KEGG   ENZYME: 2.5.1.21
Entry
EC 2.5.1.21                 Enzyme                                 
Name
squalene synthase;
farnesyltransferase;
presqualene-diphosphate synthase;
presqualene synthase;
squalene synthetase;
farnesyl-diphosphate farnesyltransferase;
SQS
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
(2E,6E)-farnesyl-diphosphate:(2E,6E)-farnesyl-diphosphate farnesyltransferase
Reaction(IUBMB)
2 (2E,6E)-farnesyl diphosphate + NAD(P)H + H+ = squalene + 2 diphosphate + NAD(P)+ (overall reaction) [RN:R06223];
(1a) 2 (2E,6E)-farnesyl diphosphate = diphosphate + presqualene diphosphate [RN:R00702];
(1b) presqualene diphosphate + NAD(P)H + H+ = squalene + diphosphate + NAD(P)+ [RN:R02872]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
presqualene diphosphate [CPD:C03428]
Product
squalene [CPD:C00751];
diphosphate [CPD:C00013];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
presqualene diphosphate [CPD:C03428]
Comment
This microsomal enzyme catalyses the first committed step in the biosynthesis of sterols. The enzyme from yeast requires either Mg2+ or Mn2+ for activity. In the absence of NAD(P)H, presqualene diphosphate (PSPP) is accumulated. When NAD(P)H is present, presqualene diphosphate does not dissociate from the enzyme during the synthesis of squalene from farnesyl diphosphate (FPP) [8]. High concentrations of FPP inhibit the production of squalene but not of PSPP [8].
History
EC 2.5.1.21 created 1976, modified 2005, modified 2012
Pathway
ec00100  Steroid biosynthesis
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00801  farnesyl-diphosphate farnesyltransferase
Genes
HSA2222(FDFT1)
PTR740684(FDFT1)
PPS100987932(FDFT1)
GGO101151217(FDFT1)
PON100173463(FDFT1)
NLE100603333(FDFT1)
MCC696396(FDFT1)
MCF102131949(FDFT1)
MTHB126961065
CSAB103215320(FDFT1)
CATY105579387(FDFT1)
PANU101007572(FDFT1)
TGE112629684(FDFT1)
RRO104679113(FDFT1)
RBB108536688(FDFT1)
TFN117063482(FDFT1)
PTEH111551352(FDFT1)
CJC100405611 100410988(FDFT1)
SBQ101048204(FDFT1)
CSYR103275040(FDFT1)
MMUR105864814(FDFT1)
LCAT123626545(FDFT1)
OGA100952312(FDFT1)
MMU14137(Fdft1)
MCAL110309079(Fdft1)
MPAH110325250(Fdft1)
RNO29580(Fdft1)
MCOC116085395(Fdft1)
MUN110561867(Fdft1)
CGE100689192(Fdft1)
MAUA101843686(Fdft1)
PLEU114703363(Fdft1)
MORG121456447(Fdft1)
MFOT126507570
AAMP119799759(Fdft1)
NGI103729974(Fdft1)
HGL101709374(Fdft1)
CPOC100714445(Fdft1)
CCAN109682022(Fdft1)
DORD105991597(Fdft1)
DSP122125269(Fdft1)
NCAR124982419
OCU100345480(FDFT1)
OPI101517883(FDFT1)
TUP102482751(FDFT1)
CFA477362(FDFT1)
CLUD112669643(FDFT1)
VVP112926755(FDFT1)
VLG121496785(FDFT1)
AML100479603(FDFT1)
UMR103675932(FDFT1)
UAH113269919(FDFT1)
UAR123793571(FDFT1)
ELK111156663
LLV125092925
MPUF101693986(FDFT1)
ORO101375815(FDFT1)
EJU114217460(FDFT1)
ZCA113924774(FDFT1)
MLX118022143(FDFT1)
NSU110588631(FDFT1)
FCA101084620(FDFT1)
PYU121026992(FDFT1)
PBG122474400(FDFT1)
LRUF124520614
PTG102968349(FDFT1)
PPAD109262394(FDFT1)
AJU106975818(FDFT1)
HHV120222042(FDFT1)
BTA281767(FDFT1)
BOM102284633(FDFT1)
BIU109562774(FDFT1)
BBUB102411072(FDFT1)
CHX102173564(FDFT1)
OAS101119109(FDFT1)
ODA120856933(FDFT1)
