KEGG   ENZYME: 2.7.1.159
Entry
EC 2.7.1.159                Enzyme                                 

Name
inositol-1,3,4-trisphosphate 5/6-kinase;
Ins(1,3,4)P3 5/6-kinase;
inositol trisphosphate 5/6-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase
Reaction(IUBMB)
(1) ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate [RN:R03428];
(2) ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate [RN:R03429]
Reaction(KEGG)
R03428 R03429
Substrate
ATP [CPD:C00002];
1D-myo-inositol 1,3,4-trisphosphate [CPD:C01243]
Product
ADP [CPD:C00008];
1D-myo-inositol 1,3,4,5-tetrakisphosphate [CPD:C01272];
1D-myo-inositol 1,3,4,6-tetrakisphosphate [CPD:C04477]
Comment
In humans, this enzyme, along with EC 2.7.1.127 (inositol-trisphosphate 3-kinase), EC 2.7.1.140 (inositol-tetrakisphosphate 5-kinase) and EC 2.7.1.158 (inositol pentakisphosphate 2-kinase) is involved in the production of inositol hexakisphosphate (InsP6). InsP6 is involved in many cellular processes, including mRNA export from the nucleus [2]. Yeasts do not have this enzyme, so produce InsP6 from Ins(1,4,5)P3 by the actions of EC 2.7.1.151 (inositol-polyphosphate multikinase) and EC 2.7.1.158 (inositol-pentakisphosphate 2-kinase) [2]. The enzymes from animals and plants also have the activity of EC 2.7.1.134, inositol-tetrakisphosphate 1-kinase.
History
EC 2.7.1.159 created 2006
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K00913  inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase
K01765  inositol-1,3,4-trisphosphate 5/6-kinase
Genes
HSA: 3705(ITPK1)
PTR: 453121(ITPK1)
PPS: 100980755(ITPK1)
GGO: 101134664(ITPK1)
PON: 100448118(ITPK1)
NLE: 100590495(ITPK1)
MCC: 698756(ITPK1)
MCF: 102119398(ITPK1)
CSAB: 103229579(ITPK1)
CATY: 105596596(ITPK1)
PANU: 101022831(ITPK1)
RRO: 104679048(ITPK1)
RBB: 108519106(ITPK1)
TFN: 117071511(ITPK1)
PTEH: 111538240(ITPK1)
CJC: 100396941(ITPK1)
SBQ: 101039869(ITPK1)
MMUR: 105856742(ITPK1)
MMU: 217837(Itpk1)
MCAL: 110307175(Itpk1)
MPAH: 110324479(Itpk1)
RNO: 500709(Itpk1)
MCOC: 116079633(Itpk1)
MUN: 110541472(Itpk1)
CGE: 100768438(Itpk1)
PLEU: 114706069(Itpk1)
NGI: 103724593(Itpk1)
HGL: 101700462(Itpk1)
CCAN: 109693572(Itpk1)
OCU: 100345790(ITPK1)
OPI: 101533405(ITPK1)
TUP: 102479480(ITPK1)
CFA: 490591(ITPK1)
VVP: 112909607(ITPK1)
VLG: 121492932(ITPK1)
AML: 100484787(ITPK1)
UMR: 103673773(ITPK1)
UAH: 113267338(ITPK1)
ORO: 101385854(ITPK1)
ELK: 111148744
MPUF: 101684430(ITPK1)
EJU: 114205219(ITPK1)
MLX: 118002511(ITPK1)
FCA: 101087672(ITPK1)
PYU: 121032216(ITPK1)
PBG: 122469466(ITPK1)
PTG: 102951160(ITPK1)
PPAD: 109274481(ITPK1)
AJU: 106980827(ITPK1)
HHV: 120220241(ITPK1)
BTA: 518488(ITPK1)
BOM: 102279411(ITPK1)
BIU: 109575578(ITPK1)
BBUB: 102415988(ITPK1)
CHX: 102183460(ITPK1)
OAS: 101115161(ITPK1)
ODA: 120874979(ITPK1)
CCAD: 122454855(ITPK1)
SSC: 100152339(ITPK1)
CFR: 102508931(ITPK1)
CBAI: 105079999(ITPK1)
CDK: 105095826(ITPK1)
BACU: 103011955(ITPK1)
LVE: 103084508(ITPK1)
OOR: 101270326(ITPK1)
DLE: 111176142(ITPK1)
PCAD: 102992293(ITPK1)
ECB: 100063828(ITPK1) 111770385
EPZ: 103556533(ITPK1)
EAI: 106825383(ITPK1)
