KEGG   ENZYME: 2.5.1.101
Entry
EC 2.5.1.101                Enzyme                                 
Name
N,N'-diacetyllegionaminate synthase;
neuB (gene name);
legI (gene name)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
phosphoenolpyruvate:2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose 1-(2-carboxy-2-oxoethyl)transferase
Reaction(IUBMB)
2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + phosphoenolpyruvate + H2O = N,N'-diacetyllegionaminate + phosphate [RN:R10304]
Reaction(KEGG)
R10304
Substrate
2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose [CPD:C20424];
phosphoenolpyruvate [CPD:C00074];
H2O [CPD:C00001]
Product
N,N'-diacetyllegionaminate [CPD:C20418];
phosphate [CPD:C00009]
Comment
Requires a divalent metal such as Mn2+. Isolated from the bacteria Legionella pneumophila and Campylobacter jejuni, where it is involved in the biosynthesis of legionaminic acid, a virulence-associated, cell surface sialic acid-like derivative.
History
EC 2.5.1.101 created 2012
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K18430  N,N'-diacetyllegionaminate synthase
Genes
CITZE4Z61_12350(neuB)
PMAICF386_03205(neuB)
PTWTUM18999_39430
MLQASQ50_04385
MARJMARI_04460(legI)
SKHSTH12_02025(legI_1)
SLITJQC75_12045(neuB)
COZA3Q34_06165
PTUPTUN_a3149(neuB)
PSYMJ1N51_14005(neuB)
ASPAOR13_2481
ASQAVL57_11080
AAWAVL56_10220
ALEAV939_10100
ALZAV940_09870
TTUTERTU_1310
LPNlpg0752(neuB)
LPHLPV_0878(neuB)
LPOLPO_0833(neuB)
LPULPE509_02459
LPMLP6_0732(neuB)
LPFlpl0789(neuB)
LPPlpp0818(neuB)
LPCLPC_2540(neuB)
LPAlpa_01160
LPElp12_0762
LCDclem_09455(neuB_2)
LWASAMEA4504053_1066(spsE)
LANTTUM19329_12800(neuB)
FPHFphi_1167
FPIBF30_1411(neuB)
FPXKU46_147(neuB)
FHACDV26_09130(neuB)
FRCKX01_1747(neuB)
TCXTcr_1458
HTREPV75_07835(neuB)
HMARHVMH_1511(spsE)
TAOTHIAE_07350
THIOAYJ59_06075
THIGFE785_07450(neuB)
TXAHQN79_08330(neuB)
TSETHMIRHAS_08930(spsE)
TANIJ8380_09295(neuB)
TEETel_08595
HAHEENC22_10850
OMEOLMES_5580
AALLI6G90_07895
ARIVKYK33_12495
SUTRL0B52_04055(neuB)
TBNTBH_C0740
THINCRN91_03145(neuB) CRN91_03215
THOSP60_02330
EPSL0Y14_02440 L0Y14_02510
DEEHQN60_14860 HQN60_14875
CARIFNU76_04765(neuB)
PIGEGT29_04955
POSDT070_03545(neuB)
RTEAHK414_20340(neuB)
JAJEKL02_02185(neuB)
TINTint_2652
THITHI_3181
METRBSY238_2009(neuB)
ARESIWH25_01425(neuB)
ACOMCEW83_19880(neuB)
HCPHCN_1148
HCBHCBAA847_0824
TDNSuden_0595
SPALFM071_00635(neuB)
SSEIFJR45_00975(neuB) FJR45_04420(neuB)
SMASHUE87_09365(neuB)
SULRB649_08560
CJECj1327(neuB2)
CJBBN148_1327(neuB2)
CJICJSA_1263(neuB2)
CJSCJS3_1421
CJPA911_06450
CJEJN564_02255
CJEUN565_02345
CJENN755_02405
CJEIN135_01415
CJERH730_07590
CJYQZ67_01463(legI_2)
CJQUC78_1270(legI)
CJLPJ17_07020
CJWPJ18_06820
CJRCJE1516(ptmC)
CJDJJD26997_0385(ptmC)
CJZM635_02330
CJXBN867_13120
CCOCCC13826_2303(legI)
CCOCCCON33237_1630(legI)
CLACLA_1235(legI)
CLLCONCH_0304
CCOLBN865_08100c
CCCG157_02185
CCQN149_1290(legI)
CCFYSQ_02215
CCYYSS_07200
CCOIYSU_02250
CCOFVC76_06660(legI)
