KEGG   ENZYME: 2.6.1.7
Entry
EC 2.6.1.7                  Enzyme                                 

Name
kynurenine---oxoglutarate transaminase;
kynurenine transaminase (cyclizing);
kynurenine 2-oxoglutarate transaminase;
kynurenine aminotransferase;
L-kynurenine aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
L-kynurenine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O (overall reaction) [RN:R12688];
(1a) L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate [RN:R01956];
(1b) 4-(2-aminophenyl)-2,4-dioxobutanoate = kynurenate + H2O (spontaneous) [RN:R03445]
Reaction(KEGG)
R01956 R03445 R12688;
(other) R03954 R04171
Substrate
L-kynurenine [CPD:C00328];
2-oxoglutarate [CPD:C00026];
4-(2-aminophenyl)-2,4-dioxobutanoate [CPD:C01252]
Product
kynurenate [CPD:C01717];
L-glutamate [CPD:C00025];
H2O [CPD:C00001];
4-(2-aminophenyl)-2,4-dioxobutanoate [CPD:C01252]
Comment
A pyridoxal-phosphate protein. Also acts on 3-hydroxykynurenine. The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.
History
EC 2.6.1.7 created 1961, modified 1983
Pathway
ec00380  Tryptophan metabolism
ec01100  Metabolic pathways
Orthology
K00816  kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase
K00825  kynurenine/2-aminoadipate aminotransferase
K14264  kynurenine aminotransferase
Genes
HSA: 51166(AADAT) 56267(KYAT3) 883(KYAT1)
PTR: 456999(KYAT3) 461601(AADAT) 473069(KYAT1)
PPS: 100980672(KYAT1) 100993985(KYAT3) 100995091(AADAT)
GGO: 101128027(KYAT3) 101137144(KYAT1) 101151419(AADAT)
PON: 100435746(AADAT) 100436953(KYAT3) 100452866(KYAT1)
NLE: 100579800(KYAT3) 100584784(AADAT) 100598335(KYAT1)
MCC: 114669740(KYAT1) 694023(KYAT3) 695264(AADAT) 717142
MCF: 101925086(KYAT3) 102122792(AADAT) 102142392(KYAT1)
CSAB: 103224481(KYAT3) 103236521(AADAT) 103239781(KYAT1)
CATY: 105576210(CCBL1) 105593622(CCBL2) 105597812(AADAT)
PANU: 100137446(KYAT1) 101015989(KYAT3) 101023965(AADAT)
RRO: 104660517(KYAT1) 104662870(AADAT) 104664603(KYAT3)
RBB: 108512836(KYAT1) 108514569(KYAT3) 108522848(AADAT)
TFN: 117072758(KYAT1) 117086121(AADAT) 117092220(KYAT3)
PTEH: 111540055(KYAT3) 111545867(KYAT1) 111552456(AADAT)
CJC: 100390682(KYAT1) 100392205(KYAT3) 100403876(AADAT)
SBQ: 101034905(CCBL1) 101047103(AADAT) 101049363(CCBL2)
MMUR: 105862730(KYAT3) 105874630 105874631 105875269(KYAT1)
MMU: 229905(Kyat3) 23923(Aadat) 70266(Kyat1)
MCAL: 110290062(Kyat1) 110290637(Kyat3) 110299840(Aadat)
MPAH: 110318657(Kyat1) 110320405(Kyat3) 110336979(Aadat)
RNO: 29416(Aadat) 311844(Kyat1) 541589(Kyat3)
MCOC: 116069340(Aadat) 116089939(Kyat1) 116093877(Kyat3)
MUN: 110543366 110552266(Kyat3) 110555182(Kyat1)
CGE: 100769821(Kyat1) 100771070(Kyat3) 100771752
PLEU: 114681712(Kyat3) 114701105(Aadat) 114702736(Kyat1) 114709784
NGI: 103727134(Aadat) 103730106(Kyat3) 103742867(Kyat1)
