KEGG   ENZYME: 2.7.1.145
Entry
EC 2.7.1.145                Enzyme                                 

Name
deoxynucleoside kinase;
multispecific deoxynucleoside kinase;
ms-dNK;
multisubstrate deoxyribonucleoside kinase;
multifunctional deoxynucleoside kinase;
D. melanogaster deoxynucleoside kinase;
Dm-dNK;
ATP:deoxynucleoside 5'-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:deoxyribonucleoside 5'-phosphotransferase
Reaction(IUBMB)
ATP + a 2'-deoxyribonucleoside = ADP + a 2'-deoxyribonucleoside 5'-phosphate [RN:R05806]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
2'-deoxyribonucleoside [CPD:C02269]
Product
ADP [CPD:C00008];
2'-deoxyribonucleoside 5'-phosphate [CPD:C00676]
Comment
The enzyme from embryonic cells of the fruit fly Drosophila melanogaster differs from other 2'-deoxyribonucleoside kinases [EC 2.7.1.76 (deoxyadenosine kinase) and EC 2.7.1.113 (deoxyguanosine kinase)] in its broad specificity for all four common 2'-deoxyribonucleosides.
History
EC 2.7.1.145 created 2001
Pathway
ec00230  Purine metabolism
ec00240  Pyrimidine metabolism
ec01100  Metabolic pathways
Orthology
K05961  deoxynucleoside kinase
Genes
DME: Dmel_CG5452(dnk)
DER: 6554072
DSE: 6620705
DSI: Dsimw501_GD19261(Dsim_GD19261)
DYA: Dyak_GE25572
DAN: 6505870
DSR: 110186665
DPO: Dpse_GA18891
DPE: 6588091
DMN: 108156402
DWI: 6647251
DGR: 6568426
DAZ: 108620993
DNV: 108658836
DHE: 111602690
DVI: 6631195
CCAT: 101450470
BOD: 106617808
MDE: 101896877
SCAC: 106090041
LCQ: 111680959
ACOZ: 120953957
AARA: 120898076
AAG: 5579214
CPII: 120424947
AME: 552840
ACER: 107998280
BIM: 100744576
BBIF: 117205012
BVK: 117230963
BVAN: 117153269
BTER: 100648317
BPYO: 122567739
CCAL: 108626754
OBB: 114878736
MGEN: 117221411
NMEA: 116423874
CGIG: 122398991
PCF: 106784413
PFUC: 122519186
VPS: 122630646
FAS: 105270889
DAM: 107041802
AGIF: 122861087
CCIN: 107262785
ATD: 109602144
PXY: 105393061
AGS: 114125562
FCD: 110842433
DMK: 116929646
HAME: 121868408
HAZT: 108665785
DPTE: 113789910
 » show all
Reference
1  [PMID:9461577]
  Authors
Munch-Petersen B, Piskur J, Sondergaard L.
  Title
Four deoxynucleoside kinase activities from Drosophila melanogaster are contained within a single monomeric enzyme, a new multifunctional deoxynucleoside kinase.
  Journal
J Biol Chem 273:3926-31 (1998)
DOI:10.1074/jbc.273.7.3926
  Sequence
Reference
2  [PMID:10692477]
  Authors
Munch-Petersen B, Knecht W, Lenz C, Sondergaard L, Piskur J
  Title
Functional expression of a multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster and its C-terminal deletion mutants.
  Journal
J Biol Chem 275:6673-9 (2000)
DOI:10.1074/jbc.275.9.6673
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.145
IUBMB Enzyme Nomenclature: 2.7.1.145
ExPASy - ENZYME nomenclature database: 2.7.1.145
BRENDA, the Enzyme Database: 2.7.1.145
CAS: 52227-81-3

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