5)
NGI103739804(St3gal5)
HGL101699085(St3gal5)
CPOC100728609(St3gal5)
CCAN109696130(St3gal5)
DORD106000225(St3gal5)
DSP122116892(St3gal5)
NCAR124962985
OCU100341761(ST3GAL5)
OPI101524576(ST3GAL5)
TUP102502390(ST3GAL5)
CFA612022(ST3GAL5)
VVP112916669(ST3GAL5)
VLG121491257(ST3GAL5)
AML100469790(ST3GAL5)
UMR103671460(ST3GAL5)
UAH113243005(ST3GAL5)
UAR123799693(ST3GAL5)
ELK111148102
LLV125108483
MPUF101679411(ST3GAL5)
ORO101377844(ST3GAL5)
EJU114223482(ST3GAL5)
ZCA113937947(ST3GAL5)
MLX118007900(ST3GAL5)
FCA101092099(ST3GAL5)
PYU121044504(ST3GAL5)
PBG122497125(ST3GAL5)
PTG102964432(ST3GAL5)
PPAD109264005(ST3GAL5)
AJU106978128(ST3GAL5)
HHV120245540(ST3GAL5)
BTA404164(ST3GAL5)
BOM102266477(ST3GAL5)
BIU109566161(ST3GAL5)
BBUB102397894(ST3GAL5)
CHX102190883(ST3GAL5)
OAS101104977(ST3GAL5)
ODA120851510(ST3GAL5)
CCAD122441752(ST3GAL5)
SSC100625751(ST3GAL5)
CFR102505366(ST3GAL5)
CBAI105072111(ST3GAL5)
CDK105104164(ST3GAL5)
VPC102545029(ST3GAL5)
BACU103002546(ST3GAL5)
LVE103075319(ST3GAL5)
OOR101270788(ST3GAL5)
DLE111165451(ST3GAL5)
PCAD102983416(ST3GAL5)
PSIU116764105(ST3GAL5)
ECB100067118(ST3GAL5) 111771968 111771995
EPZ103556956(ST3GAL5)
EAI106838594(ST3GAL5)
MYB102245810(ST3GAL5)
MYD102759471(ST3GAL5)
MMYO118668784(ST3GAL5)
MLF102442422(ST3GAL5)
MNA107528667(ST3GAL5)
PKL118717621(ST3GAL5)
HAI109371317(ST3GAL5)
DRO112302949(ST3GAL5)
SHON118982212(ST3GAL5)
AJM119059867(ST3GAL5)
PDIC114500089(ST3GAL5)
PHAS123811510(ST3GAL5)
MMF118631229(ST3GAL5)
RFQ117032887(ST3GAL5)
PALE102879934(ST3GAL5)
PGIG120594581(ST3GAL5)
PVP105298536(ST3GAL5)
RAY107506062(ST3GAL5)
MJV108405884(ST3GAL5)
TOD119259137(ST3GAL5)
SARA101548851(ST3GAL5)
LAV100673997(ST3GAL5)
TMU101361139
DNM101431587(ST3GAL5)
MDO100029907(ST3GAL5)
SHR100919035(ST3GAL5)
PCW110196314(ST3GAL5)
OAA100080527(ST3GAL5)
GGA407775(ST3GAL5)
PCOC116225715(ST3GAL5)
MGP100547934(ST3GAL5)
CJO107314000(ST3GAL5)
NMEL110398704(ST3GAL5)
APLA101803297(ST3GAL5)
ACYG106034105(ST3GAL5)
AFUL116488990(ST3GAL5)
TGU100229190(ST3GAL5)
LSR110473300(ST3GAL5)
SCAN103823564(ST3GAL5)
PMOA120509366(ST3GAL5)
OTC121335112(ST3GAL5)
PRUF121363254(ST3GAL5)
GFR102038355(ST3GAL5)
FAB101819557(ST3GAL5)
PHI102100405(ST3GAL5)
PMAJ107203387(ST3GAL5)
CCAE111928296(ST3GAL5)
CCW104690804(ST3GAL5)
ETL114058521(ST3GAL5)
ZAB102071310(ST3GAL5)
FPG101917839(ST3GAL5)
FCH102058346(ST3GAL5)
CLV102084795(ST3GAL5)
EGZ104135244(ST3GAL5)
NNI104018542(ST3GAL5)
ACUN113479340(ST3GAL5)
TALA104363197(ST3GAL5)
PADL103923514(ST3GAL5)
ACHC115343163(ST3GAL5)
AAM106488111(ST3GAL5)
AROW112965547(ST3GAL5)
NPD112943034(ST3GAL5)
DNE112990776(ST3GAL5)
ASN102372315(ST3GAL5)
AMJ102562268(ST3GAL5)
CPOO109322185(ST3GAL5)
GGN109303897(ST3GAL5)
PSS102453544(ST3GAL5)
CMY102933732(ST3GAL5)
CPIC101941756(ST3GAL5)
TST117877626
CABI116829575
MRV120406521(ST3GAL5)
ACS100561853(st3gal5)
PVT110080831(ST3GAL5)
PBI103065629(ST3GAL5)
PMUR107283194
