KEGG   ENZYME: 2.6.1.118
Entry
EC 2.6.1.118                Enzyme                                 
Name
[amino-group carrier protein]-gamma-(L-lysyl)-L-glutamate aminotransferase;
lysJ (gene name)
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
2-oxoglutarate:[amino-group carrier protein]-C-terminal-[gamma-(L-lysyl)-L-glutamate] aminotransferase
Reaction(IUBMB)
an [amino-group carrier protein]-C-terminal-[gamma-(L-lysyl)-L-glutamate] + 2-oxoglutarate = an [amino-group carrier protein]-C-terminal-[N-(1-carboxy-5-oxopentyl)-L-glutamine] + L-glutamate [RN:R09778]
Reaction(KEGG)
R09778
Substrate
[amino-group carrier protein]-C-terminal-[gamma-(L-lysyl)-L-glutamate];
2-oxoglutarate [CPD:C00026]
Product
[amino-group carrier protein]-C-terminal-[N-(1-carboxy-5-oxopentyl)-L-glutamine];
L-glutamate [CPD:C00025]
Comment
The enzyme participates in an L-lysine biosynthesis pathway in certain species of archaea and bacteria.
History
EC 2.6.1.118 created 2019
Pathway
ec00300  Lysine biosynthesis
Orthology
K05830  [amino-group carrier protein]-gamma-(L-lysyl/L-ornithyl)-L-glutamate aminotransferase
Genes
MICZGL2_37030(argD_2)
GEKkuro4_23310(argD)
RRSRoseRS_2722
RCARcas_3460
CAUCaur_3656
CHLChy400_3943
CAGCagg_0221
HAUHaur_3309
TROtrd_1515
STISthe_0219
ATMANT_12380(argD)
PSUBPelsub_P1477
LEKhrd7_27830(argD)
CAPCLDAP_41060(argD)
KBSEPA93_38775
THUGKNN16_06525
TTRTter_0321
PMETG4Y79_18410
DRADR_0794
DGEDgeo_1416
DDRDeide_16910(argD)
DMRDeima_2454
DGODGo_CA1721
DPDDeipe_2735
DSWQR90_11225
DCHSY84_01295
DABAUC44_08575
DPUSU48_09375
DEZDKM44_05115
DWUDVJ83_07340
DFCDFI_08425
DEINDAAJ005_12805
DGADEGR_15170(argD_1)
DPHEHF33_04200
TRATrad_1401
TTHTT_C1393
TTJTTHA1755(TTHA1755)
TTSThthe16_1770
TTLTtJL18_0289
TSCTSC_c03550(rocD)
THCTCCBUS3UF1_19640
TOSTheos_2048
TAQTO73_0260
TANTKNN15_06010
MSVMesil_0348
OPROcepr_1797
MHDMarky_0665
UAMUABAM_02295
CTMCabther_A0540
CVLJ8C06_03105
CHLOJ8C02_02620
SCORJ3U87_02895
TAITaci_0450
TLITlie_1472
AMOAnamo_0987
CPORBED41_13065
MROMROS_0161
CABYCabys_1935 Cabys_3152(argD)
PFUPF1685
PFIPFC_10180(argD)
PHOPH1716(PH1716)
PABPAB2440(argD)
PYNPNA2_0326
PYSPy04_1633
TKOTK0275
THSTES1_0510
THVADU37_CDS10080
TCHCHITON_1976
THEIK1720_00630
HDLHALDL1_01640
HHBHhub_3651(argD)
HNOLT974_00095
HLULT972_14165
HJEHacjB3_00975
HALHHTSR_0667(argD)
HHSRHSR6_0693(argD)
HSUHLASF_2140(argD)
HSFHLASA_2174(argD)
SALRFQU85_04720
HALREFA46_004285
HAADMW046_06590
HALXM0R89_05940
HAXZM0R88_06125
SALIL593_07900
SAIMK0C01_05780
HARAAArcS_3064(argD)
HMArrnAC2675(argD)
HHIHAH_3080(argD)
HHNHISP_15680
HABSG26_07775
HTABVU17_14990
HALJG9465_02490
HSINKDQ40_13810
NPHNP_5264A(argD)
NMONmlp_1240(argD)
NHOHWV23_08495
NSALHWV07_10870
HUTHuta_1499
HTIHTIA_1542
HALAHrd1104_12280
HMUHmuk_0775
HALZE5139_07060
HALLLC1Hm_3291(argD)
HAZPGBQ70_07055
HALIBV210_07090
HSNDV733_03380
HDSHSR122_1702(argD)
HRRHZS55_04390
HPELHZS54_04340 HZS54_10875
HLTI7X12_08380
HARCHARCEL1_01510
HDOMUK72_02350
HWAHQ_3717A(argD)
HWCHqrw_4132(argD)
HVOHVO_0043(argD)
HMEHFX_0043(argD)
HGIABY42_00205
HALEG3A49_00595
HLSKU306_04855
HBOHbor_01760
HAQDU484_03070
HAJDU500_03510