HGL: 101701445(Kyat3) 101707012(Aadat) 101714047(Ccbl1)
CCAN: 109677660(Aadat) 109682136(Kyat3) 109697703(Kyat1)
OCU: 100351221(KYAT1) 100355602(AADAT) 100358799(KYAT3)
TUP: 102479498(AADAT) 102484200(KYAT3) 102492301(KYAT1)
CFA: 479959(KYAT3) 486059(AADAT) 491310(KYAT1)
VVP: 112924506(KYAT3) 112927954(KYAT1) 112934158(AADAT)
VLG: 121473545(KYAT1) 121487504(KYAT3) 121497055(AADAT)
AML: 100466080(KYAT3) 100469458(AADAT) 100484335(KYAT1)
UMR: 103658154(AADAT) 103662922(KYAT3) 103670433(KYAT1)
ORO: 101379355(CCBL2) 101379671(AADAT) 101381784(CCBL1)
MPUF: 101674405(CCBL2) 101676221(CCBL1) 101684949(AADAT)
EJU: 114208442(KYAT3) 114210149(AADAT) 114212744(KYAT1)
MLX: 118017611(KYAT1) 118019175(KYAT3) 118022159(AADAT)
FCA: 101082171(KYAT3) 101082605(KYAT1) 101091616(AADAT)
PYU: 121027289(AADAT) 121027431(KYAT3) 121035077(KYAT1)
PBG: 122474657(AADAT) 122474852(KYAT1) 122480743(KYAT3)
PTG: 102949681(AADAT) 102956075(KYAT1) 102960707(KYAT3)
PPAD: 109246230(KYAT3) 109250056(KYAT1) 109262426(AADAT)
AJU: 106966305(KYAT1) 106968046(KYAT3) 106985264(AADAT)
HHV: 120219764(KYAT3) 120221686(AADAT) 120230186(KYAT1)
BTA: 104968656 508712(KYAT3) 508929(AADAT) 520638 528582(CCBL1)
BOM: 102268017(KYAT3) 102269904(AADAT) 102270370 102274277(KYAT1) 102274974
BBUB: 102391958(KYAT3) 102400140(KYAT1) 102415820(AADAT)
CHX: 102180605(KYAT1) 102182368(KYAT3) 102190411(AADAT)
ODA: 120852065(KYAT1) 120854924(AADAT) 120856897(KYAT3)
CCAD: 122436720(KYAT3) 122442240(KYAT1) 122452979 122452981
SSC: 100152011(AADAT) 100157176(KYAT3) 100515071(KYAT1)
CFR: 102514713(KYAT1) 102515842(AADAT) 102522240
CBAI: 105066004(CCBL1) 105073348(AADAT) 105075460(CCBL2)
CDK: 105084526(KYAT3) 105092558(KYAT1) 105101723(AADAT)
BACU: 103001193(KYAT3) 103002075(AADAT) 103002354 103010164(KYAT1)
LVE: 103071573 103073927(KYAT1) 103077196(AADAT) 103090268(KYAT3)
DLE: 111164035(KYAT3) 111171140 111177147(KYAT1)
PCAD: 102981051(AADAT) 102983157(KYAT3) 102995891 102996912(KYAT1)
ECB: 100052141(KYAT3) 100067095(AADAT) 100070151(KYAT1)
EPZ: 103550870(KYAT1) 103554076(AADAT) 103557170(KYAT3)
EAI: 106831581(KYAT3) 106843200(AADAT) 106845422(KYAT1)
MYB: 102246710(KYAT1) 102246937(KYAT3) 102255657(AADAT)
MYD: 102764566(AADAT) 102770113(KYAT1) 102774189(KYAT3)
MMYO: 118658626(AADAT) 118666988(KYAT1) 118676933(KYAT3)
MNA: 107524667(CCBL1) 107527518(AADAT) 107535764(CCBL2)
HAI: 109373940 109376722(KYAT3) 109382267(KYAT1)
DRO: 112306314(KYAT1) 112309337(KYAT3) 112312469(AADAT)
SHON: 118980383(KYAT1) 118996845(AADAT) 118997332(KYAT3)
AJM: 119042749(KYAT3) 119051024(KYAT1) 119056569(AADAT)
MMF: 118615431(AADAT) 118615432 118626470(KYAT3) 118630138(KYAT1)
PALE: 102885606(KYAT3) 102886879(AADAT) 102890346(KYAT1)
PGIG: 120583313(KYAT3) 120601679(KYAT1) 120613379(AADAT)
RAY: 107504518(CCBL1) 107512524(AADAT) 107512700(CCBL2)