MYB: 102246792(ITPK1)
MYD: 102764458(ITPK1)
MMYO: 118659788(ITPK1)
MNA: 107531577(ITPK1)
PKL: 118704212(ITPK1)
HAI: 109376793(ITPK1)
DRO: 112311350(ITPK1)
SHON: 118976637(ITPK1)
AJM: 119037888(ITPK1)
MMF: 118631619(ITPK1)
PALE: 102877958(ITPK1)
PGIG: 120619630(ITPK1)
RAY: 107511245(ITPK1)
MJV: 108409820(ITPK1)
TOD: 119239449(ITPK1)
LAV: 100668527(ITPK1)
TMU: 101341573
MDO: 100014342(ITPK1)
SHR: 100924957(ITPK1)
PCW: 110217744(ITPK1)
OAA: 100079832(ITPK1)
GGA: 423421(ITPK1)
PCOC: 116228893(ITPK1)
MGP: 100541150(ITPK1)
CJO: 107315185(ITPK1)
NMEL: 110402115(ITPK1)
APLA: 101801656(ITPK1)
ACYG: 106033487(ITPK1)
TGU: 100222999(ITPK1)
LSR: 110476414(ITPK1)
SCAN: 103826463(ITPK1)
PMOA: 120503728(ITPK1)
OTC: 121341610(ITPK1)
PRUF: 121355947(ITPK1)
GFR: 102034047(ITPK1)
FAB: 101819235(ITPK1)
PHI: 102106037(ITPK1)
PMAJ: 107205493(ITPK1)
CCAE: 111929864(ITPK1)
CCW: 104688688(ITPK1)
ETL: 114060630(ITPK1)
FPG: 101920131(ITPK1)
FCH: 102048369(ITPK1)
CLV: 102088692(ITPK1)
EGZ: 104135355(ITPK1)
NNI: 104022228(ITPK1)
ACUN: 113480449(ITPK1)
PADL: 103923943(ITPK1)
AAM: 106483074(ITPK1)
AROW: 112972647(ITPK1)
NPD: 112953422(ITPK1)
DNE: 112990288(ITPK1)
ASN: 102373418(ITPK1) 112548809
AMJ: 102575334(ITPK1) 109280689
CPOO: 109321703(ITPK1)
GGN: 109298509(ITPK1)
PSS: 102452019(ITPK1)
CMY: 102932685 102933310(ITPK1)
CPIC: 101948262(ITPK1) 101949054
TST: 117876182(ITPK1) 117888741
CABI: 116822434 116827590(ITPK1)
ACS: 100566274(itpk1)
PVT: 110083634(ITPK1)
PBI: 103054635(ITPK1)
PMUR: 107295460(ITPK1)
TSR: 106549451(ITPK1)
PGUT: 117665930(ITPK1)
PMUA: 114590768(ITPK1)
ZVI: 118080978(ITPK1)
GJA: 107123858(ITPK1)
XLA: 108698651(XB5961849.L) 108700483(itpk1.S) 379828(itpk1.L)
XTR: 100144987 549890(itpk1)
NPR: 108788675(ITPK1) 108804962
DRE: 100148744(itpk1b) 406290(itpk1a)
TRU: 101069194(itpk1) 101072928
LCO: 104927221 109142672(itpk1)
NCC: 104941855(itpk1) 104945354
ELY: 117259817 117267012(itpk1b)
PLEP: 121942983 121953725(itpk1b)
SLUC: 116035499(itpk1b) 116038963
ECRA: 117936056(itpk1b) 117942589
PFLV: 114547221(itpk1) 114553241
GAT: 120823661 120832914(itpk1b)
PPUG: 119216237 119227175(itpk1b)
MSAM: 119883006 119910030(itpk1b)
CUD: 121522245 121526496(itpk1b)
MZE: 101469029(itpk1) 101485309
ONL: 100691819 100698428(itpk1)
OAU: 116321627 116334744(itpk1b)
OLA: 101157334(itpk1)
OML: 112145038(itpk1b)
XMA: 102220593(itpk1)
XCO: 114133945(itpk1)
XHE: 116708711(itpk1)
PRET: 103458928(itpk1)
CVG: 107099127(itpk1)
CTUL: 119771439(itpk1b)
NFU: 107392041(itpk1)
KMR: 108237618(itpk1b)
ALIM: 106521176(itpk1)
AOCE: 111566021 111578952(itpk1)
CSEM: 103377198(itpk1) 103378259
SDU: 111225701(itpk1) 111232797
SLAL: 111654242 111659818(itpk1)
XGL: 120792565 120795007(itpk1b)
HCQ: 109510866 109516026(itpk1)
BPEC: 110153603 110155270(itpk1)
MALB: 109955064(itpk1)
OTW: 112250446(itpk1a) 112256745(itpk1b) 112261728 112265274
OMY: 110497861 110505606(itpk1b) 110507571 110529743(itpk1a)
SFM: 108919611(itpk1)
PKI: 111838846(itpk1) 111854941
LOC: 102683027 102693298(itpk1)
LCM: 102351625(ITPK1) 102366649
CMK: 103185398(itpk1a)
RTP: 109917182 109929038(itpk1)