HAERDU502_01255
HRAEI982_12710
HLMDV707_00755
HALMFCF25_06940
HLAHlac_2613
HALPDOS48_13120
HALBEKH57_10840
HEZZEO776_15110
HALQHrr1229_007360
HSSJ7656_01810
HSAIHPS36_07345
HAZZKI388_13095
SRUBC2R22_20795
HAEhalTADL_1876
HALNB4589_001590
HALGHUG10_12780
HALUHUG12_02025
HMPK6T50_10100
HREK6T36_09865
HRMK6T25_06285
HACBHbl1158_01740
HDFAArcSl_0040(argD)
HAHHalar_1205
HTUHtur_0325
HDABB347_12535
HSALJMJ58_07550
HLOJ0X27_11115
HAKZJ0X25_08120
NMGNmag_1758(argD)
HXAHalxa_1381
NATNJ7G_0260
NPENatpe_3683
NVRFEJ81_17590
NPLFGF80_16415
NAYHYG81_11435
HALYHYG82_14950
HJTDVR14_08495
NGENatgr_1615
HRUHalru_0402
NOUNatoc_0151
HLRHALLA_05505
HLCCHINAEXTREME04200
NAJB1756_08235
NAGAArcMg_3557
NANAArc1_3501
NBGDV706_07705
NASGCU68_04990
SAWLNGM29_05200
PTOPTO1470
FACFACI_IFERC01G1526
FAIFAD_0507(lysJ)
CDIVCPM_0546
APEAPE_1464(lysJ)
ACJACAM_0924(lysJ)
IHOIgni_0944
IISEYM_01870
IAGIgag_1751
PFMPyrfu_1804
PDLPyrde_1838
STOSTK_01910(argD_lysJ)
SOHD1869_00425
SSOSSO0160(argD)
SOLSsol_1138
SSOASULA_1174
SSOLSULB_1175
SSOFSULC_1173
SSHIJ5U23_00104
SCASSACC_00730
SAISaci_0755(argD)
SACNSacN8_03670
SACRSacRon12I_03655
SACSSUSAZ_03385
SISLS215_2144
SIAM1425_1979
SIMM1627_2057
SIDM164_1985
SIYYG5714_2102
SINYN1551_0816
SIILD85_2240
SIHSiH_1923
SIRSiRe_1850
SICSiL_1832
SULABFU36_05135
SULEGFS03_10840
SULLEWF20_01865
MSEMsed_0169
MEMJMJ1HA_0248
MCNMcup_1904
MHKDFR87_05965
MPRUDFR88_05795
MTENGWK48_06245
MJNMjAS7_0752
AHOAhos_0888
AMANB6F84_08290
ABRIDFR85_06555
ASULDFR86_07305
AAMBD1866_12335
ACIHHS5_22630
SACDHS1genome_0849
SAZOD1868_01570
CSTYKN1_18120
STEPIC006_1907
PAIPAE2515
PISPisl_1923
PCLPcal_0283
PASPars_1404
PYRP186_1106
POGPogu_0801
TNETneu_1167
PYWPYWP30_01222
CMACmaq_0767
TTNTTX_0623(lysJ_argD)
TUZTUZN_0263
VDIVdis_0197
NMRNmar_1291
NIRNSED_07165
NKRNKOR_07285
NIDNPIRD3C_0833(argD)
NINNADRNF5_0665(argD)
NIWNisw_07275
NCLC5F47_06955
NOXC5F49_06965
NUEC5F50_09720
NIPNsoK4_01580
NCTNMSP_0397(hemL_1)
NICDSQ20_07920
CSYCENSYa_1205
NGANgar_c29940(argD2)
NVNNVIE_016480(argD1)
NEVNTE_00736
TAANMY3_02224(argD)
NFNNFRAN_2986(argD)
NCVNCAV_1249(argD)
CSUCSUB_C1307
NBVT478_1046(argD)
TAHSU86_009065
NIUDSQ19_03210
NDVNDEV_1626(argD)
CCAINAS2_0269
KCRKcr_0813
BARBAOA66_0022(hemL_1)
 » show all
Reference
1  [PMID:11489859]
  Authors
Miyazaki J, Kobashi N, Nishiyama M, Yamane H
  Title
Functional and evolutionary relationship between arginine biosynthesis and prokaryotic lysine biosynthesis through alpha-aminoadipate.
  Journal
J Bacteriol 183:5067-73 (2001)
DOI:10.1128/JB.183.17.5067-5073.2001
  Sequence
[tth:TT_C1393]
Reference
2  [PMID:19620981]
  Authors
Horie A, Tomita T, Saiki A, Kono H, Taka H, Mineki R, Fujimura T, Nishiyama C, Kuzuyama T, Nishiyama M
  Title
Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus.
  Journal
Nat Chem Biol 5:673-9 (2009)
DOI:10.1038/nchembio.198
  Sequence
[tth:TT_C1393]
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.118
IUBMB Enzyme Nomenclature: 2.6.1.118
ExPASy - ENZYME nomenclature database: 2.6.1.118
BRENDA, the Enzyme Database: 2.6.1.118

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