CCAD122452913(FDFT1)
SSC100312971(FDFT1)
CFR102519424(FDFT1)
CBAI105083369(FDFT1)
CDK105101899(FDFT1)
VPC102528755(FDFT1)
BACU102999512(FDFT1)
LVE103090735(FDFT1)
OOR101283685(FDFT1)
DLE111185363(FDFT1)
PCAD102983337
PSIU116754942(FDFT1)
ECB100060929(FDFT1)
EPZ103558181(FDFT1)
EAI106822581(FDFT1)
MYB102240587(FDFT1)
MYD102770912(FDFT1)
MMYO118658183(FDFT1)
MLF102429845(FDFT1)
MNA107527502(FDFT1)
PKL118711675(FDFT1)
HAI109379549(FDFT1)
DRO112312249(FDFT1)
SHON118984314(FDFT1)
AJM119049446(FDFT1)
PDIC114504108(FDFT1)
PHAS123814148(FDFT1)
MMF118615563(FDFT1)
RFQ117037967(FDFT1)
PALE102883195(FDFT1)
PGIG120613355(FDFT1)
PVP105291574(FDFT1)
RAY107507225(FDFT1)
MJV108402363(FDFT1)
TOD119258044(FDFT1)
SARA101558986(FDFT1)
LAV100677178(FDFT1)
TMU101340573
DNM101421740(FDFT1)
MDO100029000(FDFT1)
GAS123237005(FDFT1)
SHR100920775(FDFT1)
PCW110207626(FDFT1)
OAA100082427(FDFT1)
GGA422038(FDFT1)
PCOC116235583(FDFT1)
MGP100545674(FDFT1)
CJO107306801 107312392(FDFT1)
NMEL110395599(FDFT1)
APLA101796770(FDFT1)
ACYG106038131(FDFT1)
AFUL116487611(FDFT1)
TGU100217567(FDFT1)
LSR110481436(FDFT1)
SCAN103821286(FDFT1)
PMOA120496833(FDFT1)
OTC121347490(FDFT1)
PRUF121360818(FDFT1)
GFR102034631(FDFT1)
FAB101815980(FDFT1)
PHI102102388(FDFT1)
PMAJ107202506(FDFT1)
CCAE111927374(FDFT1)
CCW104696873(FDFT1)
CBRC103613271(FDFT1)
ETL114069200(FDFT1)
ZAB102068654(FDFT1)
ACHL103807813(FDFT1)
FPG101924340(FDFT1)
FCH102049604(FDFT1)
CLV102084937(FDFT1)
EGZ104127262(FDFT1)
NNI104014688(FDFT1)
PLET104614294(FDFT1)
PCAO104053455(FDFT1)
ACUN113478475(FDFT1)
TALA104355579(FDFT1)
PADL103913227(FDFT1)
AFOR103906890(FDFT1)
ACHC115350922(FDFT1)
HALD104320689(FDFT1)
CSTI104557663(FDFT1)
EHS104506675(FDFT1)
CMAC104480636(FDFT1)
MUI104543323(FDFT1)
FGA104078894(FDFT1)
GSTE104264075(FDFT1)
LDI104352392(FDFT1)
MNB103778160(FDFT1)
OHA104336469(FDFT1)
NNT104412622(FDFT1)
DPUB104306745(FDFT1)
PGUU104462004(FDFT1)
ACAR104524293(FDFT1)
AVIT104267164(FDFT1)
CVF104289048(FDFT1)
CUCA104060731(FDFT1)
AAM106483925(FDFT1)
AROW112963756(FDFT1)
NPD112948541(FDFT1)
TGT104565951(FDFT1)
DNE112991184(FDFT1)
SCAM104138989(FDFT1)
ASN102368591 102380768 102385901
AMJ102562543 102573401(FDFT1) 109282694
CPOO109311510(FDFT1)
GGN109300253(FDFT1)
PSS102453225(FDFT1) 102453483
CMY102929796 102930012
CPIC101942357(FDFT1) 101942618
TST117875402 117875403
CABI116815291 116815294
MRV120401035 120401036
ACS100553538 100553739 100560926(fdft1) 100563293 100563486 100563681
PVT110070449(FDFT1)
SUND121916997 121936038 121937029
PBI103051265(FDFT1)
PMUR107289313(FDFT1)
CTIG120318462(FDFT1)
TSR106546572(FDFT1)
PGUT117667727(FDFT1)
VKO123033638(FDFT1)
PMUA114594907(FDFT1)
ZVI118082978(FDFT1)
GJA107120762(FDFT1)
STOW125444834 125444876
XLA108717235(fdft1.L) 108718290(fdft1.S)
XTR100216201(fdft1)
NPR108797917 108797918
RTEM120935611 120936188 120936189 120936190
BBUF120997198 120997199 120997200 120998952
BGAR122944545 122944547 122944548 122944549 122944550 122944551 122944552
DRE571911(fdft1)
SRX107739179(fdft1)
SANH107661354 107671088
SGH107557019(fdft1)
CCAR109065757 109065791
CAUA113068573 113073347 113120553
PPRM120492021(fdft1)
MAMB125278587(fdft1)