CIN: 100181853
SCLV: 120335626
SPU: 580408
APLC: 110977634
SKO: 102806915
AME: 551726
ACER: 107994503
BIM: 100740014
BBIF: 117209626
BVK: 117234605
BVAN: 117158611
BTER: 100647743
CCAL: 108625595
OBB: 114880042
MGEN: 117223447
NMEA: 116426113
CGIG: 122402622
SOC: 105195554
MPHA: 105840617
AEC: 105150186
ACEP: 105618310
PBAR: 105426206
VEM: 105569711
HST: 105181094
DQU: 106743443
CFO: 105250081
FEX: 115234407
LHU: 105673912
PGC: 109863770
OBO: 105280103
PCF: 106784291
PFUC: 122520621
NVI: 100117094
CSOL: 105361542
TPRE: 106658451
MDL: 103578390
FAS: 105270176
DAM: 107048650
CCIN: 107263896
TCA: 660348
DPA: 109544935
ATD: 109595277
AGB: 108906123
LDC: 111504364
NVL: 108567762
APLN: 108733110
PPYR: 116168817
OTU: 111415796
BMOR: 101744563
MSEX: 115442955
BANY: 112048167
PMAC: 106719950
PPOT: 106101603
PXU: 106121615
PRAP: 110991381
ZCE: 119832883
HAW: 110378751
TNL: 113495593
PXY: 105397344
API: 100159102
DNX: 107163234
AGS: 114125796
RMD: 113548798
BTAB: 109030649
CLEC: 106662859
HHAL: 106683832
NLU: 111054941
FOC: 113218210
ZNE: 110837839
FCD: 110844108
DMK: 116930195
PVM: 113809605
HAME: 121861033
HAZT: 108677926
DSV: 119435525
RSAN: 119401323
RMP: 119163988
VDE: 111243985
VJA: 111262704
DPTE: 113793158
CSCU: 111635823
PTEP: 107453142
SDM: 118187866
PCAN: 112570001
BGT: 106055341
GAE: 121371138
CRG: 105337850
MYI: 110440574
PMAX: 117323184
OBI: 106874910
OSN: 115209398
NVE: 5508018
EPA: 110247170
ATEN: 116308392
AMIL: 114966681
PDAM: 113668546
SPIS: 111319149
LJA: Lj1g3v2095610.1(Lj1g3v2095610.1) Lj2g3v1495070.1(Lj2g3v1495070.1) Lj4g3v1107900.1(Lj4g3v1107900.1) Lj4g3v1477230.1(Lj4g3v1477230.1) Lj4g3v1882000.1(Lj4g3v1882000.1) Lj4g3v1882000.2(Lj4g3v1882000.2) Lj4g3v1882010.1(Lj4g3v1882010.1) Lj5g3v2063140.2(Lj5g3v2063140.2)
DOSA: Os02t0466400-01(Os02g0466400) Os03t0230500-01(Os03g0230500) Os03t0726200-01(Os03g0726200) Os09t0518700-01(Os09g0518700) Os10t0103800-01(Os10g0103800) Os10t0576100-01(Os10g0576100)
APRO: F751_4717
DDI: DDB_G0269746(ITPK1)
DFA: DFA_02662(ITPK1)
EHI: EHI_042120(11.t00022) EHI_100310(151.t00008)
SPAR: SPRG_04523
 » show all
Reference
1  [PMID:8662638]
  Authors
Wilson MP, Majerus PW
  Title
Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme.
  Journal
J Biol Chem 271:11904-10 (1996)
DOI:10.1074/jbc.271.20.11904
  Sequence
[bta:518488]
Reference
2  [PMID:15531582]
  Authors
Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW
  Title
The pathway for the production of inositol hexakisphosphate in human cells.
  Journal
J Biol Chem 280:1911-20 (2005)
DOI:10.1074/jbc.M411528200
Reference
3  [PMID:15837423]
  Authors
Miller GJ, Wilson MP, Majerus PW, Hurley JH.
  Title
Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase.
  Journal
Mol Cell 18:201-12 (2005)
DOI:10.1016/j.molcel.2005.03.016
  Sequence
[ehi:EHI_100310] [hsa:3705]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.159
IUBMB Enzyme Nomenclature: 2.7.1.159
ExPASy - ENZYME nomenclature database: 2.7.1.159
BRENDA, the Enzyme Database: 2.7.1.159
CAS: 288307-53-9

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