KEGG   ENZYME: 2.7.1.151
Entry
EC 2.7.1.151                Enzyme                                 

Name
inositol-polyphosphate multikinase;
IpK2;
IP3/IP4 6-/3-kinase;
IP3/IP4 dual-specificity 6-/3-kinase;
IpmK;
ArgRIII;
AtIpk2alpha;
AtIpk2beta;
inositol polyphosphate 6-/3-/5-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase
Reaction(IUBMB)
2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (overall reaction) [RN:R10065];
(1a) ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate [RN:R05800];
(1b) ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate [RN:R05801]
Reaction(KEGG)
R05800 R05801 R10065;
(other) R10953
Substrate
ATP [CPD:C00002];
1D-myo-inositol 1,4,5-trisphosphate [CPD:C01245];
1D-myo-inositol 1,4,5,6-tetrakisphosphate [CPD:C11555]
Product
ADP [CPD:C00008];
1D-myo-inositol 1,3,4,5,6-pentakisphosphate [CPD:C01284];
1D-myo-inositol 1,4,5,6-tetrakisphosphate [CPD:C11555]
Comment
This enzyme also phosphorylates Ins(1,4,5)P3 to Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 to Ins(1,3,4,5,6)P5, and Ins(1,3,4,5,6)P4 to Ins(PP)P4, isomer unknown. The enzyme from the plant Arabidopsis thaliana can also phosphorylate Ins(1,3,4,6)P4 and Ins(1,2,3,4,6)P5 at the D-5-position to produce 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate (InsP6), respectively [3]. Yeast produce InsP6 from Ins(1,4,5)P3 by the actions of this enzyme and EC 2.7.1.158, inositol-pentakisphosphate 2-kinase [4].
History
EC 2.7.1.151 created 2002, modified 2006
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K00915  inositol-polyphosphate multikinase
Genes
HSA: 253430(IPMK)
PTR: 450471(IPMK)
PPS: 100973083(IPMK)
GGO: 101154364(IPMK)
PON: 100462505(IPMK)
NLE: 100592716(IPMK)
MCC: 703630(IPMK)
MCF: 102143477(IPMK)
CSAB: 103216169(IPMK)
CATY: 105581528(IPMK)
PANU: 101003525(IPMK)
RRO: 104665616(IPMK)
RBB: 108540730(IPMK)
TFN: 117082769(IPMK) 117096508
PTEH: 111521921(IPMK) 116418853
CJC: 100415637(IPMK)
SBQ: 101051501(IPMK)
MMUR: 105870285(IPMK)
MMU: 69718(Ipmk)
MCAL: 110303748(Ipmk)
MPAH: 110326626(Ipmk)
RNO: 171458(Ipmk)
MCOC: 116074588(Ipmk)
MUN: 110559937(Ipmk)
CGE: 100772629(Ipmk)
PLEU: 114698543(Ipmk)
NGI: 103730748(Ipmk)
HGL: 101700113(Ipmk)
CCAN: 109696228(Ipmk)
OCU: 100355723(IPMK)
OPI: 101527456(IPMK)
TUP: 102483332(IPMK)
CFA: 119871453(IPMK)
VVP: 112931055(IPMK)
VLG: 121488030(IPMK)
AML: 100478367(IPMK)
UMR: 103667727(IPMK)
UAH: 113259062(IPMK)
ORO: 101366273(IPMK)
ELK: 111144965
MPUF: 101670948(IPMK)
EJU: 114224749(IPMK)
FCA: 101098826(IPMK)
PYU: 121036629(IPMK)
PBG: 122492770(IPMK)
PTG: 102959812(IPMK)
PPAD: 109258863(IPMK)
AJU: 106973131(IPMK)
HHV: 120226790(IPMK)
BTA: 615135(IPMK)
