KEGG ENZYME: 2.5.1.4

ENZYME: 2.5.1.4

Entry

EC 2.5.1.4                  Enzyme

Name

adenosylmethionine cyclotransferase;
adenosylmethioninase

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

S-adenosyl-L-methionine alkyltransferase (cyclizing)

Reaction(IUBMB)

S-adenosyl-L-methionine = S-methyl-5'-thioadenosine + 2-aminobutan-4-olide [RN:R00180]

Reaction(KEGG)

R00180

Substrate

S-adenosyl-L-methionine [CPD:C00019]

Product

S-methyl-5'-thioadenosine [CPD:C00170];
2-aminobutan-4-olide [CPD:C02926]

History

EC 2.5.1.4 created 1965

Reference

1 [PMID:13610898]

Authors

MUDD SH.

Title

Enzymatic cleavage of S-adenosylmethionine.

Journal

J Biol Chem 234:87-92 (1959)

Reference

2 [PMID:13672964]

Authors

MUDD SH.

Title

The mechanism of the enzymatic cleavage of S-adenosylmethionine to alpha-amino-gamma-butyrolactone.

Journal

J Biol Chem 234:1784-6 (1959)

Other DBs

ExplorEnz - The Enzyme Database:

2.5.1.4

IUBMB Enzyme Nomenclature:

2.5.1.4

ExPASy - ENZYME nomenclature database:

2.5.1.4

BRENDA, the Enzyme Database:

2.5.1.4

CAS:

9030-34-6

All links

Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (16)   
   RefSeq(nuc) (10)   
   GenBank (3)   
   EMBL (3)   
Protein domain (1)   
   InterPro (1)   
All databases (31)   

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