KEGG   ENZYME: 2.6.1.63
Entry
EC 2.6.1.63                 Enzyme                                 

Name
kynurenine---glyoxylate transaminase;
kynurenine-glyoxylate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
L-kynurenine:glyoxylate aminotransferase (cyclizing)
Reaction(IUBMB)
(1) L-kynurenine + glyoxylate = kynurenate + glycine + H2O (overall reaction) [RN:R12692];
(1a) L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine [RN:R01957];
(1b) 4-(2-aminophenyl)-2,4-dioxobutanoate = kynurenate + H2O (spontaneous) [RN:R03445];
(2) 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O (overall reaction) [RN:R12693];
(2a) 3-hydroxy-L-kynurenine + glyoxylate = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine [RN:R12694];
(2b) 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate = xanthurenate + H2O (spontaneous) [RN:R03954]
Reaction(KEGG)
Substrate
L-kynurenine [CPD:C00328];
glyoxylate [CPD:C00048];
4-(2-aminophenyl)-2,4-dioxobutanoate [CPD:C01252];
3-hydroxy-L-kynurenine [CPD:C03227];
4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate [CPD:C05645]
Product
kynurenate [CPD:C01717];
glycine [CPD:C00037];
H2O [CPD:C00001];
4-(2-aminophenyl)-2,4-dioxobutanoate [CPD:C01252];
xanthurenate [CPD:C02470];
4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate [CPD:C05645]
Comment
This enzyme, characterized from animals, belongs to a family of aminotransferases some members of which can use other amino acceptors (cf. EC 2.6.1.7, kynurenine---oxoglutarate transaminase). The products, 4-(2-aminophenyl)-2,4-dioxobutanoate and 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate, are converted to kynurenate and xanthurenate, respectively, by spontaneous reactions.
History
EC 2.6.1.63 created 1983
Reference
1  [PMID:25837]
  Authors
Harada I, Noguchi T, Kido R.
  Title
Purification and characterization of aromatic-amino-acid-glyoxylate aminotransferase from monkey and rat liver.
  Journal
Hoppe Seylers Z Physiol Chem 359:481-8 (1978)
DOI:10.1515/bchm.1978.359.1.481
Reference
2
  Authors
Harada, I.
  Title
[Glucagen inducible kynurenine aminotransferase.].
  Journal
Wakayama Igaku 31:61-68 (1980)
Reference
3  [PMID:11880382]
  Authors
Han Q, Fang J, Li J.
  Title
3-Hydroxykynurenine transaminase identity with alanine glyoxylate transaminase. A probable detoxification protein in Aedes aegypti.
  Journal
J Biol Chem 277:15781-7 (2002)
DOI:10.1074/jbc.M201202200
  Sequence
[aag:5564787]
Reference
4  [PMID:16262702]
  Authors
Rossi F, Lombardo F, Paglino A, Cassani C, Miglio G, Arca B, Rizzi M.
  Title
Identification and biochemical characterization of the Anopheles gambiae 3-hydroxykynurenine transaminase.
  Journal
FEBS J 272:5653-62 (2005)
DOI:10.1111/j.1742-4658.2005.04961.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.63
IUBMB Enzyme Nomenclature: 2.6.1.63
ExPASy - ENZYME nomenclature database: 2.6.1.63
BRENDA, the Enzyme Database: 2.6.1.63
CAS: 74506-33-5

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