KEGG   ENZYME: 2.6.1.110
Entry
EC 2.6.1.110                Enzyme                                 
Name
dTDP-4-dehydro-2,3,6-trideoxy-D-glucose 4-aminotransferase;
SpnR;
TDP-4-keto-2,3,6-trideoxy-D-glucose 4-aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose:2-oxoglutarate aminotransferase
Reaction(IUBMB)
dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2-oxoglutarate = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate [RN:R08931]
Reaction(KEGG)
R08931
Substrate
dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose [CPD:C18033];
2-oxoglutarate [CPD:C00026]
Product
dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose [CPD:C18032];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. The enzyme, isolated from the bacterium Saccharopolyspora spinosa, participates in the biosynthesis of forosamine.
History
EC 2.6.1.110 created 2016
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13329  dTDP-4-dehydro-2,3,6-trideoxy-D-glucose 4-aminotransferase
Genes
GPLM1B72_03435
SAMBSAM23877_5617(srm20)
SLXSLAV_40480(arnB2)
SFKKY5_6527c
SCALI6J39_29655
SGOBtest1122_15695
AABA4R43_01825
Reference
1  [PMID:18345667]
  Authors
Hong L, Zhao Z, Melancon CE 3rd, Zhang H, Liu HW
  Title
In vitro characterization of the enzymes involved in TDP-D-forosamine biosynthesis in the spinosyn pathway of Saccharopolyspora spinosa.
  Journal
J Am Chem Soc 130:4954-67 (2008)
DOI:10.1021/ja0771383
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.110
IUBMB Enzyme Nomenclature: 2.6.1.110
ExPASy - ENZYME nomenclature database: 2.6.1.110
BRENDA, the Enzyme Database: 2.6.1.110

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