CCOOATE51_00910(legI)
CAJCIG1485E_0029(legI)
CISCINS_1194(legI)
CVOCVOL_1214(legI)
CSMCSUB8521_1417(legI)
CSFCSUB8523_1517(legI)
CHVCHELV3228_1655(legI)
CLXCLAN_1241(legI)
CAVICAV_1241(legI)
CAMZCVIC12175_0322(legI)
CAMYCSUIS_1328(legI)
COJCORN_1305(legI)
CUXCUP3940_0184(legI)
CARMCARM_1264(legI)
CMUCCMCT_0197(legI)
CNVCNZW441b_0374(legI)
ABTABED_0620
ATPATR_1813
ACIBACBT_0334
ACREACRYA_0150
ALANALANTH_0840
AELLAELL_2683
ACLOACLO_2510
AVPAVENP_1995
ARCABLL_0809
APAIAPAC_2452
HBVABIV_2490
GLOGlov_3405
GSBGSUB_14715
PACEA6070_09825
PEFA7E78_05520 A7E78_05530
DVLDvul_2590
DFLDFE_2603
DDEDde_3681
DASDaes_1985
DPIBN4_12680
DEJAWY79_10375
DDNDND132_0780
PSEFPSDVSF_07840(spsE)
DSXGD604_13335
DOAAXF15_00580
DALDalk_1661
DTOTOL2_C35400(neuB)
DAODesac_1879
BBAEFRD01_15935(neuB)
EMXFKV68_30710(neuB)
RHTNT26_3141(neuB)
DEIC4375_03855(neuB)
DEAFPZ08_13230(neuB)
MHEYH2LOC_005785
RBMTEF_17315
BSBBresu_0507
RPONG3256_17745
BOOE2K80_11695
PAEDG5B38_20080
FAQG5B39_16690(neuB)
MMRMmar10_1974
SLANGV829_10185(neuB)
PMASNCF86_12570
ALIAZOLI_p60097
MAGXXM1_0956
MAGQMGMAQ_1137
NACINUH88_13130(neuB)
MGMMmc1_0562
PELSAR11G3_00118
BSOBSNT_10307
BSTGYO_4022
FPNABE65_018195
MEKUHUW50_13940(neuB) HUW50_13960
PPYPPE_04401
PTAHPL003_04495
PDUPDUR_25200
PPEOABE82_23145
PAIHASL14_14800
PRZGZH47_18500(neuB)
PLYCGXP70_28100(neuB)
PALOE6C60_3854
KEBGXN75_11660(neuB)
EFCEFAU004_01372
EFAUEFAU085_00958
EFUHMPREF0351_10916(neuB)
AUIAPT62_03100
CARCNY10_960
CNONT01CX_1784
CBLCLK_2101
CBKCLL_A1556
CBBCLD_1854
CBNCbC4_0996
CBTCLH_1466
CKLCKL_2109 CKL_2472
CKRCKR_1848 CKR_2186
CCBClocel_2387
CEUA7L45_12145
CTAEBGI42_06575(neuB)
CFMBJL90_06975
CCHVBTM20_03650
CGASJ1C67_16000(neuB)
CMAHC1I91_08395(neuB)
CALEFDN13_00880(neuB)
CRSFQB35_02420(neuB)
CPRFK7H06_04875 K7H06_14850(neuB)
CTHCthe_2641
CTXClo1313_0230
CCLClocl_4180
SVJNQ490_02935(neuB)
BPBbpr_I0428(neuB1)
CLEClole_3572
CSHClosa_2917
LBWC3V36_05580(neuB)
CSTCLOST_0367
TEBT8CH_0143(legI)
CMICcaldi_28170
DDLDesdi_3209
DMTDESME_12780
DORDesor_0348
DAUDaud_0019
FWADCMF_13725
TJRTherJR_2780
AWOAwo_c24840(neuB)
CBARPATL70BA_2643(legI)
VPYHZI73_23120
THEPDYI95_003445
CTHMCFE_2539
TITThit_0481
MTAMoth_0756
MTHOMOTHE_c07000(legI)
MTHZMOTHA_c07940(legI)
CCHAELD05_07925(neuB)
TXYThexy_1876
TSHTsac_2668
HORHore_16950 Hore_17000
HPKHprae_0327
HALSD7D81_05095(neuB) D7D81_17935(neuB)
IFNGM661_06780(neuB) GM661_18095 GM661_18120(neuB)
AFTBBF96_11100
SPOAEQM13_03525(neuB)
LPILLIP_2376
XCLG4Z02_01770(neuB)
MSEDE3O41_11625
ARIUM93_07605
ICAIntca_1261
TEHGKE56_00615
PLAKA1s21155_00145
NHIB1s21160_05740
SYGsync_0174
SYWSYNW0448(neuB)
PMFP9303_01101(spsE)
PMHP9215_14811(spsE)
PMJP9211_12451(spsE)
MPROBJP34_35240
FGIOP10G_3269
RMLFF011L_46220(neuB_1)
RLCK227x_18880(legI)
GMRGmarT_17240(legI)
GIMF1728_06160(neuB)
GPNPan110_17070(legI)
PHMPSMK_29840
PCORKS4_08840(legI)
MCADPan265_05270(legI)
HBSIPV69_22560
UAMUABAM_06153
TPEDTPE_0201
SCDSpica_0510
LILLA_1609(spsE)
LIELIF_A1296(spsE)
