KEGG   ENZYME: 2.7.1.206
Entry
EC 2.7.1.206                Enzyme                                 
Name
protein-Npi-phosphohistidine---L-sorbose phosphotransferase;
sorABFM (gene names);
L-sorbose PTS permease;
EIISor;
Enzyme IISor
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
protein-Npi-phospho-L-histidine:L-sorbose Npi-phosphotransferase
Reaction(IUBMB)
[protein]-Npi-phospho-L-histidine + L-sorbose[side 1] = [protein]-L-histidine + L-sorbose 1-phosphate[side 2] [RN:R04076]
Reaction(KEGG)
R04076
Substrate
[protein]-Npi-phospho-L-histidine [CPD:C04261];
L-sorbose[side 1] [CPD:C00247]
Product
[protein]-L-histidine [CPD:C00615];
L-sorbose 1-phosphate[side 2] [CPD:C02888]
Comment
This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
History
EC 2.7.1.206 created 1972 as EC 2.7.1.69, part transferred 2016 to EC 2.7.1.206
Pathway
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
Orthology
K02812  sorbose PTS system EIIA component
K02813  sorbose PTS system EIIB component
Genes
ECEZ5616 Z5617
ECSECs_5001(sorB) ECs_5002(sorF)
ECFECH74115_5497
ETWECSP_5094 ECSP_5095
ELXCDCO157_4684 CDCO157_4685
EOIECO111_4837 ECO111_4838
EOJECO26_5130 ECO26_5131
ECOOECRM13514_5147 ECRM13514_5148
ECOHECRM13516_4884 ECRM13516_4885
ECGE2348C_4333 E2348C_4334
EOKG2583_4843(sorB) G2583_4844(sorF)
ELRECO55CA74_23170 ECO55CA74_23175
EUNUMNK88_4870 UMNK88_4871
ECPECP_4236 ECP_4237
ENAECNA114_4174 ECNA114_4175
ECOSEC958_4473 EC958_4474
ECVAPECO1_2449 APECO1_2450
ECOAAPECO78_00875 APECO78_00880
ECMEcSMS35_4479 EcSMS35_4480
ECQECED1_4733 ECED1_4734
EUMECUMN_4551 ECUMN_4552
ECTECIAI39_4415 ECIAI39_4416
EOCCE10_4707(sorB) CE10_4708
ECIUTI89_C4586 UTI89_C4587
EIHECOK1_4503 ECOK1_4504
ECZECS88_4491 ECS88_4492
ECCc4984 c4985
ELOEC042_4387(sorB) EC042_4388(sorF)
ELNNRG857_20075 NRG857_20080
ESEECSF_3875 ECSF_3876
EABECABU_c45410 ECABU_c45420
ELUUM146_20205 UM146_20210
ELCi14_4573 i14_4574
ELDi02_4573 i02_4574
ELFLF82_635 LF82_636
ECOIECOPMV1_04398(sorB) ECOPMV1_04399(manX_7)
ECOJP423_22300 P423_22305
EFEEFER_4080 EFER_4081
EALEAKF1_ch1894 EAKF1_ch1895(manX)
EMAC1192_18410 C1192_18415
ESZFEM44_11860 FEM44_11865
SFLSF4091(sorB) SF4092(sorF)
SFXS3638(sorF) S3639(sorB)
SFVSFV_4096(sorB) SFV_4097(sorF)
SFESFxv_4461 SFxv_4462
SFNSFy_5869 SFy_5870
SFSSFyv_5936 SFyv_5937
SFTNCTC1_04447(sorB) NCTC1_04448(manX_4)
SSNSSON_4197(sorF)
SBOSBO_4046(sorB) SBO_4047(sorF)
SBCSbBS512_E4522
ENFAKI40_0087
KPNKPN_04405(manX) KPN_04406(manX)
KPMKPHS_02390 KPHS_02400
KPHKPNIH24_01310 KPNIH24_01315
KPWKPNIH30_01340 KPNIH30_01345
KPYKPNIH31_01340 KPNIH31_01345
KPGKPNIH32_01345 KPNIH32_01350
KPCKPNIH10_01305 KPNIH10_01310
KPQKPR0928_01310 KPR0928_01315
KPTVK055_3068 VK055_3069(manX2)
KPOKPN2242_00065 KPN2242_00070
KPRKPR_0387(sorA)
KPJN559_4895 N559_4896
KPID364_22435 D364_22440
KPAKPNJ1_05187 KPNJ1_05188
KPSKPNJ2_05185 KPNJ2_05186
KPNEKU54_025385 KU54_025390
KPNULI86_25225 LI86_25230
KPNKBN49_5027(sorF) BN49_5028(sorB)
KVAKvar_4840 Kvar_4841
KPEKPK_5268(sorF) KPK_5269(sorB)
KPKA593_12115 A593_12120
KVDKR75_09555 KR75_09560
KVQSP68_16145 SP68_16150
KOXKOX_08110 KOX_08115