BOM: 102287037(IPMK)
BIU: 109553141(IPMK)
BBUB: 102400077(IPMK)
CHX: 102177585(IPMK)
OAS: 101120714(IPMK)
ODA: 120873755(IPMK)
CCAD: 122446282(IPMK)
SSC: 100623323(IPMK)
CFR: 102520396(IPMK)
CBAI: 105071313(IPMK)
CDK: 105093838(IPMK)
BACU: 103013713(IPMK)
LVE: 103080830(IPMK)
OOR: 101280269(IPMK)
DLE: 111172551(IPMK)
PCAD: 102975028 102996268(IPMK)
ECB: 100072153(IPMK)
EPZ: 103550049(IPMK)
EAI: 106838737(IPMK)
MYB: 102254091(IPMK)
MYD: 102753565 102755711(IPMK)
MMYO: 118670018(IPMK)
MNA: 107543337(IPMK)
PKL: 118719240(IPMK)
HAI: 109377792 109380619(IPMK)
DRO: 112305490(IPMK)
SHON: 118998517(IPMK)
AJM: 119045275(IPMK)
MMF: 118632590(IPMK)
PALE: 102888012(IPMK)
PGIG: 120609380(IPMK)
RAY: 107501472(IPMK)
MJV: 108394158(IPMK)
TOD: 119233810(IPMK)
LAV: 100665963(IPMK)
TMU: 101348316
MDO: 100024450(IPMK)
SHR: 100931610(IPMK)
PCW: 110216387(IPMK)
OAA: 100076322(IPMK)
GGA: 101751177(IPMK)
PCOC: 116234745(IPMK)
MGP: 100539865(IPMK)
CJO: 107315641(IPMK)
NMEL: 110400645(IPMK)
APLA: 101804228(IPMK)
ACYG: 106030987(IPMK)
TGU: 100225175(IPMK)
LSR: 110473330(IPMK)
SCAN: 103814222(IPMK)
PMOA: 120507239(IPMK)
OTC: 121336120(IPMK)
PRUF: 121357693(IPMK)
GFR: 102036262(IPMK)
FAB: 101808343(IPMK)
PHI: 102102225(IPMK)
PMAJ: 107215911(IPMK)
CCAE: 111931648(IPMK)
CCW: 104695108(IPMK)
ETL: 114060290(IPMK) 114071299
FPG: 101922653(IPMK)
FCH: 102053151(IPMK)
CLV: 102098297(IPMK)
EGZ: 104128403(IPMK)
NNI: 104013568(IPMK)
ACUN: 113481828(IPMK)
PADL: 103916492(IPMK)
AAM: 106498578(IPMK)
AROW: 112969800(IPMK)
NPD: 112952212(IPMK)
DNE: 112986634(IPMK)
ASN: 102379224(IPMK)
AMJ: 102574742(IPMK)
CPOO: 109312519(IPMK)
GGN: 109290904(IPMK)
PSS: 102448749(IPMK)
CMY: 102934554(IPMK)
CPIC: 101949940(IPMK)
TST: 117879840(IPMK)
CABI: 116816554(IPMK)
ACS: 100560539(ipmk)
PVT: 110073675(IPMK)
PBI: 103050503(IPMK)
PMUR: 107285107(IPMK)
TSR: 106550724(IPMK)
PGUT: 117670648(IPMK)
PMUA: 114597267(IPMK)
ZVI: 118096563(IPMK)
GJA: 107124655(IPMK)
XLA: 108697359(ipmk.S) 447535(ipmk.L)
XTR: 100485175(ipmk)
NPR: 108788857(IPMK)
DRE: 100151036(ipmka) 790916(ipmkb)
IPU: 108263300 108274002(ipmk)
PHYP: 113527504(ipmk) 113541013
AMEX: 103031896 103035921(ipmk)
EEE: 113576897 113577017(ipmk)
TRU: 101068659(ipmk)
LCO: 104938069(ipmk)
NCC: 104954473(ipmk)
CGOB: 115024534(ipmk)
ELY: 117247374(ipmkb)
PLEP: 121958552(ipmkb)
SLUC: 116067490(ipmkb)
ECRA: 117936754(ipmkb)
PFLV: 114548723(ipmk)
GAT: 120819346(ipmkb)
PPUG: 119212786(ipmkb)
MSAM: 119915599(ipmkb)
CUD: 121528144(ipmkb)
MZE: 101484766(ipmk)
ONL: 100697543(ipmk)
OAU: 116320007(ipmkb)
OLA: 101168158(ipmk)
OML: 112162347(ipmkb)
XMA: 102236019(ipmk)
XCO: 114150691(ipmk)
XHE: 116726967(ipmk)
PRET: 103482182(ipmk)