IPU108258919(fdft1)
PHYP113529277(fdft1)
SMEO124401516(fdft1)
TFD113662394(fdft1)
AMEX103034009(fdft1)
EEE113572100(fdft1)
TRU101070689(fdft1)
TNGGSTEN00030353G001
LCO104930557(fdft1)
NCC104947343(fdft1)
CGOB115003765(fdft1)
ELY117270781(fdft1)
EFO125896923(fdft1)
PLEP121955973(fdft1)
SLUC116066148(fdft1)
ECRA117961241(fdft1)
ESP116706387(fdft1)
PFLV114573034(fdft1)
GAT120807893(fdft1)
PPUG119194662(fdft1)
MSAM119908829(fdft1)
CUD121520924(fdft1)
ALAT119012154(fdft1)
MZE101480536(fdft1)
ONL100709794(fdft1)
OAU116310709(fdft1)
OLA101165780(fdft1)
OML112158394(fdft1)
XMA102222352(fdft1)
XCO114158820(fdft1)
XHE116734372(fdft1)
PRET103457575(fdft1)
PFOR103138606(fdft1)
PLAI106957405(fdft1)
PMEI106928318(fdft1)
GAF122825018(fdft1)
CVG107082709(fdft1)
CTUL119785111(fdft1)
GMU124882512(fdft1)
NFU107377586(fdft1)
KMR108240060(fdft1)
ALIM106516931(fdft1)
NWH119418539(fdft1)
AOCE111569937(fdft1)
MCEP124999410(fdft1)
CSEM103380825(fdft1)
POV109636192(fdft1)
SSEN122784065(fdft1)
HHIP117758360(fdft1)
HSP118099515(fdft1)
LCF108895640
SDU111239337(fdft1)
SLAL111653027(fdft1)
XGL120789223(fdft1)
HCQ109516774(fdft1)
BPEC110171978
MALB109953260(fdft1)
BSPL114849797(fdft1)
SASA100380689(fdft1)
STRU115190294(fdft1)
OTW112217679(fdft1)
OMY110522339(fdft1)
OGO123995188(fdft1)
ONE115139301(fdft1)
SALP111972695(fdft1)
SNH120019036(fdft1)
CCLU121548820(fdft1)
ELS105006434(fdft1)
SFM108924113(fdft1)
PKI111841359(fdft1)
AANG118230084(fdft1)
LOC102695894(fdft1)
PSPA121315995(fdft1)
ARUT117403065(fdft1)
LCM102352076(FDFT1)
CMK103171628(fdft1)
BFO118404551
BBEL109473113
SPU586013
APLC110975329
SKO100368580
BCOO119082415
BTAB109040729
FCD110850303 110850304 110857438 110861147
HROHELRODRAFT_68312
LGILOTGIDRAFT_56072
PCAN112562354
BGT106055953
GAE121377538
HRF124146791
HRJ124257403
OSN115232110
LAK106150730
TADTRIADDRAFT_27912
AQU100641044
ATHAT4G34640(SQS1) AT4G34650(SQS2)
ALY110230201 9303181 9305204
CRB17877456 17878476
CSAT104716666 104716668 104721325 104729749 104729750 109124813
EUSEUTSA_v10025338mg EUTSA_v10025392mg
BRP103834400 103836007 103836099 103862364 103862654
BNA106353454 106353554 106361022 106371265 106428751 106428793 111208288 111212693 111212694 111214348
BOE106301985 106304831 106308593 106324379 106328821 106330848
RSZ108819316 108842645 108842646 108849231
THJ104804345 104819625
CPAP110808186 110808189 110808190
CIT102577972
CICCICLE_v10028537mg
PVY116130012 116130038 116130072 116134221
MINC123214512 123227889
TCC18607702
GRA105772833 105795347
GHI107908820 107928014 107928928 107937000
GAB108476174 108480508
DZI111281998 111297181 111308825
EGR104415898 104415901 104417873 104428608 104453100 104453372
GMX100775983 547940
GSJ114376748 114380149
PVUPHAVU_011G040100g
VRA106756236
VAR108340525
VUN114169582
CCAJ109818400
APRC113865323
MTR11441556
CAM101494936
PSAT127101272
LJALj3g3v3386550.1(Lj3g3v3386550.1) Lj3g3v3386560.1(Lj3g3v3386560.1)
ADU107458988 107476630
AIP107609146 107628845
AHF112703107 112736932 112765062 112789149
LANG109325850 109344046
FVE101299914
RCN112169992
PPER18766621
PMUM103335730
PAVI110768502
PDUL117614717 117638854
MDM103445128 114824777
