KEGG   ENZYME: 2.7.1.203
Entry
EC 2.7.1.203                Enzyme                                 
Name
protein-Npi-phosphohistidine---D-glucosaminate phosphotransferase;
dgaABCD (gene names);
2-amino-2-deoxy-D-gluconate PTS permease
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
protein-Npi-phospho-L-histidine:2-amino-2-deoxy-D-gluconate Npi-phosphotransferase
Reaction(IUBMB)
[protein]-Npi-phospho-L-histidine + 2-amino-2-deoxy-D-gluconate[side 1] = [protein]-L-histidine + 2-amino-2-deoxy-D-gluconate 6-phosphate[side 2] [RN:R10407]
Reaction(KEGG)
R10407
Substrate
[protein]-Npi-phospho-L-histidine [CPD:C04261];
2-amino-2-deoxy-D-gluconate[side 1] [CPD:C03752]
Product
[protein]-L-histidine [CPD:C00615];
2-amino-2-deoxy-D-gluconate 6-phosphate[side 2] [CPD:C20589]
Comment
This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
History
EC 2.7.1.203 created 1972 as EC 2.7.1.69, part transferred 2016 to EC 2.7.1.203
Pathway
ec00030  Pentose phosphate pathway
ec01120  Microbial metabolism in diverse environments
Orthology
K17464  D-glucosaminate PTS system EIIA component
K17465  D-glucosaminate PTS system EIIB component
Genes
EOIECO111_3681 ECO111_3682
EOJECO26_4032 ECO26_4033
ECWEcE24377A_3276 EcE24377A_3277
ECVAPECO1_2997 APECO1_2998
ECRECIAI1_3066 ECIAI1_3067
ECIUTI89_C3970 UTI89_C3971
EIHECOK1_3884
ECZECS88_3858 ECS88_3859
ELUUM146_17400 UM146_17405
ECOIECOPMV1_03775(manX_5) ECOPMV1_03776(manX_6)
EALEAKF1_ch2499c EAKF1_ch2500c
EMAC1192_15205 C1192_15210
STYSTY4013 STY4014
STTt3746 t3747
SEXSTBHUCCB_39480 STBHUCCB_39490
SENTTY21A_19000 TY21A_19005
STMSTM3771 STM3772
SEOSTM14_4547 STM14_4548
SEVSTMMW_37601 STMMW_37611
SEYSL1344_3736 SL1344_3737
SEMSTMDT12_C38280 STMDT12_C38290
SEJSTMUK_3757 STMUK_3758
SEBSTM474_3945 STM474_3946
SEFUMN798_4099 UMN798_4100
SETUSTU288_19055 STU288_19060
SETCCFSAN001921_21585 CFSAN001921_21590
SENRSTMDT2_36541 STMDT2_36551
SENDDT104_37551 DT104_37561
SENICY43_19560 CY43_19565
SEENSE451236_02055 SE451236_02060
SPTSPA3621 SPA3622
SEKSSPA3383 SSPA3384
SPQSPAB_04687 SPAB_04688
SEISPC_3850 SPC_3851
SECSCH_3691(ptfB) SCH_3692
SEHSeHA_C4101 SeHA_C4102
SHBSU5_04247 SU5_04248
SENHCFSAN002069_13175 CFSAN002069_13180
SEEHSEEH1578_05005 SEEH1578_05010
SEESNSL254_A4050 SNSL254_A4051
SENNSN31241_1070 SN31241_1080
SEWSeSA_A3978 SeSA_A3979
SEASeAg_B3996 SeAg_B3997
SENSQ786_18480 Q786_18485
SEDSeD_A4164 SeD_A4165
SEGSG3656 SG3657