CVG: 107087638(ipmk)
CTUL: 119796126(ipmkb)
NFU: 107396954(ipmk)
KMR: 108248332(ipmkb)
AOCE: 111588282(ipmk)
CSEM: 103381652(ipmk)
POV: 109627029(ipmk)
LCF: 108876813(ipmk)
SDU: 111237040(ipmk)
SLAL: 111664336(ipmk)
XGL: 120794277(ipmkb)
HCQ: 109529284(ipmk)
BPEC: 110154216(ipmk)
MALB: 109966674(ipmk)
OTW: 112223433 112224288(ipmkb)
OMY: 110491367 110498974(ipmkb)
SNH: 120029550(ipmkb) 120046128
ELS: 105006191(ipmk)
SFM: 108932688 108939714(ipmk)
PKI: 111853742(ipmk)
AANG: 118217809 118221123(ipmkb)
LOC: 102686411(ipmk)
LCM: 102351435(IPMK)
CMK: 103180913(ipmkb)
RTP: 109929881(ipmk)
BBEL: 109478728
CIN: 100181124
SCLV: 120348086
SPU: 576026
APLC: 110988184
DME: Dmel_CG13688(Ipk2)
DER: 6542207
DSE: 6617275
DSI: Dsimw501_GD22857(Dsim_GD22857)
DSR: 110178181
DPE: 6589590
DMN: 108162765
DWI: 6644172
DGR: 6561379
DAZ: 108611529
DNV: 115561995
DHE: 111599180
DVI: 6628196
CCAT: 101458418
BOD: 106623115
MDE: 101890959
SCAC: 106091576
LCQ: 111680509
AAG: 5576218
AALB: 115260379
CPII: 120416726
AME: 724909
ACER: 108002233
BIM: 100741069
BBIF: 117207299
BVK: 117239739
BVAN: 117165843
BTER: 100647372
CCAL: 108626431
OBB: 114875638
MGEN: 117227288
NMEA: 116424812
CGIG: 122402198
SOC: 105194884
MPHA: 105829000
AEC: 105153183
ACEP: 105621350
PBAR: 105427938
VEM: 105570074
HST: 105184462
DQU: 106743474
CFO: 105253694
FEX: 115242999
LHU: 105671661
PGC: 109861092
OBO: 105277647
PCF: 106789901
PFUC: 122516496
NVI: 100121919
CSOL: 105367488
TPRE: 106659782
MDL: 103576872
FAS: 105266160
DAM: 107048271
CCIN: 107268450
TCA: 661775
DPA: 109544545
ATD: 109608507
AGB: 108903974
LDC: 111506169
NVL: 108558778
PPYR: 116177684
OTU: 111413637
BMOR: 101740910
BMAN: 114250148
MSEX: 115444175
BANY: 112044078
PMAC: 106713113
PPOT: 106105167
PXU: 106125612
PRAP: 110999112
ZCE: 119840114
HAW: 110380263
TNL: 113503788
API: 100166192
AGS: 114122779
RMD: 113553182
BTAB: 109033460
DCI: 103505053
CLEC: 106674014
HHAL: 106691230
NLU: 111050213
FOC: 113211335
ZNE: 110831036
CSEC: 111869034
FCD: 110853922
DMK: 116936222
HAME: 121876450
HAZT: 108672573
DSV: 119436325
RSAN: 119402555
RMP: 119187519
TUT: 107360338
DPTE: 113799174
CSCU: 111638123
PTEP: 107444393
CEL: CELE_ZK795.1(ipmk-1)
CBR: CBG13522
BMY: BM_BM7551(Bma-ipmk-1)
TSP: Tsp_05937
PCAN: 112556725
BGT: 106065597
GAE: 121379338
CRG: 105329464
MYI: 110449876
PMAX: 117330160
OBI: 106870575
OSN: 115213900
LAK: 106156040
NVE: 5502168
ADF: 107358834
AMIL: 114972815
PDAM: 113678722
SPIS: 111328026
DGT: 114528564
HMG: 101241397
ATH: AT5G07370(IPK2a) AT5G61760(IPK2BETA)
THJ: 104818295
CPAP: 110820479
CIT: 102615927
PVY: 116135663
TCC: 18605232
DZI: 111291280
GMX: 100127407(IPK2)
GSJ: 114378283
VRA: 106756308