PXB103965221 103966922
ZJU107426708
MNT21391810
CSV101205767
CMO103499718
BHJ120088762
MCHA111015463
CMAX111484252 111499841
CMOS111448190 111451168
CPEP111776748 111795790
RCU8284359
JCU105630097
HBR110637585 110644111 110646492
MESC110612813 110626763
POP7461247 7494303
PEU105134469 105141825
PALZ118039704 118058960
JRE108986986 109006527
QSU112001025 112030281 112035919
QLO115968189
TWL120002694 120014357
VVI100265798
VRI117911338
SLY100316899(SQS1) 101252241 101258416
SPEN107001734 107001821 107008117
SOT102580869 102581159(PSS1) 102582345 102582647
SSTN125857406 125861810 125866352
CANN107840471 107843931 107844779
NTA107759374 107760995 107790933(TSS) 107791556 107792297 107799710 107813695
NSY104211830 104212796 104220676 104248076
NTO104088294 104090848 104111326 104121410
NAU109210175 109232373 109233469 109244014
INI109161942 109165153 109165155 109165158
ITR116023019 116032372 116032549 116033681
SIND105169693 105172921
OEU111374919 111379472 111380678 111380702 111410086 111412627
EGT105952034 105957692
SSPL121746788 121748033 121751570 121760195 121763316 121787688
HAN110884690 110912998
ECAD122606631 122610869
LSV111887746 111903774
CCAV112522476 112525044
DCR108192971 108223403
CSIN114262997
BVG104904268 104904269
SOE110793850 110793851 110793852
CQI110705161 110705162 110705164 110718883 110718885 110718886
NNU104602023
MING122079422
TSS122658164 122661696
PSOM113288764 113289395 113346193
NCOL116260289
OSA4334492 4342663
DOSAOs03t0805100-01(Os03g0805100) Os07t0200700-01(Os07g0200700)
OBR102703113 102718194
BDI100825967 100831520
ATS109770541
TDC119303656 119312351
TAES123105516 123113831 123123327
TUA125511040
SBI8061131
ZMA100191601 541614
SITA101779179
SVS117840988
PVIR120649394 120688373
PHAI112875283
PDA103711437 103712070
EGU105036860 105054520
MUS103975715 103981888
DCT110113711 110115088
PEQ110018227 110030022
AOF109833377
ATR18431444
SMOSELMODRAFT_96714
PPP112280540 112281267 112282546
CRECHLRE_03g175250v5
VCNVOLCADRAFT_79344
MNGMNEG_3837
CSLCOCSUDRAFT_35284
CVRCHLNCDRAFT_18492(SQS)
APROF751_6725
OLUOSTLU_31144
OTAOT_ostta04g02080
BPGBathy06g04270
MISMICPUN_108133
MPPMICPUCDRAFT_57124
CMECYME_CMG178C
GSLGasu_00950
CCPCHC_T00001581001
SCEYHR190W(ERG9)
SEUBDI49_2593
SPAOSPAR_H02310
AGOAGOS_AFR444C
ERCEcym_1390
KLAKLLA0_D08866g
KMXKLMA_20722(ERG9)
LTHKLTH0F06886g
VPOKpol_541p19
ZROZYRO0A00924g
CGRCAGL0M07095g
NCSNCAS_0C00280(NCAS0C00280)
NDINDAI_0K00290(NDAI0K00290)
TPFTPHA_0C04820(TPHA0C04820) TPHA_0I00370(TPHA0I00370)
TBLTBLA_0D03330(TBLA0D03330)
TDLTDEL_0B00260(TDEL0B00260)
TGBHG536_0H00260
KAFKAFR_0L01990(KAFR0L01990)
KNGKNAG_0K00660(KNAG0K00660)
ZMKHG535_0C05760
PPAPAS_chr3_0317
DHADEHA2D02552g
PICPICST_83429(ERG9)
PGUPGUG_05132
SPAASPAPADRAFT_60279
LELLELG_02428
CALCAALFM_C208610WA(ERG9)
CTPCTRG_01858
COTCORT_0C06180
CDUCD36_22740(ERG9)
CTENCANTEDRAFT_112210
YLIYALI0A10076g
CLUCLUG_00485
CLUSA9F13_15g01562
CAURCJI97_004865
SLBAWJ20_4389(ERG9)
PKZC5L36_0B02440
BNNFOA43_004291
BBRXBRETT_002088
OPAHPODL_02049
SLUDSCDLUD_001249
NCRNCU06054
NTENEUTE1DRAFT67078(NEUTE1DRAFT_67078)
SMPSMAC_07413
PANPODANSg2377
TTTTHITE_76823
MTMMYCTH_112159