KOEA225_0286 A225_0287
KOYJ415_01630 J415_01635
KOMHR38_06785 HR38_06790
KOKKONIH1_01650 KONIH1_01655
KOCAB185_05475 AB185_05480
KQVB8P98_26195 B8P98_26200
KLLBJF97_01500 BJF97_01505
KLWDA718_27650 DA718_27655
KARLGL98_23640 LGL98_23645
KGRJJJ10_26115 JJJ10_26120
RORRORB6_17415 RORB6_17420
RONTE10_03640 TE10_03645
RPLNB1209_25500
RAODSD31_24325 DSD31_24330
RTGNCTC13098_06890(manX_11) NCTC13098_06892(sorB_2)
REEelectrica_04781(manX_4) electrica_04782(sorB)
CBRAA6J81_15555 A6J81_15560
CYOCD187_22505 CD187_22510
CPOTFOB25_09780 FOB25_09785
CAMAF384_22140 F384_22145
CAFAL524_04920 AL524_04925
CIFAL515_02795 AL515_02800
CFARCI104_23545 CI104_23550
CIRC2U53_11505 C2U53_11510
CPARCUC49_20795 CUC49_20800
CTELGBC03_06365 GBC03_06370
CITZE4Z61_15570 E4Z61_15575
CENLH86_06510 LH86_06515
KINAB182_23575 AB182_23580
PSGCG163CM_32910(sorF) G163CM_32920(sorB)
EBFD782_4247 D782_4248
YENYE0813(sorB) YE0814(sorF)
YEPYE105_C0701 YE105_C0702
YEYY11_22381 Y11_22391
YELLC20_04325 LC20_04326
YEWCH47_2673 CH47_2674(sorB)
YETCH48_2517(sorB) CH48_2518
YEFFORC2_3284 FORC2_3285
YEEYE5303_25211(sorF) YE5303_25221(sorB)
YFRAW19_13(sorB) AW19_14
YINCH53_867 CH53_868(sorB)
YKRCH54_1648 CH54_1649
YMADA391_17835 DA391_17840
YHID5F51_14890 D5F51_14895
YCAF0T03_04675 F0T03_04680
YMOHRD69_09890 HRD69_09895
YASN0H69_04405 N0H69_04410
GQUAWC35_15440 AWC35_15445
GAPGAPWK_0307 GAPWK_0308
PACEA6070_08410
DESDSOUD_1307
DVMDvMF_0422
BMURABE28_013770
ACURJZ785_23080
STKSTP_1527
SPATA0O21_09945 A0O21_09950
SCHJDDV21_000310 DDV21_000315
LAWLACWKB8_0333 LACWKB8_0334
LHSDLD54_01590 DLD54_01595
LCSLCBD_0428 LCBD_0429
LCELC2W_0423 LC2W_0424
LCWBN194_04330(levD) BN194_04340(sorB)
LCBLCABL_04250(sorA) LCABL_04260(sorB)
LRLLC705_00408(sorA) LC705_00409(sorB)
LRALRHK_421 LRHK_422(sorB)
LROLOCK900_0394 LOCK900_0395
LRCLOCK908_0415 LOCK908_0416
LNGBSQ50_04820 BSQ50_04825
LMALLM596_09975 LM596_09980
BFPMOO45_04310 MOO45_04315
EGVEGCR1_11510 EGCR1_11515
EAVEH197_22890 EH197_22895
ERAFJ9537_13590 J9537_13595
TKRC7K43_01675
ACGAWM71_03595
CBKCLL_A3359
CBEILF65_05130
CPASClopa_1339 Clopa_1340
CPATCLPA_c28990(sorB) CLPA_c29000
CPAECPAST_c28990(sorB) CPAST_c29000
CDYF3K33_23370
BPRLCL2_07370 CL2_07380
TTOThethe_01741
APRApre_0157
ERLAOC36_10705
PSUBPelsub_P0901
STRSterm_1992 Sterm_1993
 » show all
Reference
1  [PMID:7700234]
  Authors
Wehmeier UF, Wohrl BM, Lengeler JW
  Title
Molecular analysis of the phosphoenolpyruvate-dependent L-sorbose: phosphotransferase system from Klebsiella pneumoniae and of its multidomain structure.
  Journal
Mol Gen Genet 246:610-8 (1995)
DOI:10.1007/bf00298968
  Sequence
Reference
2  [PMID:10613875]
  Authors
Yebra MJ, Veyrat A, Santos MA, Perez-Martinez G
  Title
Genetics of L-sorbose transport and metabolism in Lactobacillus casei.
  Journal
J Bacteriol 182:155-63 (2000)
DOI:10.1128/JB.182.1.155-163.2000
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.206
IUBMB Enzyme Nomenclature: 2.7.1.206
ExPASy - ENZYME nomenclature database: 2.7.1.206
BRENDA, the Enzyme Database: 2.7.1.206

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