TSR106549664(ST3GAL5)
PGUT117664877(ST3GAL5)
VKO123032414(ST3GAL5)
PMUA114604199(ST3GAL5)
ZVI118079076(ST3GAL5)
GJA107116130(ST3GAL5)
STOW125431528(ST3GAL5)
XLA108697625(st3gal5.L) 108706512(st3gal5.S)
XTR100329191(st3gal5)
NPR108802045(ST3GAL5)
RTEM120924345(ST3GAL5)
BBUF120990425(ST3GAL5)
BGAR122939067(ST3GAL5)
DRE394230(st3gal5)
SRX107746174
SANH107677008 107677010 107688584
SGH107571828 107580674
CCAR109045093 109047824
CAUA113113436(st3gal5) 113114353
PPRM120494851(st3gal5)
MAMB125261075(st3gal5)
IPU108269097(st3gal5)
PHYP113542676(st3gal5)
SMEO124386518(st3gal5)
TFD113635947(st3gal5)
AMEX103033675
EEE113584806
TRU777948(st3gal5)
LCO104939171(st3gal5)
CGOB115015108(st3gal5)
ELY117261196(st3gal5)
PLEP121948416(st3gal5)
SLUC116036587(st3gal5)
ECRA117951371(st3gal5)
PFLV114562610(st3gal5)
GAT120817074(st3gal5)
PPUG119210590(st3gal5)
MSAM119888660(st3gal5)
MZE101486925(st3gal5)
ONL100705347(st3gal5)
OAU116333953(st3gal5)
OLA101156587(st3gal5)
OML112153239(st3gal5)
XMA102216472(st3gal5)
XCO114138892(st3gal5)
XHE116714719(st3gal5)
PRET103471010(st3gal5)
PFOR103151708(st3gal5)
PLAI106934612
PMEI106931039
GAF122836795(st3gal5)
CVG107094163(st3gal5)
CTUL119794102(st3gal5)
GMU124860546(st3gal5)
NFU107390897(st3gal5)
KMR108240047(st3gal5)
ALIM106533017
NWH119408572(st3gal5)
AOCE111580987(st3gal5)
CSEM103391463(st3gal5)
POV109625986(st3gal5)
SSEN122778864(st3gal5)
HHIP117768951(st3gal5)
LCF108901518
SDU111226677(st3gal5)
SLAL111667589
XGL120785328(st3gal5)
HCQ109515789(st3gal5)
BPEC110156361(st3gal5)
MALB109957532(st3gal5)
OTW112256003(st3gal5)
OMY110504737(st3gal5)
OGO124011042(st3gal5)
ONE115129272(st3gal5)
SALP111967309(st3gal5)
SNH120062485(st3gal5)
ELS105026834(st3gal5)
SFM108920350(st3gal5)
PKI111837711(st3gal5)
AANG118232380(st3gal5)
LOC102684259(st3gal5)
PSPA121325705 121331013
ARUT117408868 117420817
CMK103181477
RTP109937636(st3gal5)
 » show all
Reference
1  [PMID:4631392]
  Authors
Basu S, Kaufman B, Roseman S.
  Title
Enzymatic synthesis of glucocerebroside by a glucosyltransferase from embryonic chicken brain.
  Journal
J Biol Chem 248:1388-94 (1973)
Reference
2  [PMID:4022]
  Authors
Fishman PH, Bradley RM, Henneberry RC.
  Title
Butyrate-induced glycolipid biosynthesis in HeLa cells: properties of the induced sialyltransferase.
  Journal
Arch Biochem Biophys 172:618-26 (1976)
DOI:10.1016/0003-9861(76)90116-8
Reference
3  [PMID:3838172]
  Authors
Higashi H, Basu M, Basu S.
  Title
Biosynthesis in vitro of disialosylneolactotetraosylceramide by a solubilized sialyltransferase from embryonic chicken brain.
  Journal
J Biol Chem 260:824-8 (1985)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.3.9
IUBMB Enzyme Nomenclature: 2.4.3.9
ExPASy - ENZYME nomenclature database: 2.4.3.9
BRENDA, the Enzyme Database: 2.4.3.9
CAS: 125752-90-1

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