SELSPUL_3790 SPUL_3791
SEGASPUCDC_3776 SPUCDC_3777
SETSEN3593 SEN3594
SENAAU38_18345 AU38_18350
SENOAU37_18535 AU37_18540
SENVAU39_18540 AU39_18545
SENQAU40_20670 AU40_20675
SENLIY59_18980 IY59_18985
SENJCFSAN001992_14785 CFSAN001992_14790
SEECCFSAN002050_01760 CFSAN002050_01765
SEEBSEEB0189_001020 SEEB0189_001025
SEEPI137_18190 I137_18195
SENBBN855_38630 BN855_38640
SENEIA1_18315 IA1_18320
SENCSEET0819_02675 SEET0819_02680
SBGSBG_3343 SBG_3344
SBZA464_3842 A464_3843
SBVN643_16640 N643_16645
SALZEOS98_00335 EOS98_00340
KPYKPNIH31_18240 KPNIH31_18245
KOXKOX_02420 KOX_02425
KOEA225_4922 A225_4923
KOYJ415_07360 J415_07365
KOMHR38_00785 HR38_00790
KOKKONIH1_24755 KONIH1_24760
KOCAB185_11700 AB185_11705
EAEEAE_10140 EAE_10145
EARCCG31961 CCG31962
KLLBJF97_24605 BJF97_24610
KLWDA718_04740 DA718_04745
KGRJJJ10_04755 JJJ10_04760
RAODSD31_22465 DSD31_22470
RTGNCTC13098_03935(manX_7) NCTC13098_03936(manX_8) NCTC13098_06470 NCTC13098_06471(levE)
REEelectrica_04414 electrica_04415(levE)
CKOCKO_05131 CKO_05132
CFDCFNIH1_06355 CFNIH1_06360
CBRAA6J81_17515 A6J81_17520
CWECO701_22375 CO701_22380
CYOCD187_00250 CD187_00255
CPOTFOB25_11655 FOB25_11660
CSEDJY391_00250 JY391_00255
CAMAF384_19960 F384_19965
CAFAL524_02745 AL524_02750
CIFAL515_01055 AL515_01060
CFARCI104_00295 CI104_00300
CIRC2U53_09400 C2U53_09405
CIEAN232_04660 AN232_04665
CPARCUC49_18970 CUC49_18975
CTELGBC03_04065 GBC03_04070
CARSE1B03_25895 E1B03_25900
CEMLH23_01840 LH23_01845
CENLH86_01835 LH86_01840
ESCEntcl_3811 Entcl_3812
KLEAO703_02845 AO703_02850
YREHEC60_20740 HEC60_20745
SFWWN53_22590 WN53_22595
SFGAV650_18420 AV650_18425
SOFNCTC11214_04106 NCTC11214_04107(levE)
SGLSG2426 SG2427
SODSant_0067 Sant_0068
HAVAT03_07685 AT03_07690
HPARAL518_17880 AL518_17885
OPODSM2777_12975 DSM2777_12980
PRAGEKN56_11355 EKN56_11360
ORBIPMB12_08385 IPMB12_08390 IPMB12_11185
JEUBJP62_06010 BJP62_06015
DMADMR_25820
DCBC3Y92_11925
PMASNCF86_16805 NCF86_16810
VIRX953_16400 X953_16405
LPAABHS01_08870
LAWLACWKB8_0071 LACWKB8_1712
LKLDKL58_02470 DKL58_08925
LHSDLD54_00345 DLD54_08120
LCZLCAZH_2764
LCSLCBD_0390 LCBD_0415 LCBD_0416 LCBD_2951
LCELC2W_0385 LC2W_0410 LC2W_0411 LC2W_2925
LCWBN194_03940 BN194_04200(manX) BN194_04210(manX_2) BN194_28660(levE_5)
LCLLOCK919_0433 LOCK919_3015
LPILBPG_01356
LCBLCABL_04120(ptnA) LCABL_04130(ptfB)
LCXLCA12A_0450
LACALAC1533_2217
LHOLOOC260_108700
EFAEF2979 EF2980
EFLEF62_0065(mopB) EF62_0066(mopA)