VAR: 108320741
APRC: 113852757
CAM: 101499122
LJA: Lj3g3v0463560.1(Lj3g3v0463560.1)
ADU: 107463105
AIP: 107612848
FVE: 101314526
RCN: 112178712
PPER: 18776852
PMUM: 103337905
PAVI: 110757800
PDUL: 117627275
ZJU: 107423333
MNT: 21388124
CSV: 101222676
CMO: 103494615
BHJ: 120070188
MCHA: 111015224
CMAX: 111479614
CMOS: 111457968
CPEP: 111790999
RCU: 8275463
JCU: 105648688
HBR: 110659725
JRE: 108999223
VVI: 100250912(IPK2)
VRI: 117904528
SOT: 102577543(IPMK) 102599548
INI: 109183005
ITR: 116006224
SIND: 105158271
MING: 122071037
OSA: 4329509
DOSA: Os02t0523800-01(Os02g0523800)
OBR: 102703374
BDI: 100838319
ATS: 109732235
SBI: 8059604
SITA: 101764096
PHAI: 112874040
MUS: 103971160
DCT: 110100476
PEQ: 110032183
ATR: 18434574
PPP: 112287121
MNG: MNEG_1909
APRO: F751_5641
SCE: YDR173C(ARG82)
ERC: Ecym_4203
KMX: KLMA_50536(ARG82)
NCS: NCAS_0B03200(NCAS0B03200)
NDI: NDAI_0A01200(NDAI0A01200)
TPF: TPHA_0C02470(TPHA0C02470)
TBL: TBLA_0H01030(TBLA0H01030)
TDL: TDEL_0F04950(TDEL0F04950)
KAF: KAFR_0B06020(KAFR0B06020)
CAL: CAALFM_C209730CA(IPK2)
SLB: AWJ20_3593(ARG82)
NCR: NCU06315
NTE: NEUTE1DRAFT60460(NEUTE1DRAFT_60460)
MGR: MGG_14150
SSCK: SPSK_09096
CMT: CCM_08832
MBE: MBM_03256
ANI: AN0156.2
ANG: ANI_1_1358164(An18g04520)
ABE: ARB_03060
TVE: TRV_06092
PTE: PTT_17736
TASA: A1Q1_04820
ABP: AGABI1DRAFT121474(AGABI1DRAFT_121474)
ABV: AGABI2DRAFT209575(AGABI2DRAFT_209575)
MGL: MGL_0277
MRT: MRET_1034
SPAR: SPRG_07163
 » show all
Reference
1  [PMID:10574768]
  Authors
Saiardi A, Erdjument-Bromage H, Snowman AM, Tempst P, Snyder SH
  Title
Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases.
  Journal
Curr Biol 9:1323-6 (1999)
DOI:10.1016/S0960-9822(00)80055-X
  Sequence
[sce:YDR173C]
Reference
2  [PMID:10720331]
  Authors
Odom AR, Stahlberg A, Wente SR, York JD.
  Title
A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control.
  Journal
Science 287:2026-9 (2000)
DOI:10.1126/science.287.5460.2026
Reference
3  [PMID:12226109]
  Authors
Stevenson-Paulik J, Odom AR, York JD
  Title
Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases.
  Journal
J Biol Chem 277:42711-8 (2002)
DOI:10.1074/jbc.M209112200
  Sequence
Reference
4  [PMID:15531582]
  Authors
Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW
  Title
The pathway for the production of inositol hexakisphosphate in human cells.
  Journal
J Biol Chem 280:1911-20 (2005)
DOI:10.1074/jbc.M411528200
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.151
IUBMB Enzyme Nomenclature: 2.7.1.151
ExPASy - ENZYME nomenclature database: 2.7.1.151
BRENDA, the Enzyme Database: 2.7.1.151
CAS: 9077-69-4

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