CTHRCTHT_0047830
MGRMGG_09239
PPEIPpBr36_07572
TMNUCRPA7_2120
SSCKSPSK_09158
FGRFGSG_09381
FPUFPSE_05092
FVRFVEG_03929
FOXFOXG_06061
NHENECHADRAFT_75492
TRETRIREDRAFT_122653
TRRM419DRAFT_25484
MAWMAC_08985
MAJMAA_06577 MAA_10247
CMTCCM_07634
PLJVFPFJ_10019
VALVDBG_07304
VDAVDAG_06011
CFJCFIO01_04616
CLUPCLUP02_14275
CHIGCH63R_06219
SAPOSAPIO_CDS6942 SAPIO_CDS7603
ELAUCREL1_1682
PFYPFICI_06798
SSLSS1G_02527
BFUBCIN_06g02400(Bcerg9)
MBEMBM_09225
PSCOLY89DRAFT_504931
GLZGLAREA_11903
ANIAN3376.2
AFMAFUA_7G01220
ACTACLA_066340
NFINFIA_113940
AORAO090010000204
ANGANI_1_256104(An12g01890) ANI_1_3012024(An02g11000)
AFVAFLA_013755
ALUCAKAW2_10929S(ERG9_1) AKAW2_81142A(ERG9_3)
ACHEACHE_70882S(ERG9)
APUUAPUU_31416A(ERG9)
PCSPc21g13930
PDPPDIP_55100
TMFPMAA_016650
TRGTRUGW13939_11746
CIMCIMG_04821 CIMG_08115
CPWCPC735_021300 CPC735_070290
UREUREG_02386 UREG_04164
PBLPAAG_12679(PAAG_09054)
PBNPADG_08600
ABEARB_06257
TVETRV_00831
AJEHCAG_07922
BGHBDBG_08773
PNOSNOG_00755
PTEPTT_14326
BZECOCCADRAFT_82062
BSCCOCSADRAFT_35564
BORCOCMIDRAFT_89307
AALTCC77DRAFT_1015801
ZTRMYCGRDRAFT_65850(ERG9)
PFJMYCFIDRAFT_26282
FFUCLAFUR5_02085
BCOMBAUCODRAFT_73663
NPAUCRNP2_1856
TMLGSTUM_00004443001
SPOSPBC646.05c(erg9)
CNECNC05660
CNBCNBC1530
CNGCNAG_07510
CGICGB_C8220W
TMSTREMEDRAFT_67037
TASAA1Q1_00880
TVSTRAVEDRAFT_148221
DSQDICSQDRAFT_125356
PCOPHACADRAFT_264568
SHSSTEHIDRAFT_69654
HIRHETIRDRAFT_323009
PSQPUNSTDRAFT_141374
ADLAURDEDRAFT_115501 AURDEDRAFT_135052
FMEFOMMEDRAFT_170309
GTRGLOTRDRAFT_128035
CCICC1G_03978
ABPAGABI1DRAFT21221(AGABI1DRAFT_21221)
ABVAGABI2DRAFT50291(AGABI2DRAFT_50291)
PCUBJR316_0007733
MPRMPER_08376 MPER_11859
MRRMoror_1285 Moror_16613
MOREE1B28_000697
SCMSCHCO_02603898(SCHCODRAFT_02603898)
CPUTCONPUDRAFT_112596
SLASERLADRAFT_341452
WSEWALSEDRAFT_48978
WICJ056_001663
UMAUMAG_04374
PFPPFL1_05706
MGLMGL_3284
MRTMRET_2411
MSYMMSY001_3104
PGRPGTG_00663
MLRMELLADRAFT_50370
MBRMONBRDRAFT_38891
SREPTSG_05848
DDIDDB_G0292072(fdfT)
DPPDICPUDRAFT_147378
DFADFA_00629(fdfT)
ACANACA1_089030
SMINv1.2.017867.t1(symbB.v1.2.017867.t1)
PTIPHATRDRAFT_13160
FCYFRACYDRAFT_209449(PSY4)
TPSTHAPSDRAFT_268488
AAFAURANDRAFT_2849
SPARSPRG_06233
EHXEMIHUDRAFT_68651
GTTGUITHDRAFT_92939
TBRTb927.8.7120
TBGTbgDal_VIII7370
TCR507897.20 508369.20
LMALMJF_31_2940
LIFLINJ_31_3050
LDOLDBPK_313050
LMILMXM_30_2940
LBZLBRM_31_3310
LPANLPMP_312810
NGRNAEGRDRAFT_77230
LFALFA_3652
TEETel_06600
MARSA8C75_17560
RPJN234_21900
CNCCNE_2c01930
CUHBJN34_21065
REUReut_A3084
RMERmet_5617
CTIRALTA_B0216
CBWRR42_s1268
CCUPBKK81_19140
CUPBKK80_22805
CUUBKK79_28080
CPAUEHF44_21120
COXE0W60_06995
CCAMM5D45_28090
BMABMAA1840
BMVBMASAVP1_0843
BMLBMA10229_1132
BMNBMA10247_A2107
BMALDM55_3941
BMAEDM78_4853
BMAQDM76_4638
BMAIDM57_06815
BMAFDM51_3534
BMAZBM44_3901
BMABBM45_4676
BPSBPSS0232
BPMBURPS1710b_A1762(sqs)
BPLBURPS1106A_A0327
BPDBURPS668_A0418
BPSEBDL_6125
BPSMBBQ_5979
BPSUBBN_3615
BPSDBBX_5294
BPZBP1026B_II0255
BPQBPC006_II0311
BPKBBK_5428
BPSHDR55_5128
BPSABBU_5898
BPSOX996_4894
BUTX994_4443
BTEBTH_II2156
BTQBTQ_5440
BTJBTJ_4096
BTZBTL_4908
BTDBTI_4497
BTVBTHA_5315
BTHEBTN_4565
BTHMBTRA_4830
BTHADR62_4674