MJV: 108393128(KYAT3) 108395766(KYAT1) 108404791(AADAT)
TOD: 119232904(KYAT1) 119235416(KYAT3) 119257971(AADAT)
LAV: 100653952(AADAT) 100674418(KYAT1) 100676040(KYAT3)
MDO: 100013642(KYAT1) 100027687(KYAT3) 100031005
SHR: 100913887(AADAT) 100925132(KYAT1) 100928200(KYAT3)
PCW: 110193638(KYAT1) 110210007(KYAT3) 110216000(AADAT)
OAA: 100074153(KYAT1) 100074828(KYAT3) 100076580(AADAT)
GGA: 417202(CCBL1) 424517(KYAT3) 428728(AADAT)
PCOC: 116234217(KYAT1) 116242842(AADAT) 116243568(KYAT3)
MGP: 100539859(AADAT) 100545698(KYAT1) 100546759(KYAT3)
CJO: 107313054(AADAT) 107317420(KYAT3) 107321728(KYAT1)
NMEL: 110398293(AADAT) 110402407(KYAT3) 110407085(KYAT1)
APLA: 101796959(KYAT3) 101797673(AADAT) 101804188(KYAT1)
ACYG: 106032348(AADAT) 106034104(CCBL2) 106047313(CCBL1)
TGU: 100223564(KYAT3) 100226378(KYAT1) 100228964(AADAT)
LSR: 110468554(KYAT3) 110482286(KYAT1) 110483400(AADAT)
SCAN: 103814906(KYAT3) 103819020(KYAT1) 103825924(AADAT)
PMOA: 120497924(AADAT) 120507390(KYAT1) 120510825(KYAT3)
OTC: 121337043(KYAT1) 121345082(KYAT3) 121348448(AADAT)
PRUF: 121357586(KYAT1) 121360257(AADAT) 121361975(KYAT3)
GFR: 102038773(AADAT) 102043066(KYAT3) 102045568(KYAT1)
FAB: 101809203(KYAT1) 101816765(KYAT3) 101817402(AADAT)
PHI: 102108384(KYAT3) 102109435(KYAT1) 102114032(AADAT)
PMAJ: 107203407(AADAT) 107207980(KYAT3) 107212063(KYAT1)
CCAE: 111927908(AADAT) 111932822(KYAT3) 111936982(KYAT1)
CCW: 104688281(KYAT1) 104690544(AADAT) 104695321(KYAT3)
ETL: 114054522(KYAT1) 114057091(KYAT3) 114065438(AADAT)
FPG: 101916601(AADAT) 101923826(KYAT3) 101924602(KYAT1)
FCH: 102052592(KYAT1) 102055107(KYAT3) 102059338(AADAT)
CLV: 102087961(AADAT) 102092812(KYAT3) 102097970(KYAT1)
EGZ: 104122512(CCBL1) 104122910(CCBL2) 104123112(AADAT)
NNI: 104015478(CCBL2) 104021266(AADAT) 104023148(CCBL1)
ACUN: 113479346(AADAT) 113482894(KYAT3) 113486546(KYAT1)
PADL: 103915302(CCBL1) 103922551(AADAT) 103925131(CCBL2)
AAM: 106484015(AADAT) 106490298(KYAT1) 106499802(KYAT3)
AROW: 112961912(KYAT3) 112962980(KYAT1) 112971092(AADAT)
NPD: 112946144(KYAT3) 112955399(AADAT) 112956011(KYAT1)
DNE: 112989555(KYAT1) 112993135(KYAT3) 112997064(AADAT)
ASN: 102377511(KYAT3) 102381063(KYAT1) 102384291
AMJ: 102564187(KYAT1) 102573373(AADAT) 102574637(KYAT3)
PSS: 102443615 102446036(KYAT1) 102459761(KYAT3) 102463594(AADAT)
CPIC: 101933473(AADAT) 101948590(KYAT3) 101949101 101949140(KYAT1)
CABI: 116818835(KYAT3) 116835199(KYAT1) 116838450(AADAT)
PVT: 110079452(KYAT3) 110079688(KYAT1) 110085380(AADAT) 110085384
PBI: 103050097(AADAT) 103054557(KYAT3) 103058068(KYAT1)
PMUR: 107286149(AADAT) 107298201(KYAT3) 107299327 107301622
TSR: 106546061(CCBL2) 106549085(AADAT)
PGUT: 117657956 117658261 117676582(KYAT1) 117677164(KYAT3)
PMUA: 114589595(KYAT1) 114598781(KYAT3) 114603887 114604287(AADAT)
GJA: 107107125(AADAT) 107107127 107115481(KYAT1) 107126241(KYAT3)
