KEGG   ENZYME: 2.6.1.106
Entry
EC 2.6.1.106                Enzyme                                 

Name
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase;
desV (gene name);
megDII (gene name);
eryCI (gene name)
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose:2-oxoglutarate aminotransferase
Reaction(IUBMB)
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2-oxoglutarate = dTDP-3-dehydro-4,6-deoxy-alpha-D-glucose + L-glutamate [RN:R06426]
Reaction(KEGG)
R06426
Substrate
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose [CPD:C11910];
2-oxoglutarate [CPD:C00026]
Product
dTDP-3-dehydro-4,6-deoxy-alpha-D-glucose [CPD:C11909];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. The enzyme is involved in the biosynthesis of dTDP-alpha-D-desosamine, a sugar found in several bacterial macrolide antibiotics including erythromycin, megalomicin A, mycinamicin II, and oleandomycin. The reaction occurs in the reverse direction.
History
EC 2.6.1.106 created 2014
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13310  dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase
K16436  dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose/dTDP-2,6-dideoxy-D-kanosamine transaminase
Genes
DTX: ATSB10_36020
PPF: Pput_3928
PVD: CFBP1590__4426(fdtB)
PGY: AWU82_24255
OME: OLMES_5572
BOK: DM82_922
BOC: BG90_13
BUU: WS70_10345
VEI: Veis_0694
CSER: CCO03_02175
GUR: Gura_4276
GBM: Gbem_3307
GEO: Geob_0430
GEM: GM21_0941
DMA: DMR_07600
DBR: Deba_0354
BRAD: BF49_6200
RPE: RPE_1521
MAGN: WV31_12980
SGR: SGR_631
SLE: sle_09260(sle_09260)
SRN: A4G23_00481(fdtB_1) A4G23_02284(fdtB_3)
SALJ: SMD11_1659
NCA: Noca_4220
NDA: Ndas_4709
NAL: B005_1433
STRR: EKD16_15580(fdtB)
TCU: Tcur_2777
SEN: SACE_0734(eryCI)
SACC: EYD13_16495(fdtB)
AOI: AORI_1500
AJA: AJAP_32020(dnrJ)
AMYY: YIM_11615(fdtB1) YIM_22860(fdtB2)
AORI: SD37_33620
SESP: BN6_58910(sam30)
KAL: KALB_6580(acuN1)
AHG: AHOG_05440(fdtB1) AHOG_15460(fdtB2)
ALO: CRK56086
SAQ: Sare_2337
MIL: ML5_4433
MCAB: HXZ27_04125(evdS12)
PLS: VT03_24275(fdtB)
 » show all
Reference
1  [PMID:17456741]
  Authors
Burgie ES, Thoden JB, Holden HM
  Title
Molecular architecture of DesV from Streptomyces venezuelae: a PLP-dependent transaminase involved in the biosynthesis of the unusual sugar desosamine.
  Journal
Protein Sci 16:887-96 (2007)
DOI:10.1110/ps.062711007
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.106
IUBMB Enzyme Nomenclature: 2.6.1.106
ExPASy - ENZYME nomenclature database: 2.6.1.106
BRENDA, the Enzyme Database: 2.6.1.106

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