BTHLBG87_4897
BOKDM82_4236
BOCBG90_3787
BUUWS70_18550
BSAVWS86_19945
BHGI6G56_30625
BVIBcep1808_4828
BVEAK36_4090
BURBcep18194_B1749
BCMBcenmc03_3255
BCHBcen2424_4262
BCJBCAM1397A
BCENDM39_3608
BCEWDM40_4285
BCEOI35_5250 I35_5971
BAMBamb_3686
BACBamMC406_4159
BMUBmul_4328
BMKDM80_3507
BMULNP80_4290
BCTGEM_4358
BCEDDM42_3690 DM42_5871
BCEPAPZ15_17670
BDLAK34_4114
BPYRABD05_29210
BCONNL30_05675
BUBBW23_5074
BDFWI26_19980
BLATWK25_23795
BTEIWS51_04665
BSEMWJ12_26785
BPSLWS57_03525 WS57_07100
BMECWJ16_25375
BSTGWT74_25750
BSTLBBJ41_20040
BANNJFN94_24065
BARINLX30_31615
BGLbglu_2g21520
BGUKS03_3775
BUGBC1001_4577
BGFBC1003_4920
BGDbgla_2g28530
BGOBM43_6592
BYIBYI23_D009940
BUKMYA_4392
BUEBRPE67_DCDS12000
BULBW21_4019
BUQAC233_27140
BGPBGL_2c28380
BPLAbpln_2g28380
BUDAQ610_20800
BUMAXG89_36185
BUIAX768_16315
BURKDM992_18960
BXEBxe_B0485
BXBDR64_5820
BPHBphy_5450
BGEBC1002_4739
BPXBUPH_01141
BPYBphyt_4026
BUZAYM40_22630
BFNOI25_6198
BCAIK788_0003181
PSPWBJG93_22885
PARABTO02_31230
PARBCJU94_27110
PHSC2L64_25725
PTERC2L65_22685
PGPCUJ91_29080
PCJCUJ87_29120
PTSCUJ90_22600
PCAFDSC91_000414
PMEGFNZ07_32035
PTROG5S35_17240
PGISI6I06_26880
PACPFAZ97_17710
PACSFAZ98_22175
PEWKZJ38_33445
PDIOPDMSB3_2935.1
BRHRBRH_03907
PTXABW99_15165
BUOBRPE64_DCDS10660
VCVGJV44_00554(crtB)
LIHL63ED372_01027(crtB_3)
STHMIS481_08960
NMUNmul_A0957
NLCEBAPG3_013085
NIZNNRS527_01000
CCXCOCOR_05517
PAUUE8A73_027890
LLUAKJ09_01004
MRMA7982_03038 A7982_08127
BSEDDN745_03535
PCAYFRD00_01740
SBFJCM31447_05490
BIFN288_13025
BFDNCTC4823_04052
BSHILGQ02_01945
BBADK7T73_14480
BACOOXB_0648
BACQDOE78_21825
BCOHBC6307_21660
BMQBMQ_3872
BMDBMD_3864
BMHBMWSH_1351
BMEGBG04_787
BEOBEH_04580
BKOCKF48_03340
CGOTJ1899_04780
CSOALIS82_16115
OIHOB0469
OCNCUC15_02355
AXLAXY_13700
LSPBsph_2162
LGYT479_08465
LFUHR49_15375
LYSLBYS11_07695
LYBC3943_09785
LYZDCE79_06440
LYGC1N55_08600
LPAKGDS87_08905
LAGRFJQ98_09425
LMACI6G82_10300
LYCFH508_0009075
LCAPICJ70_16525
VIRX953_02190
VHLBME96_01535
VIGBKP57_13845
VILCFK37_04585
VNECFK40_00110
VPNA21D_00748(crtB)
VPTKBP50_16095
VNTOLD84_02985
LAOAOX59_12230
LEXLen3610_17185
BSJUP17_15900
BMURABE28_014765
PBUTDTO10_02825
PASABAOM_3627
PPSRI6J18_21125
PFRIL8956_16630
PSYHD0S48_11445
PSYOPB01_00910
MEKUHUW50_23320
MSEMGMB29_18830
MDGK8L98_15610
MLITKDJ21_016800
PSUAFLK61_26830
SLMSMM221_03980
SSPSSP1103
SXYBE24_05955
SXLSXYLSMQ121_1141
SXOSXYL_01204
SEQOSE1039_14830
SCOHBZ166_10095
SNLBJD96_06085
SKLC7J89_00860
SARLSAP2_11940
SLLOISP08_12280
SPSDJMB28_06430
ESIExig_2456
EANEab7_2303
EXMU719_13530
EXUESP131_15580
EACEKKI46_13425
PJDPjdr2_5389
GYMGYMC10_3503
PMSKNP414_05298
PMQPM3016_4687
PMWB2K_24305
PIHUB51_24265
PNPIJ22_01770
POWIJ21_27720
PCXLPB68_09590
PVOPVOR_18054
PLWD5F53_12750
PALBEJC50_20545
PBKBack11_17400
PPRTET464_05595
PRZGZH47_01750
PCELHUB94_17500
ASOCCB4_02805
SIVSSIL_2638
SSILSOLI23_05430
SOBCSE16_06435
PLNPlano_0409
PKUAUO94_14530
PRTAUC31_07615
PLLI858_005330
PANABBH88_00330
PDGBCM40_13670
PHCBBI08_15050
PMARB0X71_02575
PPLABBI15_14405
PFAEAJGP001_02570
PLXCW734_03750
PMATBBI11_03500
PDECH1Q58_02645
PGQFK545_10130
KURASO14_1907
KZONCTC404_01803
SPSYAZE41_12340