XLA: 108715667(kyat3.S) 380432(kyat3.L) 398787(aadat.L) 432067(aadat.S) 734936(kyat1.L)
XTR: 496662(aadat) 496736(kyat1)
NPR: 108789894(AADAT) 108791027(KYAT3) 108794311(KYAT1)
DRE: 103911233 393315(ccbl2) 557979(aadat) 571201(si:ch73-97h19.2) 791592(kyat1)
CCAR: 109055696
AMEX: 103027162(kyat3) 103040807(aadat) 103046817(kyat1)
EEE: 113570275 113584540(kyat3) 113585158(aadat)
TRU: 101064758(kyat1) 101066451 101078353(aadat)
LCO: 104931917(kyat3) 104938006(aadat) 104939087(kyat1)
NCC: 104946129(ccbl1) 104951126(aadat) 104955761(ccbl2)
CGOB: 115006759(kyat3) 115024017(aadat)
SLUC: 116053376(aadat) 116062917(kyat1) 116063354
ECRA: 117934578(aadat) 117950718 117959864(kyat1)
PFLV: 114546135(aadat) 114561511(kyat3) 114570879(kyat1)
GAT: 120821257(aadat) 120823744 120831551(kyat1)
PPUG: 119217017 119222303(aadat) 119226342(kyat1)
MSAM: 119906512 119911291(aadat) 119914413(kyat1)
MZE: 101466800(kyat1) 101486988(kyat3) 101487147(aadat)
ONL: 100694072(kyat1) 100694678(kyat3) 100694950(aadat)
OAU: 116312954 116314328(aadat) 116331847(kyat1)
OLA: 101156284(aadat) 101164171(kyat1) 101173380
OML: 112150824 112155887(aadat) 112162734(kyat1)
XMA: 102233774(aadat) 102235261(kyat3) 102237088(kyat1)
XCO: 114149155(kyat1) 114151606(kyat3) 114157293(aadat)
XHE: 116724408(kyat1) 116726503(kyat3) 116732287(aadat)
PRET: 103463971(kyat3) 103473416(kyat1) 103475938(aadat)
CVG: 107082414 107085254(aadat) 107089769(ccbl1)
CTUL: 119773339(aadat) 119796043 119798994(kyat1)
NFU: 107374788(ccbl1) 107377046(aadat) 107397216(ccbl2)
KMR: 108231028(kyat1) 108241208 108249082(aadat)
AOCE: 111564084(kyat1) 111575097(kyat3) 111576833(aadat)
CSEM: 103376809(kyat3) 103388590(aadat) 103390101(kyat1)
POV: 109625862(kyat3) 109626496(kyat1) 109634852(aadat)
LCF: 108874059 108874060(kyat1) 108878962(kyat3) 108903085(aadat)
SDU: 111231920(kyat3) 111235631(aadat) 111237361(kyat1)
XGL: 120791385 120797772(aadat) 120806273(kyat1)
HCQ: 109508374(aadat) 109517170(kyat1) 109529744(kyat3)
BPEC: 110154758 110154910 110157436(kyat1) 110170749(aadat)
MALB: 109965770(kyat3) 109971345(kyat1) 109971451(aadat)
SASA: 100195431(kat3) 106569847 106608880(aadat)
SALP: 111952834(aadat) 111961864(kyat1) 112071986(kyat3)
SNH: 120025802(kyat1) 120049740(aadat) 120055094
ELS: 105015286(kyat1) 105026755(aadat) 105030533(kyat3)
SFM: 108921052(aadat) 108927270 108927271(kyat1)
PKI: 111841854(kyat1) 111850985(aadat) 111854627(kyat3)
AANG: 118212819(kyat1) 118225054 118226471 118231553(aadat)
LOC: 102688235(aadat) 102689615(ccbl2) 102690907(ccbl1)
PSPA: 121309726(kyat1) 121327307 121328812(aadat)
LCM: 102348380(KYAT1) 102363875(AADAT) 102366870(KYAT3)
CMK: 103171755(kyat1) 103174679 103180238(aadat)
SKO: 102808740
DME: Dmel_CG6950(Kyat)
DER: 6553988
DSE: 6606764
DSI: Dsimw501_GD20629(Dsim_GD20629)
