KEGG   ENZYME: 2.6.1.58
Entry
EC 2.6.1.58                 Enzyme                                 
Name
phenylalanine(histidine) transaminase;
phenylalanine (histidine) aminotransferase;
phenylalanine(histidine):pyruvate aminotransferase;
histidine:pyruvate aminotransferase;
L-phenylalanine(L-histidine):pyruvate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
L-phenylalanine:pyruvate aminotransferase
Reaction(IUBMB)
L-phenylalanine + pyruvate = phenylpyruvate + L-alanine [RN:R00692]
Reaction(KEGG)
R00692;
(other) R09254
Substrate
L-phenylalanine [CPD:C00079];
pyruvate [CPD:C00022]
Product
phenylpyruvate [CPD:C00166];
L-alanine [CPD:C00041]
Comment
L-Histidine and L-tyrosine can act instead of L-phenylalanine; in the reverse reaction, L-methionine, L-serine and L-glutamine can replace L-alanine.
History
EC 2.6.1.58 created 1978
Pathway
ec00350  Tyrosine metabolism
ec00360  Phenylalanine metabolism
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec00960  Tropane, piperidine and pyridine alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K05821  aromatic amino acid aminotransferase II
Genes
SCEYHR137W(ARO9)
SPAOSPAR_H01780
KLAKLLA0_D11110g
KMXKLMA_60423(ARO9)
LTHKLTH0B06270g
VPOKpol_1035p30
ZROZYRO0G05346g
CGRCAGL0G06028g
NCSNCAS_0B07220(NCAS0B07220)
NDINDAI_0B04550(NDAI0B04550)
TPFTPHA_0O01520(TPHA0O01520)
TBLTBLA_0B00990(TBLA0B00990)
TDLTDEL_0F00900(TDEL0F00900)
TGBHG536_0G04140
KNGKNAG_0H03730(KNAG0H03730)
ZMKHG535_0G00510
PPAPAS_chr1-3_0154 PAS_chr4_0147
PICPICST_34099(ARO9.1)
PGUPGUG_05380
LELLELG_05645
CALCAALFM_C405560CA(ARO9)
CTPCTRG_03861
COTCORT_0B00660
CDUCD36_45160
CTENCANTEDRAFT_120671
YLIYALI0C05258g
CLUCLUG_04493
CLUSA9F13_25g00781
CAURCJI97_003294
PKZC5L36_0E05810 C5L36_0E05820
BNNFOA43_004514
BBRXBRETT_003466
OPAHPODL_02093
 » show all
Reference
1  [PMID:14070]
  Authors
Minatogawa Y, Noguchi T, Kido R.
  Title
Species distribution and properties of hepatic phenylalanine (histidine):pyruvate aminotransferase.
  Journal
Hoppe Seylers Z Physiol Chem 358:59-67 (1977)
DOI:10.1515/bchm2.1977.358.1.59
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.58
IUBMB Enzyme Nomenclature: 2.6.1.58
ExPASy - ENZYME nomenclature database: 2.6.1.58
BRENDA, the Enzyme Database: 2.6.1.58
CAS: 72560-98-6

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