SPORSporoP33_00610
SPOPSporoP37_01010
SURESporoP32a_00790
SPOSDV702_04870
SPOOJ3U78_10215
RSTATY39_08105
PAEKD3873_01540
PANCE2636_14775
PLAYDNR44_000875
VIJJNUCC6_21670
KPULGXN76_14860
KEBGXN75_13015
HORHore_15920
HASHalsa_0837
HPKHprae_0589
HALSD7D81_05700
IFNGM661_03155
SXISXIM_42260
SALFSMD44_p20058
SQZFQU76_13590 FQU76_14520
SSPBCP982_41385
SHARHUT13_20945
KPHYAOZ06_17435
SYNsll0513
SYZMYO_128830
SYYSYNGTS_2857(sll0513)
SYTSYNGTI_2856(sll0513)
SYSSYNPCCN_2855(sll0513)
SYQSYNPCCP_2855(sll0513)
SYJD082_03960
SYOC7I86_14915
SYNESyn6312_0495
SYNPSyn7502_01211
AMRAM1_3670
WNAKA717_34890
TVNNIES2134_106440
SLWBRW62_04760
TELtll1096
THNNK55_01680
THECFFX45_11760
LENLEP3755_22020
LBOLBWT_25830
KOVK9N68_21530
LSCKIK02_09840
LSKJ5X98_07015
HHGXM38_041660(crtB_2)
GENGM3709_2090
GEEGM3708_2008
MARMAE_33550
MPKVL20_3202
MIQB5D77_04150
MVZmyaer102_08850
CANCyan10605_1983
CYUUCYN_07200
CYTcce_1843
CWACwatDRAFT_2696
CYPPCC8801_0502
CYHCyan8802_0519
CYCPCC7424_1894
CYJCyan7822_0086
CYNCyan7425_4822
TERTery_2043
PAGHNIES204_22780
PPSUNO713_01753
MICMic7113_5950
MPROBJP34_21315
PHORJWS08_14650
PYHNEA10_17180
GVIglr4058
GLJGKIL_2412
GMLISF26_20935
ANAalr1805
NPUNpun_R2917
NOSNos7107_3780
NOPNos7524_0570
NONNOS3756_49790
NFLCOO91_04180
NOECLI64_12435
NSHGXM_00272
NEDHUN01_10770
AVAAva_4808
ANBANA_C13133(crtB)
ACYAnacy_0443 Anacy_3489
AWAAA650_13640
ANNEH233_12130
CSGCylst_2356
RSINB6N60_00366
CALOCal7507_4175
CALTCal6303_3755
CALNNIES2098_38370
FISFIS3754_26870
DOUBMF77_03711(crtM)
DFSHGD76_23310
DHTNG743_23695
CCURIAR63_06770
CRKL3I90_15020
AFLOHEQ12_08660
TOQHCG51_05025
NCNBZZ01_05280
PLPPle7327_0752
SCSSta7437_1688
STANSTA3757_45920
CEOETSB_0935
CERRGRSB_0890
KBSEPA93_16000
AMUAmuc_0365
AGLPYTT_1876
ROOG5S37_18030
LUOHHL09_19990
LAMBKBB96_12525
SOAG3M56_007710
XIIAMD24_00445
PNDPla175_40230(crtB)
UAMUABAM_06690
BHYBHWA1_01292
BHDBHYOB78_09595
BRMBmur_0892
BPOBP951000_1818
BPJB2904_orf631
BPIPBPP43_06085
BPWWESB_0660
BIPBint_0560
BHPBHAMNSH16_10015
GMAAciX8_0961
ABASACPOL_3990
EMIEmin_0169
FSUFisuc_3119
FSCFSU_0391
GAUGAU_0461
GPHGEMMAAP_03045
GGRHKW67_12785
GBAJ421_2363
FTEFluta_3222
CRMK6119_02980
CABYCabys_3345
NDENIDE1238
NMVNITMOv2_1134
NIONITINOP_3226
NJANSJP_2267
NKFNkreftii_002478
NIFW02_35250
NLIG3M70_01165
MOXDAMO_2922
HALVNG_0680G(fdfT)
HSLOE_2014F(fdfT)
HDLHALDL1_07580
HHBHhub_1512(fdfT)
HAGSJT689_04105
HABOJRZ79_02620
HNOLT974_03110
HLULT972_09210 LT972_12210
HANRLJ422_02840
HJEHacjB3_11465
HSUHLASF_1560(fdfT)
HSFHLASA_1547(fdfT)
SALRFQU85_01560
HALXM0R89_16730
HAXZM0R88_16845
SALIL593_06570
SAIMK0C01_09145
HARAAArcS_0805(erg9)
HMArrnAC1477(fdfT)
HHIHAH_2050(fdfT)
HHNHISP_10440
HABSG26_02750
HTABVU17_10000
HALJG9465_15135
HSINKDQ40_03185
NMONmlp_1097(fdfT)
HUTHuta_0934
HTIHTIA_0787
HALAHrd1104_01440 Hrd1104_03360
HMUHmuk_0902
HALZE5139_07670
HALLLC1Hm_0102(erg9) LC1Hm_4111(fdfT)
HAZPGBQ70_07665
HSNDV733_15750
HDSHSR122_1540(erg92)
HRRHZS55_18095
HPELHZS54_21650
HLTI7X12_17605
HARCHARCEL1_08125
HDOMUK72_03780
HWAHQ_2353A(fdfT)
HWCHqrw_2600(fdfT)
HVOHVO_1139(fdfT)
HMEHFX_1151(fdfT)
HGIABY42_05560
HALEG3A49_08915
HLSKU306_10410
HBOHbor_21020
HAQDU484_06905
HAJDU500_07175