EFIOG1RF_12261 OG1RF_12262
EFDEFD32_2559 EFD32_2560
EFSEFS1_2414 EFS1_2415
EFNDENG_02865(manX) DENG_02866(manX)
EFQDR75_1709 DR75_1710
ENEENT_27240 ENT_27250
EGAAL523_14025
EGVEGCR1_00400 EGCR1_00405 EGCR1_06920
EAVEH197_04875 EH197_05755 EH197_13405 EH197_13430 EH197_20170 EH197_22810
ERAFJ9537_02295 J9537_02300 J9537_17040
TOOC7K38_07815
AURHMPREF9243_0281
AUNAWM73_08030
ABAECL176_01980
MARRBKP56_11400
GFEGferi_12420
CSHClosa_1940
ARFAR1Y2_0100 AR1Y2_0199 AR1Y2_0228 AR1Y2_0500 AR1Y2_0556 AR1Y2_0557 AR1Y2_0584 AR1Y2_1427 AR1Y2_2500 AR1Y2_3267 AR1Y2_3371 AR1Y2_3428
ACACEYQ97_00595 EYQ97_01005 EYQ97_01475 EYQ97_08030 EYQ97_11065 EYQ97_13895 EYQ97_14100 EYQ97_14110 EYQ97_15510 EYQ97_16525
CBOLCGC65_04935
CDFCD630_02860 CD630_02870
PDCCDIF630_00410 CDIF630_00411 CDIF630_00621
CDCCD196_0302 CD196_0303 CD196_0449
CDLCDR20291_0289 CDR20291_0290 CDR20291_0435
PDFCD630DERM_02860 CD630DERM_02870 CD630DERM_04920
TTETTE0193
TEXTeth514_0135
THXThet_0171
TPDTeth39_2067
TITThit_0168
TMTTmath_0225
TBOThebr_2112
TWIThewi_1906 Thewi_1910 Thewi_2122
TTMTthe_1735 Tthe_2469
TXYThexy_0798
TSHTsac_2503
TEPTepRe1_1694 TepRe1_1698 TepRe1_2538
TAETepiRe1_1826 TepiRe1_1830 TepiRe1_1831 TepiRe1_2736
TOCToce_0295 Toce_1900 Toce_1904
KMEH0A61_00398(sorB)
SPOAEQM13_03010 EQM13_03935 EQM13_06690 EQM13_09900 EQM13_11945 EQM13_14140 EQM13_14145
PUFUFO1_0311
PFTJBW_03181 JBW_03182 JBW_04324
ERDG7062_03590 G7062_03625
EIOH9L01_05360
CIUG4D55_00860 G4D55_00895 G4D55_02060 G4D55_02265 G4D55_03155 G4D55_08505 G4D55_17265 G4D55_18945 G4D55_19060 G4D55_19320 G4D55_19715 G4D55_20465
LCGL3BBH23_01770
ERBA4V01_00185 A4V01_00635 A4V01_01190 A4V01_02605 A4V01_02640 A4V01_03885 A4V01_04100 A4V01_04820 A4V01_09745 A4V01_21605 A4V01_21685
SGMGCM10017557_25720
TIOINP52_09200
CGOCorgl_1551
STRSterm_0951 Sterm_3205 Sterm_3206 Sterm_3863 Sterm_3864
GGRHKW67_06895
CPOCOPRO5265_1192
TMGUS01_C0001G0873
 » show all
Reference
1  [PMID:23836865]
  Authors
Miller KA, Phillips RS, Mrazek J, Hoover TR
  Title
Salmonella utilizes D-glucosaminate via a mannose family phosphotransferase system permease and associated enzymes.
  Journal
J Bacteriol 195:4057-66 (2013)
DOI:10.1128/JB.00290-13
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.203
IUBMB Enzyme Nomenclature: 2.7.1.203
ExPASy - ENZYME nomenclature database: 2.7.1.203
BRENDA, the Enzyme Database: 2.7.1.203

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