LICLIC_12173(neuB)
LBJLBJ_1133
LBLLBL_1187
LSTLSS_16461 LSS_19373
LAJA0128_07320 A0128_07375
LMAYDPV73_15970(neuB) DPV73_16020
LWLFHG68_08325
LKBLPTSP3_g21330
BPOBP951000_1153(spsE)
BPJB2904_orf2564
BPIPBPP43_09345
BPWWESB_2577
FVAFV113G1_25420
FULC4N20_01280(neuB)
BNOK8P02_14905(neuB)
BVUBVU_4040
BDHGV66_21475
TFOBFO_1066(neuB)
DUNFDZ78_02060(neuB)
COPRCop2CBH44_22070(legI)
CHIHGWR21_01080(neuB) GWR21_20995(neuB)
PGOFSB84_04825(neuB)
PEPAQ505_02055
PSTYBFS30_06850
PEJFYC62_11660(neuB)
SHGSph21_1815
SDJNCTC13534_05285(spsE_1) NCTC13534_05286(spsE_2)
SCNSolca_4307
MMABHQ865_06375(neuB)
MGIKGO620_005080(neuB)
AGDFRZ59_07155(neuB) FRZ59_07170
OLIFKG96_05940(neuB)
EMAIKZP23_21780(neuB)
ALMAO498_13850
DFEDfer_3363
DSNHWI92_21155
PACTCA264_12450
ASWUHUW51_14155(neuB)
FPFDCC35_14845(neuB)
FBTD770_00730
FUVJR347_14630(neuB)
GFOGFO_0569
GRLLPB144_06590
GFLGRFL_2392
FINKQS_03395
FPALHYN49_06980
FSEDI487_03495
FENJ0383_14250(neuB)
COLAM608_07315
ZPRZPR_1117
FBCFB2170_05795
MARTBTR34_08470
MARBCJ263_08140(neuB)
LVNBWR22_10530
MUTGVT53_17455(neuB)
NDODDD_3554
NOBCW736_09215
NOJEJ995_10795
POMMED152_05685
POLABXQ17_13925
PHALH9I45_03450
PPECH9W90_01215
PBATJL193_16055
PCEAJ3359_01875
WIJBWZ20_06350
TJETJEJU_1144(legI)
LULLPB138_01915
WFUAXE80_08450
FOPFNB79_09370
SALTAO058_07925
SMISLDL76_16105
SEONBWZ22_01500
KOSKORDIASMS9_03609(legI)
KANIMCC3317_05800(legI)
AFLAFHG64_14730
ANPFK178_08465
ALTIALE3EI_0110
SAHNJRG66_01115(neuB)
CJGNCTC13459_02715(spsE)
CANTNCTC13489_01541(spsE)
FTEFluta_2184
CHYDH4K34_10465
PPHPpha_0527
PMXPERMA_1627(neuB)
TTKTST_1473(neuB)
TNPTnap_0417
DDFDEFDS_0370
DAPDacet_0450
DTPJZK55_10000
NLIG3M70_03950 G3M70_11130(neuB)
MMQMmarC5_0506
MMAKMMKA1_03760
MAEMaeo_0420
METJFZP68_08655(neuB)
MEWMSWAN_1357 MSWAN_1360
MSJMSSAC_2015
MSWMSSIT_2302
MBUMbur_1586
MRTJKHC33_01430
MENDL6E24_13055(neuB)
MFOMetfor_1307
SAIMK0C01_02745(neuB)
HMUHmuk_1456
HALZE5139_10440(neuB)
HAZPGBQ70_10435(neuB)
HPELHZS54_05935
HALPDOS48_05315(neuB)
HAEhalTADL_2399
NMGNmag_0151(neuB)
NIDNPIRD3C_0036
NINNADRNF5_2117
NIWNisw_04230
NUEC5F50_00695
NCTNMSP_0147
NICDSQ20_00905
NDVNDEV_0150(NeuB) NDEV_0210(neuB2) NDEV_0212
 » show all
Reference
1  [PMID:18275154]
  Authors
Glaze PA, Watson DC, Young NM, Tanner ME
  Title
Biosynthesis of CMP-N,N'-diacetyllegionaminic acid from UDP-N,N'-diacetylbacillosamine in Legionella pneumophila.
  Journal
Biochemistry 47:3272-82 (2008)
DOI:10.1021/bi702364s
  Sequence
[lpn:lpg0752]
Reference
2  [PMID:19282391]
  Authors
Schoenhofen IC, Vinogradov E, Whitfield DM, Brisson JR, Logan SM
  Title
The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors.
  Journal
Glycobiology 19:715-25 (2009)
DOI:10.1093/glycob/cwp039
  Sequence
[cje:Cj1327]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.101
IUBMB Enzyme Nomenclature: 2.5.1.101
ExPASy - ENZYME nomenclature database: 2.5.1.101
BRENDA, the Enzyme Database: 2.5.1.101

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