HAERDU502_05600
HRAEI982_08915
HLMDV707_10300
HALMFCF25_13950
HLAHlac_1206
HALPDOS48_04460
HALBEKH57_06590
HEZZEO776_05910
HALQHrr1229_016115
HSSJ7656_10305
HSAIHPS36_01100
HAZZKI388_03465
SRUBC2R22_07285
HAEhalTADL_0071
HALNB4589_003805
HALGHUG10_06045
HALUHUG12_10675
HMPK6T50_05450
HREK6T36_05175
HRMK6T25_10780
HACBHbl1158_11115
HDFAArcSl_0902
HAHHalar_1461
HTUHtur_1173
HDABB347_02735
HSALJMJ58_02805
HLOJ0X27_16985
HAKZJ0X25_12810
NMGNmag_2309(fdfT)
HXAHalxa_2641
NATNJ7G_3653
NPENatpe_2859
NVRFEJ81_13325
NPLFGF80_12995
NAYHYG81_16770
HALYHYG82_19165
HJTDVR14_04415
NGENatgr_0050
HRUHalru_1244
NOUNatoc_0972
HLRHALLA_08855
HLCCHINAEXTREME19195
NAJB1756_15010
NAGAArcMg_1067
NANAArc1_2556
NBGDV706_01600 DV706_15670
NASGCU68_12135
SAWLNGM29_00125
NACAQV86_03740
 » show all
Reference
1  [PMID:3805037]
  Authors
Kuswik-Rabiega G, Rilling HC.
  Title
Squalene synthetase. Solubilization and partial purification of squalene synthetase, copurification of presqualene pyrophosphate and squalene synthetase activities.
  Journal
J Biol Chem 262:1505-9 (1987)
Reference
2  [PMID:1527001]
  Authors
Ericsson J, Appelkvist EL, Thelin A, Chojnacki T, Dallner G.
  Title
Isoprenoid biosynthesis in rat liver peroxisomes. Characterization of cis-prenyltransferase and squalene synthetase.
  Journal
J Biol Chem 267:18708-14 (1992)
Reference
3  [PMID:11111077]
  Authors
Tansey TR, Shechter I.
  Title
Structure and regulation of mammalian squalene synthase.
  Journal
Biochim Biophys Acta 1529:49-62 (2000)
DOI:10.1016/S1388-1981(00)00137-2
Reference
4  [PMID:8239656]
  Authors
LoGrasso PV, Soltis DA, Boettcher BR.
  Title
Overexpression, purification, and kinetic characterization of a carboxyl-terminal-truncated yeast squalene synthetase.
  Journal
Arch Biochem Biophys 307:193-9 (1993)
DOI:10.1006/abbi.1993.1578
Reference
5  [PMID:1569107]
  Authors
Shechter I, Klinger E, Rucker ML, Engstrom RG, Spirito JA, Islam MA, Boettcher BR, Weinstein DB.
  Title
Solubilization, purification, and characterization of a truncated form of rat hepatic squalene synthetase.
  Journal
J Biol Chem 267:8628-35 (1992)
  Sequence
[rno:29580]
Reference
6  [PMID:26684]
  Authors
Agnew WS, Popjak G.
  Title
Squalene synthetase. Stoichiometry and kinetics of presqualene pyrophosphate and squalene synthesis by yeast microsomes.
  Journal
J Biol Chem 253:4566-73 (1978)
Reference
7  [PMID:10896663]
  Authors
Pandit J, Danley DE, Schulte GK, Mazzalupo S, Pauly TA, Hayward CM, Hamanaka ES, Thompson JF, Harwood HJ Jr.
  Title
Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis.
  Journal
J Biol Chem 275:30610-7 (2000)
DOI:10.1074/jbc.M004132200
  Sequence
[hsa:2222]
Reference
8  [PMID:10677224]
  Authors
Radisky ES, Poulter CD.
  Title
Squalene synthase: steady-state, pre-steady-state, and isotope-trapping studies.
  Journal
Biochemistry 39:1748-60 (2000)
DOI:10.1021/bi9915014
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.21
IUBMB Enzyme Nomenclature: 2.5.1.21
ExPASy - ENZYME nomenclature database: 2.5.1.21
BRENDA, the Enzyme Database: 2.5.1.21
CAS: 9077-14-9

DBGET integrated database retrieval system