DAN: 6505708
DPE: 6594315
DMN: 108155108
DWI: 6650503
DGR: 6563504
DAZ: 108620865
DNV: 108654748
DHE: 111593314
DVI: 6630118
CCAT: 101455319
BOD: 106627790
MDE: 101891461
SCAC: 106093036
LCQ: 111678011
ACOZ: 120954623
AARA: 120900196
AAG: 5564787
AALB: 109417150
DPA: 109533718
MSEX: 115443331
CLEC: 106666336
ZNE: 110837661
CSEC: 111870631
VDE: 111243343
VJA: 111258857
DPTE: 113793296
CSCU: 111641275
PTEP: 107438209
SDM: 118185943
CEL: CELE_F28H6.3(nkat-1) CELE_R03A10.4(nkat-3)
CBR: CBG07704(Cbr-nkat-3) CBG10206 CBG10259
BMY: BM_BM5187(Bm5187)
NVE: 5505352
EPA: 110244036
ATEN: 116293035
AMIL: 114950115
PDAM: 113686698
SPIS: 111323701
DGT: 114518840
AQU: 100641141
APRO: F751_0981
SCE: YJL060W(BNA3)
KMX: KLMA_50067(BNA3)
NCS: NCAS_0A09200(NCAS0A09200)
NDI: NDAI_0G05760(NDAI0G05760)
TPF: TPHA_0O01450(TPHA0O01450)
TDL: TDEL_0D01900(TDEL0D01900)
KAF: KAFR_0A01710(KAFR0A01710)
SLB: AWJ20_1268(BNA3)
NCR: NCU03347(nic-4)
NTE: NEUTE1DRAFT84478(NEUTE1DRAFT_84478)
MGR: MGG_03264
SSCK: SPSK_04279
MAW: MAC_05770
MAJ: MAA_01732
CMT: CCM_08981
BFU: BCIN_14g04940(Bcbna3)
MBE: MBM_06522
ANI: AN5616.2
ANG: ANI_1_2944024(An02g10160) ANI_1_908184(An04g05490) ANI_1_922084(An09g00070)
ABE: ARB_02285
TVE: TRV_04968
PTE: PTT_12703
CNE: CNA00190
CNB: CNBA0180
TASA: A1Q1_06557
ABP: AGABI1DRAFT38406(AGABI1DRAFT_38406)
ABV: AGABI2DRAFT67810(AGABI2DRAFT_67810)
MGL: MGL_1970
MRT: MRET_1502
DFA: DFA_03567 DFA_11928(ccbl)
NGD: NGA_0728200(CCBL) NGA_2018300(AADAT) NGA_2105700(ARO8)
 » show all
Reference
1  [PMID:13357462]
  Authors
BONNER DM, JAKOBY WB.
  Title
Kynurenine transaminase from neurospora.
  Journal
J Biol Chem 221:689-95 (1956)
Reference
2  [PMID:13449053]
  Authors
MASON M.
  Title
Kynurenine transaminase of rat kidney; a study of coenzyme dissociation.
  Journal
J Biol Chem 227:61-8 (1957)
Reference
3  [PMID:1218085]
  Authors
Noguchi T, Minatogawa Y, Okuno E, Nakatani M, Morimoto M.
  Title
Purification and characterization of kynurenine--2-oxoglutarate aminotransferase from the liver, brain and small intestine of rats.
  Journal
Biochem J 151:399-406 (1975)
DOI:10.1042/bj1510399
Reference
4  [PMID:18620547]
  Authors
Han Q, Cai T, Tagle DA, Robinson H, Li J
  Title
Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II.
  Journal
Biosci Rep 28:205-15 (2008)
DOI:10.1042/BSR20080085
Reference
5  [PMID:19029248]
  Authors
Han Q, Robinson H, Cai T, Tagle DA, Li J.
  Title
Biochemical and structural properties of mouse kynurenine aminotransferase III.
  Journal
Mol Cell Biol 29:784-93 (2009)
DOI:10.1128/MCB.01272-08
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.7
IUBMB Enzyme Nomenclature: 2.6.1.7
ExPASy - ENZYME nomenclature database: 2.6.1.7
BRENDA, the Enzyme Database: 2.6.1.7
CAS: 9030-38-0

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