KEGG   ENZYME: 2.7.1.214
Entry
EC 2.7.1.214                Enzyme                                 
Name
C7-cyclitol 7-kinase;
valC (gene name);
vldC (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:C7-cyclitol 7-phosphotransferase
Reaction(IUBMB)
(1) ATP + valienone = ADP + valienone 7-phosphate [RN:R11234];
(2) ATP + validone = ADP + validone 7-phosphate [RN:R11406]
Reaction(KEGG)
R11234 R11406
Substrate
ATP [CPD:C00002];
valienone [CPD:C17696];
validone [CPD:C21371]
Product
ADP [CPD:C00008];
valienone 7-phosphate [CPD:C17697];
validone 7-phosphate [CPD:C21218]
Comment
The enzyme, characterized from the bacterium Streptomyces hygroscopicus var. jinggangensis, is involved in the biosynthesis of the antifungal agent validamycin A.
History
EC 2.7.1.214 created 2016
Pathway
ec00525  Acarbose and validamycin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K20433  C7-cyclitol 7-kinase
Genes
PAEWKIH87_05095
CJACJA_3253
SURSTAUR_1374(gacM)
SHYSHJG_0278
SHOSHJGH_0112
SGUSGLAU_01045(gacM)
SNQCP978_00080
SSPODDQ41_30755
SGFHEP81_06980
Reference
1  [PMID:17335096]
  Authors
Minagawa K, Zhang Y, Ito T, Bai L, Deng Z, Mahmud T
  Title
ValC, a new type of C7-Cyclitol kinase involved in the biosynthesis of the antifungal agent validamycin A.
  Journal
Chembiochem 8:632-41 (2007)
DOI:10.1002/cbic.200600528
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.214
IUBMB Enzyme Nomenclature: 2.7.1.214
ExPASy - ENZYME nomenclature database: 2.7.1.214
BRENDA, the Enzyme Database: 2.7.1.214

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